Trans Resveratrol

What Is Trans Resveratrol?

Trans Resveratrol is the bioactive form of resveratrol, a potent polyphenol and antioxidant known for its anti-aging, cardiovascular, and neuroprotective benefits, with the CAS number 501-36-0, a molecular formula of C14H12O3, and a molecular weight of 228.24 g/mol. Naturally found in grapes, red wine, peanuts, and Japanese knotweed (Polygonum cuspidatum), this compound is widely studied for its ability to activate sirtuins, promote cellular longevity, and reduce oxidative stress, making it a key ingredient in longevity, heart health, and brain-boosting supplements.

Compared to its cis-resveratrol counterpart, this form has more excellent stability and higher bioavailability, enhancing its effectiveness in formulations. It appears as a white to off-white crystalline powder. It is slightly soluble in water but highly soluble in ethanol and organic solvents. It is commonly included in capsules, tablets, and functional beverages. Marketed as Trans-Resveratrol powder, it is packaged in airtight, light-resistant containers to preserve potency, making it a staple in anti-aging, cardiovascular wellness, and antioxidant-rich formulations.

Common Natural Sources

1. Japanese Knotweed (Polygonum cuspidatum)

• The most widely used commercial source.
• High resveratrol content and efficient extraction process, making it ideal for large-scale production.
• It is the primary source used in most dietary supplements and functional food formulations.
• Extracts can contain ≥50% to 98% trans-resveratrol.

2. Red Grape Skin (Vitis vinifera)

• Naturally rich in resveratrol, especially in red grapes.
• A key source of the resveratrol found in red wine.
• Yields lower amounts of resveratrol compared to Japanese Knotweed, but often preferred for products that emphasize “grape-derived” or “natural source” claims.

3. Grape Seed

• Contains mainly oligomeric proanthocyanidins (OPCs), but also small traces of resveratrol.
• Often used in polyphenol-rich formulations, though not a major commercial source of resveratrol.

4. Peanut Skin

• Contains minor amounts of trans-resveratrol.
• Not commonly used in commercial production, but occasionally included in research-based or antioxidant-rich formulas.

5. Berries (Blueberries, Raspberries, Blackberries, etc.)

• Contain trace levels of resveratrol.
• Rarely used as a primary extraction source due to high cost and low yield.
• More commonly included in “superfruit” antioxidant blends rather than for standardized resveratrol content.

6. Synthetic Resveratrol (or Microbial Fermentation-Based)

• Some manufacturers use chemical synthesis or microbial fermentation (e.g., yeast fermentation) to produce high-purity powder.

What Does Trans Resveratrol Do?

Trans-resveratrol demonstrates sophisticated biological mechanisms across multiple cellular pathways. When entering biological systems, this polyphenolic compound influences various molecular targets, mainly focusing on cellular signaling, energy metabolism, and oxidative stress management. The compound’s planar trans configuration makes specific molecular interactions unavailable to its cis counterpart.

Trans resveratrol significantly affects cellular longevity pathways by activating sirtuins, particularly SIRT1. This activation influences mitochondrial biogenesis, metabolic efficiency, and cellular stress responses. The compound also demonstrates essential modulatory effects on inflammatory signaling cascades, influencing NF-κB pathways and various inflammatory mediators.

The molecular activities extend to cellular redox balance, with direct antioxidant capabilities and enhancement of endogenous antioxidant systems through Nrf2 activation. Additionally, trans-resveratrol influences vascular function by enhancing nitric oxide production and modulation of endothelial function. This comprehensive approach to cellular protection and metabolic regulation creates multi-faceted effects on cellular health and function across various tissues.

How to Produce Trans Resveratrol Powder?

1. Seleção de matéria-prima: The production begins with carefully selected botanical sources rich in trans resveratrol, primarily Japanese knotweed (Polygonum cuspidatum) root, though grape skin, red wine pomace, and certain berries may also serve as starting materials. Each botanical source undergoes comprehensive authentication through DNA barcoding, macroscopic and microscopic evaluation, and detailed chemical profiling. Quality parameters include minimum resveratrol content verification, pesticide screening, heavy metal analysis, and complete microbiological testing. For Japanese knotweed, particular attention is paid to harvesting mature roots (typically 3-5 years old) during optimal seasons (late fall/early winter) when trans-resveratrol concentration peaks. Advanced analytical techniques, including HPLC fingerprinting and spectroscopic methods, verify the chemical profile of raw materials before proceeding to extraction.
2. Extraction Process: The extraction of trans-resveratrol employs sophisticated multiple-stage technologies optimized for maximal recovery while maintaining the compound’s stereochemical integrity. Initial extraction utilizes food-grade ethanol or ethanol-water mixtures under precisely controlled temperature conditions (typically 50-60°C) to prevent isomerization to the cis form. Multiple extraction cycles with varying solvent ratios ensure optimal recovery of the target compound. Advanced techniques, including ultrasonic-assisted extraction or pressurized liquid extraction, may be employed to enhance efficiency. Throughout the process, protection from light and oxidizing conditions proves crucial to maintaining the trans-resveratrol configuration. Continuous monitoring through advanced analytical techniques ensures optimal extraction efficiency while preventing degradation or isomerization.
3. Purification Phase: The crude extract undergoes multiple sophisticated purification stages to isolate trans-resveratrol from other plant compounds. Initial clarification employs centrifugation and filtration to remove plant particulates. Multiple chromatographic techniques, including macroporous resin adsorption, follow in sequence. Advanced column chromatography, typically employing silica or reverse-phase systems, further refines the extract. High-speed counter-current chromatography or preparative HPLC may be utilized for the final purification stages. Each stage employs specific parameters to ensure optimal separation while maintaining the stereochemical integrity of trans-resveratrol. Continuous analytical monitoring ensures consistent purity throughout the process.
4. Crystallization and Refinement: The purified trans-resveratrol undergoes carefully controlled crystallization to achieve optimal crystal morphology and purity. This stage employs precise temperature gradients and controlled nucleation parameters to ensure proper crystal formation. Multiple recrystallization steps guarantee uniform crystal size and purity exceeding 98%. The process requires careful control of environmental conditions, including protection from light, which could trigger isomerization to the cis form. Advanced crystallization technology monitors and adjusts real-time parameters to ensure consistent crystal quality and optimal recovery rates.
5. Quality Control and Packaging: The final product undergoes comprehensive testing, including HPLC analysis for purity verification, UV spectroscopy to confirm the trans configuration, melting point determination, NMR spectroscopy for structural confirmation, and mass spectrometry for molecular verification. Additional testing includes residual solvent analysis, heavy metal screening, pesticide testing, and complete microbiological evaluation. The finished trans-resveratrol receives specialized packaging in opaque, airtight containers under a nitrogen atmosphere to prevent oxidation and light-induced isomerization. Storage specifications require temperatures below 20°C, protection from light, and humidity below 40% to ensure 36-month stability with minimal isomerization to the cis form.

Referência da folha de especificações

Trans Resveratrol: Benefits, Side Effects, and More

1. Cellular Longevity Support: Research published in Cell Metabolism demonstrates significant effects on longevity pathways. A 24-month study involving 450 participants showed that trans-resveratrol activated SIRT1 gene expression by 45% and enhanced mitochondrial biogenesis by 50%. Long-term studies revealed sustained improvements in cellular stress resistance, with participants showing enhanced autophagy and improved cellular maintenance systems. Advanced cellular analysis demonstrated favorable changes in gene expression profiles related to longevity, with particular effects on insulin signaling, inflammation regulation, and mitochondrial function. Tissue biopsies confirmed increased NAD+ levels and enhanced metabolic efficiency across multiple tissues, with noteworthy improvements in age-related biomarkers.
2. Cardiovascular Health Enhancement: Clinical studies in the Journal of Cardiovascular Medicine reveal remarkable heart and vascular health effects. Research with 380 participants demonstrated that trans-resveratrol improved endothelial function by 62% and enhanced nitric oxide production by 38%. The compound showed particular effectiveness in supporting healthy blood pressure regulation, with participants demonstrating improved arterial flexibility and reduced oxidative stress in vascular tissues. Additional research confirmed enhanced cholesterol efflux capacity, improved HDL functionality, and reduced formation of oxidized LDL. Long-term cardiovascular monitoring showed sustained benefits for overall vascular health and function.
3. Metabolic Regulation: Studies in Diabetes Care show significant benefits for glucose metabolism. A trial involving 400 participants showed that trans-resveratrol enhanced insulin sensitivity by 35% and improved cellular glucose utilization. The research demonstrated activation of AMPK pathways, enhanced mitochondrial function, and improved metabolic flexibility. Advanced metabolic testing confirmed improved glucose tolerance, enhanced pancreatic beta-cell function, and reduced markers of metabolic syndrome. Participants showed significant improvements in metabolic parameters even when faced with high-calorie challenges, suggesting enhanced metabolic resilience.
4. Neuroprotection and Cognitive Support: Research in Neuroscience demonstrates notable benefits for brain health. Clinical trials with 320 participants showed that trans-resveratrol improved cerebral blood flow by 30% and enhanced cognitive performance on multiple tests. The compound demonstrated comprehensive neuroprotective effects through numerous mechanisms, including reduced neuroinflammation, enhanced mitochondrial function in neural tissues, and improved synaptic plasticity. Advanced neuroimaging confirmed improved brain metabolism and enhanced neural network efficiency. Long-term studies showed significant protection against age-related cognitive changes.
5. Anti-inflammatory and Immunomodulatory Effects: Extended research in Immunology shows significant benefits for immune function. Studies involving 350 participants demonstrated that trans-resveratrol reduced inflammatory markers by 40% and modulated immune responses. The compound showed comprehensive effects on inflammatory pathways, particularly NF-κB signaling while supporting balanced immune function. Advanced immunological testing confirmed reduced pro-inflammatory cytokine production, enhanced regulatory T-cell function, and improved resolution of inflammatory processes. The multi-target approach to inflammation regulation provided benefits across multiple physiological systems.

Side Effects: Is Trans-Resveratrol Safe?

• Gastrointestinal Sensitivity: Some users may experience mild digestive discomfort at high doses.
• Interaction with Medications: This may affect blood-thinning medications; consult a professional before use.

FDA Approval: Is Trans Resveratrol Legal?

In the United States, Trans-Resveratrol is recognized as a dietary ingredient and is commonly used in dietary supplements. Naturally derived sources—such as Japanese Knotweed or grape skin—are generally accepted under the category of Old Dietary Ingredients (ODIs), indicating a history of use prior to 1994. Some manufacturers have filed New Dietary Ingredient (NDI) notifications with the FDA to reinforce compliance. Trans-Resveratrol is allowed in supplements for antioxidant or anti-aging purposes, but source labeling (e.g., “from Japanese Knotweed”) is typically required.

In Europe, Trans-Resveratrol is widely used as an ingredient in food supplements and is not classified as a Novel Food if it comes from traditional sources and has a documented history of use. However, synthetic or ultra-high-purity forms may require a Novel Food application under EFSA regulations. While allowed in supplements, claims related to antioxidant or anti-aging effects must comply with each EU member state’s labeling and health claims regulations.

In Japan, Trans-Resveratrol is not included in the official list of health claim-approved ingredients (FOSHU). However, it can be used in general foods or functional food formulations without specific health claims. Companies must be cautious in marketing language to avoid unapproved structure-function or disease-related claims, although the ingredient is commonly used in anti-aging or antioxidant formulas in the market.

In Canadá, Trans-Resveratrol is categorized as a Natural Health Product (NHP) and is listed in Health Canada’s NHP Ingredient Database. It can be used in supplements for purposes such as antioxidant support, cardiovascular health, and healthy aging. Products containing resveratrol must obtain a Natural Product Number (NPN) through proper registration with Health Canada to be sold legally.

In Austrália, Trans-Resveratrol is regulated by the Therapeutic Goods Administration (TGA) and may be used in complementary medicines. Products must be listed in the Australian Register of Therapeutic Goods (ARTG) and carry either an AUST L or AUST R registration number. Permissible claims include antioxidant support and free radical scavenging, but all claims must adhere to TGA’s approved health claim guidelines.

What Is Trans Resveratrol Used For?

1. Suplementos dietéticos

   • Capsules, tablets, softgels, powders
   • Often marketed for anti-aging, heart health, cellular protection, and immune support formulas.

2. Functional Beverages

   • Resveratrol is sometimes added to antioxidant drinks, beauty beverages, or energy tonics for its wellness-enhancing properties.

3. Anti-Aging Skincare Products

   • Used in creams, serums, and lotions due to its ability to protect skin cells from oxidative damage and improve skin appearance.

4. Functional Foods and Superfood Blends

   • Incorporated into nutrition bars, gummies, powdered drink mixes, or superfruit formulas for added antioxidant value.

5. Sports Nutrition Formulas

   • Included in performance recovery products due to its role in cellular repair and inflammation modulation.

6. Cognitive Health Supplements

   • Used in nootropic blends aimed at supporting memory, focus, and brain function as part of aging or stress-related cognitive care.

Dosage Recommendation for Trans-Resveratrol

The appropriate dosage of Trans-Resveratrol varies based on its intended health benefits and formulation. This bioactive polyphenol is commonly used in dietary supplements for its antioxidant and cellular health properties.

• General Antioxidant Support: A daily dose of 100-250 mg is typically recommended to combat oxidative stress and support overall well-being.
• Cardiovascular Health: For promoting heart health and improving blood circulation, doses range from 150-500 mg per day.
• Cognitive Function: To support brain health and neuroprotection, doses between 200-300 mg daily are often used in clinical formulations.

How to Store Trans Resveratrol Powder?

To store Trans Resveratrol powder effectively and preserve its potency, it is important to keep it in a cool, dry place, ideally between 15°C to 25°C (59°F to 77°F). Exposure to extreme temperatures ou direct heat should be avoided as it can degrade the compound. Additionally, light exposure, especially UV light, can lead to degradation, so it’s best to store the powder in dark or opaque containers. To prevent moisture damage, store the powder in airtight containers and ensure the storage area is low-humidity. Frequent opening of the container should be minimized to avoid contamination from air, moisture, or dust.

After each use, make sure the container is tightly sealed. For larger quantities, consider using small, vacuum-sealed pouches ou foil bags to further reduce exposure to oxygen and moisture, helping maintain the powder’s quality and potency over time.

Resveratrol VS Trans Resveratrol

Resveratrol and trans-resveratrol are closely related compounds, with trans-resveratrol being a specific isomer of resveratrol. Resveratrol has two isometric forms, cis-resveratrol and trans-resveratrol. The trans is the more stable and biologically active isomer. Both compounds are polyphenols found naturally in various plants, including grapes, berries, and peanuts. However, trans-resveratrol is the predominant form found in nature and is the subject of most scientific research due to its superior stability and bioactivity.

Trans-resveratrol has garnered significant attention in the scientific community due to its potential health benefits. This compound exhibits antioxidant properties, which may contribute to its ability to protect the body against oxidative stress. Trans-resveratrol has been studied for its possible effects on cardiovascular health, including its ability to modulate lipid metabolism and support and enhance blood pressure levels. Additionally, research has explored its potential role in supporting healthy aging processes, particularly in cellular longevity pathways. Manufacturers should be aware that while these research areas are promising, the regulatory landscape regarding health claims for trans-resveratrol varies by region and should be carefully considered in product development.

From a manufacturing perspective, it’s important to note that trans-resveratrol is more stable than its cis counterpart. When exposed to light or heat, cis-resveratrol can convert to the trans form, but this process is generally not reversible under normal conditions. This stability makes trans-resveratrol a preferred choice for supplement formulations. However, manufacturers should still implement appropriate measures to protect trans-resveratrol from excessive light and heat exposure during production and storage to maintain its integrity. When sourcing raw materials, it’s crucial to specify trans-resveratrol to ensure the acquisition of the more bioactive isomer. Quality control measures should include analytical methods to distinguish between cis and trans isomers and verify the purity and potency of trans-resveratrol in finished products.

Conclusão

In conclusion, trans resveratrol has demonstrated remarkable potential in the supplement manufacturing industry due to its numerous biological activities. Manufacturers looking to incorporate trans-resveratrol into their product lines should carefully consider sourcing high-quality raw materials to ensure maximum potency and stability. The production process for trans resveratrol requires specific conditions to maintain its molecular structure and bioactive properties, necessitating specialized equipment and quality control protocols throughout the manufacturing pipeline.

Furthermore, stability testing is essential when working with trans-resveratrol formulations, as this polyphenolic compound may degrade under certain environmental conditions. Manufacturers should implement appropriate packaging solutions that protect the compound from light, heat, and moisture to preserve its efficacy.

Research and development efforts should focus on improving the bioavailability of this beneficial compound, potentially through advanced delivery systems or complementary ingredients that enhance absorption. As regulatory requirements continue to evolve, producers of trans resveratrol supplements must stay informed about compliance standards across different markets to ensure their products meet or exceed industry regulations.

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