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What Is Diosmin?
Citrus fruits are the main source of diosmin, a naturally occurring flavonoid glycoside that is used extensively for its anti-inflammatory and vascular-protective qualities. Because it strengthens capillary walls and increases blood circulation, it is frequently used to treat haemorrhoids, varicose veins, and chronic venous insufficiency. It has the chemical formula C28H32O15 and a molecular weight of 608.54 g/mol. Its CAS (Chemical Abstracts Service) number is 520-27-4.
Physically, it is a yellow-to-yellow-brown crystalline powder with a slightly bitter taste. It is practically insoluble in water but soluble in dimethyl sulfoxide (DMSO), ethanol, and other organic solvents. It is relatively stable under normal storage conditions, though it should be kept in a cool, dry place to prevent degradation.
Due to its potent antioxidant, anti-inflammatory, and vasoprotective effects, it is widely used in pharmaceutical formulations, particularly in combination with hesperidin, another flavonoid, to enhance its bioavailability and efficacy. It is commonly found in dietary supplements and prescription medications aimed at promoting vascular health and reducing symptoms of venous disorders.
Common Sources
Diosmin is a naturally derived flavonoid compound widely used in circulatory health applications, particularly for supporting venous function and protecting microvascular integrity. Its primary raw material source is hesperidin, a natural flavonoid abundantly found in citrus fruits.
In commercial production, Diosmin is not directly extracted from plants. Instead, it is produced through a semi-synthetic process, where natural hesperidin is used as the precursor and converted into high-purity Diosmin through chemical modifications such as methylation. Hesperidin is commonly extracted from the peels of citrus fruits such as sweet oranges, grapefruits, and lemons, offering a green and sustainable raw material source.
This manufacturing approach not only improves yield and stability but also ensures consistent pharmacological activity and quality control of Diosmin, meeting the strict standards of modern dietary supplements and functional food formulations.
What Does Diosmin Do?
Diosmin operates through multiple physiological pathways, primarily influencing vascular integrity and microcirculation. For those asking what diosmin is, it’s a naturally occurring flavonoid glycoside that enhances venous tone through noradrenaline-mediated mechanisms. It’s powder increases venous contractility by prolonging norepinephrine activity on venous walls, thereby improving venous return and reducing venous stasis.
At the microcirculatory level, diosmin significantly affects capillary resistance and permeability. When explaining what it is in terms of capillary function, it reduces capillary hyperpermeability by inhibiting various inflammatory mediators, including histamine, bradykinin, and leukotriene B4. It’s powder strengthens capillary walls by protecting the microvascular endothelium and reducing fluid leakage into surrounding tissues.
The anti-inflammatory mechanisms of diosmin involve multiple pathways affecting leukocyte activity and inflammatory cascades. It inhibits leukocyte activation, adhesion, and migration, thereby reducing inflammatory responses in vessel walls. For those researching what diosmin is for inflammation control, it also inhibits the production of pro-inflammatory cytokines and downregulates inflammatory signalling pathways.
The lymphatic effects of its powder involve enhanced lymphatic drainage and improved lymph flow dynamics. It increases lymphatic vessel contractility and frequency of lymphatic contractions, enhancing the removal of fluid, proteins, and waste products from interstitial spaces. This comprehensive activity on venous, capillary, and lymphatic systems makes diosmin particularly effective for venous and lymphatic insufficiency conditions.
How to Extract Diosmin Powder?
- Initial Raw Material Processing: The production begins with hesperidin, a natural flavonoid extracted from citrus fruits. For those asking its sourcing, these raw materials undergo rigorous quality testing to ensure optimal purity and potency in the final product.
- Extraction Process: Producing high-quality diosmin powder involves specialized methods to isolate hesperidin from citrus sources. This step requires carefully controlled conditions to maximize yield while maintaining the integrity of the flavonoid structure.
- Conversion Reaction: The transformation of hesperidin to diosmin involves a controlled oxidation process. This critical step requires precise regulation of reaction parameters to ensure optimal conversion efficiency. For those researching its synthesis, this oxidation primarily targets the hesperidin molecule’s ring structure.
- Purification: The synthesized product undergoes multiple purification steps, including chromatographic separation and filtration. These steps ensure the removal of unreacted hesperidin and other impurities while maintaining the purity of its powder..
- Crystallization: The purified diosmin undergoes controlled crystallization, which requires precise control of temperature, pH, and solvent conditions to achieve optimal crystal structure and purity.
- Micronization: The crystallized powder undergoes specialized micronization processes. This phase is crucial for those questioning what diosmin bioavailability is, as particle size significantly influences absorption and therapeutic efficacy.
- Final Processing: The micronized diosmin undergoes final processing steps, including precise blending and standardization. This phase ensures the diosmin powder’s consistent potency and homogeneity.
- Quality Control: The final diosmin undergoes comprehensive quality testing at multiple stages. This includes HPLC analysis for purity verification, particle size distribution analysis, and stability assessment. Additional testing ensures that those inquiring about diosmin quality receive a product that meets all specifications throughout its shelf life.
Specification Sheet Reference
| Property | Details |
| Type | Supplement Ingredient |
| Appearance | Yellow crystalline powder |
| Purity | ≥ 98% |
| CAS Number | 520-27-4 |
| Molecular Formula | C28H32O15 |
| Molecular Weight | 608.54 g/mol |
| Solubility | Poorly soluble in water, soluble in ethanol |
| Test Methods | HPLC, UV-Vis |
| Certifications | ISO available. Please contact sales team for details. |
| MOQs | 25 kg |
| Sample | Available (10-20g/bag) |
| OEM Service | Available |
| ODM Service | Available |
| Private Label | Available |
| Contract Manufacturing | Available |
Diosmin: Benefits, Side Effects, and More
- Venous Insufficiency and Circulation Research published in Phlebology (2023) demonstrates that diosmin significantly improves symptoms of chronic venous insufficiency. The study showed reduced leg heaviness, pain, and swelling in diosmin powder supplementation patients. For those researching its effectiveness, the clinical data documented improved venous tone, reduced capillary permeability, and enhanced microcirculation. Participants experienced a 62% reduction in leg oedema and substantially improved quality of life metrics.
- Hemorrhoid Management Clinical trials in Digestive Diseases and Sciences (2022) revealed that diosmin substantially relieves hemorrhoidal symptoms. The research demonstrated that its powder reduced bleeding, pain, and inflammation associated with haemorrhoids. Patients taking it experienced faster resolution of acute symptoms and improved long-term management of chronic haemorrhoids. The study documented a 76% reduction in bleeding episodes and a significant improvement in overall comfort.
- Lymphatic System Support Studies in Lymphology (2023) showed that it significantly enhances lymphatic function and drainage. The research found that patients with lymphedema supplemented with diosmin powder experienced reduced limb circumference and improved tissue texture. For those asking what is it for lymphatic health, the compound demonstrated the ability to increase lymphatic vessel contractility and enhance lymph flow. Participants showed a 40% improvement in lymphatic drainage parameters.
- Antioxidant and Anti-inflammatory Protection Research in Inflammation Research (2023) demonstrated that diosmin provides significant antioxidant and anti-inflammatory benefits. The study revealed reduced oxidative stress and inflammation markers in participants taking its powder. Regular supplementation was associated with decreased levels of pro-inflammatory cytokines and enhanced antioxidant enzyme activity—those studying it for inflammatory conditions found particularly notable effects in vascular inflammation models.
- Post-Thrombotic Syndrome Prevention Clinical studies in Thrombosis Research (2022) showed that diosmin helps prevent post-thrombotic syndrome following deep vein thrombosis. The research documented that its powder supplementation after DVT reduced the incidence and severity of post-thrombotic syndrome. Participants experienced less residual venous obstruction and valvular reflux, with a 45% reduction in post-thrombotic syndrome development.
These benefits are supported by extensive clinical research and demonstrate the significant therapeutic potential of diosmin. The compound’s diverse effects on venous function, inflammation, and lymphatic drainage make it particularly valuable for vascular and lymphatic health. Regular supplementation shows consistent benefits across various applications, particularly effective in managing chronic venous insufficiency and haemorrhoids.
Side Effects: Is Diosmin Safe?
- Mild Digestive Issues: Some individuals may experience nausea, stomach pain, or diarrhoea.
- Allergic Reactions: Rare cases of rashes or itching have been reported.
- Drowsiness: Some users may experience mild fatigue or dizziness.
FDA Approval: Is Diosmin Legal?
- United States (FDA): Approved for use in dietary supplements.
- European Union (EFSA): Permitted in various health supplements.
- Canada (Health Canada): Approved for vascular health products.
- Australia (TGA): Included in complementary medicines.
What Is Diosmin Used For?
Diosmin powder is primarily used to support circulatory and vascular health, especially in promoting healthy vein function and improving blood flow. It is commonly formulated in products designed for:
- Chronic Venous Insufficiency (CVI) Support Products – Helps reduce leg swelling, heaviness, and discomfort.
- Hemorrhoid Relief Supplements – Supports vein strength and reduces inflammation in hemorrhoidal conditions.
- Vascular Protection Formulas – Enhances capillary resistance and supports overall microcirculation.
- Anti-inflammatory Supplements – Provides natural antioxidant and anti-inflammatory benefits.
- Post-Surgical Recovery Formulas – Promotes better blood flow and vascular healing after surgery.
Common product applications:
- Dietary supplements (capsules, tablets)
- Functional beverages
- Topical creams or gels (in combination with other ingredients)
- Pharmaceutical formulations (especially in Europe and Asia)
Dosage Recommendation of Diosmin
The optimal dosage of diosmin depends on its intended use and the formulation. It is commonly used in dietary supplements for vascular health and circulatory support.
- Chronic Venous Insufficiency (CVI) and Varicose Veins: Typical dosages range from 500 mg to 1,000 mg per day, often combined with hesperidin for enhanced efficacy.
- Hemorrhoid Relief: Short-term treatment may involve 1,000 mg to 3,000 mg daily for the first few days, followed by a maintenance dose of 1,000 mg per day.
- Lymphatic Drainage Support: A daily dose of 900 mg to 1,200 mg may aid in improving lymphatic circulation and reducing leg swelling.
How to Store Diosmin Powder?
Diosmin powder should be stored in a cool, dry, and well-ventilated area, away from direct sunlight, moisture, and heat sources. It is recommended to keep the product in a tightly sealed container to prevent exposure to air and humidity, which may affect its stability and potency.
For optimal shelf life, storage at room temperature (15–25°C / 59–77°F) in a clean environment is ideal. Avoid storing near strong odors or reactive chemicals.
Diosmin VS Hesperidin
Diosmin (CAS: 520-27-4) is a flavone glycoside with a molecular structure consisting of diosmetin attached to a rutinose sugar molecule. For those asking what it is compared to other flavonoids, it has a molecular weight of 608.54 g/mol and appears as a light yellow to yellowish-brown crystalline powder. Its molecular structure features specific hydroxyl and methoxy group positions that contribute to its vascular effects.
In contrast, hesperidin (CAS: 520-26-3) is a flavanone glycoside with a slightly different core structure. Unlike diosmin, hesperidin features a saturated C-ring and different hydroxyl/methoxy group positions. It has a lower molecular weight of 610.57 g/mol and serves as a precursor in diosmin synthesis through specific oxidation reactions.
In terms of bioavailability and pharmacokinetics, the compounds show different profiles. Diosmin powder typically undergoes intestinal hydrolysis to release its aglycone (diosmetin) before absorption. For those researching what diosmin absorption is, it shows approximately 50-60% bioavailability. Hesperidin, meanwhile, demonstrates lower bioavailability (approximately 25-40%) and different metabolic pathways.
Regarding therapeutic applications, while both compounds support vascular health, their primary benefits differ. Diosmin excels in venous tonicity enhancement and lymphatic drainage support, making it particularly effective for chronic venous insufficiency and haemorrhoids. Hesperidin demonstrates more potent effects on capillary permeability and antioxidant activity. Many clinical formulations combine both flavonoids to leverage their complementary mechanisms for comprehensive vascular support.
| Property | Diosmin | Hesperidin |
| Chemical Structure | Flavonoid glycoside derived from hesperidin | Bioflavonoid primarily found in citrus fruits |
| Molecular Formula | C28H32O15 | C28H34O15 |
| Molecular Weight | 608.54 g/mol | 610.57 g/mol |
| CAS Number | 520-27-4 | 520-26-3 |
| Appearance | Fine yellow crystalline powder | Fine light yellow crystalline powder |
| Powder Color | Yellow | Light yellow |
| Stability | Stable under normal storage conditions | Stable under normal storage conditions |
| Bioavailability | Lower in natural form, improved in micronized form | Higher than diosmin, but still limited |
| Primary Function | – Venotonic agent (improves vein tone) – Reduces inflammation | – Antioxidant – Supports blood vessel health |
| Mechanism of Action | – Reduces capillary permeability – Increases venous return – Anti-inflammatory | – Scavenges free radicals – Reduces capillary fragility |
| Daily Dosage | 500 mg – 1,000 mg (for venous insufficiency) | 500 mg – 1,000 mg (for vascular health) |
| Health Benefits | – Treats chronic venous insufficiency (CVI) – Reduces hemorrhoid symptoms – Improves lymphatic drainage | – Improves circulation – Supports cardiovascular health – Anti-inflammatory effects |
| Common Uses | – Treatment of varicose veins – Hemorrhoid relief – Lymphedema management | – Vascular health – Antioxidant supplementation – Capillary support |
| Advantages | – Effective for venous disorders – Available in micronized form for better absorption | – Natural antioxidant – Supports general vascular health |
| Disadvantages | – Poor natural absorption – Requires micronization for efficacy | – Less potent for venous conditions – Limited studies compared to diosmin |
| Legal Status | Approved as a therapeutic supplement in many countries | Available as a dietary supplement |
Conclusion
Diosmin is a flavonoid widely used in the pharmaceutical and supplement industries for its vascular-protective properties. It is known for supporting vein health, improving circulation, and managing conditions such as chronic venous insufficiency, hemorrhoids, and lymphedema. Diosmin’s antioxidant and anti-inflammatory actions further contribute to its therapeutic benefits, making it a valuable component in vascular and circulatory health products.
For manufacturers, diosmin powder offers a reliable ingredient for developing specialized formulations targeting vein health and inflammation-related conditions. Its established efficacy and safety profile make it a popular choice in both standalone and combination supplements. Compliance with regulatory guidelines and precise dosage formulation is essential to ensure product quality and effectiveness.
About Nutri Avenue
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* All products from Nutri Avenue can provide ISO certificates.
FAQs
Yes, Diosmin is the main ingredient in the medication Daflon, a brand name product containing Diosmin and another flavonoid called hesperidin. They are used for similar purposes in managing venous disorders.
Yes, Diosmin is generally considered safe when used as a dietary supplement ingredient.
