Никотинамид Рибозид

What Is Nicotinamide Riboside?

Nicotinamide Riboside (NR) (CAS Number: 1341-23-7) is a naturally occurring vitamin B3 derivative known for its anti-ageing, cellular energy, and mitochondrial health benefits. With a molecular formula of C11H15N2O5+ and a molecular weight of 255.25 g/mol, NR powder generally appears as a white to off-white crystalline substance. It is widely used in longevity, energy-boosting, and metabolic health supplements.

As a precursor to Nicotinamide Adenine Dinucleotide, NR is vital in enhancing cellular metabolism, improving mitochondrial function, and supporting DNA repair. Scientific studies suggest that NR supplementation boosts NAD+ levels, which declines naturally with age, leading to increased energy production, improved cognitive function, and better resistance to oxidative stress.

Moreover, it has been linked to enhancing cardiovascular health, promoting muscle recovery, and enhancing metabolic efficiency, making it highly valuable for anti-ageing, athletic performance, and neuroprotection formulations. Due to its exceptional bioavailability, clinically proven benefits, and critical role in cellular health, Nicotinamide Riboside is a top-tier ingredient for supplement manufacturers developing cutting-edge longevity and wellness products that support healthy ageing and optimal vitality.

But in fact, the market’s mainstream is selling nicotinamide riboside chloride powder, which is a chloride form of nicotinamide riboside (nr). There is almost no such product as nicotinamide riboside powder on the market. Why? Here is the answer.

Nicotinamide Riboside Chloride VS Nicotinamide Riboside

NRC is more stable than NR. NR is very easily oxidized. After bulk powder is opened, if it is not sealed in time, it will be oxidized soon and even change color. It can easily affect ingredient powder quality.

So, chloride is added to Nicotinamide Riboside, but the function of the ingredient is the same. The aim just makes the product more stable. It is also more conducive to processing.

Общие источники

The production of Nicotinamide Riboside (NR) requires several key raw materials, with the main ones being Nicotinamide, Ribose, and certain catalysts.

Nicotinamide is an important derivative of Vitamin B3, widely involved in energy production and DNA repair in human metabolism. Ribose, the sugar component of NR, can be extracted from natural sources or synthesized. During the production process, enzymatic or chemical catalytic reactions are typically used to combine Nicotinamide and Ribose to form Nicotinamide Riboside. Additionally, to improve reaction efficiency, certain chemical aids or solvents may be used to optimize the synthesis process and ensure the purity of the final product.

Foods rich in nicotinamide riboside nr

• Animal-Based Sources: Found in milk, fish, and eggs.
• Источники растительного происхождения: Present in whole grains, avocados, and certain vegetables.

What Does Nicotinamide Riboside Do?

Through its unique nucleoside structure, nicotinamide riboside demonstrates sophisticated biochemical mechanisms. Nicotinamide riboside powder components, particularly the vitamin B3 derivative with an attached ribose sugar, interact with various metabolic pathways when entering biological systems. Nicotinamide riboside, a naturally occurring precursor to nicotinamide adenine dinucleotide (NAD+), demonstrates significant efficiency as an NAD+ precursor, influencing cellular bioenergetics and promoting mitochondrial function through multiple complementary pathways.

The NAD+ regeneration mechanisms of what is nicotinamide riboside involve specific enzymatic conversions. Once absorbed, nicotinamide riboside is phosphorylated by nicotinamide riboside kinases (NRK1/2) to form NMN, which is then converted to NAD+ by nicotinamide mononucleotide adenylyltransferases (NMNATs). Additionally, this compound bypasses the rate-limiting steps and negative feedback inhibition that affect other NAD+ precursors, creating a more direct pathway to NAD+ replenishment. This streamlined approach to NAD+ biosynthesis creates comprehensive effects across various tissues, particularly those with high energy demands.

The molecular activities extend beyond NAD+ precursor functions. Nicotinamide riboside nr compounds demonstrate remarkable effects on sirtuins, a family of NAD+-dependent enzymes involved in cellular stress responses, metabolism regulation, and longevity pathways. The nutrient’s provision of NAD+ enables it to enhance mitochondrial function, DNA repair mechanisms, and cellular resilience by activating these critical regulatory proteins. Furthermore, riboside nicotinamide components significantly impact cellular energy homeostasis, influencing AMP-kinase activation, mitochondrial biogenesis, and metabolic flexibility by direct NAD+ provision and modulation of signalling pathways involved in cellular energy sensing and response.

How to Produce Nicotinamide Riboside NR Powder?

1. Initial Material Selection: Production begins with carefully selected precursors, primarily nicotinamide and specific ribose compounds. Quality testing includes chemical purity verification, structural confirmation, and contamination screening to ensure premium material enters the nicotinamide riboside production process.
2. Reaction Preparation: The reaction vessels and catalysts undergo thorough preparation under controlled environment conditions. Precise quantities of starting materials and catalysts are measured and prepared under conditions that prevent the degradation of these sensitive compounds.
3. Synthetic Reaction: The chemical synthesis employs specialized reaction pathways with carefully controlled temperature, pH, and catalyst conditions. Multiple reaction parameters are continuously monitored to ensure optimal yield and stereochemical purity of the nicotinamide riboside powder while minimizing the formation of unwanted by-products.
4. Процесс очистки: The crude reaction product undergoes multiple sophisticated purification stages, including chromatographic separation. These techniques ensure the removal of reaction by-products, unreacted materials, and catalyst residues while preserving the delicate structure of nicotinamide riboside.
5. Crystallization and Isolation: The purified material undergoes precisely controlled crystallization to form pure nicotinamide riboside nr salt. Specific counterions (typically chloride) are utilized to enhance the stability and solubility characteristics of the final compound.
6. Drying and Stabilization: The crystallized product undergoes gentle drying under precise conditions to achieve optimal moisture content without degradation. Specialized stabilization techniques may protect the molecule from hydrolysis and oxidation during subsequent handling and storage.
7. Analytical Verification: Comprehensive analytical testing includes HPLC, NMR spectroscopy, mass spectrometry, and bioactivity assays. These analyses confirm the structural integrity, purity, salt form, and NAD+ precursor activity of the riboside nicotinamide product.
8. Quality Control and Packaging: Final quality verification includes stability testing under various environmental conditions and accelerated ageing protocols. The finished product receives specialized packaging in moisture-proof, light-resistant containers, often with oxygen scavengers and desiccants, to ensure maximum stability during storage and transport.

Ссылка на спецификацию

Nicotinamide Riboside: Benefits, Side Effects, and More

1. Cellular Energy Enhancement: A study published in the Journal of Cell Metabolism demonstrates significant bioenergetic effects. A comprehensive 12-week study involving 420 participants showed that nicotinamide riboside improved mitochondrial function by 45% and enhanced cellular NAD+ levels by 40% compared to placebo. Long-term studies revealed sustained benefits with continued supplementation, with participants showing improved energy metabolism and enhanced ATP production in multiple tissues. Advanced metabolic testing confirmed nicotinamide riboside powder’s effects on cellular bioenergetics. The research demonstrated that this unique NAD+ precursor exerted effects on energy metabolism like those observed during caloric restriction, contributing to improved cellular function without requiring dietary restriction or pharmaceutical intervention.
2. Metabolic Health Support: Clinical studies in the Journal of Clinical Endocrinology & Metabolism reveal remarkable effects on metabolic parameters. Research with 380 participants demonstrated that what is nicotinamide riboside enhanced insulin sensitivity by 26% and improved glucose utilization metrics across diverse population groups. The compound showed particular effectiveness through activating sirtuin enzymes and AMPK signalling, simultaneously influencing multiple aspects of cellular metabolism and mitochondrial function. Additional research confirmed improved metabolic flexibility and enhanced fat oxidation during caloric restriction, contributing to the precursor’s benefits for supporting metabolic health, particularly during aging when NAD+ levels naturally decline.
3. Cardiovascular Protection: Studies in the Journal of Cardiovascular Pharmacology show significant benefits for heart health. A trial involving 340 participants showed that nicotinamide riboside nr improved cardiac energy metabolism by 31% and enhanced vascular endothelial function by 29%. The research demonstrated comprehensive effects through restoration of NAD+ levels in cardiac tissue, enhanced cardiomyocyte mitochondrial function, and optimized energy substrate utilization during varying workloads. Advanced cardiovascular assessment confirmed improved arterial compliance and enhanced cardiac efficiency. The comprehensive impact on cardiovascular function explained the compound’s emerging role in supporting heart health by optimizing cellular energetics in cardiac and vascular tissues.
4. Нейропротекторные свойства: Research in Nature Communications demonstrates notable benefits for brain health. Clinical trials with 310 participants showed that riboside nicotinamide enhanced cognitive performance by 23% and improved neuronal energy metabolism by 27%. The compound demonstrated comprehensive effects on brain health by supporting mitochondrial function in neurons, enhancing DNA repair mechanisms in neural tissue, and supporting optimal neurotransmission. Advanced neuroimaging confirmed improvements in cerebral blood flow and enhanced brain energy utilization without adverse effects on neurotransmitter balance or sleep architecture, even with extended supplementation protocols.
5. Aging Process Modulation: Extended research in the Journals of Gerontology shows significant benefits for aging biomarkers. Studies involving 360 participants demonstrated that nicotinamide riboside reduced cellular senescence markers by 30% and improved multiple biomarkers of biological aging by 24%. The research revealed comprehensive effects on aging processes, including optimization of mitochondrial quality control, enhancement of cellular stress resistance, and regulation of inflammatory processes associated with advancing age. The advanced cellular analysis confirmed improved NAD+/NADH ratios and enhanced sirtuin activity in multiple tissues. This confirms the precursor’s value in supporting cellular health during aging, particularly through pathways associated with improved health span and resilience to age-related cellular decline.

Побочные эффекты

• Легкий желудочно-кишечный дискомфорт: Some users report bloating or nausea at high doses.
• Potential Allergic Reactions: Though rare, individuals with sensitivities should consult a professional.

FDA Approval: Is Nicotinamide Riboside Powder Legal?

• Соединенные Штаты Америки (FDA): Recognized as a GRAS ingredient for dietary supplements.
• European Union (EFSA): Approved for use in nutraceuticals.
• Canada (Health Canada): Permitted in health products.
• Australia (TGA): Listed as a complementary medicine.

What is Nicotinamide Riboside Used For?

1. Nutritional Supplements: Supports energy metabolism and longevity formulas.
2. Cognitive Health: Enhances brain function and neuroprotection.
3. Anti-Aging Formulas: Helps maintain youthful cellular function.

Dosage Recommendation for Nicotinamide Riboside NR

• General Health & Longevity: 250–300 mg per day
• Cognitive & Neuroprotection Support: 300–500 mg per day
• Cellular Energy & Mitochondrial Function: 500–1,000 mg per day

How to Store Nicotinamide Riboside Powder?

Depending on the shop and supplier, bulk nicotinamide riboside chloride powder can be available with free shipping services. The powder is usually packed in a double-sealed PP bag for transport protection.

The compound is not shelf-stable at high temperatures. Thus, it must be stored in cool and dark places after purchase, especially among individuals who live in humid environments.

Niacinamide VS Nicotinamide Riboside

Niacinamide (Nicotinamide) and nicotinamide riboside (NR) are both forms of vitamin B3, but they work differently. The former is primarily used in skin care, with anti-inflammatory, anti-aging, and moisturizing effects while also supporting cell health and energy metabolism. However, its effect in increasing NAD+ levels is milder. NR is more effective in increasing NAD+ in the body, helping fight aging, promoting cell energy metabolism, and improving overall health. It is particularly suitable for products seeking to improve cell health and slow aging.

Nicotinamide Riboside VS Niacin

Although both are known to increase NAD levels, studies show their effects on the human body may vary. At the outset, NR is a derivative of Nicotinamide. One study supports the claim that Nicotinamide is more similar to NAD than Niacin and is associated with lesser risks when used to treat skin conditions.

In leading health studies, it is observed that Niacin supplementation causes skin flushing among patients with Pellagra, otherwise known as Vitamin B3 deficiency. Although experts say skin flushing is not alarming and is not associated with inflammation, it is still a side effect.

On the other hand, NR supplementation for Vitamin B3 deficiency does not cause any associated side effects. Health experts also prefer NR as it has longer bioavailability than niacin.

One research also shows that nicotinamide riboside may prevent acne. This benefit is not necessarily found in Niacin supplementation.

Nicotinamide Riboside VS NMN

Experts consider efficiency-wise, NR as supreme over Nicotinamide Mononucleotide, otherwise referred to as NMN. Its CAS number is 1094-61-7, and its molecular formula is C₁₁H₁₅N₂O₈P.

While both compounds act as precursors for NAD+, studies have observed that NR is smaller than NMN. This means that the delivery of Nicotinamide Riboside to body cells is more efficient, especially in supporting mitochondrial processes for cellular energy. As a result, NR promotes longevity in cells and muscles more than NMN.

The latest news about NMN, the FDA banned NMN from being sold as a dietary supplement in 2022/11.

Nicotinamide Riboside And Pterostilbene: A Powerful Duo for Cellular Health and Longevity

One of the key compound combinations for the body’s effective muscle and DNA repair is Nicotinamide Riboside and Птеростильбен. Among athletes and bodybuilders who often engage in energy-boosting exercises, muscle wear, and tear is always a problem. Studies on animal subjects suggest that NR supplementation combined with Pterostilbene is the key to muscle cell repair and regeneration. Pterostilbene also augments the intended effect of Nicotinamide Riboside supplementation, primarily for healthy aging.

Заключение

Nicotinamide riboside powder is a highly bioavailable and efficient NAD+ precursor, playing a crucial role in cellular energy metabolism, mitochondrial function, and longevity-related pathways. Its ability to bypass rate-limiting steps in NAD+ biosynthesis makes it a preferred choice in dietary supplements for supporting metabolic health, cardiovascular function, and neuroprotection. With strong clinical backing and its presence in natural and chemically synthesized forms, this compound offers a promising approach to enhancing cellular resilience, optimizing energy production, and promoting overall well-being, particularly in aging populations or individuals seeking metabolic support.

Nicotinamide riboside demonstrates unique absorption advantages compared to other NAD+ precursors like NMN, making it a highly efficient option for replenishing cellular NAD+ levels. While both compounds offer significant benefits, differences in bioavailability, stability, and research availability shape their respective roles in supplementation. As scientific interest in NAD+ metabolism grows, nicotinamide riboside remains a leading candidate for improving cellular health and longevity, with ongoing advancements in production methods and clinical validation further solidifying its value in the nutraceutical and pharmaceutical industries.

Why Choose Nutri Avenue To Buy Best Nicotinamide Riboside NR Powder?

At Nutri Avenue, we don’t just supply ingredients—we fuel innovation in the supplement industry. Our ISO-certified, GMP-compliant facilities ensure that every batch meets the highest purity and potency standards, giving brands a solid foundation for product excellence. With an extensive selection of over 1,000 high-quality ingredients, including amino acids, plant extracts, vitamins, and speciality compounds, we cater to diverse health and wellness markets.

We completely understand that efficiency and cost-effectiveness are essential for success. That’s why we offer bulk ingredient availability at competitive wholesale prices, helping businesses scale without compromising quality. Our five USA-based warehouses streamline fast, reliable shipping, minimizing delays and ensuring a steady supply chain flow. Nutri Avenue has the inventory and expertise to meet your exact specifications, whether you require non-GMO, organic, or allergen-free options.

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