Palmitoylethanolamide is a chemical in the body whose primary function is to reduce chronic pain and inflammation. Studies are currently being conducted to determine its potential effects in depression and other mental health issues, as well as in the management of joint pain conditions. It is also claimed that the compound may have effects in enhancing overall immunity.
What is Palmitoylethanolamide?
Palmitoylethanolamide is a cannabinoid receptor-inactive ECB-related molecule that is used in the formulation of dietary supplement products. It is an N-(long-chain-acyl)ethanolamine which is a derivative of hexadecanoic acid. The compound was first discovered in 1957 but its potential use in the medical field was only discovered in the 1980s. It has applications as an anti-inflammatory agent, an analgesic, an antinociceptive, an anticonvulsant, and a neuroprotective product. Palmitoylethanolamide cannot be considered a classic endocannabinoid because it lacks affinity for the cannabinoid receptors CB1 and CB2.
The compound Palmitoylethanolamide is also known as Hydroxyethylpalmitamide, Palmidrol, N-Palmitoylethanolamine, and Palmitoylethanolamide. Other names of the compound include Ultramicronized palmitoylethanolamide, Palmitoyl Ethanolamide, Micronized PEA 99%, Mirica®, Levagen PEA, OptiPEA®, and Palmitic acid mono-ethanolamide.
The CAS number of the compound is 544-31-0 and its molecular formula is C18H37NO2. The molecular weight of the compound is 299.5 g/mol.
In powder forms, the compound has a white to off-white appearance and is soluble in DMSO, ethanol, and chloroform. The compound is practically insoluble in water.
Palmitoylethanolamide forms and specifications
Several Palmitoylethanolamide forms are available in the market for use in various applications. The most common forms include Standard Palmitoylethanolamide Powder 99%, Water-Dispersible Palmitoylethanolamide 99%, Liposomal Palmitoylethanolamide 99%, and Palmitoylethanolamide-Oxazoline (PEA-OXA). You may avail of any of the foregoing products depending on your needs.
If you are looking for Palmitoylethanolamide powder, you may find the product at Nutriavenue, an ingredient supplier which offers high-quality dietary supplement ingredients at very affordable prices. You may avail of specific packaging material when you buy Palmitoylethanolamide powder in bulk from Nutriavenue. The standard packaging materials for bulk purchases in our company are paper drums with two layers of poly bags inside. Each paper drum contains 25 kilograms net weight. You may also avail of a different packaging option when you buy products in lesser quantities.
Palmitoylethanolamide vs Phenylethylamine
Both Palmitoylethanolamide and Phenylethylamine are referred to in dietary supplement products as PEA. However, these compounds are not the same and are substantially different in several aspects.
Phenylethylamine is a natural monoamine alkaloid that directly acts in the human brain as a neurotransmitter. Unlike Palmitoylethanolamide, Phenylethylamine is not necessarily associated with anti-inflammatory and analgesic effects. Phenylethylamine is mostly used to improve overall mood and prevent depression.
CBD vs Palmitoylethanolamide
Cannabidiol or CBD is a popular medicinal compound found in Cannabis Sativa. It is used in the treatment of various conditions including anxiety, post-traumatic stress disorder, and depression.
Both CBD and Palmitoylethanolamide are known to be effective in inflammation and pain control. They are also known to provide neuroprotective benefits. However, the main difference between these compounds is that CBD is found in plants, while Palmitoylethanolamide is naturally found in the body. Hence, the mechanism of action of Palmitoylethanolamide is safer than CBD.
Palmitoylethanolamide and Luteolin
Luteolin is a famous flavonoid compound that displays several biological actions. In a recent study, experts found that the combination of Palmitoylethanolamide and Luteolin may result in the effective management of chronic disorders as these compounds fight off both inflammation and oxidative stress. In the said same study, models for common chronic illnesses like Parkinson’s Disease and Dementia were used. It was found that Palmitoylethanolamide with Luteolin may reduce neuroinflammatory and apoptotic pathways and improve the expression of neurotrophic factors.
Palmitoylethanolamide and Sleep
The endogenous fatty acid amide Palmitoylethanolamide is also found to be quite effective in managing sleep disorders and improving the overall quality of life. It is believed that the compound may help improve sleep by interacting with the endocannabinoid system. The compound is also found to restore dysregulated Anandamide signaling, thereby possibly facilitating better sleep patterns.
Palmitoylethanolamide Mechanism of Action
As an anti-inflammatory compound, it is believed that Palmitoylethanolamide works by inhibiting the release of pro-inflammatory molecules from mast cells, monocytes, and macrophages. It also reduces the production of histamines and TNF-alpha which are factors affecting inflammation.
The compound is also believed to bind certain cells in the human body to reduce pain and swelling.
Palmitoylethanolamide Manufacturing Process
There are several ways by which Palmitoylethanolamide is obtained for inclusion in dietary supplement products. These methods include fermentation, synthetic manufacturing under laboratory procedures, and natural extraction from sources like safflower seed oil.
Health Benefits of using Palmitoylethanolamide
The following are among the many benefits of using the compound Palmitoylethanolamide in dietary supplement products:
It provides natural pain relief
The compound Palmitoylethanolamide naturally provides relief from pain brought about by various factors. It may also be useful against neuropathic pain and other long-term pain conditions.
It works as an anti-inflammatory agent
Studies also reveal that Palmitoylethanolamide may work in preventing inflammation and swelling. Hence, it may be used against several inflammatory conditions including joint inflammations.
It provides joint and nerve support
Palmitoylethanolamide also plays a vital role in supporting nerve and joint health. It may be beneficial among adults and elderly individuals who are experiencing discomfort due to nerve and joint pains.
It may provide immune and nervous system health
It has also been found that the compound may enhance overall immunity responses. Palmitoylethanolamide may also help in the management of nervous system conditions, especially those which are associated with degenerative cellular damage.
Palmitoylethanolamide side effects
Most users of Palmitoylethanolamide supplements do not experience side effects when taking the compound within recommended doses. Nonetheless, some users have experienced mild symptoms involving the gastrointestinal tract, as well as headaches and dizziness. The use of the compound should be discontinued if it results in severe adverse reactions.
The compound is usually taken at 300 to 1,200 mg per day. However, the said dosing may vary as per the physician’s prescription based on the individual user’s weight, age, and overall physical conditions.
Where to buy bulk Palmitoylethanolamide powder?
Palmitoylethanolamide powder may be bought in bulk at Nutriavenue, and an FDA-registered ingredient supplier which has been in the market of ingredient supply for several years. Our company is recognized by various entities including Kosher, GMP, and Halal.
We also offer many other ingredients which are of proven purity and quality. For our customer’s convenience, we also provide shipping services through air, sea, or couriers like UPS and FedEx.
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