NADH is a naturally occurring substance in the human body. It is the abbreviation of reduced nicotinamide adenosine dinucleotide. It is the reduced form of NAD+. NADH and NAD+ convert each other and help mitochondria produce energy. However, NAD+ VS NADH, which one is the best antioxidant? Read the following content. And maybe you will know.
NAD+ VS NADH: What Are They?
They are the two states of the same molecule, the oxidation and reduction of nicotinamide dinucleotide. The oxidized form refers to NAD+. The reduced form refers to NADH.
NAD+ is a coenzyme found in every living cell. But sometimes, it is colloquially called NAD without the plus sign. However, the plus sign is important. The term NAD academically is used to collectively refer to two different forms of NAD, including NAD+ and NADH.
The Relationship Between NAD+ And NADH: Mutual Transformation And Inseparable
NAD+ and NADH are not opposites. In fact, NAD+ and NADH are both very important in important life processes such as aging, metabolism, and disease. The two transform and balance each other in the body.
The positive effects of NADH on cells are irreplaceable. Normal mitochondrial function requires the production of NADH within the mitochondria. At the same time, NADH and NAD+ in the cytoplasm can be converted into each other. It is converted into NADH in mitochondria through the NADH shuttle mechanism to help mitochondria function normally.
There is mutual conversion of NADH and NAD+ in both the cytoplasm and mitochondria. Cytoplasmic NADH affects NADH homeostasis in mitochondria through the NADH shuttling mechanism.
In May 2005, researchers from the University of California, Rijinshan, published a paper confirming that the intake of NADH can significantly increase NAD+ levels. Experimental results found that NADH can significantly increase intracellular NAD+ levels. Moreover, when adding the same concentration of NADH and NAD+, NADH can protect cells better than NAD+ and reduce cell death rate. It fully demonstrates the protective effect of NADH on cells.
NADH not only increases NAD+ levels but is also the most efficient way to convert NAD+. Compared with precursors such as NR and NMN, reduced precursors are a more efficient way to increase the overall levels of cellular NAD+ and NADH. NADH is an active ingredient among the reduced precursors that has been approved as a dietary supplement.
In October 2019, research published in Molecular Metabolism by Judith Giroud-Gerbetant of the Nestlé Institute of Health Sciences and the Ecole Polytechnique Fédérale de Lausanne in Switzerland showed that reducing precursors to increase NAD+ levels through NADH will be a solution to the current conversion efficiency of some precursors. Low effective way.
NAD+ VS NADH: How To Supplement? How To Choose?
NAD+ participates in various enzymatic reactions in the body, activates longevity factors in the body, and delays human aging. However, in the market, consumers’ widely accepted knowledge is that NAD+ cannot enter cells. Therefore, cells must rely on NAD+ precursors to replenish NAD+. Research data shows that NAD+ has 5 precursor substances, including nicotinic acid, tryptophan, nicotinamide, NR, and β-nicotinamide mononucleotide (NMN). Theoretically, all five precursors can be converted into NAD+. However, in actual applications, they are very different. Only NR is the most effective precursor for synthesizing NAD+ in clinical trials. But in fact, through the above-mentioned “NAD+ VS NADH relationship,” we can find that the relationship between the two is very close.
On the market, the anti-aging mechanism of NAD+ is mainly due to the various signal reactions caused by the decomposition of NAD+ by sirtuins and PARP1, which participate in cell repair. These effects do not involve NADH. However, the latest research has found that the lack of NAD+ biosynthetic enzymes in the body will accelerate ovarian aging in women.
At this time, we are more willing to recommend choosing NADH ingredients. NADH is a naturally occurring nutrient in the human body. It is safe and has no side effects. It is involved in the metabolism of sugar, fat, protein, and energy formation. It is a substance necessary for the metabolism of substances to ultimately produce energy.
When NADH is taken into the body, it produces NAD+ and activates the longevity protein sirtuins. It can also achieve the body’s comprehensive anti-aging and cell energy supply. In addition to this, it also decomposes special biological hydrogen, “H+.” It brings cell protection, energy, antioxidant, and neurosynthetic effects. It provides powerful energy to immune cells and more. It enhances metabolic activity and superoxide conversion capacity. It can also repair inflammatory responses and damage caused by oxidative stress in immune cells. NADH enhances the killing ability of phagocytes and activates the immune system in all aspects.
NADH: Powerful Antioxidant Effect
Human cells are affected by various stresses, toxins, chemicals, radiation, and other factors, causing an explosion of free radicals. Cell antioxidants neutralize free radicals and prevent damage to key cell components, such as membrane lipids, proteins, and DNA.
Ordinary hydrogen molecules cannot penetrate deep into cells. It can only scavenge a small amount of free radicals outside free cells. The special biological hydrogen decomposed by NADH can enter the mitochondria, the stronghold of free radicals inside the cell. Kill free radicals at their source. At present, hydrogen has been proven by many experiments to be able to treat many diseases, including metabolic syndrome, type 2 diabetes, allergies, chronic colitis, rheumatoid arthritis, obesity, atherosclerosis, hangovers, and malignant tumors. More than 200 species. In addition, hydrogen also has a significant improvement effect on the sexual function of men and women.
Unlike other antioxidants, NADH works at a deeper level. As a strong reducing substance in mitochondria, it can neutralize strong oxidizing free radicals. In addition, as the deepest antioxidant of the cellular antioxidant defense system, it can regenerate other antioxidants, like vitamin C, vitamin E, CoQ10, alpha-lipoic acid, glutathione, etc.
Conclusion: NAD+ VS NADH: Which One Is The Best Antioxidant?
Comparing NAD+ VS NADH, the latter can protect cells better than the former and reduce cell death rate. NADH, as a naturally occurring nutrient in the human body, not only increases NAD+ levels but is also the most efficient way to convert NAD+. Its security is higher. It also aids in the regeneration of other antioxidants.
Nutri Avenue believes that although NAD+ has good maturity and recognition in clinical trial data and the market, the more powerful antioxidant effect of NADH cannot be ignored. We provide various antioxidant ingredients, including NADH, NR powder, Vitamins, CoQ10 powder, reduced l-glutathione, etc. Welcome to contact us for more product information.