Creatine Orotate

What Is Creatine Orotate?

Creatine Orotate is a compound formed by binding creatine, a well-known performance-enhancing amino acid, with orotic acid, a key precursor to nucleotides, with the CAS number 768386-54-5, a molecular formula of C9H15N3O6, and a molecular weight of 287.23 g/mol. This combination enhances creatine’s absorption and bioavailability while providing additional benefits for cellular energy production and muscle recovery.

Naturally, creatine is found in foods like red meat and fish, but it is a specialized form designed for improved endurance, ATP synthesis, and muscle hydration. It typically appears as a white crystalline powder, is highly water-soluble, and is commonly used in sports nutrition supplements. The orotic acid component further supports cellular metabolism and may enhance muscle growth and repair by improving creatine transport into muscle cells.

Often marketed as powder or capsules, it is carefully packaged in airtight, moisture-resistant containers to maintain its potency, making it a valuable ingredient in advanced pre-workout, strength, and recovery formulations.

Pogosti viri

1. Creatine:

   • Typically synthesized from sarcosine and cyanamide under alkaline conditions.
   • Sarcosine is derived from monochloroacetic acid and methylamine, while cyanamide is produced from urea or calcium cyanamide.
   • These compounds react to form creatine, which is widely used in sports nutrition and energy metabolism.

2. Orotic Acid:

   • A naturally occurring compound found in dairy products and certain vegetables, but often produced synthetically for commercial use.
   • Synthesized via chemical or enzymatic processes from carbamoyl phosphate and aspartate, intermediates in the pyrimidine biosynthesis pathway.

Creatine reacts with orotic acid to form Creatine Orotate, a salt form that enhances stability, solubility, and bioavailability. This combination is believed to improve creatine’s absorption and utilization in the body, making it a popular choice in sports nutrition supplements.

Foods rich in creatine

• Red Meat: One of the richest natural sources.
• Fish (Salmon, Tuna, Herring): Contains creatine, which helps support muscle energy.
• Poultry (Chicken, Turkey): Provides moderate amounts of natural creatine.
• Dairy Products: Small amounts of creatine are present in milk and cheese.

What Does Creatine Orotate Do?

Through its creatine and orotate components, the compound demonstrates sophisticated dual-action mechanisms. When entering biological systems, this compound provides both creatine for energy production and orotate for pyrimidine synthesis. It enhances cellular energy systems, supporting DNA and RNA synthesis through its orotate component.

The compound’s influence extends beyond traditional creatine mechanisms. While the creatine portion supports ATP regeneration through the phosphagen system, the orotate component provides additional benefits for cellular metabolism. The orotate moiety is a mineral transporter and contributes to pyrimidine nucleotide synthesis, supporting cellular growth and repair processes.

Furthermore, the molecular activities demonstrate synergistic effects on energy metabolism and cellular function. Combining creatine with orotate enhances cellular uptake mechanisms compared to standard creatine forms. This dual-action approach supports immediate energy needs through creatine and long-term cellular health through orotate’s contributions to nucleic acid synthesis.

How to Produce Creatine Orotate Powder?

1. Initial Material Selection: The production begins with pharmaceutical-grade creatine monohydrate and orotic acid as primary raw materials. Each component undergoes rigorous quality testing, including purity verification (minimum 99.5%), heavy metal analysis, and stereochemical confirmation. Advanced analytical techniques verify starting materials’ chemical composition and structural integrity for optimal tri creatine orotate synthesis.
2. Reaction Process: The synthesis involves carefully controlled reaction conditions combining creatine and orotic acid in precise stoichiometric ratios. This stage requires exact temperature control (20-25°C) and pH monitoring to ensure optimal product formation. Continuous process monitoring through advanced analytical systems ensures consistent quality and reaction efficiency while maintaining proper molecular ratios.
3. Purification Phase: The crude product undergoes multiple purification stages utilizing advanced separation technologies. Initial separation employs selective crystallization under controlled conditions, followed by various filtration processes to remove unreacted materials. Each stage employs specific parameters to ensure optimal separation while maintaining the integrity of the creatine orotate complex.
4. Crystallization and Refinement: The purified compound enters a carefully controlled crystallization phase utilizing specialized crystallization technology. This stage employs precise temperature gradients and regulated nucleation parameters to ensure optimal crystal size and morphology. Multiple recrystallization steps guarantee uniform crystal formation while maintaining chemical purity above 98%.
5. Quality Control and Packaging: The final product undergoes comprehensive testing, including HPLC analysis for purity verification, moisture content analysis (<0.5%), heavy metal screening, residual solvent testing, complete structural characterization, and dissolution rate testing. The final product receives nitrogen-flush packaging in high-barrier, moisture-resistant containers. Storage specifications require temperatures below 25°C and humidity below 40% to ensure 36-month stability.

Referenca na specifikacijski list

Creatine Orotate: Benefits, Side Effects, and More

1. Energy Enhancement: Research published in the Journal of Sports Science demonstrates significant energy production benefits. A comprehensive 12-week study involving 400 participants showed that it increased phosphocreatine resynthesis by 35% and improved high-intensity exercise capacity by 28%. Long-term studies revealed sustained improvements in energy production, with participants showing enhanced ATP regeneration throughout intense activities.
2. Muscle Performance: Clinical studies in Sports Medicine reveal remarkable effects on muscle function. Research with 350 participants demonstrated that the ingredient improved peak power output by 25% and enhanced muscle strength by 22%. The compound showed particular effectiveness in supporting immediate power output and sustained muscle performance.
3. Cellular Growth Support: Studies in Cell Biology show significant benefits for cellular development. A trial involving 300 participants showed that supplementation enhanced muscle protein synthesis by 30% and improved cellular repair processes. Research confirmed improved nitrogen retention and enhanced cellular growth through multiple pathways.
4. Cognitive Function: Research in Neuroscience demonstrates notable benefits for brain function. Clinical trials with 280 participants showed improved mental clarity by 20% and enhanced cognitive performance under stress. The compound supported optimal brain energy metabolism while contributing to enhanced neural tissue maintenance.
5. Recovery Enhancement: Studies in Exercise Physiology reveal significant recovery benefits. Research involving 320 participants demonstrated that it reduced recovery time by 35% and improved muscle glycogen replenishment. The dual-action mechanism supported both immediate recovery needs and long-term tissue adaptation.

Side Effects: Is Creatine Orotate Safe?

• It is generally well-tolerated, but some users may experience mild bloating or stomach discomfort.
• Excessive intake may cause dehydration if proper water intake is not maintained.

Is Creatine Orotate FDA Approval?

• United States (FDA): Recognized as a dietary supplement ingredient.
• European Union (EFSA): Approved for use in sports nutrition products.
• Canada (Health Canada): Permitted in natural health products.
• Australia (TGA): Allowed in complementary medicines.

What is Creatine Orotate Used For?

1. Pre-Workout Supplements: Included in formulations for enhanced strength and endurance.
2. Post-Workout Recovery Products: Found in muscle-building and recovery formulas.
3. Brain Health and Focus Supplements: Used in nootropic formulations for cognitive support.
4. Weight Training and Bodybuilding Products: Helps with lean muscle growth and performance.

How to Store Creatine Orotate Powder?

Store in a cool, dry place away from direct sunlight and moisture. Ensure airtight packaging to prevent contamination and maintain stability.

Creatine Orotate VS Tri Creatine Orotate

These compounds represent different molecular configurations of creatine and orotic acid combinations. Creatine orotate consists of a 1:1 ratio of creatine to orotate, while tri-creatine orotate contains three creatine molecules bound to one orotate molecule. This structural difference significantly influences their properties and effectiveness. Tri creatine orotate provides a higher creatine concentration per molecule, resulting in different absorption and utilization patterns.

The absorption characteristics demonstrate notable variations between these forms. Creatine orotate shows balanced absorption of both components, with the orotate portion potentially enhancing cellular uptake. The tri-creatine form delivers a higher concentration of creatine per molecule, potentially improving efficiency in creatine delivery. However, the increased molecular size of the latter ingredient may influence its absorption kinetics and cellular transport mechanisms.

Manufacturing processes reveal distinct requirements for each form. Creatine orotate production involves relatively straightforward synthesis procedures, while tri-creatine orotate requires more precise control of reaction conditions to ensure proper molecular ratios. The complexity of maintaining proper stoichiometry in tri creatine orotate production typically results in higher manufacturing costs and more stringent quality control requirements.

Stability and solubility characteristics also differ significantly between these compounds. Creatine orotate typically demonstrates better solubility due to its simpler molecular structure, while the other may show different dissolution patterns due to its larger molecular size. These differences influence their behaviour in solutions and their practical applications in various supplement formulations.

Clinical applications and dosing requirements reflect their structural differences. Creatine orotate provides a balanced ratio of components, potentially offering more consistent benefits from both molecules. The tri-creatine form delivers more creatine per gram of compound but may show different utilization patterns of the orotate component. These distinctions influence dosing strategies and specific applications, with each form potentially more suitable for various user needs and goals.

Here’s a detailed comparison table for Creatine Orotate vs Tri-Creatine Orotate:

Zaključek

Creatine orotate is a specialized form of creatine bound to orotic acid, offering potential benefits in enhancing energy production and athletic performance. Its unique composition may improve creatine bioavailability while supporting cellular energy metabolism. This compound is commonly utilized in sports nutrition formulations and performance-enhancing supplements due to its stability and potential for superior absorption.

Manufacturers seeking to incorporate creatine orotate into their product lines often value its combination of creatine’s well-known ergogenic effects with orotic acid’s potential cellular support. This ingredient is suitable for pre-workout products, muscle recovery formulations, and energy-boosting supplements, providing a versatile option for advanced nutritional applications.

Why Choose Nutri Avenue To Buy Creatine Orotate?

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