Spermidine

What Is Spermidine?

It, or called spermidine trihydrochloride, was first discovered in human semen. In 1677, Dutch scientist Antony van Leeuwenhoek, the father of microscopy, discovered the existence of sperm from his semen using a homemade microscope and obtained a crystal of a compound, the precursor of spermidine.

For hundreds of years after this, this compound was ignored. In 2009, researchers Frank Madeo and Tobias Eisenberg of the University of Graz, Austria, discovered in an experiment that after adding 0.2 mmol spermidine to the nematode diet, the life span of the experimental group was extended by 15% compared with the control group. This effect is even more significant in the yeast experimental model. The lifespan of the yeast experimental group with four mmol spermidine was 400% that of the control group. The experimental results were published in Cell Biology, a sub-journal of Nature.

Since then, this ingredient has gone from being unknown to a life-extending treasure. In 2018, a review from the world’s top journal, “Science,” gave a solid record of the life-extending effect of this substance, which is both true and false. A review of 130 relevant scientific papers suggested that the substance’s life-extending hypothesis may be true.

The Largest Human Experiment In Human History Proves

Long-term intake of spermidine can extend life span by 5.7 years!

In 2018, researchers selected 829 participants aged 45-84 and followed them for 20 years to analyze potential associations between dietary intake and human mortality.

The study divided the population into three groups according to spermidine intake.

• low intake group (<62.2 µmol/d)
• medium intake group (62.2–79.8 µmol/d)
• high intake group (>79.8 µmol/d)

341 deaths were recorded during the follow-up period, including 137 from vascular disease, 94 from cancer, and 110 from other causes. The calculated crude mortality rates for the low, middle, and high groups were 40.5%, 23.7%, and 15.1% respectively. These data indicate a significant inverse association between intake and all-cause mortality.

The similarity in mortality risk between the highest and lowest intakes, associated with being 5.7 years younger, supports the belief that long-term spermidine intake contributes to longevity.

foods source (foods high in spermidine)

It is abundantly found in various plant-based and fermented foods. Notable sources include wheat germ, soybeans, and aged cheeses like cheddar and Parmesan. Fermented items such as natto (fermented soybeans) and certain mushrooms, including shiitake and maitake, are also rich in it. Furthermore, this polyamine is present in whole grains, legumes, and specific fruits and vegetables, such as broccoli, cauliflower, and oranges, making these foods significant for enhancing cellular health and promoting longevity.

Specification sheet reference

Its purity is ≥98.0% in general. If this ingredient is extracted from wheat germ, the purity is only 1%.

Spermidine Powder: How To Produce It?

There are two manufacturing processes for this ingredient.

1. Food Extraction. There are many dietary sources, including wheat, beans, aged cheeses, and mushrooms. Extractions of this ingredient from traditional food sources are limited in purity and potency. Potential allergens, such as gluten, are another common concern among consumers.
2. Biosynthesis. Advanced biotechnology synthesis replaces the traditional extraction method. Biosynthesized way solves the allergen problem. High concentrations of synthetic spermidine can unleash its full health potential in longevity. Consumers can now enjoy safe ingredient without any worries.

What Does Spermidine Do?

As a naturally occurring compound, it is vital for cellular health by activating autophagy, the body’s process of cleaning out damaged cells and regenerating newer, healthier ones. This process is critical to preserving cell function and extending cellular life. Studies indicate that it may also support heart health, boost brain function, and help slow down aging by enhancing the body’s ability to repair itself. Additionally, it may protect against age-related diseases, improve metabolic processes, and promote overall vitality by maintaining cellular integrity.

Spermidine Trihydrochloride VS Spermidine

Spermidine trihydrochloride is a chemically stabilized version of Spermidine designed to improve its solubility, stability, and bioavailability in supplements.

Unlike regular form, naturally found in foods like wheat germ, soybeans, and aged cheeses, spermidine trihydrochloride is synthetically produced to ensure consistent potency and effectiveness in therapeutic use. This form allows for precise dosing and enhanced absorption in the body, making it particularly useful in clinical settings or for those seeking specific health benefits through supplementation. While beneficial, regular form from food sources can vary in concentration and effectiveness due to food processing, individual metabolism, and bioavailability, making it less predictable for targeted therapeutic outcomes.

Spermidine trihydrochloride is often considered superior to regular form because of its improved stability and absorption, leading to more consistent and powerful health benefits. The trihydrochloride form overcomes the challenges posed by natural spermidine’s variable concentrations in foods and its less predictable absorption in the digestive system. By offering a more stable and concentrated version, the trihydrochloride form ensures that the body receives an effective dose, maximizing the benefits for cellular health, longevity, and other therapeutic effects. This makes trihydrochloride form a preferred option in supplements that support autophagy, cardiovascular health, cognitive function, and other areas where consistent spermidine intake is essential for achieving optimal health outcomes.

Spermidine VS NMN

Both are anti-aging substances, but their anti-aging pathways differ. NMN responds to aging signals. Spermidine starts by renewing damaged cells and fundamentally solves the problem of aging.

As we age, our ability to produce natural spermidine levels through our gut microbiota or diet decreases significantly. This decline causes the autophagy process in our bodies to stall, preventing cell regeneration. Ingesting spermidine can promote autophagy, trigger mitophagy, etc., making it a golden choice for longevity supplements.

Spermidine Trihydrochloride: Benefits, Side Effects, And More

For skin. As the largest organ in the body, the skin is continuously exposed to harmful environmental factors like Ultraviolet radiation, pollution, and free radicals that accelerate aging and cause damage. It aids skin health by stimulating autophagy, a vital process that clears out damaged cells and promotes the regeneration of new ones. It is essential for maintaining youthful skin and preventing aging signs like wrinkles, fine lines, and reduced elasticity. Additionally, spermidine enhances the skin’s barrier function, which is crucial for retaining moisture and shielding against external threats, leading to improved hydration, smoother texture, and a more even complexion. Its anti-inflammatory properties also help alleviate irritated skin and lower the risk of inflammatory conditions like acne, eczema, and psoriasis.

For weight loss. It is emerging as a promising aid in weight management, influencing metabolic processes by enhancing the efficiency of mitochondria, the cell’s energy centers. By boosting mitochondrial function, spermidine increases energy expenditure, which can support fat loss and overall weight management. Its role in promoting autophagy—the body’s process of clearing out damaged cellular components—further contributes to healthy metabolism, particularly under conditions like caloric restriction or intermittent fasting. Through these mechanisms, it may help maintain cellular health and energy balance, potentially assisting in achieving and sustaining a healthy weight.

For hair growth. This compound shows potential in promoting hair growth by extending the anagen phase, the active growth stage of the hair cycle, resulting in thicker and fuller hair. This extension helps prevent hair thinning and loss, addressing issues commonly caused by aging, stress, and hormonal changes. Additionally, spermidine supports the health and regeneration of hair follicles, ensuring their continued activity in producing new hair strands. Its anti-inflammatory properties contribute to a healthy scalp environment, which is essential for sustained hair growth. Regular intake, through diet or supplementation, helps maintain hair density and reduce age-related hair loss.

For cancer. Research suggests this aging ingredient may play a role in cancer prevention, primarily due to its ability to induce autophagy, which helps remove damaged cells before they become cancerous. By maintaining cellular homeostasis by eliminating dysfunctional cells, it reduces the risk of tumor formation. Its anti-inflammatory and antioxidant capabilities further contribute to cancer prevention by mitigating chronic inflammation and oxidative stress, both known to increase cancer risk. While further research is necessary, current evidence indicates that spermidine could be an essential component of strategies to reduce the likelihood of cancer development.

For cardiovascular health. It has been found to support cardio health by enhancing endothelial function and reducing arterial stiffness, both of which are crucial in preventing cardiovascular diseases. It also supports healthy blood pressure levels, which may reduce the possibility of heart attacks and strokes.

For cognitive function. Its neuroprotective effects are especially relevant for preventing age-related mental decline. Enhancing autophagy in brain cells helps remove toxic proteins that may cause Alzheimer’s and Parkinson’s. Therefore, Regular spermidine intake may improve cognitive function and memory retention.

For longevity. Its role in promoting cellular health and autophagy is strongly linked to increased lifespan and an extended health span—the duration of life spent in good health. By bolstering the body’s natural repair processes, spermidine helps delay the onset of age-related diseases, contributing to sustained vitality as one age.

For immune support. It may boost immune function by aiding the regeneration of immune cells and supporting a balanced immune response. Maintaining a robust immune system is vital for protecting against infections and other health challenges, especially as the body ages.

Side Effects: Is It Safe?

Spermidine is typically safe when consumed through regular dietary sources, but it may lead to mild side effects in some individuals. These effects, such as gastrointestinal discomfort, nausea, or bloating, are more familiar with high doses or when used as a supplement.

Dosage And Used For

Most brands on the market choose wheat germ as the source. Typically, the finished product using this traditional extraction method contains only 1%. Because of its insufficient purity, it will cause the related finished products to be beige or off-white. For consumers, the impression is average.

In order to solve this problem, biosynthetic technology can be used to produce pure spermidine powder with a concentration of up to 98%. This method is nearly 100 times more effective than products extracted from wheat germ.

Simply put, high concentration means fewer additives, impurities and less chance of poisons accumulating in the body, especially when the recommended daily spermidine dosage is up to 13 mg.

In addition, there is an ammonia smell in its powder. Biosynthetic technology also solves this problem.

This ingredient can be used in facial and eyelash essences, granules, hair growth or hair care products, etc.

Bulk Spermidine Trihydrochloride Supplier: Nutri Avenue

Nutri Avenue is the best raw ingredients supplier to offer bulk spermidine trihydrochloride powder with high purity. Each batch of this ingredient passes rigorous self-inspection and third-party testing. It has obtained ISO 9001, HALAL, HACCP, Micro quality labs, and other qualification certifications.

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