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CoQ10 Ubiquinone

Название продукта CoQ10 Ubiquinone
Другие имена Ubiquinone-10, Ubidecarenone, Vitamin Q10, 2,3-Dimethoxy-5-Methyl-6-Decaprenyl-1,4-Benzoquinone
Номер CAS 303-98-0
Молекулярная формула C59H90O4
Молекулярная масса 863.36 g/mol.
Приложения Personal Care, Dietary supplements, Functional Foods, Animal Nutrition, etc.
Пакет 1 кг, 5 кг/мешок, 25 кг/барабан

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What Is CoQ10?

It, the full name of Coenzyme Q10, is also known as Ubiquinone (UQ), Coenzyme Q (CoQ). Other names are Water-soluble Coenzymen Q10, Hydrosoluble Coenzymen Q10, QH 10, Water-soluble QH10, and so on. It is a coenzyme present in all aerobic respiration eukaryotes. The Q in its name represents the quinone group, and the 10 represents the number of isoprenes tailed to the quinone group. The structure of Coenzyme Q10 is similar to vitamin E, vitamin K, etc.

The molecular formula of CoQ10 is C59H90O4, and the molecular weight is 863.34 g/mol. The appearance is a white to yellow crystalline powder. It is insoluble in water and methanol and soluble in acetone and ether. Its melting point is 48-52°C. This powder is easily decomposed when light exposure, making the color darker.

CoQ10 powder structure

Food sources from

CoQ10 is found in certain foods, especially organ meats (heart, liver, kidney), fatty fish (like salmon, mackerel), and plant-based sources like spinach, cauliflower, and nuts.

What Is Ubiquinone?

Ubiquinone is another name for Coenzyme Q10 (CoQ10) in its oxidized form. It is a fat-soluble compound found in the mitochondria of cells and plays a crucial role in energy production and antioxidant protection.

  1. Energy Production. It is involved in the electron transport chain, a critical part of cellular respiration. It helps transfer electrons within mitochondria, enabling the production of adenosine triphosphate (ATP), the primary energy carrier in cells.

  2. Antioxidant. In its reduced form, ubiquinol, it acts as a powerful antioxidant, neutralizing harmful free radicals and preventing oxidative damage to cells and tissues.

  3. Versatility. The name “ubiquinone” comes from the word “ubiquitous,” reflecting its presence throughout the body in nearly all cells. It’s found in high concentrations in energy-demanding organs like the heart, liver, and kidneys.

Ubiquinone structure consists of a “1,4-benzoquinone ring” and a long “isoprene side chain” consisting of “ten isoprene units.” The benzoquinone ring enables it to undergo redox reactions in the electron transport chain, while the long chain allows it to dissolve and move through cell membranes, especially mitochondrial membranes. This unique structure makes Co Q10 both hydrophilic and hydrophobic, which helps it play an important role in cellular energy metabolism and antioxidant protection.

Ubiquinone VS Ubiquinol

Ubiquinone is the oxidized form of CoQ10, and once it’s in the body, it can be converted to ubiquinol, its reduced form.

Ubiquinol is more directly used as an antioxidant and is considered more bioavailable. Some supplements provide Co-Q10 in the ubiquinol form for improved absorption, especially for older adults or people with specific health conditions.

However, due to the complexity of Ubiquinol’s specific stable form and manufacturing method, some companies have patents on its production process and stability. For example, the Japanese company Kaneka is one of the major players in the Ubiquinol coq10 market. The company has developed patented technology for manufacturing and stabilizing Ubiquinol. Since Ubiquinol is relatively unstable and easily oxidized to Ubiquinone, Kaneka’s patent covers preparing Ubiquinol into a stable supplement. Therefore, many commercial Ubiquinol products use technology protected by Kaneka’s patent.

Most patents on Ubiquinol do not directly protect the Ubiquinol molecule itself but rather how to stabilize Ubiquinol during manufacturing so that it is not oxidized during storage and consumption. This type of technical patent protects the production process, preparation method, and stable form of the supplement.

Due to the existence of patents, companies that provide Ubiquinol coq10 products on the market usually need to obtain authorization or cooperation from companies holding relevant patents.

Therefore, Nutri Avenue recommends that coq1o supplement manufacturers use the Ubiquinone form.

Ссылка на спецификацию

Due to patent issues involving Ubiquinol (reduced form), Nutri Avenue provides Ubiquinone (oxidized form) raw materials.

  1. 10%/20% Co Q10 oxidized form (water soluble)
  2. 98% Ubiquinone (fat-soluble)
  3. etc.

The order quantity provided by Nutri Avenue is 1KG, 5KG, 25KG, and so on. The larger the purchase volume, the more favorable the price.

For other detailed specification requirements and purchase volume, please communicate with Nutri Avenue. You can get detailed product information, including COA, price, and more.

Тип

Supplement ingredient

Внешний вид

Fine, yellow to orange powder

Content

98% minimum

Чистота

99% minimum

Размер частиц

80 mesh

Сертификаты

Please contact our sales team to get.

Water Content

0.2% maximum

Метод испытания

HPLC

MOQ (минимальное количество заказа)

1 кг

Образец

В наличии (10-20 г/мешок)

Обслуживание OEM

Доступны капсулы, таблетки, пилюли и т.д.

Услуги ODM

Доступно

Частная марка

Доступно

Контрактное производство

Доступно

How To Produce Co Q10?

Its manufacturing process mainly includes two methods: fermentation and chemical synthesis. These two methods have their own advantages and disadvantages and have different qualities and costs.

Microbial Fermentation. It is produced by fermentation using microorganisms (such as yeast or bacteria) under specific conditions. These microorganisms can convert simple carbon sources (such as sugars) into Coenzyme Q10 through fermentation.

  1. Cultivation of microorganisms: The selected microorganisms are cultured on a large scale in a controlled culture environment.
  2. Fermentation process: Providing appropriate nutrients and environmental conditions in the culture medium enables microorganisms to produce Co-Q10.
  3. Extraction and purification: Extraction from the fermentation broth through solvent extraction and other purification techniques to remove impurities and obtain high-purity Coenzyme Q10.
  • Advantages: Biofermentation can produce high-purity powders and is generally more environmentally friendly than chemical synthesis.
  • Disadvantages: The production process is more complicated, and the cost is higher.

Chemical Synthesis. The raw materials are synthesized through chemical reactions. This method usually involves multiple synthesis steps to synthesize Coenzyme Q10 from simple chemical precursors.

  1. Synthetic precursors: The precursor substances are synthesized through chemical reactions.
  2. Synthesis process: Convert the precursor substance into Coenzyme Q10 and obtain the final product through chemical reaction and purification.
  3. Purification: Use various separation and purification techniques to remove by-products and impurities in the synthesis process.
  • Advantages: The production cycle is usually short, and the production scale can be controlled.
  • Disadvantages: Chemical synthesis may involve harmful chemicals and have a greater environmental impact.
Coq10 bulk powder

CoQ10: Benefits, Side Effects, And More

Supports Heart Health. CoQ10 is often used to improve heart function, especially in conditions like heart failure, high blood pressure, and coronary artery disease.

It helps enhance energy production in heart cells and reduces oxidative stress, improving symptoms and reducing the risk of complications in heart disease patients.

Reduces Symptoms of Heart Failure. Studies show that its supplementation can help improve symptoms of congestive heart failure by improving the energy production in weakened heart muscles, reducing fatigue, and enhancing exercise capacity.

Improves Mitochondrial Function and Energy. This compound is essential for the function of mitochondria, the cell’s energy producers. This makes it beneficial for individuals with chronic fatigue, fibromyalgia, or other conditions linked to impaired mitochondrial function.

Acts as a Powerful Antioxidant. It helps neutralize harmful free radicals, protecting cells from oxidative damage contributing to aging and developing various diseases, including cancer.

May Help with Migraine Prevention. It has been shown to reduce the frequency and severity of migraines. It’s believed to do this by improving mitochondrial function and reducing inflammation in the brain.

Supports Skin Health. Due to its antioxidant properties, the oxidized form, Ubiquinone, can help reduce skin damage caused by ultraviolet (UV) radiation and other environmental factors. It can also improve the appearance of fine lines and wrinkles by promoting energy production in skin cells.

Improves Exercise Performance. Its supplementation has been linked to enhanced physical performance, particularly by reducing oxidative stress in muscles, decreasing fatigue, and improving endurance.

May Help with Diabetes Management. In some studies, CoenzymeQ10 has been shown to improve insulin sensitivity and regulate blood sugar levels. Its antioxidant properties also help reduce oxidative stress, which is a contributing factor in diabetic complications.

Supports Brain Health. By reducing oxidative damage and supporting mitochondrial function, Co-Q10 may help protect against age-related cognitive decline and neurodegenerative diseases like Alzheimer’s and Parkinson’s.

Improves Fertility. CoQ10 can improve sperm quality and egg quality by boosting energy production and reducing oxidative damage, which are important factors in fertility, especially in older individuals.

Helps Combat Statin Side Effects. Statin drugs, used to lower cholesterol, can reduce Co Q10 levels in the body and lead to side effects such as muscle pain and fatigue. Its supplementation may help alleviate these side effects in some individuals.

Is There Any Side Effects?

Co Q10 is generally safe but may cause mild side effects in some cases, including stomach upset, nausea, diarrhea, and loss of appetite. Some people may experience headaches or insomnia. In addition, this compound may interact with certain medications, such as anticoagulants.

Overall, the side effects of CoQ10 are few and mild, and most people can use it safely.

Dosage: Is It Safe?

Generally, CoQ10 dosages range from 90 to 200 mg daily. Certain health conditions such as heart disease, migraines, or high blood pressure may require higher doses, even up to 300 to 600 mg. For older adults or those taking statins, the dosage may be increased.
For reference only.

What Is CoQ10 Used For?

It is a popular ingredient in dietary supplements for person and animals, like dogs, cats, etc., and functional foods due to its potential health benefits, such as supporting cardiovascular health, enhancing exercise performance, and reducing the side effects of certain medications.

The oxidized form, Ubiquinone is used in cosmetic formulations as an anti-aging ingredient, as it can help reduce the appearance of fine lines and wrinkles, improve skin hydration and elasticity, and protect against UV-induced damage.

It is an active ingredient in some prescription medications for treating certain conditions, such as mitochondrial disorders and statin-induced myopathy.

It is added to animal feed as a nutritional supplement for livestock and poultry, as it can improve growth performance, enhance immune function, and reduce oxidative stress.

It is used in various industrial applications, such as the production of rubber and polymers, the synthesis of semiconductors and electronic materials, and the formulation of lubricants and surfactants.

Nutri Avenue also provides OEM and ODM services for CoQ10 supplements that can be marketed. Specifically, our raw materials are made into various finished supplement forms, such as capsules, soft gels, tablets, liquids, etc., and provided to product manufacturers for direct distribution to the market.

We also have various formulas, such as CoQ10, which can be used with Vitamin E, Vitamin C, Omega-3, Piperline, L-Carnitine, Resveratrol, and Hyaluronic Acid.

Red Yeast Rice With CoQ10: Optimizing Cholesterol Management

Red yeast rice combined with CoQ10 is a common supplement pairing, especially for supporting cholesterol management and heart health.

Why Combine Red Yeast Rice With CoQ10?

Red Yeast Rice contains a natural compound called monacolin K, which is similar to lovastatin, a statin drug used to lower cholesterol. However, like statins, red yeast rice can lower Co Q10 levels in the body, which may lead to side effects like muscle pain and fatigue.

Supplementing with CoenzymeQ10 helps counteract the its depletion caused by red yeast rice (or statins). It supports mitochondrial energy production, reduces muscle pain, and protects heart health.

In summary, red yeast rice with CoQ10 work together to effectively manage cholesterol levels while minimizing side effects related to Co Q10 depletion, especially for those on statin-like treatments.

Buy Best CoQ10 Ubiquinone Supplier Globally: Nutri Avenue

Nutri Avenue has decades of experience in the supplement ingredients industry, and we are an FDA-registered ingredients supplier, so we offer  CoQ10 Ubiquinone form on our official website.

This powder on our one-stop online store is tested by a third party. Therefore, we guarantee that all ingredient powders we supply are high quality. We have regular and long-term partners, like FuFeng Group, CCB Nutrition, etc. I believe you must have heard of the need to purchase.

To provide our North American customers with more convenient services, we have arranged five warehouses in the United States to ensure that customers can quickly and easily get their purchased goods.

Вопросы и ответы

Symptoms of low CoQ10 levels may include fatigue, muscle weakness, muscle pain and cramps, difficulty exercising, and shortness of breath. In severe cases, it can lead to heart failure.

CoQ10 supplements may interact with certain medications, so it is important to consult with a healthcare provider before taking them.

Yes, it is generally safe to take CoQ10 daily. The recommended daily dose of CoQ10 ranges from 30 to 200 milligrams per day, depending on the individual’s needs and health condition.

CoQ10 supplements are regulated by the FDA, but may vary depending on local regulations and market demand.

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