Good health is a common pursuit of people in the new era, and the ceiling of this pursuit must be the awe of aging and the desire for longevity. With the rapid development of science, people will always see the stars of hope from time to time.
Since the research team of Professor David Sinclair of Harvard Medical School discovered that β-nicotinamide mononucleotide (NMN) can delay the lifespan of mice in 2013, products containing NMN have quickly become popular in the market and attracted capital crazy entry.
Although NMN has been questioned by many in China, its sales have given reality a resounding slap in the face. According to the “2021Q1 China Health Products and NMN Market Research Report”, the market size of NMN health products in China will reach 5.106 billion yuan in 2020, a year-on-year increase of 34.87%, and it is expected to climb to 27.013 billion yuan by 2023 with a growth rate of nearly 70.25%. Yuan.
More intuitively, in 2020, JD.com’s NMN sales on Double 11 increased by 1,500%. The result of this growth against the trend also fully highlights consumers’ strong desire for “anti-aging.”
There are many reasons for the aging of the body. Among them, the decline of NAD+ level is an important reason for the aging of cells and the body. Because NAD+ (nicotinamide adenine dinucleotide) is a coenzyme of thousands of enzymes, it greatly influences the energy metabolism immune system. Material metabolism plays an important role.
NMN is the precursor substance for the synthesis of NAD+, which can directly enter the cells and be converted into NAD+. It is, of course, associated with anti-aging. This kind of promotion of endogenous environmental changes is considered an effective way to delay the aging process.
Spermidine, another potential anti-aging ingredient, has received widespread attention in recent years. Its popularity in scientific research is no less than that of the popular NMN ingredient, and its function is even worse than that of NMN.
In recent years, various anti-aging methods have emerged with the rapid progress of aging research. Everything from traditional diet and lifestyle to new transfusion therapy, stem cell therapy, gene editing, etc. Recently, at the 5th Global Anti-aging Conference, a substance whose main component is Spermidine was introduced, claiming that it can promote cell renewal and prolong life. When the news came out, a crowd of male netizens immediately cheered, “It turns out that anti-aging is so simple.”
Found in Semen, it Prolongs Yeast Life by 400%
Spermidine, or spermidine trihydrochloride, was first found in human semen. In 1677, Antony van Leeuwenhoek, the father of the microscope and a Dutch scientist, used a self-made microscope to discover the existence of sperm from his semen and obtained a compound crystal, the precursor of Spermidine.
After that, Spermidine went from being unknown to a life-prolonging baby. In 2018, a review from the world’s top journal, “Science,” gave a real hammer to the life-prolonging effect of this substance, which is both true and false. According to their review of 130 related scientific papers, the life-extending hypothesis of the substance may be true.
What is The Mechanism Of Action Behind Spermidine?
In short, the mechanism of action of this ingredient is to remove senescent cells and maintain genetic stability.
In recent years, researchers have respectively verified and explored the hypothesis that “spermidine can prolong the lifespan of animals,” published in “Cell Biology,” a sub-journal of “Nature” in 2009. They found that after knocking out the genes necessary for autophagy in experimental biological models such as yeast and nematodes, the life-extending effect of Spermidine would also disappear. It is confirmed that its effect is related to autophagy.
As early as 2016, Japanese scientist Yoshinori Ohsumi won the Nobel Prize in Physiology and Medicine for elucidating the mechanism of autophagy. He believes that human cells will gradually decline with age. Some protein structures will become dysfunctional and become garbage. If it is not cleaned up in time, it will accelerate aging and bring a series of aging diseases. Spermidine can maintain gene stability by enhancing autophagy.
It is similar to the mechanism of action of the life factor nicotinamide mononucleotide discovered by Harvard University earlier. Previously, Harvard University, Washington University, and other research institutions have confirmed that nicotinamide mononucleotide can maintain gene stability by keeping telomere length and can also play a role in prolonging aging and prolonging life. In May 2020, in the famous magazine “Nature Reviews Drug Discovery,” German scientist Professor Linda Partridge and Professor Matias Fuentealba of the University of London and others also stated that NAD+ precursors such as spermidine and nicotinamide mononucleotide are extremely potent. An anti-aging substance with great potential.
It should be noted that although the autophagy mechanism of Spermidine has been proven to help prolong aging, judging from the existing research, it is not sufficient to say that it can prolong life. The spermidine supplement released by the US company this time may not be of great significance because the exogenous supplement of Spermidine is relatively simple, and it is enough to eat more soybeans, mushrooms, broccoli, etc. in daily life.
High-Speed Develop Anti-Aging Tech, Expect Overcoming Aging
Although aging is unavoidable, in recent years, more and more studies have confirmed that a certain degree of aging freezing can be achieved. In addition to spermidine and nicotinamide mononucleotide mentioned at the RAADfest conference, gene editing technology is also advancing rapidly.
A few days ago, French scientist Emmanuel Charpentier and American scientist Jennifer Anne Doudna won the 2020 Nobel Prize in Chemistry for their contributions to the CRISPR/Cas9 gene editing technology. The award committee commented that this technology could precisely change the DNA of animals, plants, and microorganisms. Genetic scissors are given the hope of saving humanity from a terminal illness. Google experts predict that if this technology is successfully developed and applied to humans, in the future, we will be able to modify genetic programming at will to prolong life expectancy and overcome aging.
Although from the current point of view, it is still far away from the realization of this technology by human beings, problems such as gene mutation and gene mosaic are all boulders stuck in this anti-aging road. But what is certain is that with the gradual maturity of technological iterations and human intervention in life, biotechnologies such as Spermidine and NAD+ have slowly changed the pattern of human survival.
What is Spermidine?
In 1678, Leeuwenhoek, the father of the microscope, discovered a crystalline compound while observing his own semen. Until 1888, German chemists Ladenburg and Abel named the crystalline compound mentioned by Leeuwenhoek as Spermine.
Spermidine (C7H19N3), also known as spermidine trihydrochloride, is an aliphatic polyamine compound in ribosomes and living tissues isolated from human semen. It inhibits neuronal synthetases and binds and precipitates DNA. It can also purify DNA-binding proteins and stimulate T4 polynucleotide kinase activity. Spermidine is a natural polyamine, and the level of Spermidine in cells decreases with aging.
Spermidine can participate in various cellular processes, such as maintaining genomic DNA stability, gene transcription, translation, cell proliferation, and cell survival. (e.g., inhibitors of histone acetyltransferases, which cause epigenetic hypoacetylation of histone H3 and trigger initiation of gene transcription). On September 1, 2013, German and Austrian scientists collaborated to find that Spermidine can prevent the onset of Alzheimer’s disease.
In addition, Spermidine can regulate various cellular processes, including DNA stability, cell growth, cell differentiation, apoptosis, and more.
What are Spermidine powder food sources?
In addition, Spermidine is a precursor for other polyamines such as spermine and pyridine. Food sources of Spermidine generally include aged cheese, mushrooms, natto, green peppers, wheat germ, cauliflower, broccoli, etc. Maitake mushrooms and oyster mushrooms (oyster mushrooms) are also high in Spermidine.
What are the potential anti-aging substances?
In 2020, an article published in the sub-journal of Nature Medicine selected 14 potential anti-aging substances ①, including rapamycin, Senolytics (clearing senescent cells), metformin, acarbose, NAD+ supplements, Lithium, and more. And Spermidine powder is also on the list.
What ingredient applications does Spermidine have?
Unlike NMN, Spermidine is not mysterious, and the foods we see daily, such as soybeans, mushrooms, cheese, etc., are rich in Spermidine. At the same time, the human intestine is also a production base of Spermidine, and the metabolites of intestinal bacteria also contain Spermidine needed by the human body.
Therefore, the dietary supply of Spermidine has two broad directions.
One is to further enrich or extract natural ingredients rich in Spermidine. Make Spermidine one of the core ingredients to achieve the necessary content requirements.
The second is to increase the supply level of intestinal Spermidine by adjusting or strengthening the structure of intestinal flora.
Prior to this, gut flora has been shown to regulate cognition, and Spermidine may also be one of the critical metabolites.
With multiple factors, such as safe and reliable raw materials and abundant sources, Spermidine is easier to transform from theory to reality. Compared with the many “clouds of doubt” that exist in NMN, Spermidine may be more easily recognized by society.
What is The Role of Spermidine?
- Can inhibit neuronal synthetase, bind, and precipitate DNA.
- Purified DNA-binding protein that stimulates T4 polynucleotide kinase activity.
- Remove senescent cells and maintain gene stability.
What Are the Spermidine Benefits?
1. Delay aging and prolong life.
Spermidine can induce autophagy-related gene transcription, thereby enhancing autophagy and inhibiting cellular oxidative stress and necrosis.
Supplementation of spermidine can reduce tumorigenesis. For example, reducing the incidence of skin tumors in the elderly, slowing the growth of colorectal tumors, and reducing the incidence of severe liver fibrosis and liver cancer. At the same time, Spermidine can also enhance the anti-tumor immune response.
3. Protect cardiovascular.
Spermidine reduces lipid accumulation in atherosclerotic plaques. It also reduces cardiac hypertrophy and improves diastolic function. It further achieves the effect of protecting the heart.
4. Regulate and protect nerves.
Oral Spermidine slows disease progression. And reduce the damage of retinal ganglion cells and improve visual function. At the same time, Spermidine regulates and protects nerves in various neurodegenerative movement disorders and dementia.
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