Berberine HCl

What Is Berberine?

It is a natural alkaloid found in some plants, such as Hydrastis canadensis, Berberis vulgaris, and Mahonia aquifolium. This ingredient has a variety of pharmacological effects. It is mainly derived from the roots and bark of Coptis chinensis, a plant of Coptis.

Berberine powder has the appearance of yellow needle-shaped crystals. Its density is 1.17g/cm³, melting point is 204-205℃, boiling point is 486.8℃, refractive index is 1.662, and vapor pressure is 3.41E-05mmHg at 25°C. It is soluble in hot water, slightly soluble in water or ethanol, and very slightly in chloroform. But it is insoluble in ether. Its molecular formula is C20H18NO4+, and its molecular weight is 336.36 g/mol. ,

It is mainly used as an antibiotic in medicine to treat intestinal infections. In addition, it has been found to have the effects of lowering blood lipids, treating diabetes, and regulating blood lipids. Pharmacological studies have shown that this natural compound has significant therapeutic effects in antibacterial and anti-inflammatory aspects and has high clinical application value for tumors, diabetes, and cardiovascular diseases.

As a dietary supplement ingredient, Berberine is available in various forms, including capsules, tablets, pills, etc. It is often used as an herbal remedy or incorporated into formulations targeting specific health concerns.

Fontes de

• Goldenseal (Hydrastis Canadensis)

It is a herbaceous perennial plant native to North America. The roots and rhizomes of goldenseal contain significant amounts of this ingredient.

• Barberry (Berberis vulgaris)

It is a shrub native to Europe, Asia, and North Africa. The bark, roots, and stem of barberry contain the active ingredient we talked about here.

• Oregon grape (Mahonia aquifolium)

It is an evergreen shrub native to western North America. The roots and rhizomes of Oregon grapes contain this natural compound.

• Chinese goldthread (Coptis chinensis)

It is a perennial herb native to China and other parts of Asia. The rhizomes of Chinese goldthread are rich in it.

What Is Berberine HCl?

Berberine HCl (full name: Berberine hydrochloride) is a derivative of berberine. It has been combined with hydrochloric acid to enhance its stability and absorption in the body. It is commonly used as a medicine or supplement, especially in traditional Chinese medicine.

Berberine VS Berberine HCl

Berberine is a natural alkaloid found in various plants with a wide range of pharmacological effects, including antibacterial, anti-inflammatory, hypoglycemic, and hypolipidemic effects. It is often used as a drug or supplement, especially in traditional Chinese medicine. It is a quaternary ammonium salt with low solubility in water.

Berberine hcl is the hydrochloride form of berberine. It increases the solubility of berberine in water, which makes it more commonly used in pharmaceutical preparations. The hydrochloride form is often used as an antibiotic to treat intestinal infections and has shown potential benefits for metabolic diseases in some studies.

In summary, the main difference between the two forms is their solubility and pharmaceutical applications. Berberine hydrochloride is more popular in the pharmaceutical industry due to its improved water solubility. Berberine itself has a longer history of use in traditional medicine.

What Is Dihydroberberine?

It is a naturally occurring isoquinoline alkaloid, a hydrogenated berberine derivative. Its CAS number is 483-15-8, with the molecular formula of C20H19NO4, and the molecular weight between 337.37-337.40 g/mol.

Berberine VS Dihydroberberine

This form is one of the 17 active metabolites of berberine. It is produced naturally by gut microbes and undergoes a reduction process before being absorbed into the intestines. Supplementing with dihydroberberine may eliminate the limiting step of microbial reduction and alleviate the gastrointestinal discomfort some people experience when using berberine supplements. This gastrointestinal discomfort may be due to malabsorption or as a result of the microbial reduction process.

Its structure (containing multiple hydrogen bonds) allows for better bioavailability and absorption and easier binding at the cellular level. Dihydroberberine is absorbed five times more in the intestine than berberine. In addition, dihydroberberine also lasts longer in the body – eight hours compared to just four hours for berberine.

Regarding controlling blood sugar levels, berberine increases blood sugar breakdown and utilization, improves insulin sensitivity, promotes fat oxidation, and inhibits adipocyte growth by activating the AMP-activated protein kinase (AMPK) pathway. Research suggests that dihydroberberine is more effective at improving insulin sensitivity. In an animal study, the group given dihydro berberine had more significant improvements in improving fat, triglyceride accumulation, and insulin sensitivity than the berberine group.

Another simulation model study compared the inhibitory effects of these two ingredients on pancreatic lipase. The results showed that dihydroberberine had a stronger inhibitory effect than regular berberine, which may make it a more effective weight-loss aid than berberine.

In studies on improving atherosclerosis, dihydroberberine showed stronger anti-inflammatory effects than berberine and was more beneficial for cardiovascular health.

Although berberine is an effective agent for improving insulin and blood sugar emissions, dihydroberberine is more effective in managing blood sugar and insulin. And it may also have positive effects on weight and cholesterol. If considering switching from berberine to dihydroberberine supplementation, the recommended dose is 400 to 500 mg, divided into two 200 mg or 250 mg doses.

Specifications Sheet Reference

• Berberine HCL powder 97%/98%

Berberine VS Metformin VS Ozempic VS Inositol VS Chromium Picolinate

Berberine is a natural compound in various plants, including witch hazel, barberry, and Oregon grape. It has been used for centuries in traditional Chinese medicine and is well known for its potential health benefits. This natural compound improves blood sugar control, promotes weight loss, and supports heart health. It regulates blood sugar levels by activating AMP-activated protein kinase (AMPK). It is often called a metabolic master switch.

Metformin is an oral antidiabetic drug. It is a first-line drug for the treatment of type 2 diabetes. Its mechanism of action includes reducing glucose production in the liver, increasing glucose absorption and utilization by muscle tissue, and possibly affecting the intestinal microbiota.

Compared with berberine, some studies have shown that berberine may be as effective as metformin in lowering blood sugar. However, metformin has been extensively clinically studied and used for a long time, and its safety and effectiveness are widely recognized. Berberine is generally considered a natural product. It is being investigated as a complementary and alternative therapy, but its long-term effects and safety still need more clinical studies to confirm.

Ozempic is a prescription medication. It is used to treat type 2 diabetes and, in some cases, for weight loss. It belongs to a class of drugs called glucagon-like peptide-1 (GLP-1) receptor agonists. Ozempic works by stimulating insulin secretion, inhibiting glucagon secretion, slowing stomach emptying, and promoting weight loss.

Although the two may have similar effects in lowering blood sugar and promoting weight loss, there are differences in their mechanisms. Ozempic acts as a GLP-1 agonist, which works in the brain to reduce hunger and increase satiety. Berberine works by improving insulin sensitivity and fat oxidation. In addition, Ozempic is administered as a prescription drug. Berberine, on the other hand, is more easily available as a dietary supplement.

Some people on social media have hailed Berberine as “nature’s Ozempic.” But it’s important to note that it is not a version of Ozempic. The mechanism of action of this natural compound does not include producing a sense of fullness in the brain as Ozempic does.

Inositol, also known as vitamin B8, is a natural compound that plays a key role in many cell functions. It is found in many foods, including fruits, legumes, and grains. Inositol has been shown to support mental health, improve insulin sensitivity, and promote healthy hair and skin.

When Berberine and Inositol are used together, they can synergize. It means that their combined benefits are greater than the sum of their individual effects. Here are the many uses this powerful combination can provide.

• Both have been shown to help regulate blood sugar levels. When used together, they can provide greater support for individuals with diabetes or insulin resistance.
• Berberine supports cardiovascular health by lowering cholesterol levels and improving blood flow. Inositol can help lower blood pressure and reduce the risk of heart disease. When used in combination, they can provide comprehensive support for heart health.
• Berberine enhances weight loss by increasing metabolism and reducing appetite. Inositol can help regulate hormones involved in weight management. They can be a powerful tool for achieving and maintaining a healthy weight when used together.
• Inositol has a positive impact on mental health. It can reduce symptoms of anxiety and depression. When combined these two ingredients together, they can provide even greater support for individuals struggling with mood disorders.

Chromium Picolinate is a nutritional supplement ingredient commonly used to support the regulation of blood sugar levels. It contains chromium, a trace element essential to metabolic processes. Chromium Picolinate is thought to enhance the effects of insulin and help cells use blood sugar more efficiently, thereby supporting healthy body composition and weight management.

Berberine Factory: How To Manufacture It?

Step 1: High-quality plant materials known to contain this natural compound, such as goldenseal, barberry, or Oregon grape, are selected as the raw materials for the extraction.

Step 2: The plant material, typically the roots, rhizomes, or bark, is processed to release it. Different extraction methods, such as solvent extraction or steam distillation, separate the active ingredient from the rest of the plant components.

Step 3: The resulting liquid extract is filtered to remove solid particles and impurities, ensuring a cleaner solution.

Step 4: The filtered extract undergoes a concentration process to remove excess moisture and increase its content. Techniques like evaporation or spray drying may be employed to achieve the desired concentration.

Step 5: The concentrated extract may undergo purification to remove impurities and obtain a higher purity level. Techniques such as chromatography or crystallization can further refine and isolate it.

Step 6: The purified extract is subjected to drying methods to remove any remaining moisture and convert it into a dry, powdered form. Techniques like spray drying or freeze drying are commonly employed to preserve the integrity of the compound during the drying process.

Step 7: The final powder undergoes rigorous testing to ensure its quality, purity, and potency. Various analytical techniques, including HPLC, may be used to verify the composition and the product’s specifications.

Step 8: The tested and approved powder is packaged in appropriate containers or materials.