CoQ10 Ubikinon

What Is CoQ10?

It, the full name of Coenzyme Q10, is also known as Ubiquinone (UQ), Coenzyme Q (CoQ). Other names are Water-soluble Coenzymen Q10, Hydrosoluble Coenzymen Q10, QH 10, Water-soluble QH10, and so on. It is a coenzyme present in all aerobic respiration eukaryotes. The Q in its name represents the quinone group, and the 10 represents the number of isoprenes tailed to the quinone group. The structure of Coenzyme Q10 is similar to vitamin E, vitamin K, etc.

The molecular formula of CoQ10 is C59H90O4, and the molecular weight is 863.34 g/mol. The appearance is a white to yellow crystalline powder. It is insoluble in water and methanol and soluble in acetone and ether. Its melting point is 48-52°C. This powder is easily decomposed when light exposure, making the color darker.

Food sources from

CoQ10 is found in certain foods, especially organ meats (heart, liver, kidney), fatty fish (like salmon, mackerel), and plant-based sources like spinach, cauliflower, and nuts.

What Is Ubiquinone?

Ubiquinone is another name for Coenzyme Q10 (CoQ10) in its oxidized form. It is a fat-soluble compound found in the mitochondria of cells and plays a crucial role in energy production and antioxidant protection.

1. Energy Production. It is involved in the electron transport chain, a critical part of cellular respiration. It helps transfer electrons within mitochondria, enabling the production of adenosine triphosphate (ATP), the primary energy carrier in cells.

2. Antioxidant. In its reduced form, ubiquinol, it acts as a powerful antioxidant, neutralizing harmful free radicals and preventing oxidative damage to cells and tissues.

3. Versatility. The name “ubiquinone” comes from the word “ubiquitous,” reflecting its presence throughout the body in nearly all cells. It’s found in high concentrations in energy-demanding organs like the heart, liver, and kidneys.

Ubiquinone structure consists of a “1,4-benzoquinone ring” and a long “isoprene side chain” consisting of “ten isoprene units.” The benzoquinone ring enables it to undergo redox reactions in the electron transport chain, while the long chain allows it to dissolve and move through cell membranes, especially mitochondrial membranes. This unique structure makes Co Q10 both hydrophilic and hydrophobic, which helps it play an important role in cellular energy metabolism and antioxidant protection.

Ubiquinone VS Ubiquinol

Ubiquinone is the oxidized form of CoQ10, and once it’s in the body, it can be converted to ubiquinol, its reduced form.

Ubiquinol is more directly used as an antioxidant and is considered more bioavailable. Some supplements provide Co-Q10 in the ubiquinol form for improved absorption, especially for older adults or people with specific health conditions.

However, due to the complexity of Ubiquinol’s specific stable form and manufacturing method, some companies have patents on its production process and stability. For example, the Japanese company Kaneka is one of the major players in the Ubiquinol coq10 market. The company has developed patented technology for manufacturing and stabilizing Ubiquinol. Since Ubiquinol is relatively unstable and easily oxidized to Ubiquinone, Kaneka’s patent covers preparing Ubiquinol into a stable supplement. Therefore, many commercial Ubiquinol products use technology protected by Kaneka’s patent.

Most patents on Ubiquinol do not directly protect the Ubiquinol molecule itself but rather how to stabilize Ubiquinol during manufacturing so that it is not oxidized during storage and consumption. This type of technical patent protects the production process, preparation method, and stable form of the supplement.

Due to the existence of patents, companies that provide Ubiquinol coq10 products on the market usually need to obtain authorization or cooperation from companies holding relevant patents.

Therefore, Nutri Avenue recommends that coq1o supplement manufacturers use the Ubiquinone form.

Specification sheet reference

Due to patent issues involving Ubiquinol (reduced form), Nutri Avenue provides Ubiquinone (oxidized form) raw materials.

1. 10%/20% Co Q10 oxidized form (water soluble)
2. 98% Ubiquinone (fat-soluble)
3. etc.

The order quantity provided by Nutri Avenue is 1KG, 5KG, 25KG, and so on. The larger the purchase volume, the more favorable the price.

For other detailed specification requirements and purchase volume, please communicate with Nutri Avenue. You can get detailed product information, including COA, price, and more.

How To Produce Co Q10?

Its manufacturing process mainly includes two methods: fermentation and chemical synthesis. These two methods have their own advantages and disadvantages and have different qualities and costs.

Microbial Fermentation. It is produced by fermentation using microorganisms (such as yeast or bacteria) under specific conditions. These microorganisms can convert simple carbon sources (such as sugars) into Coenzyme Q10 through fermentation.

1. Cultivation of microorganisms: The selected microorganisms are cultured on a large scale in a controlled culture environment.
2. Fermentation process: Providing appropriate nutrients and environmental conditions in the culture medium enables microorganisms to produce Co-Q10.
3. Extraction and purification: Extraction from the fermentation broth through solvent extraction and other purification techniques to remove impurities and obtain high-purity Coenzyme Q10.

• Advantages: Biofermentation can produce high-purity powders and is generally more environmentally friendly than chemical synthesis.
• Disadvantages: The production process is more complicated, and the cost is higher.

Chemical Synthesis. The raw materials are synthesized through chemical reactions. This method usually involves multiple synthesis steps to synthesize Coenzyme Q10 from simple chemical precursors.

1. Synthetic precursors: The precursor substances are synthesized through chemical reactions.
2. Synthesis process: Convert the precursor substance into Coenzyme Q10 and obtain the final product through chemical reaction and purification.
3. Purification: Use various separation and purification techniques to remove by-products and impurities in the synthesis process.

• Advantages: The production cycle is usually short, and the production scale can be controlled.
• Disadvantages: Chemical synthesis may involve harmful chemicals and have a greater environmental impact.