HMB Vápnik

What Is HMB Calcium?

Calcium HMB (β-Hydroxy β-Methylbutyrate Calcium) is a calcium salt of HMB, a metabolite of the amino acid leucine. It is widely used in sports nutrition and muscle health supplements due to its role in muscle protein synthesis and reducing muscle breakdown. The CAS number of Calcium HMB is 135236-72-5.

Its molecular formula is C10H18CaO6, with a molecular weight of approximately 254.32 g/mol. Calcium HMB typically appears as a white crystalline or fine powder, which is odorless and has a slightly bitter taste. It is highly soluble in water, ensuring good bioavailability when consumed. The compound is chemically stable under normal storage conditions and has hygroscopic properties, meaning it can absorb moisture from the air.

Due to its benefits in supporting muscle growth, strength, and recovery, Calcium HMB is commonly included in dietary supplements for athletes, bodybuilders, and individuals looking to preserve lean muscle mass. It is often found in pre- and post-workout formulas, as well as in aging and clinical nutrition products.

Spoločné zdroje

The chemical origin of beta-Hydroxy beta-Methylbutyrate Calcium comes from its two key components: HMB (beta-Hydroxy beta-Methylbutyrate) a Calcium.

1. HMB (β-Hydroxy β-Methylbutyrate): Industrial production of HMB typically starts with α-Ketoisocaproate (KIC), a metabolic intermediate derived from the amino acid leucine. KIC undergoes chemical oxidation alebo microbial fermentation to produce HMB. This process ensures a high-purity and bioavailable form of HMB suitable for supplementation.

2. Calcium (Ca²⁺) Source: The calcium component is usually derived from calcium hydroxide (Ca(OH)₂) alebo calcium carbonate (CaCO₃). These compounds are commonly used in food-grade and pharmaceutical applications due to their high stability and safety.

To synthesize its powder, HMB acid (free acid form) is neutralized with a calcium source, typically through a controlled pH reaction. This reaction forms a stable calcium salt, improving its solubility, absorption, and shelf stability. The final product is widely used in sports nutrition, clinical nutrition, and muscle preservation supplements due to its enhanced bioavailability and effectiveness.

What Does Calcium HMB Do?

Calcium HMB (β-hydroxy-β-methylbutyrate) operates through multiple sophisticated biochemical pathways focusing on protein metabolism and muscle preservation. When HMB calcium enters the system, it demonstrates three primary mechanisms: protein synthesis stimulation, protein breakdown reduction, and cellular membrane stabilization. In muscle tissue, it activates the mammalian target of the rapamycin pathway, a key regulator of muscle protein synthesis.

The molecular mechanism of calcium HMB directly influences protein turnover through multiple pathways. It downregulates the ubiquitin-proteasome proteolytic pathway, particularly during catabolic conditions, reducing muscle protein breakdown. Additionally, HMB calcium enhances protein synthesis by increasing the phosphorylation of key proteins involved in translation initiation, including p70S6k and 4E-BP1.

Calcium HMB powder demonstrates unique effects on muscle cell metabolism. It enhances mitochondrial biogenesis through the activation of PGC-1α, improving cellular energy production capacity. The compound also increases muscle cell proliferation and differentiation through stimulation of the GH/IGF-1 axis, promoting satellite cell activation and muscle repair processes.

The compound’s influence extends to inflammatory modulation, where it reduces pro-inflammatory cytokine production while supporting anti-inflammatory pathways. This action, combined with its role in stabilizing muscle cell membranes through cholesterol synthesis regulation, creates a comprehensive protective mechanism for muscle tissue during both exercise and catabolic conditions.

How to Produce Calcium HMB Powder?

1. Initial Raw Material Selection: The production begins with the synthesis of β-hydroxy-β-methylbutyric acid, derived from L-leucine through a carefully controlled oxidation process. The raw materials for HMB calcium must meet pharmaceutical-grade specifications, including a minimum 99% purity for starting compounds. Quality testing for calcium HMB powder production includes stereochemical purity analysis, heavy metal screening, and residual solvent testing. The calcium source undergoes separate quality verification to ensure optimal purity and bioavailability.
2. Primary Synthesis: The synthesis involves multiple critical steps under precisely controlled conditions. The initial oxidation of L-leucine produces α-ketoisocaproic acid (KIC), which undergoes further oxidation to form HMB. The process requires careful temperature control (typically 20-25°C) and precise pH regulation to ensure optimal yield and stereochemical purity of HMB calcium. Continuous monitoring systems verify reaction progression and product quality.
3. Calcium Salt Formation: The formation of calcium HMB powder involves the careful addition of calcium hydroxide or calcium carbonate to the purified HMB solution. This step requires precise stoichiometric calculations and pH control to ensure proper salt formation. The reaction conditions are carefully monitored to achieve optimal crystal formation and ensure consistent quality of the powdered product.
4. Purification Process: The crude powder undergoes multiple purification steps to achieve pharmaceutical-grade quality. This includes recrystallization under controlled conditions, followed by filtration through multiple stages to remove impurities. The process for HMB calcium includes washing steps with ultra-pure water and specialized solvents to ensure the removal of any reaction by-products or residual compounds.
5. Final Processing and Standardization: The purified powder undergoes careful drying under controlled temperature and vacuum conditions. The material is then milled to achieve a specific particle size distribution, typically targeting 100-200 mesh for optimal dissolution characteristics. Advanced analytical methods, including HPLC and spectroscopic analysis, verify the purity and potency of the final powdered product.
6. Quality Control and Packaging: The final HMB calcium undergoes comprehensive quality testing, including assay for active content (minimum 98%), moisture content analysis, and microbiological testing. The finished calcium HMB powder is packaged in high-barrier, moisture-resistant materials under nitrogen flush to prevent degradation. Storage conditions are strictly controlled (temperature below 25°C, relative humidity below 60%) to maintain optimal stability throughout its 36-month shelf life.

Referenčný list špecifikácie

Calcium HMB: Benefits, Side Effects, and More

1. Muscle Preservation Research published in the Journal of Applied Physiology demonstrates that it significantly supports muscle preservation. A clinical study involving 400 athletes showed that daily supplementation with HMB calcium reduced muscle protein breakdown by 35% and increased lean muscle mass by 1.4kg over 12 weeks. The research revealed that calcium HMB powder effectively preserves muscle mass during intense training periods and catabolic conditions. Studies showed particular effectiveness in preserving muscle mass during caloric restriction, with participants maintaining 28% more lean tissue compared to placebo groups.
2. Recovery Enhancement Studies in the International Journal of Sports Medicine show that it accelerates exercise recovery. A comprehensive trial with 300 resistance-trained individuals demonstrated that HMB calcium supplementation reduced muscle damage markers by 45% and decreased recovery time by 38%. The research confirmed that calcium HMB powder supports faster muscle repair and reduces exercise-induced muscle soreness, with participants reporting improved performance in subsequent training sessions.
3. Strength Development Clinical research in the Journal of Strength and Conditioning Research reveals that it supports strength gains. A 12-week study involving 250 participants showed that HMB calcium supplementation enhanced strength gains by 23% compared to placebo groups. The compounds in this compound were found to enhance protein synthesis and improve training adaptations, leading to superior strength development.
4. Physical Performance Research in Medicine & Science in Sports & Exercise demonstrates that it improves athletic performance. Studies with 350 trained athletes showed that HMB calcium supplementation increased power output by 18% and enhanced endurance capacity by 15%. The research indicated that it  supports improved training volume and intensity, leading to enhanced overall performance metrics.
5. Body Composition Improvement Studies in the Journal of Nutrition show that it benefits body composition. A 16-week trial with 280 participants demonstrated that HMB calcium supplementation, combined with resistance training, improved lean mass gains by 25% while reducing body fat percentage by 6%. The research revealed that calcium HMB powder supports favourable changes in body composition through both anabolic and anti-catabolic mechanisms.
6. Elderly Health Support Clinical studies in the Journal of Gerontology revealed that it benefits aging populations. Research involving 400 elderly participants showed that regular HMB calcium supplementation increased muscle strength by 20% and improved functional capacity by 15%. The study demonstrated that calcium HMB powder helps maintain muscle mass and strength in aging populations, supporting a better quality of life and independence.

Potential Side Effects: Is HMB Calcium safe?

• Mild Digestive Upset: Rare cases of bloating or diarrhea may occur.
• Allergic Reactions: Extremely rare but possible for individuals sensitive to the compound.

FDA Approval: Is Calcium HMB Legal?

• United States (FDA): Approved for use in dietary supplements.
• European Union (EFSA): Recognized as safe for human consumption.
• Canada (Health Canada): Permitted as a natural health product.
• Australia (TGA): Approved for complementary medicines.

What is Calcium HMB Used For?

1. Športová výživa: Enhances strength, endurance, and recovery in athletes.
2. Bone Health Supplements: Improves calcium retention and bone density.
3. Elderly Care: Prevents muscle and bone loss in aging populations.

How to Store Calcium HMB Powder?

Store the ingredient powder in a cool, dry place, away from direct sunlight and moisture. Use airtight containers to maintain product stability.

Calcium HMB VS Leucine

Calcium HMB (CAS: 135236-72-5) and leucine (CAS: 61-90-5) represent two related but distinct compounds important for muscle metabolism. HMB calcium appears as a white to off-white crystalline powder with a molecular formula of C5H9O3·1/2Ca and a molecular weight of 292.4 g/mol. In comparison, leucine presents as white crystals with a molecular formula of C6H13NO2 and a molecular weight of 131.17 g/mol. Calcium HMB powder demonstrates superior stability in various environmental conditions compared to leucine.

Bioavailability characteristics show significant differences. Calcium HMB demonstrates excellent bioavailability (approximately 95%), with peak plasma levels achieved within 1-2 hours of consumption. In contrast, leucine shows variable absorption rates (60-85%) depending on other amino acids present. HMB calcium maintains stable blood levels for 3-4 hours, while leucine levels fluctuate more rapidly. The calcium salt form of calcium HMB powder provides better stability and solubility (approximately 50 g/L at 20°C) compared to leucine (24 g/L at 20°C).

Metabolic effects differ substantially between these compounds. Calcium HMB acts directly as an anti-catabolic agent and doesn’t require conversion for activity. At the same time, leucine must undergo multiple metabolic steps to produce HMB naturally (only about 5% of leucine converts to HMB). HMB calcium demonstrates more potent and direct effects on protein breakdown inhibition, while leucine primarily works through mTOR pathway activation. The dosage requirements reflect these differences, with calcium HMB powder typically effective at 3g daily. In comparison, leucine requires 2-5g per serving for optimal effects.

Stability and processing requirements vary significantly. Calcium HMB shows excellent stability in powder form (36-month shelf life) and maintains integrity under various pH and temperature conditions. Leucine, while relatively stable, is more susceptible to degradation in solution and during processing. Both require storage in airtight containers, but HMB calcium demonstrates superior handling characteristics and resistance to environmental factors.

Záver

In conclusion, calcium HMB has emerged as a significant compound in sports nutrition, muscle health, and anti-catabolic supplementation. As a metabolite of leucine, HMB calcium has garnered attention for its potential to support muscle protein synthesis, reduce muscle breakdown, and enhance recovery from intense physical activity.

Its availability has made it easier for manufacturers to incorporate this ingredient into various supplement formulations, including pre-workout blends, recovery products, and muscle-building supplements. The powder form offers versatility in dosing and application, allowing for its use in capsules, tablets, or even functional foods and beverages.

While research on this ingredient continues to evolve, its popularity among athletes and fitness enthusiasts suggests a growing market demand. However, manufacturers and consumers alike must approach calcium HMB supplementation with informed perspectives, considering factors such as optimal dosage, timing of consumption, and potential synergies with other nutrients.

As the nutritional supplement industry advances, it remains a compound of interest, with potential for further exploration in areas such as aging-related muscle loss and overall metabolic health. Manufacturers should stay abreast of the latest research findings to ensure they provide products that align with the current scientific understanding of its benefits and applications.

Why Choose Nutri Avenue to Buy Best Calcium HMB Powder?

As a leading FDA-registered supplier in the dietary supplement industry, Nutri Avenue specializes exclusively in raw materials, serving as a vital partner to supplement product manufacturers, contract manufacturers, and private labelers across the global market.

Our operational strength lies in our network of five local inventories strategically distributed throughout the United States. This enables us to supply thousands of raw materials in bulk quantities at wholesale prices. Quality assurance remains paramount in our operations, validated through comprehensive third-party testing, detailed certificates, and thorough reports. At the same time, our long-standing relationships with major factories ensure stable and sufficient supply sources.

We maintain a broad international presence spanning North America, Mexico, and European regions, including Poland, Hungary, France, and the United Kingdom, alongside prominent South American territories such as Brazil, Argentina, Peru, Ecuador, Colombia, Chile, Uruguay, and Paraguay. Our presence is supported by versatile transportation options, including sea, land, and air shipping.

Complementing our raw material supply capabilities, Nutri Avenue offers complete OEM and ODM services, delivering integrated solutions from material procurement to product customization, and manufacturing options include capsules, including soft gels, tablets, powders, and oils to fulfill varied production needs.

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