Nobiletin: A Citrus Flavonoid for Anti-inflammation and Optimum Brain Health

Nobiletin may prevent the development of Alzheimer’s disease and Dementia

Nobiletin: A Citrus Flavonoid for Anti-inflammation and Optimum Brain Health

Nobiletin is a multi-functional dietary supplement ingredient that is shown to promote detoxification processes of the body through its antioxidant properties. The compound is also claimed to help maintain healthy cholesterol levels, thereby preventing several illnesses associated with hypercholesterolemia. It may also work in promoting overall cognitive function.

What is Nobiletin?

Nobiletin is a naturally occurring polymethoxylated flavonoid primarily isolated from citrus peels. It was first discovered in the 1930s from the oily matter of a Chinese drug which is made out of mandarin orange. The compound is a plant metabolite that is known to have potentially anti-tumor, anti-inflammatory, anti-neoplastic, and cardioprotective properties. With the advent of several medical pieces of research supporting health claims associated with its use, many experts say that Nobiletin is a promising candidate for drug development.

In terms of chemical structure, Nobiletin is essentially a flavone substituted by methoxy groups at positions 5, 6, 7, 8, 3′ and 4′ respectively. Its six methoxy groups are primarily responsible for its increased lipophilicity. Other names for the compound include Hexamethoxyflavone, 3′,4′,5,6,7,8-Hexamethoxyflavone, 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one, Chuanpi glycosides, 478-01-3, and Nobiletina. It is also known for its brand names Sytrinol and Nobiletil.

The compound is identified as having CAS number 478-01-3. Its molecular formula is C21H22O8 and its molecular weight is 402.399 g/mol. The compound is described as having a white to off-white powder appearance and is generally soluble in methanol. The compound is only sparingly soluble in water and ether.

Nobiletin food sources

Nobiletin occurs naturally in several food sources. One of which is Citrus Aurantium which is otherwise known as Bitter orange. Citrus Aurantium contains flavones such as apigenin, luteolin, and diosmetin. However, its Nobiletin content is believed to be primarily responsible for the major health benefits associated with it.

Another food source for Nobiletin is Citrus Sinensis or more commonly known as Sweet Orange. The fruit of Citrus Sinensis is known to yield the highest amounts of Nobiletin among other citrus fruits.

Other food sources of Nobiletin include lemon, tangerine, and grapefruit.

Nobiletin forms and specifications

In dietary supplement formulations, Nobiletin is usually included in powder form with a 98% purity assay. Nobiletin 20% Extract derived from Citrus aurantium and Nobiletin 40% Extract from Citrus Sinensis L. Fruit is also commonly used in today’s pharmaceutical fields.

Nobiletin powder is available for purchase from legitimate ingredient suppliers like Nutriavenue. When buying from Nutriavenue in bulk, the powder is usually packed in paper drums with two layers of poly bags inside. Each drum contains a net weight of 25 kilograms.

Depending on the number of your purchased products and your preference, packaging may also vary.

Tangeretin and Nobiletin stack

Tangeretin is another methoxy flavone found in citrus fruits. Along with Nobiletin and Hesperidin, the compound is believed to be responsible for the anti-neuroinflammatory properties of citrus peels.

The idea of stacking Tangeretin and Nobiletin is quite interesting among health experts as it may double the anti-inflammatory effects of the compounds through synergistic effects. Thus, for a more powerful formulation, Tangeretin and Nobiletin stack is ideal.

How does Nobiletin work?

Nobiletin plays a vital role in several activated patterns in the human body. Studies show that the compound helps protect brain cells from damage and promotes overall cognitive function by reducing tau phosphorylation and oxidative stress. It is also shown to upregulate the expression of mRNA of NMDA receptors which are essential for memory and learning. Nobiletin also helps activate the CREB signaling pathway which results in improved neural responses.

It is also claimed that the compound may work in decreasing the secretion of insulin resistance factors. It also helps regulate insulin, CREB phosphorylation in the digestive tract, and phosphorylation of signal transducer. As an anti-inflammatory agent, the compound also downgrades signaling pathways of some enzymes and chemicals for inflammatory responses.

Nobiletin benefits

Nobiletin supplementation provides various health benefits among individual users. Some of the benefits of using Nobiletin include the following:

It supports brain function

It is claimed that Nobiletin supplementation may support brain function and prevent the development of Alzheimer’s disease and Dementia. This is because it helps reduce oxidative stress in neurons and hyperphosphorylation of tau. It was also found that Nobiletin supplementation may improve cognitive deficits and pathologic features associated not only with Alzheimer’s disease but also with Parkinson’s Disease and other neurodegenerative conditions.

It promotes bone health

Another interesting benefit associated with Nobiletin is that it promotes bone health. It is found that the compound has an effect in inhibiting NFkappaB-dependent prostaglandin E synthesis, thereby suppressing bone resorption. It is also found to protect women, especially the elderly, against bone loss associated with an estrogen deficiency.

It may help control diabetes

Nobiletin is also found to be helpful among diabetic patients as it has certain mechanisms in reducing insulin resistance. Hence, it may prevent hyperglycemic storms among Type II Diabetes Mellitus patients.

It promotes weight loss

By reducing cholesterol and triglyceride levels, as well as by preventing insulin resistance, it is believed that Nobiletin may promote weight loss among obese and overweight individuals. It also helps reduce excessive adipose fat accumulation in subcutaneous layers.

It promotes sleep

Aside from its neuroprotective roles, Nobiletin is also known to enhance overall brain and body function by promoting sleep and relaxation. It is shown that the compound effectively enhances circadian rhythm or the sleep-wake cycle of individuals.

Nobiletin side effects

There are no known serious side effects associated with the use of Nobiletin in dietary supplement products. Nonetheless, some users may experience mild symptoms such as stomach aches and irritation within the first few doses of the compound. It is important to discontinue the use of the compound upon the development of serious adverse effects affecting the nervous, cardiovascular, and respiratory systems.

Nobiletin dosage

Health practitioners generally recommend the intake of citrus bioflavonoids at a maximum of 1000 mg per day. However, the said recommended dosage may vary depending on the individual user’s age, weight, and overall physical condition. Pregnant and lactating women, as well as those who are suffering from certain medical conditions, are advised to consult their physicians before using the compound.

Where to buy bulk Nobiletin powder?

You may purchase Nobiletin powder in bulk or lesser quantities from Nutriavenue, an FDA-registered ingredient supplier duly recognized and certified by Halal, Kosher, and GMP.

Our company offers the finest quality products at very affordable prices for your dietary supplement formulation needs. We also offer shipping services through air, sea, or couriers like UPS and FedEx for your convenience.

For more information on our services and a complete list of your products, you may check out our website at You may also avail of a free quote when you visit our website.  

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