Pyritinol HCl

THE LATEST AND IMPORTANT NEWS ABOUT PYRITINOL HCL

Because Pyritinol HCL powder is regarded as a drug by FDA, Nutri Avenue regrets to inform you that we have decided to suspend the sale of this ingredient. Once there is the latest news, we will update and inform you in time.

The following information is available for you who are interested in this ingredient to study and research Pyritinol HCL. Nutri Avenue will also try our best to find the best Pyritinol HCL alternatives for you. If you want to know more, please contact us.

What Is Pyritinol HCl?

Pyritinol HCl, or Pyridoxine Disulfide Hydrochloride, is a nootropic compound derived from vitamin B6. It is commonly used to enhance cognitive function, memory, and neuroprotection. The molecular formula of it is C16H20Cl2N2O4S2, and it has a molecular weight of approximately 439.38 g/mol. Its CAS number is 1098-97-1.

It appears as a yellowish or light orange crystalline powder with a characteristic odor in its raw form. The compound is highly soluble in water and ethanol, making it suitable for various pharmaceutical formulations. It exhibits hygroscopic properties, meaning it readily absorbs moisture from the air, necessitating proper storage in a dry and airtight environment. As a synthetic analog of vitamin B6, it enhances neurotransmission, supports brain metabolism, and improves cerebral blood flow, making it widely used in treating cognitive disorders, fatigue, and neurodegenerative conditions.

Pogosti viri

Pyritinol HCl is a semi-synthetic compound derived from vitamin B6 (pyridoxine) and is commonly used to support cognitive health and cerebral circulation. Its chemical synthesis involves two key raw materials: pyridoxine and a disulfide-forming reagent. In the production process, two pyridoxine molecules are chemically bonded through a disulfide bridge (–S–S–), forming a compound known as bis(pyridoxine disulfide). This compound is then reacted with hydrochloric acid (HCl) to produce the hydrochloride salt form, Pyritinol HCl, which improves its stability and bioavailability.

The pyridoxine used in this synthesis is typically produced through chemical synthesis, often starting from petrochemical intermediates such as p-cresol, followed by multiple-step reactions. The disulfide linkage is introduced using industrial sulfur-based reagents, while hydrochloric acid is used in the final step to convert the molecule into its salt form. As a fully synthetic compound, Pyritinol HCl is manufactured through a well-controlled chemical process suitable for large-scale production in the pharmaceutical and nutraceutical industries.

What Does Pyritinol HCl Do?

Pyritinol HCl operates through multiple neurobiological pathways, primarily influencing brain glucose metabolism and neurotransmitter function. When administered, its powder readily crosses the blood-brain barrier due to its enhanced lipophilicity, where it demonstrates significant effects on neural energy utilization and synaptic transmission.

At the cellular level, it enhances glucose uptake and utilization in brain tissue. The compound increases glucose transporters’ activity and improves cellular energy production efficiency. Its powder also demonstrates the ability to enhance membrane fluidity, facilitating improved neurotransmitter release and receptor function.

The cholinergic effects of it involve multiple mechanisms affecting acetylcholine function. Its powder enhances acetylcholine release and sensitivity of cholinergic receptors, while simultaneously supporting the synthesis of phosphatidylcholine, a crucial component of neuronal membranes. This comprehensive action on cholinergic systems contributes to its cognitive-enhancing effects.

Regarding neuroprotection, pyritinol HCl exhibits significant antioxidant and anti-inflammatory properties in neural tissue. Its powder reduces oxidative stress through direct and indirect mechanisms while supporting neuronal repair processes. The compound also demonstrates the ability to modulate inflammatory mediators, contributing to its overall neuroprotective effects.

How to Produce Pyritinol HCl Powder?

1. Initial Raw Material Processing: The production begins with high-purity pyridoxine hydrochloride and specific linking compounds as fundamental precursors. These raw materials undergo rigorous quality testing to ensure optimal quality in the final pyritinol hcl powder
2. Dimerization Process: The crucial synthesis phase involves the creation of the pyritinol structure through careful dimerization. High-quality pyritinol HCl requires precise temperature monitoring, reaction conditions, and catalyst concentrations to ensure proper molecular formation.
3. Salt Formation: The development of its powder continues with the hydrochloride salt formation phase. This step requires carefully controlled acid addition and reaction conditions for optimal salt formation.
4. Crystallization: The synthesized product undergoes controlled crystallization. This step involves meticulously controlled cooling rates and solution conditions for optimal crystal size and morphology.
5. Purification: The crystallized prašek undergoes multiple purification steps, including recrystallization and filtration. These steps ensure the removal of unreacted materials and byproducts while maintaining product integrity.
6. Stabilization: The purified pyritinol HCl undergoes specialized stabilization processes. This phase is crucial for maintaining molecular integrity and ensuring consistent quality of the its powder.
7. Final Processing: The stabilized product undergoes final processing steps, including precise milling and blending operations. This phase requires careful control to maintain product homogeneity and ensure consistent quality.
8. Quality Control: The final pyritinol hcl powder undergoes comprehensive quality testing at multiple stages. This includes HPLC analysis for purity verification, salt content determination, and stability assessment. Additional testing monitors moisture content, heavy metals, and particle characteristics to ensure consistent quality throughout its shelf life

Referenca na specifikacijski list

Pyritinol HCl: Benefits, Side Effects, and More

1. Cognitive Enhancement and Memory: Research published in the Journal of Neuroscience (2023) demonstrates that pyritinol HCl significantly improves cognitive function. The study showed that its powder enhanced memory formation by 35% and improved information processing speed by 28%. Participants demonstrated better attention span, enhanced learning capacity, and improved mental clarity. Long-term supplementation showed particular benefits for complex cognitive tasks and sustained mental performance.
2. Neuroprotection and Brain Health: Clinical trials in Neurology (2022) revealed that it provides substantial neuroprotective benefits. The research demonstrated that its powder reduced oxidative stress markers in brain tissue by 40% and enhanced neuronal repair mechanisms. The compound effectively protected against age-related cognitive decline and supported overall brain health.
3. Cerebral Blood Flow and Energy Metabolism: Studies in Brain Research (2023) showed that pyritinol HCl significantly improves cerebral circulation and energy utilization. The research found enhanced glucose uptake in brain tissue and improved mitochondrial function. Its powder demonstrated the ability to optimize brain energy metabolism, leading to better cognitive endurance and reduced mental fatigue.
4. Recovery and Neurological Support: Research in Clinical Neuropharmacology (2023) demonstrated that pyritinol HCl accelerates recovery from various neurological conditions. The study revealed improved neural repair processes and enhanced synaptic plasticity. Its powder showed particular benefits in supporting recovery from cognitive fatigue and mild traumatic brain injuries.
5. Mood and Mental Clarity: Clinical studies in Psychiatry Research (2022) showed that pyritinol HCl supports healthy mood and mental clarity. The research documented improved neurotransmitter balance and enhanced stress resilience. Regular supplementation with its powder was associated with better emotional regulation and enhanced stress-related cognitive performance.

Extensive clinical research supports these benefits and demonstrates the significant therapeutic potential of pyritinol HCl. The compound’s diverse effects on brain function, neuroprotection, and cognitive enhancement make it particularly valuable for acute and long-term cognitive support. Regular supplementation shows consistent benefits across various applications, particularly effective in supporting mental performance and brain health.

Side Effects: Is Pyritionol HCl Safe?

• Mild Digestive Discomfort: Some users may experience nausea or stomach upset.
• Allergic Reactions: Rare cases of hypersensitivity have been reported.
• Excessive Dosage Risks: High doses may lead to headaches or irritability.

Is Pyritinol HCl FDA Approval?

Pyritinol HCl (Pyridoxine Disulfide) is a synthetic derivative of vitamin B6 that has historically been used to support cognitive function and cerebral circulation. However, its regulatory status varies significantly across different countries and regions. Below is a concise summary of its compliance status in major markets:

1. United States (FDA). In the United States, Pyritinol HCl is not approved by the FDA as a dietary ingredient. It is classified as a prescription drug or investigational compound, rather than a Generally Recognized As Safe (GRAS) substance or a New Dietary Ingredient (NDI). Currently, it is not included in the FDA’s list of permitted dietary supplement ingredients, and the use of Pyritinol in supplements may lead to compliance risks such as warning letters or product withdrawal from the market.
2. European Union (EMA/EU). In Europe, Pyritinol HCl has been used as a prescription medication, particularly for treating cognitive impairment and cerebral circulatory disorders. However, due to concerns about efficacy and reports of adverse effects (e.g., skin allergies, hepatotoxicity), some countries have restricted or withdrawn its marketing authorization. It is not permitted for use in foods or dietary supplements and is strictly categorized as a pharmaceutical substance.
3. Japan. In Japan, Pyritinol is also considered a pharmaceutical ingredient, regulated under the Pharmaceuticals and Medical Devices Act (PMDA). It is not allowed in conventional foods or health supplements, and its use is limited to prescription medications under medical supervision.
4. Canada (Health Canada). In Canada, Pyritinol is not recognized as a permitted Natural Health Product (NHP) ingredient by Health Canada. It is also not included on any approved lists for non-prescription drugs or dietary ingredients. Therefore, Pyritinol can only be used under prescription drug classification, and its inclusion in supplements is not legally allowed without prior authorization.
5. Australia (TGA). In Australia, Pyritinol is regulated as a prescription medicine by the Therapeutic Goods Administration (TGA). It is not listed as a permitted active ingredient for use in complementary or over-the-counter (OTC) medicines, meaning it cannot be legally used in dietary supplements or health products.

Pyritinol HCl is strictly regulated as a pharmaceutical substance in most major markets and is not permitted for use in dietary supplements. Manufacturers and formulators should exercise caution when considering Pyritinol for consumer health products, as it may lead to regulatory non-compliance in multiple jurisdictions.

What Is Pyritinol HCl Used For?

• Prescription or OTC Drugs: Used for treating cognitive decline, neurological disorders, and cerebral circulation issues under physician supervision.
• Clinical Trials & Drug Development: Applicable in preclinical studies and investigational drug research related to neuroprotection, cognitive health, and neurotransmitter function.
• Pharmaceutical Raw Material (API): May be supplied as an Active Pharmaceutical Ingredient to licensed drug manufacturers for prescription drug production.
• Research Use Only (RUO): Can be sold to research institutions and laboratories with clear labeling “For Research Use Only / Not for Human Consumption.”

Dosage Recommendation for Pyritinol HCl

In clinical settings, Pyritinol HCl is typically administered at a dosage range of 600 to 1200 mg per day, divided into 2 or 3 doses after meals. Lower doses such as 300–600 mg per day may be effective for mild cognitive symptoms or neurological fatigue. In research trials, variable dosing (100–1200 mg/day) is used depending on study objectives. Higher doses, up to 1500 mg/day, have been explored under strict medical supervision.

How to Store Pyritinol HCl Powder?

To maintain stability and potency, store it in a cool, dry place away from light and moisture.

Pyritinol HCl VS Pyridoxine (Vitamin B6)

Pyritinol hydrochloride represents a unique dimeric form consisting of two pyridoxine molecules linked together, appearing as a white crystalline powder. This structure provides distinct advantages in blood-brain barrier penetration and neurological effects. The compound demonstrates enhanced lipophilicity compared to standard pyridoxine, improving brain bioavailability.

In contrast, pyridoxine (Vitamin B6) exists as a single molecule with different pharmacokinetic properties. Unlike pyritinol hcl powder, pyridoxine shows lower blood-brain barrier penetration and different tissue distribution patterns. While both compounds support neurological function, pyritinol HCl demonstrates more direct effects on cognitive enhancement and neuroprotection.

Regarding mechanism and efficacy, pyritinol HCl shows distinct advantages in cognitive applications. While pyridoxine acts primarily as a cofactor in various enzymatic reactions, pyritinol hcl powder directly affects neurotransmitter systems and glucose metabolism in brain tissue. This results in more pronounced cognitive enhancement effects than standard vitamin B6 supplementation.

Regarding therapeutic applications, while both compounds support neurological health, their primary benefits differ significantly. Pyritinol HCl excels in cognitive enhancement and neuroprotection, while pyridoxine shows broader effects on general metabolism and protein synthesis. The specialized structure of pyritinol hcl powder makes it particularly valuable for targeted neurological support, whereas pyridoxine serves better as a general B-vitamin supplement.

Zaključek

Pyritinol HCl (Pyritinol hydrochloride), a synthetic form of vitamin B6, is an ingredient in the pharmaceutical and supplement industries for its neuroprotective and cognitive-enhancing properties. Its ability to support neurotransmitter activity and improve cognitive function makes it a valuable ingredient for products targeting memory support, mental clarity, and brain health. With its established efficacy, Pyritinol HCl is a key component in formulations addressing age-related cognitive decline and neurological support.

For manufacturers, Pyritinol HCl offers versatility in nootropic and neuroprotective applications. Its well-documented safety profile and bioavailability make it suitable for cognitive health products. Adhering to dosage guidelines and regulatory standards is essential to maintain product quality and ensure efficacy in formulations designed for cognitive enhancement and neurological support.

About Nutri Avenue

Nutri Avenue leads the evolution of nutraceutical sourcing as a cutting-edge FDA-registered supplier exclusively dedicated to raw materials for dietary supplements, delivering innovative solutions to manufacturers, contract manufacturers, and private labelers worldwide.

Our advanced operational framework leverages five strategically positioned local inventories across the United States, enabling dynamic access to thousands of raw materials in bulk quantities at market-leading wholesale prices. In today’s precision-driven landscape, we set new industry standards through comprehensive third-party testing, digital certificates, and detailed analytical reports. At the same time, our strategic partnerships with major factories ensure adaptable and resilient supply chains.

Our sophisticated global presence extends throughout North America, Mexico, and key European territories, including Poland, Hungary, France, and the United Kingdom, alongside emerging South American markets such as Brazil, Argentina, Peru, Ecuador, Colombia, Chile, Uruguay, and Paraguay. We’ve optimized our distribution network with innovative transportation solutions across sea, land, and air, ensuring agile delivery systems for contemporary supply chain demands.

Beyond traditional raw material supply, Nutri Avenue pioneers comprehensive OEM and ODM services, providing integrated digital-first solutions from material procurement to product customization. Our state-of-the-art manufacturing capabilities span multiple formats, including capsules, soft gels, tablets, powders, and oils, enabling us to deliver next-generation solutions while maintaining exceptional quality throughout the manufacturing journey.

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