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branded ingredient NutriPQQ®
NutriPQQ® is a Branded product from Nutri Avenue Ltd. Fresh USA Stocks with third party test reports, guaranteed quality that exceeds your requirement. Click the button below to get a free quote today!
The Benefits for NutriPQQ®
Improve immune
NutriPQQ® enhances energy metabolism leading to sufficient energy supply.
Against Aging
NutriPQQ® helps control rapid onset of the effects of aging.
Weight Loss
NutriPQQ® enhances energy levels and promotes weight loss.
Brain Health
NutriPQQ® helps in improving brain cell function.
Prototyping
NutriPQQ® may help in prevention of degenerative brain conditions.
Cell Antioxidant
NutriPQQ® has antioxidant effects useful in cleansing body cells.
Varumärkesskyddad ingrediens
What is NutriPQQ® ?
NutriPQQ® is a Branded product from Nutri Avenue Ltd called Pyrroloquinoline quinone or PQQ.
NutriPQQ® is a recently discovered vitamin-like compound that is commonly found in plant foods. It was first discovered as a cofactor for bacteria that is similar to how B Vitamins effect humans.
Clinical studies in humans have shown that PQQ enhances short-term memory and attention, improves energy metabolism, and reduces markers of inflammation, as well as improving general feelings of well-being.
NUTRIPQQ
Vår fördel
branded ingredient NutriPQQ® from Nutri Avenue Ltd
USA fresh stock
Vi har förberett ett tillräckligt lager i både CA- och FL-lager i USA, vilket kan ge dig en stabil efterfrågan på leveranser.
3rd party test report
We will do HPLC test report on each batch of NutriPQQ® to ensure that the purity of each batch can exceed 99%.
Stability data report
We will conduct irregular tests on the Stability data report of the product to ensure that its quality is always optimal.
Free samples
Vi kan tillhandahålla gratisprover från våra lager i USA och Kina för din inspektion före beställningen.
VETENSKAP
PQQ (pyrroloquinoline quinone) is a powerful nutrient with far-reaching effects in humans that was first identified in 1979 in microorganisms. It is found in many common foods and in human milk. PQQ is now thought to be an essential nutrient and has been proposed to be classified as a new B vitamin. PQQ is useful for neuronal health, especially for protect- ing against memory loss, has potent free-radical scavenging properties, and as a dietary constituent in many foods is thought to play an essential role in growth, energy, and reproduction in mammals and humans. Good food sources include kiwi, natto, tofu, green tea, green peppers, whisky, and mother’s milk. PQQ supplementation at levels higher than what is found in food has positive effects on cognitive function, immune status, antioxidant status, cardiovascular health, and neurological function.
NutriPQQ® Compared to Another PQQ Powder
Nutripqq ® is more soluble and easily absorbed than other PQQ products on the market.The dissolution profile (Figure 1) shows a sustained release from the NutriPQQ®. By 12hrs, ~95% of the dose was in solution in a micronized form, less than 10μ particle size. With the other PQQ powder, 100% of the dose was in solution by 4hrs. The NutriPQQ® may enhance the beneficial effects in vivo by enabling the serum levels to be maintained for a longer time. This was shown in a bioavailability clinical study in two healthy subjects using NutriPQQ® and another PQQ powder with doses equivalent to 40 mg of PQQ.
Figure 1. A comparison of the Dissolution Profile of NutriPQQ® and another PQQ Powder
Figure 2. A comparison of Uptake of PQQ In Vivo
As shown in Figure 2, the uptake of PQQ from NutriPQQ® reached a maximum blood level at 2 hours, followed by sustained release for up to 9 hours. The plasma levels remained high at 9 hours, indicating a sustained release longer than 9 hours. In contrast, the other PQQ powder showed a maximum blood level at 2 hours and the plasma level was back to baseline by 9 hours. The average area under the curve for NutriPQQ® was 69.66, whereas the other PQQ was only half as much, with a value of 31.41. The ratio of the area under the curve (sustained plasma concentrations) of NutriPQQ® to the other PQQ was 2.2 times higher.
Essential Nutrient Status
Based on the observation that animal diets deficient in PQQ resulted in poor growth, low energy, and unsuccessful reproductive performance, it is thought PQQ has an essential nutrient role in the human body (Stites, 2000). Additional signs of deficiency observed in intentionally depleted diets were friable skin, hemorrhages, diverticulitis, a reduction in general fitness, reduced fertility, and defective immunity (Steinberg, 2003). In animal studies, severely affected mice had functional defects in connective tissues, decreased levels of the collagen-producing enzyme lysyl oxidase, and weakened skin collagen (Kumazawa, 1995). When PQQ is added to an artificial-nutrient-based diet, it improves growth- related variables in young mice.
Vitaminlike Effects and Potency
The biochemical properties of PQQ are similar to vitamin C in its oxidation- reductive potential, to riboflavin in its redox effects, and to vitamin B6 as a coenzyme for carbonyl group chemistry. PQQ is at least 100 times more efficient than ascorbic acid, vitamin K, isoflavonoids, and polyphenols tested in various assays related to oxidation reduction recycling reactions (Stites, 2006). PQQ can generate redox cycling on a much smaller scale than normal vitamins or well-known antioxidants (Fluckiger, et al., 1993, 1995).
Energizing Effects
Energy production may be dependent on adequate levels of PQQ since the number and size of mitochondria are affected by a deficiency. In mice deficient in PQQ, there was a 30–40% reduction in the numbers of mitochondria compared with supplemented mice. The mitochondrial area in the cell was reduced by 30% in deficient mice compared with supplemented mice (Stites, 1996). Increased synthesis of mitochondria by PQQ is caused by the activation of gene response through a pathway that controls mitochondrial biogenesis (Chowanadisai, 2009).
Neurological Health
Research has shown that PQQ facilitates nerve regeneration and enhances nerve growth factor through its function as an ultrapotent antioxidant (Murase, He). By increasing the number and efficiency of mitochondria, PQQ helps brain cells function more efficiently.
Human Studies
— Improvement of Cerebral Function and Metabolism
The effect of PQQ on cerebral function and anti-stress activity was tested in 71 human subjects over a 12-week period (Nakano, 2009). The double-blind, placebo-controlled study used 20 mg of PQQ and 20 mg of PQQ with 100 mg of CoQ10 in the form of a test food. PQQ exerted an improvement in cerebral function, and improvements were found in high-level cerebral functions, including attention and information- discriminating and processing abilities, more so than of memory. PQQ and PQQ with CoQ10 improved high-level cerebral functions in healthy middle-aged and older adults.
The metabolic effects of PQQ were investigated with dosages ranging from 0 to 40 mg per day (Harris, 2013). Decreases in levels of C-reactive protein (CRP) of 10–40% on average occurred, though the pretreatment values were considered normal. CRP was dramatically lowered in male subjects by almost 90% on average. Plasma mDNA levels were elevated following treatment, indicating increases in mitochondria synthesis. The physiological responses from PQQ were with doses that were on average 30 mg per day or lower.
A placebo-controlled, double-blind, parallel study was undertaken to see how PQQ could improve memory and other measures of cognitive function in subjects ages 50 to 70 experiencing forgetfulness. Subjects took PQQ alone, PQQ with CoQ10, or placebo for 24 weeks (Koikeda, 2011). They were evaluated using a test assessment of neuropsychological status. The study found that PQQ taken either alone or with CoQ10 had the potential to prevent or even reverse cognitive decline. PQQ improved not only immediate memory but also other higher brain functions such as spatial awareness.
Seventeen adult male and female subjects participated in a clinical trial to evaluate the effectiveness of a 20-mg dose of PQQ on stress, fatigue, quality of life, and sleep. They ingested 20 mg of PQQ daily for 8 weeks. All six measures of vigor, fatigue, tension-anxiety, depression, anger-hostility, and confusion were significantly improved following PQQ administration compared with before use. Measures for quality of life, appetite, sleep, obsession, and pain also improved significantly. Significant improvement in sleepiness at awakening, sleep onset and maintenance, and sleep duration was found. The changes in these global scores were correlated with decreases in cortisol (Nakano, 2012).
Pyrroloquinoline quinone (PQQ) disodium salt is produced via fermentation by Hyphomicrobium sp.
Chemical Name:Disodium 4,5-dihydro-4,5-dioxo-1h-pyrrolo(2,3-f) tricarboxylate
Chemical Abstract Service (CAS) Number:122628-50-6
Molekylvikt:374.17 g/mol
Utseende:Henna Powder.
Löslighet:Water soluble(3.08g/L 25°C) Composition/Information on Ingredients over 99 %
Studier av säkerhet
Ames/Reverse Mutation Assay 5000μg/plate, negative.
Chromosomal aberration test in cultured mammalian cells(In vitro)3750μg/mL, negative.
Chromosomal aberration test in human peripheral blood lymphocytes(In vitro) 3750μg/mL, negative.
Micronucleus test in mice (In vivo ) 1000~2000mg/kg, no toxicity
Subchronic oral toxicity study 400mg/kg /day, NOAEL in rats
Acute Oral Toxicity Study 1000~2000mg/kg, no toxicity
- 14-Day dose-range 768mg/kg/day, no toxicity.
Packing
Inside: Aluminum bags or tins, 500g/bag, 1kg/tin Outside: Carton
Package size can also be offered according to customer requirement.
Storage and Stability
The product should be stored in an airtight container, protected from light.
The shelf life is 24 months for unopened stored in recommended condition.
• Chowanadisai W, M. Nakano. Potential physiological importance of pyrroloquinoline quinone. Altern Med Rev. 2009; 14(3): 268–77.
• Chowanadisai W, K.A. Bauerly, E. Tchaparian, A. Wong, G.A. Cortopassi, R.B. Rucker. Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1 alpha expression. J Biol Chem. 2010; 1285(1): 142–52.
• Harris C, et al., Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects. Journal of Nutritional Biochemistry. 2013; 24: 2076–2084.
• He K, H. Nukada, T. Urakami, M.P. Murphy. Antioxidant and pro-oxidant properties of pyrroloquinoline quinone (PQQ): implications for its function in biological systems. Biochem Pharmacol. 2003; 65: 67–74.
• Koikeda T, M. Nereno, and K. Masuda. Pyrroloquinoline quinone disodium salt improves higher brain function. Medical Consultation & New Remedies. 2011; 48(5): 59-67.
• Kumazawa T, K. Sato, H. Seno, A. Ishii, O. Suzuki. Levels of pyrroloquinoline quinone in various foods. Biochem J. 1995; 15(307 Pt 2): 331–3.
• Nakano M, K. Ubukata, T. Yamamoto, H. Yamaguchi. Effect of pyrroloquinoline quinone (PQQ) on mental status of middle-aged and elderly persons. FOOD Style 21. 2009; 13(7): 50–3.
• Nakano M, et al. Effects of Oral Supplementation with Pyrroloquinoline Quinone on Stress, Fatigue, and Sleep. Functional Foods in Health and Disease. 2012; 2(8): 307–24.
• Rucker R, A. Ouchi, I. Nakano, S. Nagaoka, K. Mukai. Kinetic study of the antioxidant activity of pyrroloquinoline quinol (PQQH2, a reduced form of pyrroloquinoline quinone) in micellar solution. J Agric Food Chem. 2009; 57: 450–56.
• Stites TE, A.E. Mitchell, R.B. Rucker. Physiological importance of qu
