Phosphatidylethanolmine: A Compound Essential in Multi-Organ Systems

Phosphatidylethanolamine improve memory

Phosphatidylethanolamines are a class of naturally occurring compounds found in biological membranes. They play vital roles in many bodily processes involving multi-organ systems such as the nervous system and the lymphatic system. Phosphatidylethanolamine is included in some dietary supplement ingredients for its beneficial effects on health.

What is Phosphatidylethanolamine(PE)?

Phosphatidylethanolamines are phospholipids found in all living cells. They are important precursors and substrates to biological pathways and are important in the regulation of cardiac functions. As a dietary supplement ingredient, it is believed that Phosphatidylethanolamines may improve overall cognition and prevent rapid degeneration of neurons. Some experts also say that Phosphatidylethanolamines may have contributory effects in immunology or the ability of the body to deal with infections.

Phosphatidylethanolamine is also known as Phosphatidyl Ethanolamine or PE, Cephalin, L-Alpha-Cephalin, and L-Alpha-Phosphatidylethanolamine.

The CAS number of Phosphatidylethanolamine is 39382-08-6. Its molecular formula is C9H18NO8P and its molecular weight is 299.21 g/mol. The compound has a white to off-white powder appearance.

Phosphatidylethanolamine forms and specifications

Phosphatidylethanolamine powder 99% is the most common form of Phosphatidylethanolamine sold in the market for dietary supplement formulation and research purposes. The compound is available in several ingredient suppliers like Nutriavenue. Nutriavenue offers bulk Phosphatidylethanolamine powder packed in paper drums and two layers of poly bags inside. The net weight of the product is usually 25 kilograms. Depending on the customer’s request, the said packaging and net weight may vary.

Phosphatidylethanolamine structural formula


N acyl Phosphatidylethanolamine vs Phosphatidylethanolamine

 N-acyl Phosphatidylethanolamine or NAPE are formed from Phosphatidylethanolamine. Essentially, N-acyl Phosphatidylethanolamine works as a hormone that effectively suppresses appetite. In terms of helping persons with obesity, N-acyl Phosphatidylethanolamine is more beneficial as it directly acts in the bloodstream during the processing of fat. Phosphatidylethanolamine on its unconverted form does not necessarily have a direct action on fat metabolism.

Phosphatidylethanolamine synthesis

Generally, Phosphatidylethanolamine is created from the combination of glycerol esterified with two fatty acids and phosphoric acid. There are two pathways by which the said compound is synthesized. These pathways are the phosphatidylserine decarboxylation pathway and the cytidine diphosphate-ethanolamine pathways. In the cellular mitochondria, the main pathway for Phosphatidylethanolamine synthesis is the phosphatidylserine decarboxylation pathway.

Phosphatidylcholine and Phosphatidylethanolamine

The inclusion of choline to the phosphate group of Phosphatidylethanolamine yields Phosphatidylcholine. Both Phosphatidylethanolamine and Phosphatidylcholine are major structural components of cellular membranes. However, they differ in certain specific functions.

Phosphatidylethanolamine acts mainly in the development of lipid mediators and second messengers. In contrast, Phosphatidylcholine works in the phagocytic processes of body cells, as well as in cell division.

How does Phosphatidylethanolamine work


How does Phosphatidylethanolamine work

Phosphatidylethanolamine comprises 25% of all phospholipids in the human body. When there is a disturbance in the production of Phosphatidylethanolamine, problems with cellular proliferation and membrane movement through body cells occur.

As an important phospholipid, Phosphatidylethanolamine works in the transport of compounds and other chemicals through cellular membranes. It also has certain functions during cytokinesis.

According to studies, Phosphatidylethanolamine is also important in the lipoprotein section in the liver. It may also help in blood clotting actions of the body.

Phosphatidylethanolamine benefits

Although the body produces Phosphatidylethanolamine naturally, its supplementation may produce certain benefits which include the following:

It may improve overall cognitive functions and memory

Several scientific pieces of research have shown that Phosphatidylethanolamine supplementation has potential effects on optimizing brain health. Accordingly, it may help persons diagnosed with Dementia and Alzheimer’s disease by slowing down rapid cellular degeneration and playing an active role in supporting neurotransmitter production. Among younger individuals, it is believed that Phosphatidylethanolamine supplementation may also support memory work and improve learning abilities. It may also prevent brain cell aging.

It may promote liver health and fat metabolism

The action of Phosphatidylethanolamine in serving as an intermediary in the secretion of lipoproteins in the liver is also important in promoting liver health. Lipoproteins are important biochemicals that transport cholesterol into the bloodstream. Reduced lipoproteins may cause increased fat levels. By improving lipoprotein action, experts say that Phosphatidylethanolamine may help promote the metabolism of fats and prevent severe damage to the liver.

Phosphatidylethanolamin may protect heart cells

It may protect heart cells

Experts say that Phosphatidylethanolamine is important in helping proteins fold correctly so that their structure may be complete and their functions will be fulfilled optimally. In one study, it was found that Phosphatidylethanolamine may help protect heart cells from damage through its action in aiding in protein folding.  

Other health benefits

Phosphatidylethanolamine is also believed to help support immunity and promote autophagy. There are also researches being conducted to determine whether the compound may have effects in cancer cell proliferation control, as well as in preventing the development of the disease.

Phosphatidylethanolamine side effects

Phosphatidylethanolamine supplementation usually promotes wellness without side effects. However, it was reported by some individual users in independent product reviews that symptoms like stomachache and vomiting may occur following Phosphatidylethanolamine supplementation. Normally, these symptoms disappear in a few doses. 

Patients who experience unlikely adverse effects such as changes in vital signs, chest pains, and severe headaches are recommended to discontinue the use of the compound and immediately contact a medical health professional. Persons who are diagnosed with health conditions, as well as pregnant and lactating women, are advised to consult their physicians before use of the compound.

Phosphatidylethanolamine dosage

The dosage for use of Phosphatidylethanolamine supplements depends on the intended therapeutic effect for its use. Factors including age, weight, and overall physical condition may also affect the recommended dose for Phosphatidylethanolamine supplementation.

Where to buy bulk Phosphatidylethanolamine?

For your bulk ingredient needs for dietary supplement formulations, you may check out Nutriavenue.com.

Nutriavenue is an FDA-registered ingredient supplier which has been in the market of ingredient sale for several years. We are also recognized and certified by Halal, Kosher, and GMP. Aside from bulk Phosphatidylethanolamine, we also offer several other ingredients that are of proven quality at very affordable prices.

For a complete list of the products we offer, you may visit our page and make a simple search. If you are interested to make a purchase, you may get a quote for free. Our friendly and customer-oriented technical support staff are also willing to assist you if you have any queries regarding our products and services.

We also offer shipping services through air, sea, and couriers like FedEx and UPS. Shipping fees depend on the quantity of your purchase and your location.  

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