Sesamin: A Lignan for Healthy Weight and CVD-risk reduction

Sesamin is a Lignan for Healthy Weight and CVD-risk reduction

Sesamin is a powerful antioxidant compound that is currently the subject of many health studies for its claimed benefits in preventing and managing risk factors associated with the development of cardiovascular diseases. The compound is used in the formulation of dietary supplement products indicated for adults and elderly individuals.

What is Sesamin?

Sesamin is a dietary supplement ingredient that consists of tetrahydro-1H,3H-furo[3,4-c]furan substituted by 1,3-benzodioxole groups at positions 1 and 4 (the 1S,3aR,4S,6aR stereoisomer). It is classified as a ligan and a furofuran which possesses antineoplastic, cytotoxic, and neuroprotective properties. The compound is also a metabolite of enterolactone and is a minor constituent of sesame oil. Aside from its widespread use and application in the dietary supplement field, the compound is also useful in the production of cosmetic products as it helps inhibit Vitamin E metabolism and increase levels of circulating γ-tocopherol and γ-tocotrienol.

Other names for the compound include Sesamin EX, Black sesame extract, Sesame Seed Lignans Sesamin, Aimmura Sesamin,   Sesame Seed lignan extract, Aimmura-X, Fagarol, Sezamin, Pseudocubebin, Episesamin, Asarinin, Eleutheroside B4, D-(+)-Sesamin, d-Sesamin, and  l-Sesamin, 5,5′-[(1S,3aR,4S,6aR)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis(2H-1,3-benzodioxole). It is identified as having molecular formula C20H18O6 and CAS number 607-80-7. The molecular weight of the compound is 354.35 g/mol.

Sesamin in dietary supplement products has a white powder color appearance and is generally soluble in organic solvents like DMSO, Ethanol, and dimethyl formamide. The compound is only sparingly soluble in aqueous buffers.

Sesamin Sources

Lignans are essentially phytoestrogens that have a steroid-like chemical structure. They are found in various fruits and vegetables, as well as in whole grains and oilseeds. Concentrated quantities of lignans are found in flax seeds and sesame.

Like all other Lignans, Sesamin is also found in flax seeds and sesame. It may also be found in fruits like cranberries and whole grain products like oatmeal and barley.

Sesamin vs. Sesamolin

Sesamolin is another major lignan found in sesame oil and flax seeds. In terms of health benefits, there are no significant differences in the effects of Sesamin and Sesamolin. However, the compounds differ in molecular formula, CAS number, and other identifiers.

The molecular formula for Sesamolin is C20H18O7 while the molecular formula of Sesamin is C20H18O6. Also, the CAS number for Sesamolin is 526-07-8 while that of Sesamin is 607-80-7.

Sesamin forms and specifications

Sesamin maintains healthy lipid profiles

Sesamin comes in different forms and specifications for dietary supplement product formulations. The most common forms are those with 98%, 15%, and 70% purity based on a high-performance liquid chromatography test or HPLC. Other standardized custom forms are also available depending on the customer’s needs.

When bought from legitimate ingredient suppliers like Nutriavenue, the product is usually packed in paper drums with two layers of poly bags inside. Each paper drum contains a net weight of 25 kilograms. Customers may also avail of a different packaging material depending on their individual needs.

CLA vs Sesamin

CLA or Conjugated Linoleic Acid is a popular weight loss ingredient that is believed to work efficiently when combined with Sesamin. While both CLA and Sesamin provide health benefits in terms of combating obesity, these compounds have different mechanisms of action. 

CLA is believed to work by decreasing fat deposition and increasing adipose lipolysis. In contrast, Sesamin works by suppressing the action of lipogenic genes.

Sesamin with Schisandra extract

Sesamin with Schisandra extract is a dietary supplement formulation that is primarily indicated for persons who are at risk for developing liver diseases. Essentially, Sesamin and Schisandra extract produce a synergistic effect in supporting liver function and promoting cleansing of liver cells.

Sesamin and TTA

Tetradecylthioacetic Acid is a fat-burning ingredient that is also rising in the dietary supplement field. It is commonly used in conjunction with Sesamin and other fat-burning ingredients to produce more powerful health effects. TTA works primarily by suppressing hunger. Like Sesamin, TTA is also known to possess antioxidant properties.

CLA Sesamin Fish oil Stack

Among athletes and bodybuilders who are intending to lose and maintain their weight, the CLA-Sesamin-Fish oil Stack is believed to be quite ideal. This is because while CLA, Sesamin, and Fish oil are individually effective in promoting health, they enhance weight loss benefits when combined.

How does Sesamin work?

It is claimed that Sesamin plays various active roles in the human body. One of which is that it may promote weight loss by increasing production of liver enzymes that act on the body’s fat breakdown process. With Sesamin, the body is able to breakdown fats and eliminate them at a faster rate. The compound is also found to effectively reduce low-density lipoprotein or bad cholesterol levels and increase good cholesterol levels. Hence, abnormalities in fat metabolism brought about by problems in lipid profiles may be prevented with Sesamin supplementation.

Sesamin manufacturing process

Obtaining Sesamin from Sesame oil begins with purification procedures whereby sesame oil is passed through a cylindrical body container whose interior is filled up with chromatographic adsorbent. To elute oily impurity, a fat-soluble eluent is likewise passed through the cylindrical container. Thereafter, extraction of Sesamin is initiated by collecting an adsorbent color band layer found in the middle portion of the cylindrical body container. A solvent capable of dissolving Sesamin is then introduced to obtain the extract of Sesamin.

Health benefits of using Sesamin

The following health benefits may be obtained with Sesamin supplementation:

It may be used for weight loss

Studies have shown that Sesamin can accelerate fat loss and help prevent the body from storing fat by helping to break down essential fatty acids. Hence, this action may be useful in promoting weight loss.

It possesses anti-inflammatory and antioxidant properties

Sesamin is both an anti-inflammatory and antioxidant product. As such, it may work in supporting liver health and wellness and providing anti-hypertensive effects.

It may be used for bodybuilding

The compound may also be used by athletes and bodybuilders who want to lose weight safely and effectively. By losing excess fats, skeletal muscles grow and develop faster.

It maintains healthy lipid profiles

The action of Sesamin in interfering with genes involved in cholesterol breakdown is found to be beneficial in maintaining healthy lipid profiles among adults.

It may help promote cognitive abilities

The antioxidant properties of Sesamin are also believed to be the reason why it works as an agent for improved cognition. Hence, the compound may promote learning abilities, mental focus, and memory.

Sesamin side effects

 Other than mild forms of muscle pain, headaches, and gastrointestinal symptoms, there are no serious side effects associated with Sesamin supplementation. It is important, however, to consult a physician in cases where hypersensitivity reaction to the compound occurs.

Sesamin dosage

The recommended daily intake for Sesamin among men is 2.7 mg/kg body weight while for women, the recommended dose is 2.3 mg/kg body weight. The said dosages may vary as per the physician’s recommendation depending on the individual user’s age and overall physical condition.

Where to buy bulk Sesamin powder?

Pure and affordable bulk Sesamin powder is available at Nutriavenue. Our company is the best choice for the purchase of dietary supplement ingredient purchases as we have been in the market for several years and our products are of proven quality.

Nutriavenue is an FDA-registered ingredient supplier. We are also recognized by Kosher, GMP, and Halal. For our customer’s convenience, we also offer shipping services through the air, sea, or couriers like UPS and FedEx.

For more details on our products and services, you may contact our technical support staff at Nutriavenue.com.  

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