Pyridoxal-5-Phosphate: Active Form of Vitamin B6 for Energy Production and Neurotransmitter Synthesis

Pyridoxal-5-Phosphate is a active form of Vitamin B6 for Energy Production and Neurotransmitter Synthesis

Pyridoxal-5-Phosphate is an important electrophilic catalyst that plays an important role in the stabilization of various carbanionic reaction intermediates. It is essential in the metabolism and biosynthesis of several neurotransmitters in the brain which affects overall mood and cognitive functions. The compound is also beneficial in enhancing immunity responses and providing anti-inflammatory benefits. It also serves to increase energy levels.

What is Pyridoxal-5-Phosphate?

Also known as Pyridoxal 5 Phosphate, Pyridoxal phosphate, PLP, P-5-P, P5P, and Vitamin B6, the compound Pyridoxal-5-Phosphate is a coenzyme that serves as a helper molecule for several catalytic reactions in the human body. It is the active form of Vitamin B6 and is produced by the process of condensation of phosphoric acid with the primary hydroxy group of pyridoxals. Pyridoxal-5-Phosphate is useful in the production not only of neurotransmitters but also of amino acids, sphingolipids, and aminolevulinic acid. It is also necessary for treating dietary imbalances.

The compound is identified as having CAS number 54-47-7. Its molecular formula is C8H10NO6P and its molecular weight is 247.14 g/mol.

Pyridoxal-5-Phosphate has applications as a treatment modality for Vitamin B6 deficiency, as well as an adjunct therapy option for pernicious anemia. Its use in the dietary supplement field is also well known. The compound has an off-white to yellowish-brown crystalline powder appearance and is only slightly soluble in water. The compound is practically insoluble in ethanol.

Pyridoxal-5-Phosphate forms and specifications

Pyridoxal-5-Phosphate powder usually comes in powder forms having 99% purity based on a high-performance liquid chromatography test. It may also come in the form of Pyridoxal-5-phosphate monohydrate powder having CAS number 41468-25-1. Many manufacturers of dietary supplement products use either of these forms for Vitamin B6 deficiency.

When looking for an ingredient supplier offering Pyridoxal-5-Phospate, it is important to consider the supplier’s reputation in the ingredient supply field. Nutriavenue is a well-known ingredient supplier which has been in the market of ingredient supply for years. We offer high-quality and affordable Pyridoxal-5-Phosphate powder for all your dietary supplement formulation needs.

In case of bulk purchases, Pyridoxal-5-Phosphate powder from Nutriavenue is packed in paper drums with two layers of poly bags inside for added protection and support. Each paper drum has a net weight of about 25 kilograms. However, you may also buy the product in lesser quantities.

If you opt to avail of different packaging material, you may do so at Nutriavenue.

Pyridoxal 5 Phosphate vs Pyridoxine HCl

Pyridoxine HCl is one form of Vitamin B6 which is often included in nutritional supplements. When taken into the body, Pyridoxine HCl is converted into the active form of Vitamin B6 which is Pyridoxal 5 Phosphate. Hence, while the said compounds have no comparative differences in terms of health effects and benefits, they differ in that Pyridoxal 5 Phosphate is already in its activated form, while Pyridoxine HCl is not yet an active Vitamin B6 compound.

There are several reasons why Pyridoxal 5 Phosphate is way better than Pyridoxine HCl. One reason is that it is already in the activated Vitamin B6 form. As such, it is readily used in the body without having to undergo processes of conversion. Another reason is that it is more bioavailable as found in some studies. In one medical research, it was also found that Pyridoxal 5 Phosphate is better than Pyridoxine in controlling idiopathic intractable epilepsy.

Pyridoxal-5-Phosphate Mechanism of Action

Essentially, Pyridoxal-5-Phosphate promotes health by serving as a coenzyme or a compound needed for enzymatic production. It is useful in the body’s manufacture of neurotransmitters like Serotonin, Norepinephrine, and GABA. It also serves as a coenzyme in the production of compounds for skin, hair, and nail growth.

The compound Pyridoxal-5-Phosphate is also important in the production of enzymes for digestion and the breakdown of proteins, carbohydrates, and fats. Some enzymes for the production of red blood cells and other blood components also require Pyridoxal-5-Phospate.

By supporting amino acid production, studies also show that Pyridoxal-5-Phosphate is important in energy production.

Pyridoxal-5-Phosphate manufacturing process

One established procedure to obtain high purity Pyridoxal-5-Phosphate is through the use of a pyridoxal Schiff base prepared through the condensation of an aqueous pyridoxal mineral acid salt solution. The said Pyridoxal Schiff base is then phosphorylated with orthophosphoric acid or phosphorus pentoxide as phosphorylating agents, then hydrolyzed. The said process results in the production of phosphate solution under acidic conditions. The pH of the product is then adjusted to obtain a pyridoxal phosphate Schiff base. Lastly, pyridoxal phosphate Schiff base, under alkaline solution, is hydrolyzed to obtain Pyridoxal-5-Phospate.

Pyridoxal-5-Phosphate Health benefits

Pyridoxal-5-Phosphate supplementation provides many health benefits which include the following:

It supports energy production

Pyridoxal-5-Phosphate supplementation helps increase energy levels and prevent fatigue. Hence, it may be useful for adults who are experiencing exhaustion due to several factors including stress.

It may support nervous system health

Vitamin B6 in its active form is very useful in promoting nervous system health. This is because it serves as a backbone to the production of neurotransmitters that activate brain functions. According to researches, Pyridoxal-5-Phosphate supplementation may also enhance mood and optimize cognition.

It helps improve immunity and metabolism

Several enzymes for immunity and metabolism or digestion are produced with relative amounts of Pyridoxal-5-Phospate. Hence, supplementation of the compound may promote optimum metabolic function and immunity.

Pyridoxal-5-Phosphate side effects

Taking Pyridoxal-5-Phosphate supplements is safe and effective. However, some users have reported the development of mild side effects involving the gastrointestinal tract. Some may also experience headaches after using Pyridoxal-5-Phosphate supplements. In most cases, these symptoms disappear after the first few intakes of the compound. If symptoms persist or in cases where severe adverse reactions develop, users are advised to consult their physician immediately.

Pyridoxal-5-Phospate dosage

The individual dose for Pyridoxal-5-Phosphate supplementation is prescribed by a physician based on the user’s weight, age, and overall physical condition. In dietary supplement formulations, Pyridoxal-5-Phosphate dosage is usually 50 mg per day. Doses beyond 50mg should be taken under a physician’s recommendation. 

Where to buy bulk Pyridoxal-5-Phosphate powder?

You may buy bulk Pyridoxal-5-Phospate from the reputable ingredient supplier Nutriavenue.

Nutriavenue is an FDA-registered ingredient supplier which is recognized and certified by entities like Halal, Kosher, and GMP. We offer Pyridoxal-5-Phosphate powder and many other ingredients which you may check out at our website.

We also offer shipping services through the air, sea, or couriers like UPS and FedEx for our customers’ convenience. Rates for shipping vary depending on your location.

If you have any queries on our products and services, feel free to visit our page at and contact our technical support staff.

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