Potential Cancer-fighting Capabilities of 3,3′-Diindolylmethane


The National Cancer Institute of the United States recognize 3,3′-Diindolylmethane as a potential cancer agent, subjecting it to several intensive clinical studies conducted on human subjects but aside from helping control cancer cell growth, interest on the compound is also rising worldwide due to its possible effects in treating hormonal imbalances among women. The activities of Brassica vegetables in the body is believed to be associated with the 3,3′-Diindolylmethane contents of the food group, which has led to the idea of isolating the compound for the formulation of various health supplements.

What is 3,3′-Diindolylmethane?

In food sources, the compound 3,3′-Diindolylmethane is usually a result of the breakdown of indole-3-carbinol, an element found in vegetables such as broccoli, cabbage and sprouts. This means that the body does not readily receive the compound from vegetables as it does with supplementation. Experts say that increasing 3,3′-Diindolylmethane reserves through supplementation is more effective as the compound is more readily absorbed and no conversion is necessary. The intake of 3,3′-Diindolylmethane through food sources is not, however, discouraged.

What are the health benefits of using 3,3′-Diindolylmethane?

Supplements containing 3,3′-Diindolylmethane are beneficial for individuals of all ages for the following reasons:

  • It can prevent cancer cell growth and development

The need for agents which can positively control cancer cell growth without associated risks has risen over the years as morbidity and mortality rate associated with cancerous conditions continue to rise. Although many compounds are claimed as cancer-fighting agents, only a few elements like 3,3′-Diindolylmethane are duly recognized by institutions like the US National Cancer Institute. Experts say that the compound 3,3′-Diindolylmethane is effective against several forms of cancer which include breast, colorectal and uterine cancers. There is, however, very little understanding as to the effects of the drug against leukemia, pancreatic cancer, brain tumor and other complicated cancer types.

  • It may control pre-menstrual symptoms

The claim that the compound 3,3′-Diindolylmethane may help treat hormonal imbalances among women began with the finding that it may control pre-menstrual symptoms or PMS. PMS usually develops with sudden increase in estrogen levels which results to painful uterine contractions, muscle aches and even mood swings. Studies show that 3,3′-Diindolylmethane helps block rapid estogen production leading to the control of symptoms associated with menstrual cycle.

  1. It may prevent Benign Prostatic Hypertrophy

A high percentage of men in the early 50’s develop Benign Prostatic Hypertrophy or BPH due to changes in their hormonal balance as well as long-term exposure to unhealthy environment. Aside from controlling cancer growth, studies show that 3,3′-Diindolylmethane may also help control and prevent BPH among men, although its mechanisms of action are not yet proven.


3,3′-Diindolylmethane is best absorbed through health supplements. Its vast array of claimed health benefits are now being confirmed through actual human subject studies conducted by researchers all over the world.

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