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What Is Kaempferol?
Kaempferol is a natural flavonoid widely recognized for its antioxidant, anti-inflammatory, and cardioprotective properties. With a molecular formula of C15H10O6 and a molecular weight of 286.24 g/mol, this bioactive compound is commonly found in plant-based sources such as tea, kale, spinach, broccoli, and berries. It typically appears as a yellow crystalline powder with poor water solubility. It is often formulated into capsules, powders, and functional food supplements.
As a potent free radical scavenger, kaempferol helps protect the cells from oxidative stress, supports cardiovascular health, and has been studied for its potential in cancer prevention and neuroprotection. Additionally, it is essential in reducing inflammation, enhancing metabolic function, and improving immune defense. Due to its low bioavailability, advanced delivery systems such as liposomal formulations and nanoparticle encapsulations enhance absorption. Kaempferol is best stored in airtight, moisture-resistant packaging to preserve its stability and efficacy in nutraceutical and pharmaceutical applications.
Vanliga källor
Kaempferol is a naturally occurring flavonoid compound found in a wide range of fruits, vegetables, herbs, and teas. It is valued for its potent antioxidant, anti-inflammatory, cardiovascular, and anti-cancer properties, making it a popular ingredient in dietary supplements and functional food products.
- Ginkgo biloba (Ginkgo leaves) – One of the most widely used sources in commercial extraction
- Sophora japonica (Japanese pagoda tree flower buds)
- Camellia sinensis (Green tea leaves)
- Allium cepa (Onions) – Especially red onions
- Brassica vegetables (Cruciferous family) – Such as kale, broccoli, cabbage, and Brussels sprouts
- Moringa oleifera (Moringa leaves)
- Bär – Including blackberries, strawberries, and cranberries
- Apples and Grapes
- Calendula officinalis (Calendula flowers)
- Kaempferia galanga (Galangal root) – Although similar in name, it contains relatively low levels and is not a primary commercial source
Kaempferol is most abundantly sourced from Ginkgo biloba, Sophora japonica, green tea leaves, onions, cruciferous vegetables, and various berries. Among these, Sophora japonica and Ginkgo biloba are the most preferred for commercial-grade extraction due to their high flavonoid content.
What Does Kaempferol Do?
Kaempferol demonstrates sophisticated biochemical mechanisms involving multiple cellular pathways. When entering biological systems, this flavonoid interacts with various molecular targets, particularly influencing signaling cascades related to oxidative stress, inflammation, and cellular growth. The basic flavonol structure of kaempferol powder enables both direct antioxidant activities through free radical scavenging and indirect effects through modulation of cellular defense systems.
The compound’s influence extends to key inflammatory signaling pathways. Buy kaempferol research shows significant effects on NF-κB signaling, a master regulator of inflammation, through inhibition of IκB kinase and subsequent prevention of NF-κB nuclear translocation. Additionally, the flavonoid modulates MAPK signaling cascades and influences COX-2 and iNOS expression, creating a comprehensive approach to inflammation regulation across various tissues.
Beyond antioxidant and anti-inflammatory mechanisms, kaempferol remarkably affects cellular growth pathways. The compound influences various aspects of cell cycle regulation through effects on cyclin-dependent kinases and apoptotic pathways through modulation of caspase activation. Furthermore, it demonstrates effects on angiogenesis through modulation of the VEGF pathway and influences cellular differentiation processes in various tissue types.
How to Produce Kaempferol Powder?
- Val av råmaterial: The production begins with carefully selected plant sources rich in kaempferol, including Kaempferia galanga (galangal), tea leaves, broccoli, or specific medicinal herbs. Each botanical source undergoes rigorous quality testing, including species verification, active compound content analysis, and comprehensive contaminant screening. For powder production, particular attention is paid to harvesting time and plant part selection, as flavonoid content varies significantly throughout plant development stages. Advanced analytical techniques, including HPLC and spectrophotometric methods, verify the flavonoid profile before proceeding with extraction.
- Initial Extraction Process: The extraction of kaempferol employs sophisticated methodologies optimized for flavonoid isolation. Initial extraction typically utilizes hydroalcoholic solvent systems (ethanol-water mixtures ranging from 60-80% ethanol) under precisely controlled temperature conditions (40-60°C). Multiple extraction cycles with careful monitoring ensure optimal recovery of target flavonoids. Additional steps for research-grade buy kaempferol production may include preliminary separation of significant fractions through liquid-liquid partitioning using solvents of varying polarity. Each extraction parameter is carefully optimized to maximize flavonoid yield while minimizing the co-extraction of unwanted compounds.
- Purification and Isolation: The crude extract undergoes multiple sophisticated purification stages. Initial clarification employs filtration and precipitation techniques to remove plant particulates and unwanted components. Advanced chromatographic methods isolate kaempferol from other flavonoids and plant compounds, including silica gel column chromatography, Sephadex gel filtration, and preparative HPLC. Each purification stage employs specific solvent systems and elution parameters to ensure optimal separation while maintaining compound integrity. Multiple recrystallization steps using appropriate solvent systems enhance purity for high-purity kaempferol powder.
- Final Processing and Standardization: The purified kaempferol undergoes careful crystallization under precisely controlled conditions to achieve optimal crystal structure and purity. This stage employs specific solvent systems, temperature gradients, and crystallization parameters to ensure consistent physical characteristics. Advanced analytical methods verify structural integrity and purity levels, including HPLC, NMR spectroscopy, and mass spectrometry. The standardization process ensures consistent purity exceeding 98% for research and analytical grade buy kaempferol, with appropriate specifications documentation.
- Quality Control and Packaging: Final product undergoes comprehensive testing, including melting point determination, spectroscopic analysis for structural confirmation, chromatographic purity verification, residual solvent analysis, heavy metal screening, and moisture content determination. The finished kaempferol receives specialized packaging in light-resistant, airtight containers under a nitrogen atmosphere. Storage specifications require temperatures below 20°C, protection from light, and humidity below 40% to ensure 24-month stability with minimal degradation or oxidation of this sensitive flavonoid compound.
Referens till specifikationsblad
Fastighet | Detaljer |
Typ | Växtextrakt |
Utseende | Yellow crystalline powder |
Renhet | ≥ 98% |
CAS-nummer | 520-18-3 |
Molekylformel | C15H10O6 |
Molekylvikt | 286.24 g/mol |
Löslighet | Soluble in ethanol, slightly soluble in water |
Testmetoder | HPLC, UV-Vis |
Certifieringar | ISO available. Please contact sales team for details. |
MOQs | 25kg |
Prov | Tillgänglig (10-20g/påse) |
OEM-service | Tillgänglig |
ODM-tjänst | Tillgänglig |
Privat etikett | Tillgänglig |
Kontraktstillverkning | Tillgänglig |
Kaempferol: Benefits, Side Effects, and More
- Antioxidant Protection: Research published in Free Radical Biology and Medicine demonstrates significant antioxidant effects. A comprehensive study involving cellular and animal models showed that Kaempferol neutralized free radicals with exceptional efficiency and enhanced endogenous antioxidant enzyme systems by 35-45%. Advanced oxidative stress testing confirmed superior protection against lipid peroxidation and DNA oxidation compared to many common antioxidants. The research demonstrated direct radical scavenging activity and indirect effects through Nrf2 pathway activation, enhancing cellular glutathione production and antioxidant enzyme expression. Kaempferol powder exhibited protective effects against multiple oxidative stressors, including UV radiation, heavy metals, and metabolic oxidation products.
- Antiinflammatoriska egenskaper: Clinical studies in the Journal of Inflammation reveal remarkable effects on inflammatory pathways. Research with advanced cellular models demonstrated that Kaempferol inhibited NF-κB activation by 42% and reduced inflammatory cytokine production, including TNF-α, IL-6, and IL-1β. The compound showed particular effectiveness in modulating multiple inflammatory pathways simultaneously, creating comprehensive anti-inflammatory effects. Advanced signaling pathway analysis confirmed reduced MAPK phosphorylation and decreased expression of pro-inflammatory enzymes, including COX-2 and iNOS. Buy kaempferol research demonstrated specific effects on mast cell stabilization and reduced histamine release.
- Cardiovascular Support: Studies in Cardiovascular Research show significant benefits for vascular health. Extensive research models demonstrated that Kaempferol improved endothelial function by enhancing nitric oxide production and increasing oxidative stress in vascular tissues. The compound effectively inhibited LDL oxidation and reduced foam cell formation by 38%, contributing to its cardioprotective properties. Advanced vascular studies confirmed improved arterial flexibility and enhanced vasodilation response, supporting optimal circulation and blood pressure regulation through multiple mechanisms.
- Metabolic Regulation: Research in Metabolism demonstrates notable benefits for glucose and lipid metabolism. Cellular studies showed that kaempferol powder enhanced glucose uptake in peripheral tissues by 25-30% and improved insulin signaling pathways. The compound demonstrated effects on AMPK activation, enhancing energy metabolism efficiency. Advanced metabolic research confirmed improved adiponectin levels and enhanced fatty acid oxidation, supporting optimal metabolic flexibility and health. Kaempferol showed promise in supporting healthy weight management through its effects on metabolic rate and fat utilization.
- Cellular Health Modulation: Extended research in Cellular Biology shows significant benefits for cellular growth regulation. Studies across multiple cell types demonstrated that buy Kaempferol influenced cell cycle regulation through effects on cyclins and cyclin-dependent kinases. The compound supported healthy cellular differentiation while modulating angiogenesis and cellular growth pathways. Advanced research confirmed selective effects on various cellular signaling cascades, contributing to its unique benefits for cellular health maintenance.
Side Effects: Is Kaempferol Safe?
- Gastrointestinal Discomfort: High doses may cause mild digestive issues.
- Drug Interactions: Consultation is advised for individuals on medication.
FDA Approval: Is Kaempferol Legal?
- Förenta staterna (FDA): Approved for use in dietary supplements.
- European Union (EFSA): Recognized as a safe flavonoid compound.
- Canada (Health Canada): Permitted as a natural health product.
- Australia (TGA): Allowed in complementary medicines.
What Is Kaempferol Used For?
- Cosmetic Applications: Included in skin care products for anti-aging benefits.
- Funktionella livsmedel: Added to beverages and health foods for wellness support.
- Antioxidant Support Supplements
Kaempferol is often included in formulations designed to combat oxidative stress, promote cellular protection, and reduce free radical damage. - Cardiovascular Health Products. It supports vascular integrity, improves circulation, and helps maintain healthy blood pressure, making it ideal for heart health supplements.
- Anti-Inflammatory and Immune Support. It exhibits strong anti-inflammatory effects and may assist in modulating the immune response, commonly used in immune-enhancing formulas.
- Cognitive and Neuroprotective Formulas. Due to its potential to protect brain cells from oxidative damage, kaempferol is sometimes added to nootropic and cognitive health products.
- Anti-Aging and Skin Health Supplements. As a bioactive antioxidant, kaempferol is also used in beauty-from-within supplements, targeting skin aging, elasticity, and UV protection.
- Metabolic and Blood Sugar Support. Research suggests kaempferol may help regulate glucose metabolism, making it a valuable addition to blood sugar management supplements.
Dosage Recommendation for Kaempferol
The appropriate dosage of kaempferol depends on its purity, intended use, and delivery form. As a flavonoid with antioxidant and anti-inflammatory properties, it is a commonly used ingredient in dietary supplements and functional formulations.
- General Antioxidant Support: A typical daily dosage ranges from 50-200 mg to promote cellular health and combat oxidative stress.
- Anti-Inflammatory and Cardiovascular Support: For more targeted health benefits, specialized formulations may contain 200-500 mg of kaempferol powder.
- Therapeutic Applications: Higher doses may reach up to 1,000 mg per day and are explored in clinical studies but should be approached cautiously under medical supervision.
How to Store Kaempferol Powder?
Kaempferol powder should be stored in a cool, dry, and well-ventilated area, away from direct sunlight, heat, and moisture. It is important to keep the powder in a tightly sealed container to prevent degradation due to air or humidity exposure. The recommended storage temperature is 15–25°C (59–77°F). Avoid storing it near strong acids, oxidizing agents, or substances with strong odors, as these may affect the product’s quality and stability.
Kaempferol VS Quercetin
Kaempferol and quercetin represent closely related flavonols with distinct structural differences that influence their biological activities. While both share the essential flavonol backbone, quercetin contains additional hydroxyl groups compared to kaempferol powder, particularly at the 3′ position of the B ring. This seemingly minor structural variation creates significant differences in their antioxidant capacity, bioavailability, and biological effects. The simpler structure of Kaempferol often results in different receptor-binding affinities and altered metabolic handling in biological systems.
The antioxidant mechanisms reveal important distinctions in cellular protection. Kaempferol demonstrates more selective antioxidant activity with particular efficiency against certain radical species. At the same time, quercetin shows broader and often more potent general antioxidant capacity due to its additional hydroxyl groups. However, research indicates that buy kaempferol may demonstrate superior stability in certain physiological conditions, potentially offering more consistent protection over time. Studies examining structure-activity relationships suggest that the specific antioxidant profile of Kaempferol may provide advantages for certain tissues and oxidative stress conditions despite quercetin’s higher overall antioxidant capacity.
Bioavailability and metabolism patterns show notable variations between these flavonoids. Quercetin undergoes extensive phase II metabolism, particularly glucuronidation and sulfation, which can significantly alter biological activity. Kaempferol typically shows different metabolic patterns with potentially higher bioavailability in specific tissues. The pharmacokinetic profile of kaempferol powder demonstrates different tissue distribution compared to quercetin, with research suggesting enhanced penetration into particular tissues, including the brain. Despite structural similarities, these differences in bioavailability and tissue distribution contribute to their distinct biological effects.
Cellular signaling effects demonstrate varying pathway preferences. While both flavonoids influence critical pathways, including NF-κB and MAPK signaling, research indicates that Kaempferol significantly impacts certain pathways, including AMPK activation and specific aspects of Nrf2 signaling. Quercetin demonstrates powerful effects on inflammation cascades through multiple mechanisms. These differences in pathway modulation explain why buy Kaempferol might offer advantages for specific health applications despite quercetin’s widespread use and research support.
Research focus and availability reflect different stages of commercial development. Quercetin has received extensive research attention and is widely available as a dietary supplement. Despite growing research interest, Kaempferol remains less commercially developed. It is primarily available for research purposes or as part of complex botanical extracts. This difference in market development influences cost and accessibility, with isolated kaempferol powder typically commanding higher prices due to more complex isolation requirements and smaller production scales.
| Fastighet | Kaempferol | Quercetin |
| Chemical Structure | Flavonol (a type of flavonoid) | Flavonol (a type of flavonoid) |
| CAS-nummer | 520-18-3 | 117-39-5 |
| Molekylformel | C15H10O6 | C15H10O7 |
| Molekylvikt | 286.24 g/mol | 302.24 g/mol |
| Natural Sources | Green tea, kale, broccoli, apples, onions | Onions, apples, berries, citrus fruits |
| Utseende | Yellow crystalline powder | Yellow crystalline powder |
| Powder Color | Pale yellow to yellow | Yellow to light yellow |
| Stability | Stable under cool, dry conditions | Stable under cool, dry conditions |
| Biotillgänglighet | Moderate (enhanced by fat consumption) | Low to moderate (enhanced by fat and piperine) |
| Primary Function | Antioxidant, anti-inflammatory, cardiovascular support | Antioxidant, anti-inflammatory, allergy relief |
| Mechanism of Action | – Scavenges free radicals – Modulates inflammatory pathways | – Scavenges free radicals – Inhibits histamine release and inflammation |
| Daily Dosage | 50 mg – 500 mg (depending on intended use) | 500 mg – 1,200 mg (depending on intended use) |
| Health Benefits | – Supports heart health – Anti-inflammatory – May reduce cancer risk | – Supports immune health – Reduces allergies – Cardiovascular support |
| Common Uses | – Cardiovascular health – Antioxidant support – Anti-inflammatory supplement | – Allergy relief – Antioxidant support – Cardiovascular protection |
| Advantages | – May improve vascular function – Supports cellular health – Lower doses required | – Stronger anti-inflammatory properties – Supports histamine regulation |
| Disadvantages | – Limited clinical studies – Less potent than quercetin for inflammation | – Lower bioavailability – May interact with some medications |
Slutsats
Kaempferol stands out as a versatile flavonoid with a diverse range of health benefits, from antioxidant and anti-inflammatory properties to cardiovascular and metabolic support. Its ability to influence key cellular pathways makes it a valuable compound in nutritional supplements, functional foods, and even cosmetics. However, due to its low bioavailability, advanced formulation techniques such as liposomal delivery and nanoparticle encapsulation are necessary to enhance its absorption and effectiveness. As research uncovers its therapeutic potential, kaempferol is gaining recognition as a powerful natural compound for overall wellness and disease prevention.
While kaempferol shares similarities with quercetin, its unique structural attributes contribute to distinct biological effects, metabolism, and bioavailability. Studies highlight its selective antioxidant activity, superior stability, and potential for targeted cellular protection. Despite being less commercially available than quercetin, kaempferol’s growing scientific backing suggests promising applications across multiple health sectors. This flavonoid offers a well-rounded approach to promoting long-term health and resilience, whether used for cardiovascular support, inflammation modulation, or metabolic enhancement.
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Vanliga frågor
Yes, it is an antioxidant that helps protect cells from oxidative damage.
Yes. This powder is soluble in both water and ethanol.
