Berberine HCl

Berberine: Benefits, Uses, And More

For Weight Loss

This natural ingredient lowers blood sugar levels and improves insulin sensitivity. It helps improve metabolic syndrome and reduce the accumulation of body fat.

It may help improve the structure of the intestinal flora, reduce the entry of endotoxins into the blood, and reduce chronic inflammation. It achieves the purpose of weight loss by regulating the energy balance in the organism.

Studies have shown that this natural compound can help genetically obese mice and mice eating a high-fat diet increase energy consumption and control weight gain.

It has the effect of blocking liver lipid changes and obesity caused by a high-calorie diet.

It activates AMP-activated protein kinase (AMPK), an enzyme that regulates the body’s energy levels, helps burn fatty acids in cells, stabilizes receptors for low-density lipoprotein cholesterol, and inhibits lipid production in the liver.

The active ingredient can reduce total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels. At the same time, it increases high-density lipoprotein (“good” cholesterol) levels. It may reduce the risk of heart disease and indirectly support the weight loss process.

Finally, some clinical studies have shown that taking this substance can lead to weight loss. At the same time, it improves multiple health indicators, such as BMI and abdominal fat.

Other Benefits

• Lowers Blood Sugar Levels

It significantly reduces blood sugar levels in people with type 2 diabetes. The effects are comparable to some popular diabetes medications, such as Metformin. It works by reducing insulin resistance, increasing glycolysis, reducing sugar production in the liver, slowing the breakdown of carbohydrates in the intestines, and increasing the number of beneficial bacteria in the intestines.

• Lowers Cholesterol

Studies show that berberina compound can reduce total and LDL cholesterol and triglyceride levels while increasing HDL, which is “good” cholesterol, potentially reducing the risk of heart disease.

• Antioxidant and Anti-Inflammatory

Preliminary studies show that it may be good for depression, cancer, infections, fatty liver disease, and heart failure.

Side Effects: Is Berberine Safe?

• Digestive Issues: May cause mild stomach upset, diarrhoea, or constipation.
• Interactions: Can interact with medications like antibiotics, anticoagulants, or blood sugar regulators.

Je to legálne?

• Spojené štáty (FDA): Classified as a dietary supplement ingredient with no specific restrictions.
• European Union (EFSA): Approved for use in supplements but must comply with health claim regulations.
• Canada (Health Canada): Permission for natural health products with appropriate labelling.
• Australia (TGA): Allowed in complementary medicines with regulatory compliance.
• Japan (MHLW): Recognized as a functional ingredient in supplements.

What is Berberine Used For?

1. Doplnky stravy: A staple in metabolic health formulations.
2. Farmaceutické výrobky: Used in medications for diabetes and cholesterol management.
3. Traditional Medicine: Integral to herbal remedies in Chinese and Ayurvedic medicine.
4. Cosmetics: These are included in skincare products for their antimicrobial and anti-inflammatory properties.

Odporúčané dávkovanie a používanie

• General Use: 500–1,500 mg daily, divided into 2–3 doses.
• Diabetes Management: 1,000–1,500 mg daily per healthcare provider guidance.
• Úbytok hmotnosti: 1,000 mg daily for optimal effects.

How to Store Berberine HCL Powder?

Store in a dry location with low temperatures, maintain product integrity and use an airtight container.

Berberine VS Metformin

Berberine and Metformin (CAS: 1115-70-4) represent different glucose regulation and metabolic control approaches when comparing these metabolic regulators. Berberine HCl is a natural isoquinoline alkaloid with its molecular formula C20H18NO4Cl and molecular weight of 371.81 g/mol. In contrast, Metformin is a synthetic biguanide compound, bearing the molecular formula C4H11N5·HCl and a molecular weight of 165.63 g/mol.

Berberine HCl (berberine hydrochloride) appears as a bright yellow crystalline powder with moderate water solubility (2.1 mg/mL at 25°C) and demonstrates multifaceted effects on metabolism. Its mechanisms include AMPK activation, gut microbiota modulation, and regulation of glucose transporters. The compound shows relatively low bioavailability (less than 5%) due to P-glycoprotein efflux in the intestines but accumulates in tissues over time.

Metformin is a white crystalline powder with high water solubility (>100 mg/mL at 25°C). It primarily works through AMPK activation and reduction of hepatic glucose production, though it also influences gut microbiota and various metabolic pathways. Its bioavailability is higher than Berberine’s (50-60%), with primary liver and gastrointestinal tract accumulation.

Their mechanisms of action overlap significantly in AMPK activation, but each has unique attributes. Berberine shows broader effects through multiple pathways, including direct antimicrobial properties and lipid-lowering capabilities. Metformin’s effects focus on hepatic glucose production and insulin sensitivity improvement, with powerful effects on reducing gluconeogenesis.

Practically, both compounds require gradual dose escalation to minimize gastrointestinal effects. Berberine typically requires higher doses (1000-1500mg daily) divided into multiple administrations, while Metformin’s typical therapeutic dose ranges from 500-2000mg daily, also divided into various doses.

Note: Metformin, commonly known as Glucophage and Kuruca, is a first-line drug for the treatment of type 2 diabetes. As a pharmaceutical product, Nutri Avenue does not sell it.

Záver

Berberine powder/berberine hydrochloride is a versatile and powerful natural compound with numerous health benefits, particularly in metabolic and cardiovascular health. Its multifaceted applications make it a popular dietary supplement and traditional medicine choice.

Buy Best Berberine Powder Near Me: Nutri Avenue

As an FDA-registered supplier of raw materials for dietary supplements, Nutri Avenue has established itself as a trusted provider to manufacturers, contract manufacturers, and private labellers worldwide. Nutri Avenue offers a diverse selection of raw materials in large quantities and bulk packaging, offering its customers wholesale pricing. It is an attractive partner for those looking to streamline their supply chain operations. With five well-positioned inventories throughout the United States, the company guarantees prompt and reliable delivery to meet the demands of businesses nationwide.

Nutri Avenue’s commitment to quality is demonstrated through its adherence to rigorous third-party testing protocols, complemented by comprehensive certificates and detailed reports that affirm product integrity. The company’s longstanding partnerships with leading factories guarantee the availability of a stable and continuous supply of raw materials, ensuring that customers can depend on consistent and uninterrupted service.

In addition to its extensive product range, Nutri Avenue offers comprehensive Služby OEM a ODM, facilitating complete product customization in various forms, such as capsules, tablets, soft gels, oils, and powders. The company’s flexible logistics options – including air, sea, and land transportation – provide customers with tailored delivery solutions based on their needs. Nutri Avenue serves many international markets, including North America, Mexico, Poland, Hungary, France, and South America. This underscores its position as a global leader in dietary supplements’ raw material supply sector.

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