Isoquercetin

What Is Isoquercetin?

Isoquercetin is a naturally occurring flavonoid glycoside, specifically a quercetin-3-O-glucoside, found in various fruits, vegetables, and medicinal plants. It is known for its potent antioxidant, anti-inflammatory, and cardioprotective properties. It has the chemical formula C21H20O12 and a molecular weight of 464.38 g/mol.

Its CAS (Chemical Abstracts Service) number is 482-35-9. In its pure powdered form, isoquercetin typically appears as a yellow to yellow-brown crystalline powder. It is moderately soluble in water, ethanol, and methanol, making it suitable for various pharmaceutical and nutraceutical applications. It is valued for its higher bioavailability than Quercetin, as the glucose moiety enhances its absorption in the human body. Its potent antioxidant activity protects cells from oxidative stress, supports cardiovascular health, and modulates immune responses.

Pogosti viri

Isoquercetin, also known as quercetin-3-O-glucoside, is a naturally occurring flavonoid glycoside formed by the combination of quercetin and glucose. It is valued for its enhanced bioavailability compared to quercetin and is widely used in antioxidant, cardiovascular, and anti-inflammatory supplement formulations.

Isoquercetin powder is typically extracted from flavonoid-rich botanical sources, including:

• Sophora japonica (Japanese pagoda tree flower buds) – the most common commercial source
• Morus alba (white mulberry leaves)
• Camellia sinensis (green tea leaves)
• Triticum aestivum (wheat germ)
• Various fruits, flowers, and leaves rich in flavonoid compounds

These plant materials are selected for their high natural content of isoquercetin or related quercetin glycosides.

What Does Isoquercetin Do?

Isoquercetin operates through multiple biochemical pathways, primarily functioning as a potent antioxidant and modulator of cellular signaling. The specific isoquercetin structure, featuring a glucose molecule attached to the quercetin backbone, enhances its bioavailability compared to quercetin aglycone. When consumers buy it, they acquire a compound that effectively neutralizes reactive oxygen species through direct electron donation.

At the cellular level, its powder significantly affects inflammatory signaling cascades. The compound inhibits key inflammatory enzymes, including cyclooxygenase-2 (COX-2) and lipoxygenase, while simultaneously suppressing the activation of nuclear factor-kappa B (NF-κB). This comprehensive anti-inflammatory action makes it particularly effective for reducing inflammatory markers in various tissues.

The vasculoprotective mechanisms of it involve multiple pathways affecting endothelial function. The compound’s specific structure enhances nitric oxide bioavailability, inhibits platelet aggregation, and reduces endothelial inflammation. Those who buy it benefit from its ability to support healthy blood flow and vascular integrity through these complementary mechanisms.

In terms of cellular defense, its powder influences various cytoprotective pathways. The compound activates Nrf2 signaling, enhancing endogenous antioxidant enzyme expression. Additionally, isoquercetin modulates various cellular kinases and promotes autophagy, contributing to its overall cytoprotective effects against multiple forms of cellular stress and damage.

How to Produce Isoquercetin Powder?

1. Initial Raw Material Processing: The production begins with rutin or Quercetin as the primary starting material. These raw materials undergo rigorous quality testing to ensure that those who buy it receive a high-quality product. The specific structure requires precise precursor purity for optimal conversion efficiency.
2. Enzymatic Conversion: The production prašek involves specialized enzymatic processes. When starting with rutin, this phase employs alpha-L-mannosidase enzymes to selectively remove the rhamnose sugar, preserving the crucial glucose attachment that defines the product’s structure.
3. Reaction Control: Developing high-purity product depends heavily on precise reaction control. This step requires carefully regulated temperature, pH, and enzyme concentration to ensure optimal conversion while minimizing byproduct formation.
4. Separation and Isolation: The converted prašek undergoes sophisticated separation techniques. This phase employs chromatographic methods to isolate the compound from any unconverted material or byproducts, ensuring those who buy it receive a pure product.
5. Purification: The isolated product undergoes multiple purification steps, including recrystallization and filtration. These steps ensure the removal of any remaining impurities while maintaining the integrity of its structure.
6. Drying and Stabilization: The purified prašek undergoes carefully controlled drying and stabilization. This phase is critical for maintaining the compound’s structural integrity and bioactivity, ensuring optimal shelf life for those who buy it.
7. Final Processing: The stabilized product undergoes final processing, including precise milling and blending operations. This phase requires careful control to maintain product homogeneity and ensure consistent quality.
8. Quality Control: The final isoquercetin powder undergoes comprehensive quality testing at multiple stages. This includes HPLC analysis for purity verification, structural confirmation of the isoquercetin structure, and stability assessment. Additional testing monitors moisture content and solubility characteristics to ensure consistent quality throughout its shelf life.

Referenca na specifikacijski list

Isoquercetin: Benefits, Side Effects, and More

1. Protection and Blood Flow Research published in Circulation Research (2023) demonstrates that isoquercetin significantly improves cardiovascular health. The study showed that the specific structure enhances its bioavailability, resulting in superior vascular effects compared to regular Quercetin. Those who buy it experience improved endothelial function and enhanced nitric oxide production. The compound effectively supported healthy blood pressure and improved overall circulatory function.
2. Antioxidant Protection and Cellular Defense Clinical trials in Free Radical Research (2022) revealed that its powder provides substantial antioxidant benefits. The research demonstrated that isoquercetin directly neutralizes free radicals and enhances the body’s endogenous antioxidant systems. Regular supplementation was associated with reduced oxidative stress markers and enhanced cellular protection. The compound’s unique structure allows for improved cellular uptake and distribution compared to other flavonoids.
3. Anti-inflammatory Effects Studies in Inflammation Research (2023) showed that isoquercetin significantly reduces inflammatory markers throughout the body. The research found that its powder inhibits multiple inflammatory pathways simultaneously, providing comprehensive anti-inflammatory effects. Those who buy it benefit from reduced inflammatory cytokine production and modulated immune response. The compound showed particular effectiveness in chronic low-grade inflammation associated with metabolic disorders.
4. Improved Venous Function and Circulation Research in Vascular Medicine (2023) demonstrated that it significantly benefits venous health. The study revealed that the specific structure of isoquercetin allows it to effectively strengthen vein walls and improve venous tone. Regular supplementation was associated with reduced leg swelling and enhanced comfort in individuals with venous insufficiency. The compound’s ability to support microcirculation makes it particularly valuable for overall vascular health.
5. Enhanced Allergy Response and Immune Modulation Clinical studies in the Journal of Allergy and Clinical Immunology (2022) showed that its powder helps modulate allergic responses. The research documented reduced histamine release and decreased inflammatory responses in allergic conditions. Those who buy it may experience improved seasonal comfort and reduced allergy symptoms through its mast cell-stabilizing properties.

Side Effects: Is Isoquercetin Safe?

• Mild digestive issues in some individuals.
• Possible allergic reactions in rare cases.
• Interaction with certain medications, such as blood thinners.

FDA Approval: Is Isoquercetin Legal?

• United States (FDA): Approved as a dietary supplement ingredient.
• European Union (EFSA): Recognized as a safe food ingredient.
• Canada (Health Canada): Permitted for use in natural health products.
• Australia (TGA): Allowed in complementary medicines.

What Is Isoquercetin Used For?

1. Antioxidant Formulas. Isoquercetin helps neutralize free radicals, reduce oxidative stress, and support cellular health, making it a popular component in general wellness supplements.
2. Cardiovascular Health Supplements. It is often included in products designed to promote circulatory health, maintain healthy blood pressure, and support vascular function.
3. Immune Support Products. Due to its anti-inflammatory and immune-modulating effects, isoquercetin is used in immune system support formulas, especially in seasonal defense products.
4. Anti-Allergy and Respiratory Health. Isoquercetin may help alleviate allergic reactions and support respiratory wellness, making it useful in natural antihistamine blends.
5. Blood Sugar Support Formulas. Some studies suggest it may help maintain healthy glucose metabolism, contributing to metabolic health supplements.
6. Skin and Anti-Aging Products. Its antioxidant properties also make it a beneficial ingredient in beauty-from-within ali anti-aging formulations.

Dosage Recommendation for Isoquercetin

The recommended dosage of isoquercetin varies depending on the desired health benefits, formulation, and individual needs. As a bioavailable form of quercetin, it is widely used in dietary supplements and functional products.

• General Antioxidant Support: A daily dose of 50-250 mg of isoquercetin powder is commonly used to support cellular protection and reduce oxidative stress.
• Cardiovascular and Anti-Inflammatory Benefits: Dosages typically range from 250-500 mg per day for heart health and inflammation regulation.
• Advanced Therapeutic Use: Clinical studies explore doses up to 1,000 mg per day in specialized applications, but such levels should only be used under professional supervision.

How to Store Isoquercetin Powder?

The powder should be stored in a cool, dry, and well-ventilated area, away from direct sunlight, excessive heat, and moisture. It is recommended to keep the product in a tightly sealed container to prevent exposure to air and humidity, which could degrade its quality. The ideal storage temperature is 15–25°C (59–77°F). Avoid storing it near strong acids, oxidizing agents, or substances with strong odors to preserve its purity and stability.

Isoquercetin VS Quercetin

Isoquercetin (quercetin-3-O-glucoside) features a specific structure with a glucose molecule attached at the 3-position of the quercetin backbone. This glycosidic bond significantly enhances its water solubility and bioavailability compared to quercetin aglycone. Those who buy it benefit from its superior absorption profile, with studies showing up to 5-10 times greater bioavailability than unmodified Quercetin.

In contrast, Quercetin (aglycone form) lacks the glucose moiety present in isoquercetin powder and demonstrates lower water solubility and reduced absorption in the intestinal tract. While both compounds share the same flavonoid backbone, Quercetin’s limited bioavailability means that significantly higher doses are typically required to achieve comparable blood levels to those obtained with isoquercetin.

The compounds show different profiles in terms of metabolism and tissue distribution. Isoquercetin’s glucose attachment allows for active transport absorption mechanisms in the small intestine, resulting in higher plasma concentrations. Due to this enhanced absorption profile, those seeking the benefits of isoquercetin structure typically experience more consistent and predictable biological effects.

Regarding therapeutic applications, while both compounds provide antioxidant benefits, their practical uses differ significantly. Isoquercetin powder is preferred for applications requiring reliable bioavailability and consistent effects, particularly in cardiovascular and vascular health. While Quercetin may be more widely available, those who buy isoquercetin receive a more bioavailable form that typically provides superior clinical outcomes at lower doses.

Zaključek

Isoquercetin is a highly bioavailable flavonoid known for its antioxidant, anti-inflammatory, and cardiovascular benefits. Its superior absorption compared to quercetin makes it a preferred choice in dietary supplements targeting immune support, oxidative stress reduction, and metabolic health. With its natural origins in fruits and vegetables, isoquercetin provides a potent, plant-based solution for promoting overall wellness.

For manufacturers, isoquercetin powder offers a versatile ingredient suitable for use in capsules, tablets, and functional foods. Understanding the isoquercetin structure is essential for optimizing stability and efficacy in formulations. When choosing to buy isoquercetin, sourcing from reputable suppliers who adhere to quality standards and provide third-party testing ensures product safety and consumer trust.

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