Sanguinarine

What is Sanguinarine?

Sanguinarine is a naturally occurring benzophenanthridine alkaloid derived from plants in the Papaveraceae family, such as Sanguinaria canadensis (bloodroot) and Chelidonium majus (greater celandine). Known for its potent biological activity, sanguinarine is widely studied for its antimicrobial, anti-inflammatory, and anticancer properties.

This yellow to reddish crystalline powder has gained attention for its ability to combat microbial infections and its applications in the pharmaceutical, nutraceutical, and cosmetic industries. Its chemical complexity and broad spectrum of uses make it a valuable compound for various health and wellness formulations.

Wspólne źródła

Bloodroot (Sanguinaria canadensis): This is a key source of sanguinarine, concentrated in the rhizomes.

Greater Celandine (Chelidonium majus): It provides a rich reservoir of sanguinarine and other benzophenanthridine alkaloids.

Papaveraceae Family Plants: Trace amounts of this compound are also found in other plants within the same botanical family.

Jak to działa?

Sanguinarine disrupts cellular processes by intercalating with DNA and inhibiting enzymes involved in cell division. It exhibits potent antimicrobial activity by targeting bacterial membranes and inhibiting biofilm formation. Additionally, it induces apoptosis in cancer cells through mitochondrial pathways and regulates inflammatory mediators, contributing to its therapeutic potential.

How to Produce Sanguinarine Powder?

1. Wybór surowców: Harvest and authenticate mature Sanguinaria canadensis rhizomes during the dormancy period, ensuring the removal of contaminants and foreign materials.
2. Initial Processing: Process cleaned rhizomes through controlled drying and milling procedures to achieve uniform coarse powder suitable for extraction.
3. Ekstrakcja: Subject processed material to solvent extraction using ethanol or methanol under optimized conditions for maximum alkaloid yield.
4. Filtration and Concentration: Remove plant debris through progressive filtration stages followed by vacuum evaporation to achieve the desired extract concentration.
5. Purification: Implement chromatographic techniques to isolate and purify sanguinarine alkaloids from the concentrated extract.
6. Crystallization: Generate pure sanguinarine crystals through controlled temperature crystallization and solvent washing procedures.
7. Przetwarzanie końcowe: Convert purified crystals to standardized powder through vacuum drying and precision milling operations.
8. Kontrola jakości: Verify final product specifications through comprehensive analytical testing, including HPLC analysis and contamination screening.

Odniesienie do arkusza specyfikacji

Sanguinarine: Benefits, Side Effects, and More

Antimicrobial Properties

It exhibits strong antibacterial, antifungal, and antiviral effects, making it valuable in treating infections and enhancing oral care products.

Działanie przeciwzapalne

The compound modulates inflammatory pathways, reducing the release of pro-inflammatory cytokines and alleviating inflammation-related conditions.

Anticancer Potential

It induces apoptosis and inhibits cancer cell proliferation by targeting mitochondrial and signaling pathways.

Antioxidant Effects

By scavenging free radicals, it protects cells from oxidative stress, reducing the dangers of chronic diseases.

Supports Oral Health

It is commonly used in toothpaste and mouthwash to prevent plaque formation and combat gingivitis.

Efekty uboczne

Sanguinarine side effects are often mild and rare. The following may occur to some individuals:

• Gastrointestinal Discomfort: This may cause nausea or stomach upset at higher doses.
• Cytotoxicity: Overuse can lead to cellular toxicity, particularly in liver and kidney tissues.
• Reakcje alergiczne: Rare cases of skin irritation or sensitivity.

Czy jest to legalne?

United States: It is permitted in dietary supplements and oral care products but not approved for medical use.

European Union: It is classified as a natural additive in herbal products, subject to strict safety guidelines.

Australia: The compound is allowed in complementary medicines with the Therapeutic Goods Administration (TGA) oversight.

Japan: This ingredient is approved as a traditional herbal component in Kampo medicine formulations.

What is Sanguinarine Powder Used For?

Health Supplements

• Usage: The compound is formulated into standardized capsules and tablets through precise manufacturing processes targeting immune system enhancement.
• Benefit: The active alkaloids provide comprehensive immune support while reducing systemic inflammation through multiple pathways.

Oral Care Products

• Usage: It serves as an active ingredient in professional dental formulations through controlled incorporation into oral care products.
• Benefit: The compound effectively prevents dental plaque formation while supporting periodontal tissue health.

Pharmaceutical Research

• Usage: In advanced studies, research laboratories utilize this compound to investigate its potential anticancer and antimicrobial mechanisms.
• Benefit: The compound provides valuable insights into novel therapeutic approaches through its unique molecular interactions.

Cosmetic Applications

• Usage: Formulators incorporate precise concentrations into advanced skincare products targeting cellular protection.
• Benefit: It uses its comprehensive antioxidant properties to shield the skin while also supporting natural skin renewal processes.

Functional Food Development

• Usage: Food manufacturers integrate standardized amounts into specialized nutritional products through controlled processing methods.
• Benefit: The compound enhances product nutritional profiles while providing antioxidant support for consumer health.

Veterinary Medicine

• Usage: Animal health professionals incorporate it into feed formulations through standardized manufacturing processes.
• Benefit: The compound optimizes livestock gut health while enhancing natural disease resistance mechanisms.

Agricultural Protection

• Usage: Agricultural operations implement sanguinarine-based solutions through targeted application protocols.
• Benefit: The compound provides natural crop protection against various microbial pathogens while maintaining environmental safety.

Zalecane dawkowanie i sposób użycia

For supplements, typical doses range from 100 mg to 300 mg daily. Consult a healthcare provider for specific recommendations.

How to Store Sanguinarine Powder?

The storage of this powder requires maintenance under controlled refrigeration (2-8°C/35.6-46.4°F) in hermetically sealed containers. The compound should be protected from light exposure, temperature fluctuations, and atmospheric moisture to ensure optimal stability and preservation of therapeutic properties.

Sanguinarine VS Chlorhexidine

Sanguinarine (CAS: 2447-54-3) and Chlorhexidine (CAS: 55-56-1) function differently in oral health. Sanguinarine provides targeted antimicrobial effects while supporting tissue health and offering antioxidant benefits. Chlorhexidine works through direct antimicrobial action by coating oral surfaces.

Clinical use shows Sanguinarine naturally supports gum health and tissue regeneration, while Chlorhexidine effectively fights bacteria but may cause tooth staining and taste changes. Manufacturing costs favor Chlorhexidine’s synthetic production over Sanguinarine’s natural extraction process.

Sanguinarine proves more beneficial for ongoing oral care due to its multiple health benefits and fewer side effects. While Chlorhexidine works well for short-term dental conditions, its combination of gentle antimicrobial action and tissue support makes it better for long-term use.

Sanguinarine VS Chelerythrine

Though structurally similar, these alkaloids work differently in the body. Sanguinarine (CAS: 2447-54-3) shows broader antimicrobial effects and better tissue penetration, while Chelerythrine (CAS: 34316-15-9) specifically targets specific cellular processes. Sanguinarine demonstrates superior antioxidant protection.

Their uses reflect these differences. Sanguinarine works well in oral care products and general antimicrobial applications, while chelerythrine serves better in specific research applications and targeted treatments. Production favors Sanguinarine due to easier extraction and greater natural availability.

Overall, Sanguinarine offers more practical benefits through its wider range of applications and established safety profile, though Chelerythrine remains valuable for specialized research purposes.

Wnioski

This compound demonstrates significant therapeutic potential through its comprehensive biological activity profile, particularly in antimicrobial, anti-inflammatory, and antioxidant applications. The compound’s documented efficacy, established safety parameters, and regulatory compliance across major markets support its implementation in various commercial products, from oral care to veterinary applications. Its standardized production methods, favorable stability profile, and superior characteristics compared to alternatives like Chlorhexidine and Chelerythrine, combined with cost-effective manufacturing processes, position it as a valuable ingredient for current product development and future therapeutic innovations.

Why Choose Nutri Avenue Supplier to Buy Sanguinarine Powder?

Precision and trust are critical when sourcing an ingredient powder, and that’s where Nutri Avenue excels. Our product is developed under strict GMP-certified and ISO-compliant protocols, and every batch is verified through advanced third-party testing to ensure it meets exacting quality standards.

Beyond the product, we deliver a seamless procurement experience. Our five strategically located warehouses in the USA enable rapid order fulfillment, reducing delays and optimizing your operations. Whether you require bulk quantities or tailored formulations, our OEM/ODM services are designed to adapt to your specific needs. Nutri Avenue combines scientific rigor, logistical efficiency, and custom solutions to provide an unmatched supply experience for your business.

*ISO certificates are readily available for all of Nutri Avenue’s products.