Fisetin

What Is Fisetin?

Fisetin is a bioactive flavonoid with powerful antioxidant, anti-inflammatory, and neuroprotective properties, with the CAS number 528-48-3, a molecular formula of C15H10O6, and a molecular weight of 286.24 g/mol. Found naturally in strawberries, apples, grapes, and onions, this compound has gained attention for its potential to support brain health, promote cellular longevity, and act as a senolytic—helping to clear out aging cells.

Research suggests it may enhance cognitive function, cardiovascular health, and metabolic balance, making it a promising ingredient in nootropic and anti-aging supplements. It typically appears as a yellow crystalline powder and is poorly soluble in water but dissolves well in organic solvents. It is often formulated into capsules, tablets, and functional beverages to improve bioavailability. It is commonly marketed as powder and packaged in airtight, light-resistant containers to maintain potency. It is a key ingredient in brain-boosting, longevity, and antioxidant-support formulations.

공통 소스

• Foods rich in Fisetin

It is a naturally occurring plant flavonoid compound that is widely distributed in various fruits, vegetables, and plants. Among natural sources, strawberries are known to contain the highest levels, making them one of the most important dietary sources of this compound.

In addition, common fruits and vegetables such as apples, grapes, onions, cucumbers, persimmons, and mangoes also contain certain amounts of fisetin. Although the content is relatively lower, they still contribute nutritional value.

Beyond these food sources, Ginkgo biloba leaves are another rich source of fisetin, particularly favored in the nutritional supplement raw material market. Ginkgo leaves not only contain a higher concentration of fisetin but also allow for easier standardized extraction, making them a preferred raw material for commercial fisetin supplement production.

Overall, the abundance of natural sources provides a solid foundation for the development and application of fisetin in functional foods and dietary supplements.

What Does Fisetin Do?

One of this compound’s primary mechanisms of action is its potent antioxidant activity. It can scavenge free radicals and reactive oxygen species (ROS), protecting cellular components such as lipids, proteins, and DNA from oxidative damage. Additionally, it has been shown to enhance the activity of endogenous antioxidant systems. It can increase the expression of antioxidant enzymes like superoxide dismutase (SOD), catalase, and glutathione peroxidase through the activation of the Nrf2 (Nuclear factor erythroid 2-related factor 2) pathway. This dual action of direct scavenging and enhancement of endogenous antioxidant systems makes this compound a powerful tool in combating oxidative stress.

The compound also exhibits anti-inflammatory properties through multiple pathways. It has been shown to inhibit the activation of NF-κB (Nuclear Factor kappa-light-chain-enhancer of activated B cells), a key transcription factor involved in inflammatory responses. By suppressing NF-κB activation, it can reduce the production of pro-inflammatory cytokines and enzymes such as TNF-α, IL-6, and COX-2. Furthermore, it has been observed to modulate the activity of various inflammatory mediators, including mitogen-activated protein kinases (MAPKs) and cyclooxygenases. These anti-inflammatory actions contribute to the potential of this ingredient in addressing inflammation-related conditions.

Another significant mechanism of action of this ingredient is its ability to modulate cellular senescence and promote longevity pathways. It has been identified as a senolytic compound, meaning it can selectively induce apoptosis in senescent cells. Senescent cells are aged cells that have stopped dividing but remain metabolically active, often secreting pro-inflammatory factors contributing to age-related decline. Reducing the burden of senescent cells may help mitigate age-related tissue dysfunction. Additionally, it has been shown to activate SIRT1 (Sirtuin 1), a protein deacetylase involved in regulating cellular stress responses, metabolism, and longevity. This activation of SIRT1 by fisetin may contribute to its potential anti-aging effects.

How to Extract Fisetin Powder?

1. Initial Material Selection: The production of this ingredient begins with the selection of high-purity plant-based raw materials, primarily derived from natural sources like Rhus succedanea (wax tree) or Cotinus coggygria (smoke tree). These botanical sources undergo extensive quality testing, including active compound quantification (≥98% purity), heavy metal screening, and microbial contamination analysis. Ensuring the raw material’s high flavonoid content is crucial to optimizing the yield and potency of the compound during extraction.
2. Extraction Process: Solvent extraction is the primary method of obtaining the ingredient. This process involves ethanol or other food-grade solvents to isolate the flavonoid selectively from plant materials. The extraction process operates under controlled conditions, including a temperature range of 40-60°C and specific solvent-to-material ratios to maximize the compound’s yield while preventing degradation. Advanced ultrasonic or supercritical CO₂ extraction techniques may also be applied to enhance efficiency and purity.
3. Purification Phase: The crude extract undergoes multiple purification steps to isolate the compound with high purity. Filtration and centrifugation remove plant residues, while advanced chromatographic techniques, such as high-performance liquid chromatography (HPLC) or preparative column chromatography, further refine the product. Crystallization is employed under precisely controlled temperature and solvent conditions to ensure uniform particle formation. Optical analysis and purity verification confirm that only the highest-quality fisetin powder progresses to the final stages.
4. Drying and Crystallization: The purified powder undergoes specialized drying techniques, such as spray drying or vacuum drying, to maintain stability and prevent oxidation. Controlled crystallization follows, ensuring uniform particle size distribution and optimal solubility. Strict environmental controls, including low humidity and minimal light exposure, protect the extracted ingredient from degradation and maintain its biological activity.
5. Quality Control and Packaging: The final product undergoes comprehensive testing, including HPLC purity analysis, moisture content verification (≤0.5%), and heavy metal screening. Additional tests include residual solvent analysis, microbial contamination assessment, and particle size distribution evaluation. Once validated, the extracted compound is nitrogen-flush packaged in high-barrier, moisture-resistant containers with desiccant packs to prevent degradation. Recommended storage conditions include temperatures below 25°C and controlled humidity below 40%, ensuring a shelf life of up to 36 months.

사양서 참조

Fisetin: Benefits, Side Effects, And More

For skin

• 항산화 보호: It neutralizes free radicals, reducing oxidative stress and preventing premature skin aging.
• Anti-inflammatory Effects: It decreases inflammation, helping reduce redness, swelling, acne, and eczema.
• Collagen Production: It may boost collagen synthesis, thus preventing the skin from having wrinkles and fine lines. It also enhances the skin’s elasticity.

For bone

• Bone Density Maintenance: Fisetin helps maintain bone density by stimulating bone formation.
• 항염증 특성: By reducing inflammation, it may aid in managing arthritis and osteoporosis.
• Oxidative Stress Reduction: It protects bone cells from oxidative damage, supporting overall bone health and strength.

For brain

• Neuroprotection: Fisetin promotes neuron survival and growth, protecting against neurodegenerative diseases.
• Cognitive Function: It enhances synaptic plasticity, which is crucial for learning and memory and potentially improving cognitive abilities.
• Anti-inflammatory and Antioxidant Effects: These properties reduce brain inflammation and oxidative stress, lowering the risk of Alzheimer’s and Parkinson’s diseases.

For weight loss

• Metabolic Regulation: It improves metabolism by modulating pathways that control fat storage and energy use.
• Anti-inflammatory Effects: Reducing inflammation supports better insulin sensitivity, aiding in weight management.
• Fat Oxidation: This ingredient is believed to aid in weight loss by reducing body fat.

More healthy benefits of Fisetin

• Anti-Cancer Properties: It fights cancer by causing cancer cells to die, slowing tumor growth, and reducing the spread of cancer.
• Immune System Support: It may boost immune function by regulating immune cell activity and decreasing chronic inflammation.
• Diabetes Management: It can enhance insulin sensitivity and lower blood sugar levels, helping to manage diabetes.

Side Effects: Is Fisetin Safe?

Fisetin is generally safe for most people when taken at recommended doses. Short-term use is typically well-tolerated, with no severe adverse effects reported in human studies. However, some individuals may experience minor side effects, including:

• • Gastrointestinal discomfort: This ingredient may cause nausea, diarrhea, or stomach cramps.
  • Allergic reactions: Though rare, Fisetin may cause rashes or itching.
  • Headache: Some users might experience mild headaches.

FDA Approval: Is Fisetin Legal?

• 미국(FDA): Classified as a dietary supplement ingredient.
• European Union (EFSA): Recognized as a natural flavonoid with safe consumption levels.
• Canada (Health Canada): Permitted under the natural health product category.
• Australia (TGA): Allowed in complementary medicine formulations.

What Is Fisetin Powder Used For?

1. 인지 향상: Supports brain function and memory retention.
2. Longevity & Cellular Health: Aids in removing aging cells.
3. Inflammation Reduction: Helps manage chronic inflammatory conditions.

Dosage Recommendation For Fisetin

The appropriate dosage of Fisetin depends on its intended application, formulation, and individual requirements. As a flavonoid known for its antioxidant and senolytic properties, it is commonly used in supplements targeting cognitive health, anti-aging, and cellular protection.

• Cognitive and Neuroprotection Support: A typical dosage ranges from 100-300 mg per day to promote brain health and cognitive function.
• Anti-Aging and Cellular Senescence: For cellular health and senolytic effects, doses between 300-500 mg daily are commonly used in short-term supplementation protocols.
• General Antioxidant Support: A maintenance dose of 100-200 mg per day may assist in reducing oxidative stress and supporting overall health.

How To Store Fisetin Powder?

It should be stored in a cool, dry place, away from direct sunlight and heat. It should be kept in an airtight container to protect it from moisture and air. The storage area should be free from strong odors and chemicals that might contaminate the product.

Ideally, this ingredient should be kept at room temperature. For long-term storage, refrigeration is recommended to maintain its stability and potency.

Fisetin VS Quercetin VS Apigenin VS Resveratrol VS Spermidine

퀘르세틴 is a flavonoid widely found in fruits and vegetables. It has antioxidant, anti-inflammatory, and neuroprotective effects. Research shows that quercetin may help lower blood pressure, increase endurance in athletes, and reduce inflammation. Therefore, adding this ingredient to sports supplements may cause users to experience increased energy and vitality.

Fisetin has attracted attention primarily for its anti-aging activity in cell culture. Therefore, skin care products, anti-aging supplements, and even brain health supplements are better candidates for this ingredient.

In one study, Fisetin, 아피제닌, and Nobiletin were the strongest inhibitors. They inhibit the production of IL-4 and IL-13 by basophils activated by anti-IgE antibodies but do not affect the synthesis of leukotriene C4. It suggests that the three have potentially similar anti-inflammatory effects.

Resveratrol is also a type of flavonoid compound. Like Fisetin, it also has obvious antioxidants, anti-inflammatory, and cardiovascular health benefits. However, Fisetin may also show antiproliferative properties against several cancers. It can inhibit the growth of tumor cells and may have potential value in cancer prevention and treatment.

Unlike flavonoids, Spermidine is a polyamine found in a variety of organisms. It is present in low amounts in food. Therefore, it needs to be taken through specific nutritional supplements. Spermidine has also been linked to anti-aging. It primarily extends the lifespan of yeast, nematodes, and fruit flies through autophagy. It also has anti-inflammatory properties. However, Fisetin’s research and effects are more obvious in this regard, including neuroprotection and cardiovascular health.

결론

In conclusion, fisetin presents a promising opportunity for manufacturers in the nutraceutical and cosmeceutical industries. As a flavonoid with potent antioxidant properties, fisetin offers significant potential for product development in various sectors, including dietary supplements, functional foods, and anti-aging skincare formulations. What is fisetin in terms of its manufacturing implications? It’s a compound that requires careful consideration of sourcing, extraction methods, and formulation techniques to maximize its bioavailability and stability in finished products.

Manufacturers should be aware of the challenges associated with fisetin powder, such as its limited solubility in water and potential sensitivity to light and heat, which may impact product development and packaging decisions.

The growing body of research on fisetin and its potential health benefits provides manufacturers with opportunities to create innovative, science-backed products. However, manufacturers must stay informed about the latest scientific findings and regulatory developments of this flavonoid. When working with fisetin powder, manufacturers should invest in quality control measures to ensure purity and potency and explore advanced delivery systems to enhance its bioavailability.

Additionally, considering the increasing consumer interest in natural, plant-derived ingredients, manufacturers can leverage the natural origins of fisetin in their marketing strategies while adhering to appropriate regulatory guidelines. By addressing these factors and capitalizing on the unique properties of this flavonoid, manufacturers can develop high-quality, differentiated products that meet the evolving demands of health-conscious consumers in the competitive nutraceutical and cosmeceutical markets.

Nutri Avenue Inc: Best Wholesale Fisetin Powder Supplier Globally

Nutri Avenue provides top-notch quality supplement ingredients, including amino acids, plant extracts, vitamins, and food additives, sourced and manufactured to meet the highest industry standards. Our products are FDA-registered, GMP-certified, and compliant with Halal, Kosher, and Non-GMO requirements, ensuring unmatched safety and efficacy. Every batch undergoes rigorous third-party testing to guarantee consistency, giving you confidence in product purity and potency.

We offer bulk availability at competitive wholesale prices, making high-quality ingredients accessible to businesses of all sizes. We ensure fast and efficient shipping with five USA-based warehouses, reducing supply chain disruptions and optimizing your operations. Plus, our commitment to transparency means every purchase comes with comprehensive Certificates of Analysis (COAs) and dedicated customer support.

For businesses looking to innovate, our superb OEM/ODM services provide tailored solutions for unique formulations. We also offer exclusive trademarked ingredients like Epicatelean® and NutriPQQ®, complete with detailed lab reports and free samples for evaluation. Whether expanding your product line or launching a new brand, Nutri Avenue delivers the quality, expertise, and reliability to help you succeed.

* Nutri Avenue의 모든 제품은 ISO 인증서를 제공할 수 있습니다.

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