What Is Benfotiamine?
It is a synthetic derivative of thiamine, also known as vitamin B1. It is a fat-soluble compound that is more bioavailable than thiamine itself. Benfotiamine is frequently utilized as a dietary supplement and is purported to possess numerous potential health advantages.
One of the main reasons why this compound is used as a dietary supplement is its potential to support healthy nerve function. There is a prevailing belief that this intervention positively influences the peripheral nerves, potentially assisting in managing conditions such as diabetic neuropathy, a nerve disorder commonly associated with diabetes.
Food sources from
It is a synthetic derivative of thiamine (vitamin B1), not naturally found in foods. If you’re looking for natural food sources rich in vitamin B1, these include:
- Whole grains: Brown rice, oatmeal, and whole wheat bread.
- Legumes: Lentils, black beans, and peas.
- Seeds and nuts: Sunflower, flaxseeds, and macadamia nuts.
- Meats: Pork, beef, and chicken.
- Fish: Tuna and trout.
- Vegetables: Spinach, asparagus, and Brussels sprouts.
- Fortified foods: Cereals and some bread products often have added thiamine.
What Forms Does Vitamin B1 Have?
Vitamin B1, also known as thiamine, is available in different forms.
Thiamine hydrochloride. This synthetic form of thiamine is commonly used in dietary supplements and fortified foods. It is water-soluble and easily absorbed by the body.
Thiamine mononitrate. Another synthetic form of thiamine, it is often used in food fortification and dietary supplements. It is also water-soluble and readily absorbed by the body.
Both thiamine hydrochloride and thiamine mononitrate are converted into thiamine pyrophosphate (TPP) in the body, which is the active form of thiamine that participates in various enzymatic reactions.
Benfotiamine. Although not a naturally occurring form of thiamine, benfotiamine is a synthetic derivative that is more fat-soluble than thiamine. It is converted into thiamine in the body and has better bioavailability, allowing it to reach higher levels in the blood.
These forms of vitamin B1 are often used interchangeably in dietary supplements and fortified foods. The choice of form depends on factors such as bioavailability, stability, and formulation requirements. It’s worth noting that all forms of vitamin B1 can help address thiamine deficiency and support various bodily functions.
Specification sheet reference
Type | Vitamin |
Appearance | Fine white powder |
Content | 98% min |
Purity | 99% min |
Particle Size | < 200 mesh |
Certifications | Please contact our sales team to get |
Water Content | <1% |
Test Method | HPLC, FTIR |
MOQ (minimum order quantity) | 1kg |
Sample | Available (10-20g/bag) |
OEM Service | Available, such as capsules, tablets, pills, etc. |
ODM Service | Available |
Private Label | Available |
Contract Manufacturing | Available |
Benfotiamine VS Thiamine
These two ingredients belong to the Vitamin B1 family but differ significantly in their chemical structure and function.
Thiamine is a water-soluble vitamin that is necessary for energy metabolism and nerve function. However, its absorption in the body is limited, particularly in individuals with certain medical conditions.
On the other hand, Benfotiamine b1 is a fat-soluble derivative of thiamine, allowing it to be more easily absorbed and retained in tissues. This enhanced bioavailability makes benfotiamine vitamin b1 a more practical option for addressing conditions related to thiamine deficiency, especially in people with diabetes or other metabolic disorders.
Allithiamine VS Benfotiamine
Allithiamine is another derivative of Vitamin B1, similar to benfotiamine. Both vitamin b1 are designed to enhance thiamine absorption, but they differ in their chemical composition and bioavailability.
Allithiamine is a water-soluble form of thiamine, which can be absorbed directly through the intestines. However, benfotiamine, being fat-soluble, is more efficiently absorbed and retained in tissues, making it a superior option for long-term supplementation.
Allithiamine is often used in cases of severe thiamine deficiency, while the other form is preferred for chronic conditions where sustained thiamine levels are beneficial.
Benfotiamine VS Sulbutiamine
Sulbutiamine is another derivative of thiamine, designed to cross the blood-brain barrier more effectively than thiamine itself. While both are used to address thiamine deficiency, they have different primary applications.
Sulbutiamine is often used to enhance cognitive function, improve mood, and increase energy levels. For this reason, it is favored among individuals seeking to boost mental performance. In contrast, benfotiamine is more focused on supporting metabolic and cardiovascular health, particularly in individuals with diabetes or other metabolic disorders.
Powdered Benfotiamine Vitamin B1: How To Produce It?
Chemical synthesis. Benfotiamine is prepared by chemically modifying thiamine. Specifically, a benzyl phosphate group is introduced into thiamine through an esterification reaction. This process reacts thiamine with a phenylphosphate ester compound to form a phenylphosphate ester structure, thereby producing a form with better lipid solubility.
Purification and crystallization. After synthesis, impurities in the reactants need to be removed through multiple purification techniques such as recrystallization, washing, and filtering. The purified product is usually powder or crystalline and has high purity.
Finished product preparation and packaging. The purified ingredients can be processed into various forms, such as capsules, tablets, or powders. The final product will be packaged as needed to ensure product stability and quality control.
This process makes benfotiamine highly bioavailable, especially compared to water-soluble thiamine. It is more efficiently absorbed in the human body and is widely used to treat diseases such as diabetic neuropathy.
Benfotiamine: Benefits, Side Effects, And More
What is benfotiamine good for?
Improved Blood Sugar Control: Benfotiamine is known for managing diabetic complications, particularly diabetic neuropathy. It helps reduce oxidative stress and the formation of harmful byproducts like advanced glycation end products (AGEs), which can damage nerves and blood vessels in people with diabetes.
Neuroprotective Effects: It has shown promise in protecting nerve cells, improving nerve function, and reducing pain in cases of peripheral neuropathy. Its ability to enter cells more effectively than thiamine makes it useful for treating conditions where nerve damage occurs due to high blood sugar levels, such as diabetic or alcoholic neuropathy.
Anti-inflammatory and Cardiovascular Support: Studies suggest that benfotiamine b1 may help lower inflammation and oxidative damage in cells, contributing to better heart and vascular health. It is beneficial in preventing the cardiovascular complications often associated with conditions like diabetes and hypertension.
For Hair Loss: Yes Or No?
There is limited evidence directly linking benfotiamine to hair loss. In fact, Benfotiamine vitamin b1’s role in supporting overall cellular health might suggest a potential benefit for hair health, particularly in individuals with a thiamine deficiency. Thiamine deficiency has been associated with various health issues, including hair loss, so supplementing it may indirectly support hair growth by ensuring adequate thiamine levels in the body.
However, more research is needed to establish a definitive connection between benfotiamine and hair loss.
Side Effects: Is It Safe?
Benfotiamine is generally well-tolerated, but like any supplement, it may cause side effects in some individuals. These include mild gastrointestinal discomfort, nausea, or headaches. These side effects are usually temporary and may resolve as the body adjusts to the supplement. Followong the recommended dosage is vital to minimize the risk of side effects.
Benfotiamine Dosage Reference
The appropriate dosage can differ depending on the condition being treated. Typically, the dosages range from 150 to 600 milligrams per day. Start with low dosage and gradually increase it, as a healthcare professional recommends.
This approach helps to diminish the risk of side effects and allows the body to adjust to the supplement. For individuals using to manage conditions like diabetic neuropathy, higher doses may be required.
Benfotiamine Uses
It supports various aspects of health, particularly in individuals with conditions related to high blood sugar levels, such as diabetes. Its ability to increase thiamine pyrophosphate levels in cells makes it a valuable supplement for protecting against the complications of diabetes, including neuropathy, retinopathy, and cardiovascular disease.
Additionally, Benfotiamine may be used to support healthy aging, as it helps to reduce oxidative stress and inflammation, conditions which are associated with chronic diseases. The supplement is also explored for its potential role in cognitive health, as thiamine is essential for brain function.
Where To Buy Benfotiamine: Nutri Avenue
Nutri Avenue is the unrivaled leader in bulk powdered Vitamin B1 synthetic form – Benfotiamine. With a steadfast commitment to excellence, Nutri Avenue delivers the highest quality powder that surpasses all expectations.
We also provide OEM and ODM services to help product manufacturers get finished supplements as quickly as possible. We have a variety of formula recommendations and can directly customize raw materials into soft candies, tablets, capsules and other forms. Trust our impeccable sourcing, rigorous testing, and impeccable customer service.
Vanliga frågor
Thiamine is the most widely used and recognized form of vitamin B1. While gaining attention for its potential benefits, benfotiamine is less commonly used or widely known than thiamine.
Yes, it is a synthetic derivative of vitamin B1. It is chemically modified to enhance its fat-solubility and bioavailability compared to thiamine.
No. Unlike thiamine, which is water-soluble, benfotiamine is fat-soluble. This difference in solubility affects how the body absorbs and utilizes the two compounds.