2 Main Manufacturing Processes Of NMN Crystalline Powder

NMN crystalline powder manufacturing process

What is NMN?

NMN is the abbreviation of Nicotinamide mononucleotide. In humans, NMN is the direct precursor of NAD.

And NAD is the abbreviation of Nicotinamide Adenine Dinucleotide. NAD, also known as oxidized coenzyme I, participates in most biochemical reactions in the human body.

NMN in human body

What are the Current Production Methods of NMN?

The current production methods of NMN crystalline powder include enzymatic synthesis and chemical synthesis. Other methods have not achieved mass production, so the market says that natural extraction and fermentation methods are unreliable.

Enzymatic Synthesis

This production method simulates the metabolic pathway of NMN in vivo, expresses in vivo enzymes in vitro, realizes in vitro enzyme-catalyzed reactions, and prepares NMN.

The advantage of the enzymatic method is that the specificity of the enzyme is high, the process is consistent with the process in the body, and no additional impurities are produced.

Chemical Synthesis

Although through the later purification method, the product purity can also reach the enzymatic level. However, the impurities produced during the chemical method are not found in the human body and are additional. It cannot be ruled out that contaminants accumulate in the body and are harmful to the human body.

Now the mainstream in the market is NMN crystalline powder. Crystalline powder is relatively stable and has high density. NMN crystalline powder is suitable for filling capsules and can also be filled in relatively small capsules. It has good fluidity and reduces material loss.

What is Freeze Dried NMN?

Freeze Dried NMN is one of the earliest NMN production processes. Now the process is very stable, and there is no need for freezing. Many factories have indicated no such form of NMN powder in the ingredient market. Freeze-drying consumes a lot of energy, is not stable, is easy to absorb moisture, has a relatively low density and is relatively loose, which is not conducive to reprocessing into capsules.

Generally speaking, current customers mainly require high-density NMN, so this process is gradually eliminated.

However, if the customer must Freeze Dried NMN, Nutri Avenue can also be customized, and the purity may only be 99.1-99.2%, not above 99.8. Therefore, Nutri Avenue recommends: NMN crystalline powder is the best choice.

What is Vacuum Dried NMN?

Regarding Vacuum Dried NMN, the current process of freeze-drying and NMN crystalline powder is generally vacuum-dried, and the vacuum quickly removes ethanol and water.

Is NMN approved by FDA?

On November 4, 2022, according to the latest FDA policy, FDA does not allow NMN to be sold as a supplement in the United States. Other countries are currently available for sale normally. Please consult the Nutri Avenue team for more details.

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