Pyridoxal 5’-phosphate: Best Vitamin B6 Form

P5P Pyridoxal 5’-phosphate

Pyridoxal 5’-phosphate: Best Vitamin B6 Form

The bioavailability of Vitamin B6 in the body is vital in the sustenance of various bodily processes including brain function control and reduction and suppression of inflammatory processes. There are several types of Vitamin B6 forms which are available in the market. While most Vitamin B6 compounds are in their inactive forms, the popular health supplement ingredient Pyridoxal 5’-phosphate, also known as P5P, is gaining so much attention as it is already in its activated form and does not require any other bodily enzyme for its conversion. This means that the body can readily use the compound P5P for its benefits. Experts say that the use of P5P in the field of health supplement manufacture is convenient and beneficial for individual users of whatever age group.

What is P5P?

Known scientifically as Pyridoxal 5’-phosphate, P5P is a fast-rising health supplement ingredient not only in terms of its associated health benefits but also for its absorbability in the human body. The compound P5P, as stated in several health studies, is the most active form of Vitamin B6. It is converted in the liver without within just a few minutes from intake, as compared to other Vitamin B6 forms. With this finding, several physicians say that the use of Pyridoxal 5’-phosphate can be ideal for persons suffering from liver conditions. While persons with liver diseases are still required to obtain physician’s recommendation when taking Pyridoxal 5’-phosphate, it is believed that P5P is the best form available in the market for Vitamin B6 supplementation.

P5P benefits

P5P supplements may bring about several health benefits among individual users. These include the following:

  • It may treat P5P deficiency symptoms

Lack of P5P or Vitamin B6 in the body can result to the development of various symptoms. These include cracked and sore lips, weakened immune system, and low energy. P5P trigger finger is also a common condition arising from deficiency of Vitamin B6 which is characterized by stiffness and pain when bending the fingers. By providing sufficient amounts of Pyridoxal 5’-phosphate through P5P supplements, it is believed that these symptoms may be treated and prevented.

  • It improves mood and relaxation

One study recently conducted shows that pre-menstrual women who are often at risk for depression and mood swings may benefit with Pyridoxal 5’-phosphate supplementation. This is because Vitamin B6 is important in the production and maintenance of various neurotransmitters in the brain which are responsible for mood and affect regulation. Studies are currently being conducted to find out whether Pyridoxal 5’-phosphate may also help among persons who are diagnosed with depression and anxiety.

  • It may have effects in cancer prevention

Among the theories in the development of cancer in the body is unusual inflammation. Since Pyridoxal 5’-phosphate is known for its anti-inflammatory health effects, experts say that it may have contributory effects in the prevention of cancer cell growth. It is not necessarily suggestive, however, that Pyridoxal 5’-phosphate may cure cancer.

P5P vs B6

Generally, P5P is a type of Vitamin B6. It is, however, the most preferred type when it comes to manufacture of health supplement products as it is the most activated form. There are no significant variations between P5P and B6 as they are one and the same.

P5P dosage

The quantity of Pyridoxal 5’-phosphate to be taken is usually prescribed by a physician if the said compound is used in the treatment of some illnesses. In cases of Vitamin B6 deficiency, the usual dosage is 2.5 to 35 mg daily for a period of 21 days or three weeks. For women suffering from pre-menstrual symptoms, the usual dosage is 50-100 mg per day.

P5P toxicity is less likely to develop among normal adults taking P5P supplements. However, individuals who are diagnosed with certain health conditions are advised to strictly consult their physicians prior to using the compound for supplementation purposes.

P5P side effects

The use of Pyridoxal 5’-phosphate within recommended doses in health supplement products is generally safe for normal adults. In some instances, however, reports have been made on manifestations of mild gastrointestinal symptoms.

High doses of Pyridoxal 5’-phosphate may cause problems with the musculoskeletal system when injected to the muscles. The use of the compound is not as well recommended among patients who have just undergone surgical procedures to widen narrowed arteries. The compound may also cause unlikely symptoms among patients who have undergone weight loss surgeries.

Users of Pyridoxal 5’-phosphate must also check potential drug interactions prior to using the P5P supplements.


Health supplement manufacturers often include Pyridoxal 5’-phosphate in their formulations as it is packed with health benefits for individual users. Being the most active form of Vitamin B6, it is believed that Pyridoxal 5’-phosphate is more advantageous than other forms of the vitamin. It is, however, important for individual users to consult physicians prior to using Pyridoxal 5’-phosphate if they are suffering from certain health conditions.

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