Inositol was first extracted from muscle in 1850. Some scholars believe that myo-inositol is vitamin B, while others believe that myo-inositol is a pseudovitamin. At present, there is no conclusion in the academic circles. There are nine isomers of myo-inositol, namely: myo-inositol, D-chiro-inositol, L-chiro-inositol, scyllo-inositol, epi-ino-sitol, muco-inositol, allo-inositol, cis-inositol, and neo-inositol. Among these nine isomers, the one that exists in nature is usually “myo-inositol,” followed by “chiro-inositol.” Many people know myo-inositol because of polycystic cysts. Therefore, here is a question. Myo Inositol And D Chiro Inositol, which one is better?
D-Chiro-Inositol: Also Known As DCI, Dextro-Inositol
The “chiral” structure is mirror-symmetrical but not superimposed like our hands. So there are left and right hands. In terms of chemical structure, it is divided into left-handed and right-handed. Left-hand rotation is L, and right-hand rotation is D. Therefore, D-chiro-inositol is also known as dextro-inositol. In 1979, Professor Larner from the University of Virginia in the United States discovered that DCI is the second messenger of insulin.
D Chiro Inositol has fewer food sources. It is commonly found in cereal legumes and especially in horn beans. In addition to being contained in food, insulin target organs such as fat, muscle, and liver are present in our bodies. It can be seen that this substance is closely related to insulin. As early as 1999, Dr. Larner discovered that D Chiro Inositol can improve insulin resistance. It increases ovulation rate and improves blood lipids in women with PCOS.
Insulin resistance (IR) is a decrease in insulin sensitivity. Insulin-mediated reduction in glucose utilization regulates the body’s blood sugar levels. The body will secrete insulin compensatoryly, causing blood insulin levels to be too high for hyperinsulinemia. The prevalence of insulin resistance in diabetes is 69.7%, and the prevalence of insulin resistance in polycystic ovary syndrome is 50-70%.
However, the main function of D Chiro Inositol is an insulin sensitizer. It can be understood as improving insulin sensitivity and resistance from the root cause. Therefore, it is effective for patients with metabolic diseases such as diabetes, hypertension, hyperlipidemia, obesity, polycystic ovary syndrome, and even perimenopause. It can be said that the scope of effect is very large.
D Chiro Inositol VS Metformin: More Safe
But when it comes to improving insulin resistance, metformin is the best-known drug. Compared with metformin, the advantage of D Chiro Inositol is that it does not cause side effects such as diarrhea, nausea, and vomiting. It has a better experience and healthier ingredients. It can also achieve similar effects to metformin.
Myo Inositol: Most Present In Intracellular Pools
MI is the abbreviation for myo-inositol. It is a substance widely found in food and has a structure similar to glucose. It is mainly distributed in animals and plants. Among them, the highest content is found in fruits, beans, corn, and nuts. It is a growth factor for animals and microorganisms.
Myo Inositol plays an important role in a variety of cellular biochemical reactions. It can constitute the basic structure of the second messenger in eukaryotic cells. It plays a more important role in egg development. Myo Inositol is an important component of the follicle microenvironment. MI levels are a marker of egg quality.
Myo Inositol And D Chiro Inositol: How To Choose?
Chiro-inositol is a natural molecule found in many foods. It is also a nutrient in the human body, so there is no need to worry about side effects and rejection. And for people who lack the enzyme to digest myo-inositol, supplementing myo-inositol will not effectively convert it into chiral inositol. Therefore, what works for polycystic cysts is chiral myo-inositol rather than myo-inositol.
In addition, in the blood of polycystic women, the content of chiro-inositol is less than half that of healthy women. Supplementing chiro-inositol can more effectively improve polycystic ovary syndrome. However, Myo Inositol has a slow onset of action and requires long-term supplementation to see certain effects. Therefore, D-chiro-inositol will be more in line with the absorption characteristics of the human body and will be effective faster. You don’t have to worry about side effects as long as you do not use doses above 500mg continuously. However, if there is no insulin resistance but excessive intake of myo-inositol, especially chiro-inositol, side effects such as Hyperandrogenism and ovulation disorder will occur.
Can Combine Myo Inositol And D Chiro Inositol To Use?
According to research, the Myo: DCI of human plasma is 40:1, and the Myo: DCI of follicular fluid is 100:1. Here are three researchers testing different ratios of Myo Inositol And D Chiro Inositol on test subjects.
- Comparison of muscle/myo-inositol supplementation alone and myo-inositol to chiro-inositol 40:1 supplementation. Compared with supplementing myo-inositol or chiro-inositol alone, mixed-use can significantly improve egg quality and embryo quality in polycystic patients.
- Mouse animal experiments study the effects of different ratios, divided into Myo Inositol And D Chiro Inositol 5:1, 20:1, 40:1, and 80:1. It was found that the myo and d-chiro inositol 40:1 group was more effective. Other groups were less effective. In particular, the effect of the group with high chiral inositol was even worse, and human trials also reached similar conclusions.
- There are also experiments that give completely opposite conclusions. A randomized, multicenter, double-blind trial showed that patients receiving the 3.6:1 dose had higher pregnancy and live birth rates (for IVF patients) than the 40:1 regimen. The researchers further studied and found that patients taking myo and d-chiro inositol 1.8:1 positively impacted oocyte quality more than those taking 20:1.
Conclusion
Polycystic ovary syndrome, simply called PCOS, is one of the most common gynecological endocrine diseases. It is characterized by Hyperandrogenism, persistent anovulation, and insulin resistance (IR) and is one of the main causes of female infertility. Myo-inositol and D-chiro-inositol are two isomers of inositol. Both forms may have therapeutic effects on PCOS by improving IR, lowering androgens, improving metabolism, and reducing oxidative stress. Chiro-inositol works better for obese and insulin-resistant consumers. For consumer groups with no insulin resistance or very mild insulin resistance, pure myo-inositol is worth a try. However, using only large doses of D-chiro-inositol adversely affects egg quality. In recent years, more and more studies have shown that combining Myo Inositol And D Chiro Inositol at a physiological dose ratio of 40:1 is more effective in treating PCOS.
Nutri Avenue offers bulk ordering of Inositol powder, including Myo Inositol And D Chiro Inositol. Currently, the most common ingredient in dietary supplements is D Chiro Inositol. However, a more reasonable product formula combination may be the combination of Myo Inositol And D Chiro Inositol. If you want to know more, please contact Nutri Avenue to discuss.
