The FDA had previously accepted NMN as a New Dietary Ingredient (NDI), which allowed supplement manufacturers to market it. But, on October 11, 2022, they revoked the NDI, so companies can no longer sell it in the United States.
And recently, Amazon announced its platform would remove anti-aging supplements containing NMN after 2023/3/13 in response to FDA.
Facing these 2 news, Nutri Avenue wants to list the 10 best longevity supplement ingredients that will be NMN alternatives. In fact, NMN is not the only active ingredient in products. There are many better options to support the antioxidant and anti-aging effects. Let us get to know them now.
NMN Alternatives: 10 Best Longevity Ingredients You Should Know
What Is NMNH?
Dihydronicotinamide Mononucleotide, abbreviated as NMNH, is a compound related to nicotinamide mononucleotide (NMN). NMNH is a precursor compound of NADH (reduced coenzyme I) and plays an important role in cellular metabolism and energy production.
Know NMNH Benefits
Its core role is related to NAD+ (nicotinamide adenine dinucleotide) and NADH metabolism. NAD+ is an important coenzyme involved in cellular energy production, especially in the mitochondria of cells, and is responsible for converting nutrients into energy. NADH is the reduced form of NAD+, responsible for transferring electrons during energy production. The CAS number of NMNH is 1094-61-7. Its molecular formula is C11H15N2O8P, and its molecular weight is 334.22 g/mol.
Studies have shown that the level of NAD+ in the body gradually decreases with age, and this decrease is associated with many aging-related diseases (such as cardiovascular disease, metabolic disorders, neurodegenerative diseases, etc.). NMNH is believed to help maintain the balance of NAD+ by converting to NADH, thereby fighting aging and improving cellular energy metabolism.
Key Differences Between NMNH VS NMN
Both NMNH and NMN are precursors of NAD+. However, NMNH is closer to the metabolic form of NADH (reduced coenzyme I) and may have a stronger antioxidant effect. However, talking about NMN VS NMNH, their specific metabolic pathways and functions in the human body are still under investigation.
What Is NMNH Used For?
Due to its association with NAD+ metabolism, NMNH has potential applications in anti-aging, improving cellular energy metabolism, enhancing immune function, and improving cognitive function.
Many nutritional supplement companies are also exploring the possibility of satisfying their consumers to buy NMNH supplement to delay aging and improve overall health. NMNH is also seen as a good choice for NMN alternatives.
In summary, NMNH is an important molecule that may be important in improving energy metabolism, anti-aging, and health maintenance, but related scientific research is still ongoing.
NMN VS NR: Can NR Be A One Of NMN Alternatives?
Both are supplement ingredients that promote increased NAD+ levels in the body. But they have different metabolic pathways and properties.
First, nicotinamide riboside is a precursor to NAD+. It is converted to NMN through the NRK (nicotinamide ribokinase) pathway and NAD+. NR molecules are smaller and can pass through cell membranes more easily. Therefore, it is more effective in increasing NAD+ levels, especially when taken orally.
NMN is also a direct precursor to NAD+. It is converted to NAD+ through the NAMPT (nicotinamide phosphoribosyltransferase) pathway. Although NMN molecules are larger than NR, early studies have shown that NMN needs to enter cells through a specific transport mechanism to have an effect.
The ultimate goal of both NMN VS NR is to increase NAD+ levels. In theory, both can achieve this goal through different metabolic pathways. Therefore, in some situations, NR can play a similar role to NMN and become one of the options for NMN alternatives. In fact, NR may be easier to absorb than NMN because of its smaller molecule.
PQQ With Anti-Aging And Longevity: Does It Work?
PQQ (pyrroloquinoline quinone) shows significant potential in anti-aging and longevity. The ingredient works mainly by promoting mitochondrial generation and strong antioxidant effects. PQQ can stimulate the generation of new mitochondria, enhance cellular energy metabolism, and slow down the decline of mitochondrial function associated with aging. At the same time, as a powerful antioxidant, it can neutralize free radicals, reduce cellular oxidative damage, protect DNA and proteins, and thus delay cell aging.
In addition, PQQ also has a protective effect on neurological health, promoting the production of nerve growth factors and reducing chronic inflammation. This helps prevent age-related neurodegenerative diseases and other chronic diseases. By combining these mechanisms, PQQ can help delay aging and support a longer and healthier life.
Coenzyme Q10: Super Potent Antioxidants To Support Longevity
Coenzyme Q10 CoQ10 is an important antioxidant occurring naturally in human cells, especially in the heart, liver, and kidneys. It is responsible for helping to produce ATP (adenosine triphosphate) in the mitochondria, which provides energy to the cells.
CoQ10 levels in the body decline as we age, affecting energy metabolism, which is associated with cellular aging and various age-related diseases. By supplementing with CoQ10 supplements, mitochondrial function can be restored, cell vitality can be enhanced, and the aging process can be slowed down.
As a powerful antioxidant, it helps neutralize free radicals and reduce the damage to cells caused by oxidative stress. Excessive accumulation of free radicals can cause cell damage and aging, promoting aging and disease. The compound helps slow cell aging and delay skin aging by protecting cell membranes and mitochondria from oxidative damage.
In addition, studies have shown that CoQ10 significantly benefits cardiovascular health. This can help reduce the risk of cardiovascular disease associated with aging, improve blood circulation, and enhance heart function. CoQ10 plays an important role in delaying aging and supporting longevity by supporting cellular energy metabolism and antioxidant protection.
Omega-3 Fatty Acids: Key Nutrients To Delay Aging And Promote Longevity
Omega-3 fatty acids are essential polyunsaturated fatty acids, mainly EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid). They are essential in maintaining healthy cell membranes and promoting cardiovascular function.
Studies have shown that regular intake of omega-3 fatty acids can help reduce the risk of cardiovascular disease, including reducing thrombosis, lowering blood pressure, and improving cholesterol levels, which positively impacts longevity.
In addition, this fatty acid has anti-inflammatory properties and can reduce chronic inflammation in the body. Chronic inflammation is closely related to aging and many age-related diseases, such as arthritis, diabetes, and neurodegenerative diseases. By reducing inflammation, omega-3 fatty acids help protect cells and tissues from damage, thereby delaying the development of aging and age-related diseases.
It also has significant benefits for brain function and cognitive health, especially DHA, an important component of brain cells that can promote neuronal health and improve cognitive function. Regular intake of omega-3 can reduce the risk of Alzheimer’s disease and other neurodegenerative diseases, thus playing a key role in longevity and healthy aging.
Resveratrol: Longevity Options From Natural Extracts
Resveratrol powder is a polyphenol compound found naturally in certain plants, especially in foods such as red grape skins, berries, and peanuts. Studies have shown that resveratrol has significant antioxidant and anti-inflammatory properties, making it a popular choice for slowing aging and promoting longevity. It can neutralize free radicals and reduce oxidative stress damage to cells, thereby helping to protect cells from age-related pathologies.
Resveratrol promotes cellular self-repair and energy metabolism by activating longevity genes such as SIRT1 (sirtuin 1). SIRT1 is important in regulating cellular stress responses and metabolic processes and is closely related to multiple biological pathways associated with longevity. In addition, resveratrol has been found to improve insulin sensitivity and help prevent age-related metabolic diseases such as diabetes and obesity.
In addition, resveratrol positively impacts cardiovascular health, lowering cholesterol levels, improving blood circulation, and reducing the risk of cardiovascular disease. These combined health benefits make resveratrol powder an important nutrient for promoting longevity and healthy aging.
Curcumin: Potential Anti-Aging And Longevity Ingredient
Turmeric is a commonly used spice, and curcumin is its active ingredient. It has received widespread attention for its significant antioxidant and anti-inflammatory properties.
Studies have shown that curcumin can help reduce oxidative stress and inflammation levels. Both of these are important factors associated with aging and a variety of chronic diseases such as cardiovascular disease, diabetes, and cancer. By alleviating these effects, curcumin helps improve cellular health, promoting anti-aging and longevity.
Curcumin can also enhance the self-repair ability of cells by regulating antioxidant enzymes and cell signaling pathways. It can activate genes associated with longevity, such as Nrf2, which plays a key role in regulating cellular antioxidant responses and defense mechanisms. In addition, curcumin shows the potential to promote cellular metabolism and inhibit pathological changes associated with aging, which may help slow the aging process.
In addition, curcumin also has a positive effect on cardiovascular health, which can improve vascular function and reduce cholesterol levels, thereby reducing the risk of heart disease.
These combined effects make curcumin a noteworthy natural ingredient that may be important in promoting longevity and healthy aging.
Does Pine Bark Extract Work For Longevity?
Pine bark extract, especially proanthocyanidins, has attracted attention for its powerful antioxidant and anti-inflammatory properties. Studies have shown that pine bark extract can effectively neutralize free radicals and reduce oxidative stress, thereby protecting cells from aging and damage. Oxidative stress is an important factor in cell aging and various age-related diseases, such as cardiovascular and neurodegenerative diseases.
In addition, pine bark extract has also shown positive effects in improving blood circulation and cardiovascular health. It can enhance the elasticity of blood vessels and improve microcirculation, reducing the risk of hypertension and heart disease. Good cardiovascular health is closely related to longevity, and pine bark extract’s effects promote longevity.
Finally, pine bark extract has also been found to have anti-inflammatory properties and can help reduce chronic inflammation in the body. Chronic inflammation is associated with the aging process, and by reducing inflammation, pine bark extract may help protect cells and slow down the aging process. Therefore, as a natural ingredient, pine bark extract is expected to play an important role in anti-aging and promoting longevity.
Conclusion: Here Are More NMN Alternatives To Choose
Because NMN sales and use in the United States face certain regulatory challenges, product manufacturers, contract manufacturers, and supplement enthusiasts have begun to look for other effective supplement ingredients to support anti-aging and longevity goals. These alternative ingredients, such as NMNH, nicotinamide riboside (NR), resveratrol, and coenzyme Q10, are nutrients that have been shown to have a positive effect on promoting cellular energy metabolism, slowing the aging process, and improving overall health.
As the focus on health and longevity continues to increase, more and more NMN alternative supplement ingredients have gained recognition in the market. For example, resveratrol is highly regarded for its antioxidant properties, while omega-3 fatty acids have been widely studied for their benefits to cardiovascular health. These ingredients provide companies looking for NMN alternatives with more options to help support their product needs while circumventing current regulatory restrictions on NMN.
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