Is L-Norvaline A Valine Isomer For Boosting Muscle Mass Growth?

L-Norvaline is a popular pre-workout ingredient known to help promote muscle mass development

Is L-Norvaline A Valine Isomer For Boosting Muscle Mass Growth?

L-Norvaline is a popular pre-workout ingredient known to help promote muscle mass development by increasing workout performance and decreasing recovery time between workouts. Many users claim that the compound helps produce more energy and prevent exhaustion. Studies also show that the compound may manage Alzheimer’s disease and other degenerative conditions affecting the brain.

L-Norvaline: The Main Muscle Mass Support Ingredient

Pre-workout formulations for athletes and bodybuilders have long contained L-Norvaline plainly on the theory that the compound effectively prolongs the bioavailability of L-arginine by inhibiting arginase production, which breaks down L-arginine. However, recent scientific studies show that although L-Norvaline may not directly be associated with protein synthesis, it has several effects on the body that can affect lean muscle mass development and overall workout performance. Many health supplements of the modern days now include L-Norvaline as among the primary ingredients as it provides many health benefits to the human body without causing certain unwanted side effects.

What is L-Norvaline?

L-Norvaline is a compound classified as a non-proteinogenic unbranched-chain amino acid. It is among the typical types of modified branched amino acids advised to be taken through health supplementation for having been studied in the last several years. It is an isomer of the valine, which plays a vital role as a bacterial metabolite. The compounds are primarily used in the formulation of dietary supplements for athletes and bodybuilders as it is believed to increase nitric oxide production in the body, improving overall workout performance. Aside from its independent effects in increasing nitric oxide levels, experts say that the compound may also promote wellness by supporting arginine levels in the body.

A significant increase in nitric oxide with L-Norvaline supplementation effectively enhances workout performance by increasing blood supply towards distal portions of the body, including muscle groups needing constant oxygen and nutrient supply. With L-Norvaline, athletes and bodybuilders may enjoy performing extraneous exercises without experiencing fatigue and exhaustion.

L-Norvaline is Norvaline; L(+)-Norvaline; L(+)-2-Aminovaleric acid,2-Aminopentanoic acid, 2-Aminopentyric acid, α-Aminopentanoic acid, and Propylglycine. It is identified as having CAS number 6600-40-4 and molecular formula C5H11NO2. The molecular weight of the compound is 117.15 g/mol.

In dietary supplement products, L-Norvaline appears as a fine white crystalline powder. It is generally soluble in water.

L-Norvaline Forms And Specifications

L-Norvaline in dietary supplement formulations comes in powder forms with a 99% purity assay based on high-performance liquid chromatography. L-Norvaline powder 99% is available at various ingredient suppliers offering services online, such as Nutriavenue.

Customers may purchase the product in bulk or lesser quantities. In bulk purchases from Nutriavenue, the compound may be packed in 25-kilogram paper drums with two layers of poly bags for added protection. May also avail other packaging options may also be availed of as per request.

Difference Between L-valine And L-Norvaline

L-valine powder is a branched-chain amino acid useful in the biosynthesis of proteins. L-Norvaline is an isomer of L-valine. Hence, although these compounds have identical molecular formulas, their structure, and atomic positions differ.

Regarding health benefits, both L-valine and L-Norvaline are known to improve musculoskeletal health. However, regarding potential effects against Alzheimer’s disease, studies on L-Norvaline benefits are more extensive than that of L-valine.

Difference Between L-Norvaline And Norvaline

L-Norvaline and Norvaline are used interchangeably to refer to the same compound. However, they differ in that L-Norvaline is a stereoisomer of Norvaline labeled as L or left-handed. The L forms of amino acids like Norvaline are the forms that are mostly used in mammals.

Foods Containing L-Norvaline

As a Valine isomer, it is believed that L-Norvaline can also be obtained from food sources of valine. Valine is found in whole grains, mushrooms, soy, cheese, and vegetables. Beef, chicken, pork, and fish are also good sources of Valine and L-Norvaline.

L-Norvaline And L-citrulline Malate

L-citrulline malate is another essential workout compound that consists of Citrulline and Malate. When taken in the human body, Citrulline is converted into L-arginine.

L-Norvaline and L-Citrulline Malate are significant compounds that raise L-arginine levels. Hence, they contribute to muscle mass development and energy production.

L-Norvaline vs Agmatine sulfate

Agmatine sulfate is a compound believed to increase Nitric Oxide. It has comparative benefits with L-Norvaline and Arginine. However, while Norvaline is converted into Arginine in the human body, Arginine is converted into Agmatine. Hence, Agmatine is a metabolite of Arginine.

L-Norvaline Safety

In recent years, it has raised concerns over the use of L-Norvaline following findings that it may cause neurodegenerative diseases and even cause mitochondrial damage with long-term use.

However, in a study published in the US National Library of Medicine National Institutes of Health dated December 17, 2019, and entitled “Reports of L-Norvaline Toxicity in Humans May Be Greatly Overstated,” it was argued that the quantities of L-Norvaline used in the study claiming its toxicity was greatly above cytotoxic levels for all amino acids.

Hence, it was concluded in the said study that as long as L-Norvaline is taken within recommended doses, it will not necessarily cause cytotoxic effects.

How Does L-Norvaline Works?

It is believed that L Norvaline Bulk Powder provides health benefits primarily by regulating Nitric Oxide levels and improving blood flow toward the bones and muscles during the performance of exercises. In effect, oxygen and nutrient supply to affected muscle regions increase, and exhaustion and fatigue are reduced. It also shortens recovery time as the muscles can receive nutrient supply efficiently.

L-Norvaline, L-Ornithine And L-Arginine Combination

The combination of L-norvaline, l-ornithine and l-arginine in dietary supplement formulations is claimed to synergize the individual effects of the compounds in promoting muscle cell growth. Also found that the said compounds may significantly help decrease cognitive decline among individual users.

L-Norvaline Benefits

The following are some of the benefits of using L-Norvaline:

  • It increases nitric oxide levels.
L-Norvaline increases nitric oxide levels

An increase in nitric oxide levels results in vasodilation or the widening of the blood vessels. Hence, blood supply towards a certain body area, specifically the muscle regions, is enhanced with increased nitric oxide levels. L-Norvaline is known to improve nitric oxide levels among individual users.

  • It is useful for bodybuilding.

The compound has long been claimed to promote muscle mass growth and development among bodybuilders and athletes. It increases nutrient and oxygen supply to muscle groups during workouts.

  • You may use it for erectile dysfunction.

Increasing nitric oxide levels with L-Norvaline supplementation is believed to help treat erectile dysfunction. It is because the compound increases blood flow toward the genitals during a sexual engagement, possibly preventing erectile dysfunction.

  • It enhances tissue regeneration.

Immediately after exercises, tissue tears and damage to the muscles are expected as a result of exhaustion. It is the reason why individuals experience pain and inflammation following workout exercises. Studies show that L-Norvaline helps enhance tissue and cell regeneration, preventing lactic acid breakdown and developing pain and inflammation. The finding has been confirmed in several animal subject studies but still needs qualitative studies on human subjects. How L-Norvaline enhances tissue regeneration has yet to be fully understood by experts.

  • It may enhance weight loss.

Although the effect is indirect, some experts claim that L-Norvaline may enhance weight loss by maximizing weight loss efforts. The compound increases blood circulation throughout muscle groups during exercises and prevents exhaustion, thus effectively prolonging workouts. Some health supplements for weight loss contain L-Norvaline for its potential effects in maximizing efforts.

  • It may treat hypercholesterolemia.

Many health experts are now developing interest in L-Norvaline for its claimed effects in treating hypercholesterolemia. Increased cholesterol levels have long been known to be associated with many disorders. Reducing cholesterol through L-Norvaline can help enhance wellness and longevity.

  • Reduced inflammation

L-Norvaline may help reduce inflammation in the body, associated with several chronic diseases, including heart disease, diabetes, and cancer.

  • Improved muscle growth and recovery

L-norvaline may support muscle growth and recovery by increasing nitric oxide production and reducing muscle damage and inflammation.

  • Improved brain function

L-Norvaline may help improve cognitive function and protect against age-related decline in brain function.

  • Antioxidant effects

Antioxidant properties of L-norvaline may aid in cellular protection and lower the risk of chronic illnesses.

  • Other Benefits

In some studies, they were established that L-Norvaline might have antihypertensive properties. Hence, it may be useful in preventing strokes and myocardial infarction brought about by vasoconstriction.

L-Norvaline Side Effects

Mild gastrointestinal symptoms such as stomach irritation, nausea, and vomiting may result from L-Norvaline supplementation. Nonetheless, these symptoms are expected to disappear eventually. In cases where these symptoms progress or other adverse symptoms develop, users should discontinue using the supplement and immediately consult a physician.

L-Norvaline Dosage

Typically, experts recommend the use of L-Norvaline at 100 to 250 mg per day. However, a physician may prescribe a different dose depending on the user’s weight, age, and overall physical condition.

Where To Buy Norvaline Powder In Bulk?

Norvaline bulk powders are available at Nutriavenue, an FDA-registered ingredient supplier that offers high-quality products at affordable prices. Our company is also recognized by entities like Halal, Kosher, and GMP.

We also offer shipping services through the air, sea, or couriers like UPS and FedEx. For more information on our products and services, contact our technical support staff when you visit our website.

You may also avail of a free quote on our page.


L-Norvaline is an effective solution for muscle development. L-Norvaline supplementation will maximize workout efforts for long-term exercise without exhaustion.

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