Spermidine Powder: Not Only Can As NMN Substitutes

Spermidine powder

Spermidine Powder: Not Only Can As NMN Substitutes

Spermidine powder is a natural compound chemically classified as a polyamine. It is a pale yellow crystalline or powdery substance containing protonated guanidine groups. It contains two guanidine groups and one beta-alanine group. The ingredient is a low-odor, water-soluble molecule that readily ionizes to positively charged molecules. Often used as a standard chemical for hydrolase activity.

Spermidine is present in every cell of the body. Natural products are not actually produced by the cells but by certain gut bacteria. About one-third of Spermidine is produced in the body, while the remaining two-thirds (the vast majority) are absorbed from daily food.

In general, the levels of Spermidine in foods are as follows.

  • The fruit with the highest content is mango, with 3 mg/100 g content.
  • Among meat and fish, the highest content is ground beef – 4 mg/100 g.
  • Among nuts and dried fruits, hazelnuts are the highest at 2 mg/100 g.
  • Corn, with a content of 3 mg/100 g, is the highest among vegetables.

Others include:

  • 24.3 mg/100 g wheat germ
  • 19 mg/100 g cheddar cheese
  • 6–14 mg/100 g peas
  • 19mg/100g red beans
  • 2-10 mg/100 g broccoli and cauliflower
  • 9 mg/100 g Parisian Shiitake Mushrooms
  • 3 mg/100 g chickpeas
  • 2 mg/100 g celery and melon
  • 2 mg/100 g whole wheat bread

Spermidine supplementation in food alone is not enough. As we age, spermidine levels in humans begin to decline, and supplementation is one of the main ways to get adequate levels of Spermidine.

Spermidine Powder Sources And Specifications

Spermidine is a relatively new antiaging and longevity ingredient on the supplement market.

Natural spermidine powder can be extracted from wheat germ, but it is present in very small amounts, possibly less than 0.1% pure. Therefore, natural Spermidine is also called wheat germ extract powder (Spermidine) 1%.

In addition, there is a powder called spermidine trihydrochloride on the market. It is the trihydrochloride form of Spermidine. It is a more stable form because Spermidine is very sensitive to air. Both have the same effect.

Spermidine VS NMN

They are all popular ingredients for antiaging and longevity. All are soluble and stable in water, with high bioavailability. However, the mechanism of action of the two is different.

Since the Dutch scientist Leeuwenhoek discovered the existence of Spermidine in 1678, scientists have published many studies on Spermidine in “NATURE” and “SCIENCE.” It has been found that Spermidine resists aging mainly through the following methods: increasing autophagy, promoting lipid metabolism, and regulating cell growth and death processes.

Autophagy is the main function of Spermidine, which is to remove waste materials in cells, purify the living environment of cells, and keep the human body clean. Plays an active role in slowing down the aging process. In addition to autophagy, Spermidine promotes mitophagy, promoting mitochondrial health.

Spermidine can also open up multiple antiaging channels. On the one hand, it inhibits mTOR (excessive activity can promote cancer and accelerate aging). On the other hand, it can activate AMPK (an important longevity channel that can reduce inflammation and burn fat) to achieve all-round antiaging. In nematode experiments, supplementing Spermidine to activate AMPK can extend lifespan by 15%.

NMN powder exerts beneficial antiaging effects by increasing NAD+ levels in the body.

Spermidine supplementation is a better way to achieve the goal. The reason is because autophagy is a natural process that begins to break down and recycle damaged cells.

  • Spermidine may achieve reconciliation between humans and dementia

In addition to being the best substitute for NMN, scientists from the Federal University of Santa Maria in Brazil studied Spermidine’s effect on rats’ memory persistence. They published an article in the “European Journal of Pharmacology” magazine to find an effective way to prolong memory and an important method for persistence.

During the experiment, rats were trained with a fear conditioning device. Twelve hours after training, the researchers injected the rats intraperitoneally with solvent saline or Spermidine and conducted a conditioned reflex test. Statistical analysis showed that Spermidine at doses of 10mg/kg and 30mg/kg could improve the fear memory of mice on the 2nd and 7th day after training. That is to say, giving Spermidine 12 hours after training can improve the persistence of fear memory in rats.

Additionally, acaine is known to cause neurotoxicity. The study showed that Spermidine blocks the harmful effects of acaine on memory. These results suggest that Spermidine modulates memory and opens a range of possibilities for further investigation of Spermidine’s function.

  • Good ingredients for cardiovascular protection

In 2016, Atherosclerosis published research confirming that Spermidine reduces lipid accumulation in atherosclerotic plaques. In the same year, Nature Medicine published a study confirming that Spermidine can reduce cardiac hypertrophy and improve diastolic function. It can protect the heart and extend the life of mice. Researchers have also confirmed in humans that dietary intake of Spermidine can improve blood pressure and reduce cardiovascular disease morbidity and mortality.

  • One of the ways to improve metabolic diseases

In 2014, a study in The European Journal of Pathology showed that supplementation with Spermidine improved glucose utilization and significantly reduced body weight in obese mice.

In 2017, a study published in Cell Death & Disease, a sub-journal of Nature, showed that Spermidine could reduce the weight gain of mice caused by a high-calorie diet and improve obesity-related symptoms.

  • Hope against cancer

Multiple studies have shown that spermidine supplementation reduces tumor development in mice. For example, reducing the incidence of visible skin tumors in older female mice. Slows the growth of colorectal tumors in mice; reduces the incidence of liver cancer in mice with severe liver fibrosis. Other studies have found that Spermidine can enhance anti-tumor immune responses.

Some experiments on older adults show that taking 1.2 mg/per day of Spermidine is safe. Additionally, the Spermidine dosage range is 1-10 mg per day to obtain its general health and anti-aging benefits. The best time to take Spermidine is within 30 minutes after a meal to increase absorption.


The antiaging effect of Spermidine powder is completely comparable to that of NMN, or even better. In addition, this ingredient has improved memory, cardiovascular, and anti-cancer benefits.

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