Is NAD+ (Nicotinamide Adenine Dinucleotide) A Drug?
NAD+, the full name of Nicotinamide Adenine Dinucleotide, is a coenzyme that plays an important role in cell metabolism. Its main function is to act as a carrier of electrons and participate in various metabolic reactions in cells, including glycolysis, gluconeogenesis, tricarboxylic acid cycle, and respiratory chain. NAD+ helps transfer hydrogen atoms to other molecules in these processes, and its reduced form is NADH, which can carry two protons.
NAD plus has other important functions in cells, such as activating acetylases, regulating sleep/wake cycles, maintaining chromosome stability, and repairing DNA damage.
With age, NAD plus levels decrease, possibly related to decreased metabolic function and age-related diseases. In addition, NAD plus metabolites also play an important role in signal transduction, post-translational modification, epigenetic changes, and the regulation of RNA stability.
NAD plus requires special attention to temperature and humidity conditions during storage to maintain its stability and activity. The ingredient is stable under dry conditions and can be stably stored at 2~8℃ in dry powder form. Therefore, if special conditions such as high temperature are encountered, NAD plus powder needs to be transported with ice. It also means that the transportation component increases.
Nutri Avenue learned from the factory that the ingredient should not be transported with ice this week. In addition, NAD plus is now included in the preliminary list of new drugs. It means that one day in the future, NAD plus ingredient may be included in the list of drugs in the United States. However, for now, it still belongs to the field of supplement ingredients.
Why Is The Price Of Citrus Bioflavonoid Extract Rising?
The raw materials of Hesperidin powder are generally derived from Citrus Bioflavonoid. However, this year, there are some special circumstances.
- First, due to extreme weather, the fruit trees only bloomed but did not bear fruit. Therefore, the output was greatly reduced. It led to an increase in the price of raw materials.
- Second, due to the heavy rain, the existing raw materials were also partially affected, such as soaking in water, mildew, etc. Therefore, the existing raw materials are also reduced.
- Third, changes in the raw material market may lead to market manipulation of the price of Hesperidin raw materials.
Therefore, the price of this ingredient will also fluctuate greatly.
This week, its quotation is $22-25/kg.
How To Choose Between BHB Calcium Salt And Sodium Salt For The Product?
BHB calcium salt usually refers to the salt formed by beta-hydroxybutyrate (BHB) combined with calcium. Beta-hydroxybutyrate is a ketone body that is produced by the liver during the oxidation of fatty acids. When the body lacks an adequate supply of carbohydrates, muscles, and other tissues can use it as an energy source.
BHB calcium salt can be in the form of calcium 3-hydroxybutyrate. It is a colorless crystalline powder that is hygroscopic and can be used as a calcium supplement, especially in treating osteoporosis and rickets in children.
BHB sodium salt usually refers to beta-hydroxybutyrate sodium (BHB-Na). It is a ketone body form that dominates among ketone bodies, accounting for approximately 78% of the total ketone bodies. Sodium beta-hydroxybutyrate is a metabolite produced by the liver during fatty acid oxidation. It can be used by muscles and other tissues as an energy source when the body lacks an adequate supply of carbohydrates.
Both BHB calcium and sodium salts, as supplement ingredients, may help support a state of ketosis. That is, they can quickly increase the level of ketone bodies in the blood and help the body shift from a glucose-dominated metabolic state to a ketone-dominated metabolic state. Ketosis may benefit people who want to lose weight, improve athletic endurance, or support neurological health.
About the issue of how to choose BHB calcium and sodium salts used in products, Nutri Avenue recommends that branders and manufacturers choose products containing the required minerals, such as potassium, sodium, calcium, or magnesium, according to nutritional needs. BHB salts are combined with calcium, sodium, and magnesium minerals to improve their transportation and absorption in the intestines.
The market reference price of both products is $10-12/kg.
Cognitive Ingredient Recommendation: Uridine 5′-Monophosphate Disodium Salt
Uridine 5′-Monophosphate Disodium Salt (UMP-Na2 for short) is a nucleotide. It is a major component of ribonucleic acid (RNA). The chemical formula of UMP-Na2 is C9H11N2Na2O9P, and the molecular weight is 368.14. It is a white to light yellow crystalline powder with slight solubility in water. Its solubility is about 40 g/100 mL (20 ºC). Due to its high hygroscopicity, it usually needs to be stored in a sealed and moisture-proof condition.
UMP-Na2 participates in various biochemical processes in the body, including RNA synthesis and cellular metabolic activities. In laboratory studies, UMP-Na2 is used as a component of RNA synthesis. In some studies, it is used to study the effects of certain drugs on cholesterol and lipid metabolism.
In addition, as a supplement, UMP-Na2 may help support cognitive health and brain function. This week, its price is $85-98/kg.
Is S-Acetyl-L-Glutathione The Same As Glutathione?
S-Acetyl-L-Glutathione, or SAG for short, is a derivative of Glutathione, GSH. It enhances the stability and bioavailability of Glutathione by adding an acetyl group to the sulfur atom of Glutathione. Glutathione is an important tripeptide antioxidant composed of three amino acids: cysteine, glycine, and glutamic acid. It plays various roles in the body, including helping metabolize toxins, breaking down free radicals, and supporting immune function.
S-acetylation prevents Glutathione from metabolizing in the intestine, thereby increasing its stability in plasma. It can be directly absorbed by cells and subsequently converted to GSH. It makes S-acetyl L-Glutathione more effective than regular Glutathione in increasing intracellular GSH levels, especially when viral infections deplete GSH levels. In addition, S-acetyl L-Glutathione also shows some non-GSH-dependent activities, such as inducing apoptosis in certain human tumor cell lines in vitro.
Due to these properties of S-Acetyl L-Glutathione, it is used as a dietary supplement. It may help support liver health, cardiovascular function, cognitive function, and immune system regulation.
The market price of S-Acetyl-L-Glutathione powder is generally above $600/kg.
What Is Magnesium Citrate Nonahydrate?
Magnesium Citrate nonahydrate is a magnesium citrate compound containing nine water molecules. It is a white crystalline powder. Its chemical formula is Mg3(C6H5O7)2•9H2O, and its molecular weight is approximately 613.25g/mol. This compound dissolves in dilute acid, is slightly soluble in water and alcohol, and is sensitive to moisture.
It is often used as an analytical reagent and has applications in biochemical research. In the medical field, magnesium citrate nonahydrate is sometimes used as a laxative to help relieve constipation. In addition, magnesium citrate is also considered a way to supplement magnesium because magnesium is one of the essential minerals in the human body and is essential for maintaining nerve and muscle function, heart health, and many other physiological processes.
This week, its price is $7-9/kg.
Popular Supplement Ingredients Quotations From 7/1 To 7/7
Sodium Hyaluronate is out of stock, especially because of its low molecular weight. The market price of this ingredient is $62-65/kg. Currently, Nutri Avenue has 1mt of spots in the US warehouse.
Lycopene powder is in a price reduction. Its price is $190-195/kg. Its purity is 10%.
Creatine Monohydrate powder 200 mesh is $8.6-10/kg with a steady market trend.
Beta Alanine powder is $4-4.8/kg with the USA stock.
Alpha GPC in powder form has two purities: 50% and 99%. Its quotation is $45-98/kg. The higher the purity, the more expensive the price. Among them, 50% Alpha GPC is also available in granular form. Its market price is above $110/kg.
Coenzyme Q10 powder 98% is $185-240/kg.
100% Pure VitaminB12 Cynocobalamine is $1,820-2,000/kg.
Cayenne Pepper Extract 10:1 is $11.5-13/kg. Capsaicin with high content can only be exported through a synthetic process.
Xylitol powder is $5.5-6.5/kg. There are two sources to choose from, namely corn and wood.
Rhodiola Rosea extract 3% Salidrosides powder is $31-35/kg.
Promotional Supplement Ingredients List On Nutri Avenue This Week
Nutri Avenue can provide lower prices than the market for the following ingredients. Valid for one week.
Vitamin B5 is $10-12/kg.
Vitamin B2 ( Riboflavin Powder) is around $38/kg.
L-Citrulline powder is $10-11/kg.
L-glycine powder is $7.8-9/kg.
L-Isoleucine powder is $11-13/kg. Nutri Avenue only has the last 700kg of US warehouse stock left.
Alpha lipoic acid in powder and granular form is $45-52/kg.
Anhydrous Citric Acid powder is $1.2-1.28/lb.
Hops Extract 10:1 powder is $9-10/kg.
Chamomile Extract 10:1 powder is $10-12/kg.
Turkestancia P.E. 10% Turkesterone HPLC is generally over $120/kg.
Schisandra Berry Extract 10:1 powder is $10-12/kg.
Conclusion
Sodium Hyaluronate, especially low molecular weight content, is out of stock. Lycopene powder 10% price reduction of about $5/kg. Hesperidin powder raw materials are affected by weather, and both production and inventory have decreased significantly. Therefore, the price of this ingredient is on the rise. In addition, the quotations of most ingredient products are still very stable.
Nutri Avenue will continue to pay attention to the price trend of the raw material market. We provide the best quality ingredients, including amino acids, vitamins, food additives, plant extracts, etc., for all types of products. We help the health products market develop better.