The FDA had previously accepted NMN as a New Dietary Ingredient (NDI), which allowed supplement manufacturers to market it. But, on October 11, 2022, they revoked the NDI, so companies can no longer sell it in the United States.
And recently, Amazon announced its platform would remove anti-aging supplements containing NMN after 2023/3/13 in response to FDA.
Facing these 2 news, Nutri Avenue wants to list several longevity supplement ingredients which can alternative NMN for you.
Nicotinamide Riboside (NR)
Our internal machinery requires vast energy to perform biological functions, maintain cognition, and keep our bodies active. To create, store and recycle this energy, we rely on a complex metabolic pathway within each cell called cellular respiration. Mitochondria store and release energy for cellular respiration by creating and breaking chemical bonds. Altering electrons through these complex biochemical pathways is our body’s way of meeting the needs of our internal energy “grid.”
The two most important components of this electronic pathway are NAD+ and NADH. NAD+ levels decline as we age. We can reverse some of the natural limitations of aging by increasing the precursor molecules needed to make NAD+ and NADH. NMN is a precursor of NAD + . Another NAD+ precursor is NR.
In order to maintain baseline function, approximately 20 mg of niacin (vitamin B 3) is required to synthesize NAD+. Supplementing intermediate molecules increases the rate of NAD+ synthesis, which is thought to have anti-aging effects.
In short, underpinning our cellular energy supply may allow us to perform these vital mitochondrial functions and repair aging-related cellular damage.
Muscle, bone, skin, and tendons are mainly composed of collagen. Collagen is an extremely rich protein in the human body, accounting for 30% to 35% of all proteins in the human body. It forms connective tissue, stabilizes our skin, and allows joint movement and flexibility.
As we age, we gradually produce less and less collagen. Coupled with the stress of life and the resulting oxidative damage, it leads to the appearance of wrinkles. Taking collagen can help.
A 2008 study found that collagen peptides (proteins), taken as a dietary supplement, effectively controlled UV-B-induced skin damage and sun-related aging. The researchers concluded: “Oral supplementation with collagen peptides is effective in optimizing the characteristics of skin aging.”
A 2014 study showed that collagen supplementation could help improve skin hydration and elasticity. That same year, another study compared subjects taking collagen (3 grams per day) and astaxanthin (2 mg per day) with a placebo. As a result, skin elasticity and barrier protection were optimized in subjects taking the supplement.
Therefore, collagen is an anti-aging supplement ingredient. It comes in the form of capsules, powder, and a topical serum that can be applied directly to the skin.
PQQ (Pyrroloquinoline Quinone)
Pyrroloquinoline quinone is a small quinone molecule that has the ability to be a redox agent, capable of reducing oxidants (an antioxidant action). It is then recycled to its active form by glutathione.
PQQ appears to be fairly stable since it can go through thousands of cycles before running out, and it’s novel. Because it is associated with protein structures within cells (some antioxidants, mainly carotenoids such as beta-carotene and astaxanthin, are located in specific areas of cells. Due to the proximity, they exert proportionally more antioxidant effects. PQQ seems to do these near proteins, just as carotenoids do on cell membranes).
For human evidence, the limited evidence we currently have suggests that it may be neuroprotective in older adults (no studies in neurodegenerative clinical situations or youth) and may be anti-inflammatory. This limited evidence also suggests that PQQ’s main claim (enhancing mitochondrial function) occurs in otherwise healthy individuals supplemented with PQQ.
Coenzyme Q10, also called Co Q10, also known as ubiquinone, is a natural antioxidant all life needs. Our cells rely on CoQ10 to produce an energy molecule called ATP. This energy production is done in part through the mitochondria. Mitochondria are the cellular power plants that generate all energy in the body.
As we age, CoQ10 levels in both our blood and our cells decrease. It is mainly due to the reduction of synthesis and intestinal absorption.
Research suggests that reduced levels of CoQ10 in the blood may increase the risk of dementia and Alzheimer’s disease. A 2015 study showed that taking 100 mg of CoQ10 three times per day may help slow cognitive decline in Parkinson’s patients. Other studies have shown that CoQ10 is important in helping optimize function and memory in people with Alzheimer’s disease.
Coenzyme Q10 helps prevent common age-related diseases such as eye macular degeneration. Topical Co Q10 has the potential to reduce facial wrinkles.
The recommended oral dose is 100 to 300 mg per day.
Essential Fatty Acids
Omega-3 fatty acids, also known as PUFAs, which means polyunsaturated fatty acids, play an important role in human health. It is thought to have many benefits for the heart, brain, and joints.
In 2014, a study published in the Journal of Nutrition found that most people don’t get enough essential fatty acids in their diet, which can lead to common health problems associated with aging. A 2017 study showed that consuming more omega-3 fatty acids significantly optimized blood vessel function and control blood pressure. That same year, a Future Science study showed that omega-3 fish oils could reduce inflammation and heart disease.
Additionally, a 2017 study published in “Atherosclerosis” showed that higher levels of omega-3 fatty acids in the blood were associated with a 30 percent lower death rate from heart disease, the number one killer of populations worldwide.
Food sources of omega-3 fatty acids include as below:
- fish (mackerel, cod, and salmon are especially rich
- chia seeds
- hemp seeds
In addition to your daily diet, this important nutritional ingredient can also be taken in capsule or liquid form.
The recommended dosage range is 1,000 mg to 4,000 mg per day.
According to some scientists, resveratrol may be a health compound. Some studies show that it helps prevent age-related cataracts, vascular disease, and brain diseases like dementia. According to a 2018 study published in Biofactors, resveratrol may help extend lifespan based on its effects on telomeres.
Food sources of resveratrol include:
- red wine
- peanuts and pistachios
- dark chocolate
The scientists also identified some lifestyle behaviors that help protect telomeres (the front ends of DNA) from shortages. These behaviors included regular exercise (at least 30 minutes of moderate exercise 5 times per week) and a 30% reduction in food intake, leading to increased longevity.
According to scientific research, supplementing with resveratrol has a similar effect on our DNA. Resveratrol turns on the SIRT1 and SIRT2 genes. These genes produce proteins that help extend lifespan.
A 2018 study on resveratrol’s effects on mice’s kidneys has achieved promising results. Pathological effects are attenuated in aging kidneys, a study shows.
Pine Bark Extract (Cypressin)
Pine bark extract or Cypressin is a potent antioxidant. Originally used as an herb by the indigenous peoples of North America and Asia. French explorer Jacques Cartier, who claimed Canada as part of France, reportedly used pine bark extract during his 1535 expedition to cure scurvy, a condition caused by insufficient vitamin C intake.
Antioxidants are substances that protect tissues and organs from free radical damage. Free radicals are an oxidative mechanism that contributes to aging. A study in “Ophthalmic Research” showed that the antioxidant potency of pine bark extract is more powerful than that of vitamin C, vitamin E, alpha-lipoic acid, and coenzyme Q10.
Pine bark extract powder has been shown to help prevent cataracts, optimize heart health, control blood pressure, optimize memory, and help reduce pain associated with joint problems.
Another benefit of pine bark extract is that it appears to help protect skin health. Its powerful antioxidant capacity can help protect the skin from UV rays. It can even be applied to the face. Its antioxidant properties may also help protect collagen and elastin from oxidative damage. Oxidative damage may be the main cause of skin aging.
Turmeric, also known as Sichuan turmeric or Indian saffron, is a rooted plant in the ginger family. It is commonly eaten for its inflammation-relieving, antioxidant, and digestive health properties. Curcumin, the main molecule in turmeric, is thought to have many health benefits.
While many people have used turmeric as a spice in food for the past 4,000 years, this popular spice also plays an important role in aging. According to a 2016 report published in the disease journal, turmeric can help reduce oxidation, which many believe is a major contributor to the aging process.
A 2017 study in the journal Neural Regeneration Research showed that turmeric helps protect neural connections in the brain from inflammation and oxidative damage – two common aging processes.
A 2017 study published in the “Journal of Alzheimer’s Disease” showed that turmeric might play an important role in preventing memory loss. People who want a younger brain should consider adding turmeric to their supplementation regimen.
Vitamin C is also known as ascorbate and ascorbic acid. It has been one of the most studied vitamins over the past 50 years. Since 1968, more than 53,000 studies have been conducted on vitamin C. Research shows that vitamin C helps promote good health.
Symptoms of vitamin C deficiency:
- Fatigue and depression
- Bleeding gums
- Joint, muscle, and bone pain
According to research, taking vitamin C may help prevent cataracts. It is a disease that is common with age. It also plays an important role in producing collagen, which helps keep teeth firmly attached to the jawbone. That’s why tooth loss is common among smokers—smoking lowers vitamin C levels in the blood.
Consuming a diet rich in C vitamin can help optimize its antioxidant benefits. Vitamin C also has many benefits for the skin and is anti-aging. A 2018 study that took vitamin C as a supplement, along with a collagen supplement, showed a significant improvement in skin health after just 12 weeks.
This is a flavonoid found in strawberries, apples, and persimmons. It has been shown to have potential anti-aging effects by activating sirtuins and reducing inflammation.
This is a drug commonly used to treat type 2 diabetes. It has been shown to have potential anti-aging effects by reducing inflammation and improving metabolic function.