N- Oleoylethanolamide: A Must-Have Compound in Weight Loss


Most weight loss programs contain alternative strategies to enhance satiety and prevent hunger. While most methods involve the use of psychological approaches, recent studies revealed that supplementation of certain compounds including the naturally-occurring Oleoylethanolamide or OEA can be of great help in terms of satiety enhancement. N- Oleoylethanolamide has long been subjected to studies to establish its association with probable weight loss. Since the compound is found naturally in the human body, it is believed to function primarily in metabolism process without causing adverse effects. Along with other compounds which boost metabolism through thermoregulation pathways and enhancement of fat burning process, N- Oleoylethanolamide is said to be the key to effective weight loss.

What is N- Oleoylethanolamide?

The compound N- Oleoylethanolamide or OEA is produced naturally in the intestines. The primarily function of the compound is to produce the sensation of satiety following meals. Reduced N- Oleoylethanolamide levels have long been associated with binge eating which eventually results to rapid weight gain. There are many reasons why individuals do not produce adequate N- Oleoylethanolamide. While some causes are treatable, most causes are of unknown etiologies. This is the reason why supplementing N- Oleoylethanolamide through dietary supplements is one of the most effective solutions to regulate levels of OEA in the human body.

Health benefits of using N- Oleoylethanolamide

Taking N- Oleoylethanolamide health supplements can be very beneficial especially among high risk groups. Several quantitative studies have already been completed and are currently being conducted to determine the effects of the compound among obese and overweight subjects. Aside from potentially promoting weight loss, the following health benefits are expected with N- Oleoylethanolamide supplementation, as provided in health studies:

  1. It may prevent cardiovascular disease development

Enhancing weight loss and fat burn through satiety maintenance pathways can directly result to the prevention of various cardiovascular diseases associated with excessive fat accumulation in the heart and blood vessels. There are only limited studies on the probable effects of the compound N- Oleoylethanolamide in atherosclerosis and arteriosclerosis prevention but several studies have made recommendations on explorations for the claimed benefit.

  1. It may control depression

In one study conducted on mice subjects, experts found that the compound N- Oleoylethanolamide may help control depression through hormonal and neurological patterns. The compound effectively regulates hormonal balance as well as neurotransmitter production in the brain through certain unknown mechanisms of action. It also reduces unpredictable mild stress, as shown in the study conducted on mice.

  1. It reduces appetite-stimulating hormones

PYY, a compound which stimulates sensation of hunger, has been shown to be reduced with N- Oleoylethanolamide supplementation. This results to satiety and fat burn enhancement.


Many health compounds can be combined with N- Oleoylethanolamide to fully stimulate fat burn and weight loss. Since no qualitative studies have yet been conducted on humans, N- Oleoylethanolamide’s pharmacologic effects are not yet fully known.

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