Orotic Acid: A Mineral Carrier for Better Musculoskeletal Health

Orotic Acid is a Mineral Carrier for Better Musculoskeletal Health

Orotic Acid is a dietary supplement ingredient known to improve the absorption and metabolism of Vitamin B12 and folic acid. The compound is a metabolite that is beneficial for athletes and bodybuilders as it may increase muscle carnosine levels, speed up workout recovery, and improve muscle mass development.

What is Orotic Acid?

Orotic Acid is a pyrimidinemonocarboxylic acid known as a conjugate acid of orotate. It is naturally produced in the human body through a certain mitochondrial enzyme or a cytoplasmic enzyme. During its early days of discovery, Orotic Acid was considered a component of the Vitamin B complex and was called Vitamin B13. However, with the advent of modern clinical research, it was found that Orotic Acid plays a vital role as a vitamin and mineral carrier, thus, it is no longer considered a vitamin. The compound is medically used in the treatment of liver dysfunction along with Xanthine.

The compound is identified as having CAS number 65-86-1 and molecular formula C5H4N2O4. Other names for Orotic Acid include 2,4-dioxo-1H-pyrimidine-6-carboxylic acid, OA, Orodin, and Oropur. The molecular weight of the compound is 156.1 g/mol.

Orotic Acid has a white crystal to crystalline powder appearance. It is derived from uracil and bears a carboxy substituent at position C-6. The compound is generally soluble in water and ammonium hydroxide.

Carbamoyl phosphate to Orotic acid

The synthesis of Orotic Acid from Carbamoyl Phosphate (CP) begins with the formation of the latter in the cytoplasm or the urea synthesis in the mitochondria of the liver cells. Carbomyl Phosphate is derived from Ammonia either from glutamine or from tissue fluid. When a load of ammonia presented for urea synthesis is overwhelming, excess Carbamoyl Phosphate enters the pyrimidine pathway which, in turn, results in the formation of orotic acid.

Orotic Acid forms and specifications

The compound is generally included in dietary supplement formulations in powder form with a 99% purity assay. Orotic Acid 99% powder may be purchased in bulk quantities from legitimate ingredient suppliers online such as Nutriavenue.

When purchased in bulk from Nutriavenue, Orotic Acid 99% powder is usually packed in paper drums with two layers of poly bags inside. Each drum has a net weight of 25 kilograms. Packaging may vary depending on the quantity of your purchase and your preference.

Ornithine and Orotic Acid

Ornithine is a nonessential amino acid produced from the separation of urea from arginine. It is an important factor in the urea cycle and nitrogen excretion. A deficiency in Ornithine generally increases excess Carbomyl Phosphate and the consequent increase in Orotic Acid formation. Excessive Orotic Acid formation due to ornithine transcarbamylase deficiency, a urea cycle disorder, results in increased elimination of Orotic Acid as it is not being utilized by the body efficiently.

Orotic Acid and Lithium Orotate

Lithium Orotate is a compound composed of the alkali mineral Lithium and Orotic Acid. It is among the most common forms of Orotic Acid used in dietary supplement formulations. Aside from its effect as a mineral carrier, Lithium Orotate is preferred as it may also be used in the treatment of lithium deficiency. Concerns in Lithium Orotate use for Orotic Acid supplementation may, however, be raised as excessive Lithium in the body may be dangerous.

Orotic Acid and Magnesium Orotate

Orotic Acid has long been studied for its potential effects in protecting heart muscles from further ischemic stress following infarction. For this purpose, it has been established in studies that the most effective form of Orotic Acid for heart health is Magnesium Orotate. This is because the compound, along with the independent effects of Orotic Acid in the heart, may reduce the severity of chronic myocardial dysfunction and structural damage.

How does Orotic Acid work?

Orotic Acid plays a vital role in several biosynthesis pathways in the human body. Foremost, it works as a mineral carrier for Folic Acid and Vitamin B12. This means that it helps improve the metabolism of the said compounds so that the body may maximize its use. Orotic Acid is also found to be essential in the development of the Central Nervous System. It also helps prevent rapid degeneration of cardiac muscles among patients who have experienced myocardial infarction.

When converted into Beta-Alanine, Orotic Acid is also known to produce powerful buffering effects which are beneficial among athletes and bodybuilders. It also helps enhance the uptake of carnitine in skeletal muscles.

Health benefits of Orotic Acid

The following are among the many health benefits of using Orotic Acid:

It increases muscle carnosine levels

Beta-Alanine is a precursor to carnosine synthesis. Hence, it is useful in RNA synthesis, as well as in the growth of skeletal muscles. In one biosynthesis process, Orotic Acid is converted into Beta-Alanine. Thus, it increases muscle carnosine levels and promotes muscle growth.

It enhances endurance

It is believed that Orotic Acid supplementation may also help prevent fatigue and exhaustion following the performance of extraneous exercises. Aside from preventing rapid depletion of ATP or cellular energy, Orotic Acid is also said to boost uptake of glucose. In effect, it promotes overall endurance.

It supports the muscles

Orotic Acid is also found to support muscle growth by preventing lactic acid accumulation during exercises. This supports muscles and prevents rapid wear and tear.

It may speed up workout recovery

With excessive lactic acid accumulation, the workout recovery period may be prolonged as the muscles are worn out. The intake of Orotic Acid supplements is believed to speed up workout recovery as it protects muscles from deterioration.

It may help with metabolism Vitamin B12 and Folic Acid

Vitamin B12 and Folic Acid are essential in nerve and blood health. By increasing the metabolism of these vitamins, Orotic Acid is believed to enhance health.

It may help with the absorption of Calcium and Magnesium

The compound may also promote the absorption of minerals like Calcium and Magnesium. Hence, it may prevent mineral deficiencies and promote wellness.

Orotic Acid side effects

While there are no side effects associated with Orotic Acid supplementation, some individual users have reported the development of mild symptoms like stomach irritation, diarrhea, and nausea following Orotic Acid intake. The use of the compound must be discontinued if severe adverse effects occur.

Orotic Acid dosage

In most sources, the recommended dosage for Orotic Acid supplementation is 500 to 1000 mg per day. Nonetheless, the recommended dose may vary depending on the individual user’s age, weight, and overall physical condition.

Where to buy bulk Orotic Acid?

Orotic Acid may be bought in bulk or lesser quantities from Nutriavenue, an FDA-registered ingredient supplier recognized and certified by Halal, Kosher, and GMP.

Aside from Orotic Acid, we also offer a wide range of ingredients that may be used for dietary supplement formulations and research purposes. We also offer shipping services through air, sea, or couriers like UPS and FedEx. Rates for shipping vary depending on your location and the quantity of your purchase.

For more details on our products and services, you may contact our technical support staff when you visit our website. You may also avail of a free quote on our page.

Share this post with your friends

Get a Free Quote

Stay in Touch

How can we help? Get free samples, pricing and stock list.

USA address
1641 W Main St, Ste 222, Alhambra, CA 91801
China address:
Room 209 , Huana Business Center , NO 1733 Lianhua Road , Minhang District , Shanghai , China 201103

Top Sellers


Nutri Avenue

how can we help ?