Among the patterns determined to help resolve Vitamin B12 deficiency is the compensation brought about by sufficient B13 Vitamin or Orotic acid levels. For so long, experts have never realized the significance of Orotic Acid in vitamin and mineral absorption. Only recently did researchers find that the compound is essential in Pyramidine metabolism as an intermediary. It is also vital in several processes occurring in the human body and preventing several serious health conditions, including multiple sclerosis. Today, health supplement manufacturers include Orotic Acid in their formulations to promote wellness in various ways. It is also included in some cosmetic products as it helps improve skin health.
What Is B13?
B13, also known as Orotic Acid, is a fast-growing health supplement ingredient for its effects in enhancing the absorption of nutrients and promoting weight loss and lean muscle mass development. Despite the name, Vit B13 is not considered a vitamin as it is produced naturally by intestinal flora. Synthetic forms of Vitamin B 13 are thus produced through laboratory procedures to increase circulating levels of Orotic Acid. Studies show that Orotic Acid also plays a vital role in producing and maintaining ATP levels in body cells. This effect is very important, especially in body organs requiring high amounts of ATP to function, such as the heart and the brain.
Orotic Acid is a dietary supplement ingredient known to improve the absorption and metabolism of Vitamin B12 and folic Acid. The compound is a metabolite that benefits athletes and bodybuilders as it may increase muscle carnosine levels, speed up workout recovery, and improve muscle mass development.
Orotic Acid is a pyrimidine monocarboxylic acid known as a conjugate acid of orotate. It is naturally produced in the human body through a certain mitochondrial enzyme or a cytoplasmic enzyme. During its early days of discovery, Orotic Acid was considered a component of the Vitamin B complex called Vitamin B13. However, with modern clinical research, Orotic Acid plays a vital role as a vitamin and mineral carrier; thus, it is no longer considered a vitamin. The compound is medically used to treat liver dysfunction along with Xanthine.
The compound is identified as having CAS number 65-86-1 and molecular formula C5H4N2O4. Other names for Orotic Acid include 2,4-dioxo-1H-pyrimidine-6-carboxylic Acid, OA, Orodin, and Oropur. The molecular weight of the compound is 156.1 g/mol.
Orotic Acid has a white crystal to crystalline powder appearance. It is derived from uracil and bears a carboxy substituent at position C-6. The compound is generally soluble in water and ammonium hydroxide.
Carbamoyl Phosphate To Orotic Acid
The synthesis of Orotic Acid from Carbamoyl Phosphate (CP) begins with the formation of the latter in the cytoplasm or the urea synthesis in the mitochondria of the liver cells. Carbomyl Phosphate is derived from Ammonia, glutamine, or tissue fluid. When a load of Ammonia presented for urea synthesis is overwhelming, excess Carbamoyl Phosphate enters the pyrimidine pathway, forming orotic Acid.
Orotic Acid Forms And Specifications
The compound is generally included in powder-form dietary supplement formulations with a 99% purity assay. Orotic Acid, 99% powder, may be purchased in bulk quantities from legitimate ingredient suppliers online, such as Nutriavenue.
When purchased in bulk from Nutriavenue, Orotic Acid 99% powder is usually packed in paper drums with two layers of poly bags. Each drum has a net weight of 25 kilograms. Packaging may vary depending on the quantity of your purchase and your preference.
Ornithine And Orotic Acid
Ornithine is a nonessential amino acid produced by separating urea from arginine. It is an important factor in the urea cycle and nitrogen excretion. A deficiency in Ornithine generally increases excess Carbomyl Phosphate and the consequent increase in Orotic Acid formation. Excessive Orotic Acid formation due to ornithine transcarbamylase deficiency, a urea cycle disorder, results in increased elimination of Orotic Acid as it is not utilized by the body efficiently.
Orotic Acid And Lithium Orotate
Lithium Orotate is a compound composed of the alkali mineral Lithium and Orotic Acid. It is among the most common forms of Orotic Acid used in dietary supplement formulations. Aside from its effect as a mineral carrier, Lithium Orotate Bulk Powder is preferred as it may also use to treat lithium deficiency. Some people take lithium orotate supplements for their potential mood-stabilizing effects, as Lithium is a well-known treatment for bipolar disorder. Concerns about Lithium Orotate use for Orotic Acid supplementation may, however, be raised as excessive Lithium in the body may be dangerous.
Orotic Acid And Magnesium Orotate
Orotic Acid has long been studied for its potential effects in protecting heart muscles from further ischemic stress following infarction. For this purpose, studies have established that the most effective form of Orotic Acid for heart health is Magnesium Orotate. It is because the compound and the independent effects of Orotic Acid in the heart may reduce the severity of chronic myocardial dysfunction and structural damage.
How Does Orotic Acid Work?
Orotic Acid plays a vital role in several biosynthesis pathways in the human body. It is a mineral carrier for Folic Acid and Vitamin B12. It means that it helps improve the metabolism of the said compounds so that the body may maximize their use. Orotic Acid is also found to be essential in the development of the Central Nervous System. It also helps prevent the rapid degeneration of cardiac muscles among patients who have experienced myocardial infarction.
When converted into Beta-Alanine, Orotic Acid is also known to produce powerful buffering effects, which are beneficial among athletes and bodybuilders. It also helps enhance the uptake of carnitine in skeletal muscles.
Orotic Acid Benefits
Supplementing Orotic Acid through formulated health supplement products can provide many direct and indirect health benefits to the human body. Vitamin b13 benefits include the following:
- It may prevent fatigue and exhaustion.
Individuals engaged in weight loss programs as well as athletes and bodybuilders may experience fatigue and exhaustion following a sudden drop in the levels of ATP. Experts say that by maintaining ATP levels and preventing sudden loss of energy, Orotic Acid may help prevent fatigue and exhaustion. It may also result in effective athletic performance and improved compliance with weight loss programs.
- It provides a backbone for DNA.
Orotic Acid is also an essential intermediary in developing deoxyribonucleic Acid or DNA. Along with other compounds naturally found in the human body, One of the B13 Vitamin benefits is it helps build DNA and other organelles in body cells. Low levels of Orotic Acid can cause several illnesses and changes in the genetic composition of cells.
- It improves cardiac health.
Certain studies also suggest that Orotic Acid supplementation is essential among patients at high risk for developing lifestyle-related cardiovascular diseases. The compound helps enhance cardiac contractility and prevents the accumulation of fat molecules in the blood vessels.
- It increases muscle carnosine levels.
Beta-Alanine is a precursor to carnosine synthesis. Hence, it is useful in RNA synthesis, as well as in the growth of skeletal muscles. In one biosynthesis process, Orotic Acid is converted into Beta-Alanine. Thus, it increases muscle carnosine levels and promotes muscle growth.
- It supports the muscle.
Orotic Acid is also found to support muscle growth by preventing lactic acid accumulation during exercises. It supports muscles and prevents rapid wear and tear.
- It may speed up workout recovery.
Excessive lactic acid accumulation may prolong the workout recovery period as the muscles are worn out. Orotic Acid supplements are believed to speed up workout recovery by protecting muscles from deterioration.
- It may help with the metabolism of Vitamin B12 and Folic Acid.
Vitamin B12 and Folic Acid are essential in nerve and blood health. By increasing the metabolism of these vitamins, Orotic Acid is believed to enhance health.
- It may help with the absorption of Calcium and Magnesium.
The compound may also promote the absorption of minerals like Calcium and Magnesium. Hence, it may prevent mineral deficiencies and promote wellness.
- It supports liver health.
Orotic Acid may support liver health by promoting the regeneration of liver cells and reducing the risk of liver damage.
- It supports healthy skin.
Orotic Acid may benefit the skin, producing collagen and promoting healthy skin cells. Orotic Acid help improve the texture and hydration of the skin by promoting the growth of new skin cells and improving the skin’s barrier function.
- Immune system function
Some studies have suggested that orotic Acid may help support immune system function.
Orotic Acid B 13 Side Effects
While no side effects are associated with Orotic Acid supplementation, some users have reported mild symptoms like stomach irritation, diarrhea, and nausea following Orotic Acid intake. Must discontinue the use of the compound if severe adverse effects occur.
Vitamin B 13 Dosage Recommendation
In most sources, the recommended dosage for Orotic Acid supplementation is 500 to 1000 mg daily. Nonetheless, the recommended dose may vary depending on the user’s age, weight, and overall physical condition.
Where To Buy Bulk B13 Orotic Acid?
Orotic Acid may be bought in bulk or lesser quantities from Nutriavenue, an FDA-registered ingredient supplier recognized and certified by Halal, Kosher, and GMP.
Aside from Orotic Acid, we also offer a wide range of ingredients that may use for dietary supplement formulations and research purposes. We also offer shipping services through air, sea, or couriers like UPS and FedEx. Rates for shipping vary depending on your location and purchase quantity.
For more details on our products and services, contact our technical support staff when you visit our website. You may also avail of a free quote on our page.
The compound is produced naturally in the human body; experts stress that one must take it within recommended doses to avoid overdose. Prior consultation with a physician may be necessary for individuals suffering from certain medical conditions.