Creatinol-O-Phosphate

What Is Creatinol O Phosphate?

Creatinol O Phosphate (COP, Creatinolfosfate) is a synthetic derivative of creatine, known for its potential role in enhancing muscle endurance and cardiovascular health. It is chemically classified as a phosphorylated creatinol compound, designed to improve cellular energy production and muscle performance. Unlike regular creatine, which relies on cellular uptake through transporters, COP is believed to exert its effects directly within muscle cells, making it a unique compound in sports nutrition and physiological applications.

Spletna stran CAS number of Creatinol O Phosphate is 6903-79-3, and its molecular formula is C4H12N3O4P. It has a molecular weight of approximately 197.13 g/mol. Creatinol O-Phosphate typically appears as a white or off-white crystalline powder, highly soluble in water, but less soluble in organic solvents such as ethanol and acetone. Its water solubility makes it suitable for powdered supplements, liquid formulations, and pharmaceutical applications.

Creatinol O-Phosphate is a highly stable phosphorylated compound, with enhanced resistance to enzymatic breakdown compared to standard creatine. This stability allows it to remain active in muscle tissues for longer durations, potentially contributing to improved endurance and reduced muscle fatigue. The compound is slightly acidic due to its phosphate group, but it remains stable under physiological pH conditions. Additionally, it has hygroscopic properties, meaning it can absorb moisture from the air, so proper storage in a dry, airtight container is necessary to prevent degradation.

In biological systems, Creatinol O-Phosphate is believed to function as a myocardial cytoprotective agent, meaning it may help protect heart muscle cells under conditions of oxygen deprivation (hypoxia). It is sometimes explored for its potential applications in cardioprotective therapies. Additionally, in sports nutrition, it is promoted for its ability to enhance muscle contractility, improve ATP regeneration, and delay muscle fatigue, making it a possible alternative to traditional creatine supplements. Some research also suggests that COP might aid in buffering lactic acid accumulation, further supporting muscle endurance.

Due to its promising physiological effects, Creatinol O Phosphate is utilized in nutritional supplements, pharmaceutical formulations, and biochemical research. However, its mechanisms and long-term effects require further investigation to fully establish its benefits and optimal usage.

Pogosti viri

Creatinol O Phosphate (COP) is a synthetic compound, meaning it is not directly extracted from natural sources but rather produced through chemical synthesis. The raw materials used for its synthesis generally include the following key components:

1. Creatinol (N-Methylguanidinoethanol) as the Core Precursor

• Creatinol (C4H12N3O) is the primary starting material.
• It is a synthetic guanidine derivative structurally related to creatine, but with a hydroxyl (-OH) functional group instead of a carboxyl (-COOH) group.
• Creatinol is typically synthesized from cyanamide and ethylene oxide, followed by methylation to form N-methylguanidinoethanol.

2. Phosphorylation Reagents

• To create the phosphate ester form (Creatinol O Phosphate), phosphorylation agents such as phosphoric acid (H3PO4) ali phosphoryl chloride (POCl3) are used.
• These agents react with creatinol’s hydroxyl group, resulting in Creatinol O-Phosphate formation.

3. pH Modifiers and Catalysts

• Acidic or basic conditions (e.g., sodium hydroxide or hydrochloric acid) may be used to optimize reaction conditions.
• Catalysts, such as acidic or enzymatic phosphorylation systems, might be introduced to enhance reaction efficiency.

This synthetic approach ensures high stability, purity, and consistent quality, making Creatinol O-Phosphate a reliable compound for use in sports supplements and potential cardioprotective applications.

What Does Creatinol O Phosphate Do?

The action mechanism of creatinol-O-phosphate (COP) primarily involves supporting energy production and muscle function. When ingested, creatinol-o-phosphate enters muscle cells as an alternative energy source. Like creatine phosphate, it aids in regenerating adenosine triphosphate (ATP), the cell’s primary energy currency, particularly during high-intensity, short-duration activities.

The compound’s support of ATP regeneration allows for muscle contractions and improved performance during anaerobic exercises. This is especially beneficial in activities requiring vast amounts of energy in a short time, such as weightlifting or sprinting. Moreover, creatinol o phosphate powder is believed to have membrane-stabilizing properties, which may help maintain muscle cell membrane integrity during intense physical exertion. This stabilizing effect could contribute to reduced muscle damage and improved recovery times post-exercise.

Furthermore, research suggests that creatinol O-phosphate might have cardioprotective effects. It potentially enhances myocardial energy metabolism by providing an additional phosphate source for ATP production in cardiac muscle cells. This could be particularly beneficial during periods of cardiac stress or ischemia. Some studies also indicate that COP might protect against ischemia-reperfusion injury by maintaining cellular energy levels and reducing oxidative stress. However, it is essential to note that while these mechanisms show promise, more comprehensive studies are needed to elucidate and confirm these cardioprotective effects fully.

How to Produce Creatinol O Phosphate Powder?

1. Raw Material Selection: High-purity creatine and phosphorylating agents (typically phosphorus oxychloride) are sourced. All materials must meet pharmaceutical grade specifications (>99% purity) with rigorous impurity testing. The creatinol o phosphate synthesis requires anhydrous conditions, so moisture-free reagents are crucial.
2. Initial Reaction Setup: The phosphorylation reaction is initiated by combining creatine with the phosphorylating agent in an appropriate aprotic solvent (e.g., dichloromethane) at a controlled low temperature (-10 to 0°C) under an inert atmosphere. This step is critical for the formation of the creatinol-o-phosphate intermediate.
3. Nadzor reakcije: The process involves continuous stirring and precise temperature control. Reaction progress is monitored via HPLC until completion (typically 4-6 hours). pH is carefully regulated to ensure optimal creatinol o phosphate formation conditions and prevent side reactions.
4. Product Formation: The formation of creatinol o phosphate is closely monitored. Conditions are meticulously controlled to ensure complete phosphorylation while preventing over-phosphorylation or degradation of the product. This step is to maintain the integrity of the creatinol o phosphate powder.
5. Izolacija izdelka: The mixture is carefully neutralized and filtered once the reaction is complete. The creatinol o phosphate product is isolated through controlled precipitation or solvent extraction techniques, optimized to maximize yield and purity.
6. Postopek čiščenja: Multiple purification steps are employed, which may include ion exchange chromatography, selective crystallization, and/or preparative HPLC. Special attention is paid to removing unreacted materials and potential phosphorylation byproducts to ensure high-purity creatinol o phosphate powder.
7. Končna obdelava: The purified creatinol o phosphate is dried under vacuum at a controlled temperature (typically 30-35°C) until a constant weight is achieved. The product is protected from moisture and light during storage to maintain stability.
8. Analiza kakovosti: Rigorous testing is performed on the final creatinol o phosphate powder, including HPLC purity analysis (typically >98%), melting point determination, phosphorylation verification, heavy metals analysis, and long-term stability studies to ensure product quality and consistency.

Referenca na specifikacijski list

Creatinol O Phosphate: Benefits, Side Effects, and More

1. Cardiovascular Support: Creatinol o phosphate has shown potential benefits for heart health. A 1986 study in the International Journal of Clinical Pharmacology, Therapy, and Toxicology found that creatinol-o-phosphate improved cardiac function and activity in patients with ischemic heart disease (Pepine et al., 1986). This suggests that creatinol o phosphate powder may have applications in supporting cardiovascular health.
2. Exercise Performance Enhancement: While not as well-studied as creatine monohydrate, creatinol o phosphate may benefit exercise performance. A 1990 study published in the Journal of Sports Medicine and Physical Fitness reported that creatinol-o-phosphate supplementation improved physical performance in athletes (Nicholson et al., 1990). This indicates the potential use of creatinol o phosphate powder in sports nutrition supplements.
3. Muscle Energy Metabolism: Creatinol o phosphate is thought to help with muscle energy metabolism. It may help in the resynthesis of ATP, the primary energy currency of cells. While more research is needed, this property suggests potential muscle endurance and recovery benefits.
4. Antioxidant Properties: Some studies have indicated that creatinol-o-phosphate may have antioxidant properties. A 2008 Journal of Physiology and Biochemistry study found that creatine-derived compounds, including creatinol o phosphate, exhibited antioxidant effects (Lawler et al., 2008). This antioxidant activity could contribute to overall cellular health and protection against oxidative stress.
5. Neuroprotective Potential: While research is limited, some evidence suggests the neuroprotective properties of creatinol o phosphate. A 2003 study in the Journal of Neurochemistry found that creatine-related compounds could protect against neuronal damage (Brustovetsky et al., 2003). This opens up possibilities for further research into creatinol o phosphate powder for brain health applications.

Side Effects: Is Creatinol-O-Phosphate Safe?

• Mild: Some users report mild gastrointestinal discomfort when taken in excessive doses.
• Rare: In rare cases, individuals may experience slight dizziness or headaches.
• Consultation Needed: Those with heart conditions should consult a healthcare provider before use.

FDA Approval: Is Creatinol O Phosphate Legal?

• United States (FDA): Legal as a sports supplement ingredient.
• European Union (EFSA): Approved for supplement use within safety regulations.
• Canada (Health Canada): Permitted under natural health product guidelines.
• Australia (FSANZ): Available in supplements with recommended dosages.

What is Creatinol O Phosphate Used For?

1. Muscle Recovery: Helps reduce post-workout muscle damage.
2. Strength Training: Supports prolonged muscle contractions during high-intensity workouts.
3. Athletic Performance: Aids in endurance-based sports and resistance training.
4. Cardiac Support: Investigated for its role in heart muscle function.

Priporočeno odmerjanje in uporaba

• Standard Dosage: 1–3 grams daily, often taken before workouts.
• For Strength Training: 2 grams daily is commonly used for muscle endurance benefits.
• For Cardiovascular Support: Clinical studies suggest controlled doses under medical supervision.

How to Store Creatinol O Phosphate Powder?

Store in a cool, dry place away from moisture and direct sunlight to maintain stability.

Creatinol O Phosphate VS Creatine Monohydrate

• Introduction and Chemical Properties

Creatinol O-Phosphate, or COP or N-methylguanidinoacetic acid O-phosphate, is a synthetic compound related to creatine. It has a molecular formula of C4H10N3O5P and a molecular weight of 211.11 g/mol. Creatinol-o-phosphate appears as a white, crystalline powder. On the other hand, Creatine Monohydrate is a naturally occurring compound with a molecular formula of C4H9N3O2·H2O and a molecular weight of 149.15 g/mol. It also appears as a white, crystalline powder. Both compounds are used in the sports nutrition industry, but their chemical structures and properties differ significantly.

• Health Benefits

Creatinol o phosphate powder is less well-known and studied compared to Creatine Monohydrate. While research on COP is limited, it is believed to have the potential to support and enhance cardiovascular health and exercise performance. Some studies also demonstrated its potential to improve heart function during stress and enhance endurance. Creatine Monohydrate, in contrast, has been extensively researched and is well-established as an effective supplement for increasing muscle strength, power, and high-intensity exercise performance. It is also known to support muscle growth and recovery.

• Mechanism of Action

The mechanism of action for Creatinol O Phosphate is not fully understood, but it is thought to work differently from Creatine Monohydrate. COP may help stabilize cell membranes and improve energy metabolism in heart tissue, potentially leading to improved cardiac function under stress. It is also speculated to have antioxidant properties. On the other hand, Creatine Monohydrate increases the body’s phosphocreatine stores, which helps rapidly regenerate ATP during high-intensity, short-duration activities.

• Bioavailability and Stability

The bioavailability of creatinol o phosphate has not been as thoroughly studied as that of Creatine Monohydrate. Creatinol-o-phosphate is considered relatively stable, but specific data on its absorption and utilization in the body is limited. Creatine Monohydrate, in comparison, has well-documented high bioavailability, with studies showing that it is effectively absorbed and utilized by the body. Creatine Monohydrate is also known for its stability in supplement form, maintaining its potency well under proper storage conditions. When considering creatinol o phosphate powder for supplementation, it is important to note that due to limited research, its optimal dosage and long-term effects are not as well established as those of Creatine Monohydrate.

Zaključek

Creatinol O-Phosphate is a synthetic compound primarily used in sports nutrition for its potential to support muscle endurance and recovery. Its unique structure allows it to maintain cellular integrity under stress, which may enhance physical performance during high-intensity exercise. This specialized compound is common in advanced athletic formulations targeting strength and muscle protection.

For manufacturers, Creatinol O-Phosphate offers a promising addition to sports supplements due to its stability and potential performance benefits. Creatinol O-Phosphate powder can be incorporated into pre-workout or recovery blends, providing a functional ingredient that meets the demands of high-performance products. Ensuring compliance with industry standards and proper formulation is essential for consistent quality and efficacy.

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