L-Threonate VS L-Threonine: Which One Is Better?

L-Threonate VS L-Threonine

L-Threonate VS L-Threonine: Which One Is Better?

L-Threonate and L-threonine are two different compounds often confused because of their similar names. Today, Nutri Avenue will discuss the specifics of these two ingredients in depth with the topic “L-Threonate VS L-Threonine: Which One Is Better?” I hope it helps you read this article, understand the differences between the two, and determine which ingredient is better suited for your product needs.

L-Threonate VS L-Threonine: What Are They?

What Is L-Threonate?

Threonic acid is an aldonic acid derivative in which the aldehyde group of threose is oxidized to a carboxyl group. It is also called L-Threonate. It is a metabolite of body ascorbic acid (vitamin C). One study showed that it can inhibit the expression of DKK1 in in vitro experiments and has the potential to be used to treat androgenic alopecia.

The molecular formula of L-Threonate is C4H8O5, and its molecular weight is 136.1 g/mol. The CAS number is 7306-96-9. Its market specification is generally L-Threonate 95% HPLC.

2 Common L-Threonate Derivatives

  • Calcium L-Threonate

L-ascorbic acid and calcium carbonate react with hydrogen peroxide, are concentrated, and crystallize to obtain L-calcium threonate. It is a food additive ingredient. Its appearance is white granular. It has very good water solubility and certain fat solubility. The overall absorption rate is very high.

  • Magnesium L-Threonate

After the ascorbic acid solution and hydrogen peroxide solution are mixed and reacted, hydrogen peroxide hydrolase is added. The magnesium carbonate suspension is then added to the reaction system through the external circulation mode of the reaction system. After the reaction, it is filtered and spray-dried to obtain magnesium l threonate powder. It is extremely effective in relieving anxiety and promoting sleep.

What Is L-Threonine?

Threonine was the 20th amino acid discovered. It is the last essential amino acid discovered. In 1935, W.C. Rose and Mccoy isolated and identified it from fibrin hydrolyzate (cheese). In 1936, Meger studied its spatial structure. Because its structure is similar to that of threose, it was named threonine.

Threonine is an essential amino acid. It helps the body maintain protein balance. It plays a role in the formation of collagen and elastin. Threonine can fight fatty liver when combined with aspartic acid and methionine. It is found in the heart, central nervous system, and skeletal muscles. It prevents the accumulation of fat in the liver. It also promotes the production of antibodies to strengthen the immune system.

There are four isomers of threonine. L-threonine occurs naturally and has physiological effects.

3 Major L-Threonine Application Fields

It is mainly used in medicine, chemical reagents, food fortifiers, feed additives, etc.

First, its application as a feed additive is worth mentioning. In this area, the use of this ingredient is growing rapidly. The reason is that it has the following advantages.

  1. It adjusts the amino acid balance in the feed. It promotes growth.
  2. It improves meat quality.
  3. It improves the nutritional value of feed ingredients with low amino acid digestibility.
  4. It produces low-protein feed. It helps conserve protein resources.
  5. It reduces feed ingredient costs.
  6. It reduces the nitrogen content in livestock and poultry manure and urine and the concentration and release rate of ammonia in livestock and poultry houses.

Therefore, as the second limiting amino acid in pig feed and the third limiting amino acid in poultry feed, threonine is often added to the feed of immature piglets and poultry. In addition, feed-grade threonine is also widely used in shrimp, eel feed, etc.

L-Threonine is also an important nutritional fortifier. It can fortify cereals, pastries, and dairy products. Like tryptophan, it has the effect of relieving human fatigue and promoting growth and development.

In medicine, because the structure of threonine contains hydroxyl groups, it has a water-holding effect on human skin. It binds to oligosaccharide chains and is important in protecting cell membranes. In the body, it promotes phospholipid synthesis and fatty acid oxidation. Therefore, threonine preparations have the medicinal effect of promoting human development and fighting fatty liver. It is an ingredient in Complex Amino Acid Infusion. At the same time, this amino acid is also a raw material for manufacturing a type of highly efficient and hypoallergenic antibiotic, ionomycin.

L-Threonate VS L-Threonine: What’s The Difference?

Although the names sound similar, L-Threonate and L-Threonine are different and are not the same product.

L-Threonate, or Threonic acid, is a metabolite of ascorbic acid in the body. Its derivatives include calcium threonate, magnesium threonate, etc. Both have good bioavailability.

And L-threonine is an essential amino acid. It promotes overall health by aiding in protein synthesis and tissue maintenance. It has excellent applications in medicine, feed additives, cosmetics, nutritional health products, and other fields. For example, threonine has a water-holding effect on human skin. Therefore, its application in cosmetic products can achieve hydrating and moisturizing effects.

L-Threonate VS L-Threonine: Which One Is Better?

Although L-Threonate and L-Threonine have similar names, they are actually two completely different ingredients. So, it’s hard to define which one is better.

From the perspective of application fields alone, L-Threonine has been studied to have more benefits, and perhaps it is a more recognized and comprehensive safety ingredient.


After today’s discussion on the topic “L-Threonate VS L-Threonine: Which One Is Better?”, it can be found that L-Threonine has a large amount of information and research proving that it has many differences in different fields, including nutritional supplements, feeds, etc. benefits. There is relatively little information on L-Threonate. More are the applications of its derivatives, magnesium threonate, and calcium threonate. Both also have their own utility.

Nutri Avenue is committed to researching the effectiveness and applications of more nutritional ingredients. Welcome to contact us for more product information, such as COA and the latest quotation.

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