Top Supplement Raw Material Prices & Trends | March,17 2025 Market Report

Creatine Market Comparison: Monohydrate VS HCL – Key Differences & Latest Pricing

Creatine Monohydrate and Creatine HCL (Hydrochloride) remain the two most widely used forms of creatine in the global supplement raw material market. While both serve the same core function—supporting muscle energy and performance—their chemistry, solubility, and application differences have made them uniquely suited for different formulations.

• Creatine Monohydrate (CAS No. 6020-87-7) has a molecular formula of C4H9N3O2·H2O and a molecular weight of 149.15 g/mol. It typically appears as a white to off-white crystalline powder with moderate solubility and no noticeable taste.
• Creatine HCL (CAS No. 17050-09-8), with a formula of C4H10ClN3O2 and molecular weight of 167.59 g/mol, is a salt form offering enhanced water solubility and improved stability. It dissolves rapidly in water and has a slightly sour taste, making it ideal for high-end, fast-absorbing formulas.

Tillämpningar och användningsområden:

• Monohydrate remains the gold standard in sports nutrition and strength-building supplements due to its extensive research support.
• HCL, favored for its superior solubility and reduced gastrointestinal side effects, is gaining traction in instant drinks, capsule formulas, and clinical nutrition.

Current Market Prices:

• Creatine Monohydrate (80 mesh): $6.5–7.8/kg
• Creatine Monohydrate (200 mesh): $5.5-6.5/kg
• Creatine HCL: $17.8–20/kg

Alpha Yohimbine Sees Price Surge Over $200/kg Amid Tariff Pressures

Alpha Yohimbine (Rauwolscine), a high-potency CNS stimulant and fat metabolism enhancer, has experienced a sharp price increase due to tariff-related supply chain disruptions.

• CAS No. 146-48-5 | Molekylär formel: C21H26N2O3 | Molekylvikt: 354.44 g/mol
• Widely used in thermogenic fat burners, focus-enhancing pre-workouts, and elite cutting formulas, Alpha Yohimbine is often preferred over traditional Yohimbine for its enhanced effects and lower incidence of side effects.

Updated Price Range: $2,980–3,100/kg

Phosphatidylserine Price Update – Soy VS Sunflower Sources

Phosphatidylserine (PS), a key cognitive support supplement raw material, has also seen recent price movements. Both soy-derived and sunflower-derived options are available in varying purities:

• Soy-Based PS (50%): $110–115/kg
• Sunflower-Based PS: $90–399/kg (Available in 20%, 50%, 70%, and other purities)

Vitamin Market Watch: NRC & B12 Cyanocobalamin Price Hikes

Nicotinamide Riboside Chloride (NRC) and Vitamin B12 Cyanocobalamin are this week’s top movers in the vitamin sector.

• NRC Powder is now priced at $105.5–114/kg, reflecting a $5/kg increase.
• Vitamin B12 Cyanocobalamin rises to $1,620–1,680/kg, marking a significant week-over-week spike.

Stable Pricing for Other Key Vitamins:

• Vitamin B2 (Riboflavin): $38–44/kg
• Pyridoxal 5-Phosphate (P5P): $145–153.5/kg
• Riboflavin Sodium Phosphate: $80–85/kg
• Benfotiamine: $75–80/kg
• NMN (Nicotinamide Mononucleotide): $108–113.5/kg
• D-Chiro Inositol: $256–261/kg
• Vitamin B1 HCl: $46–49/kg
• Vitamin B1 Mononitrate: $36–39.5/kg
• Vitamin B3 (Niacinamide): $10.5–13/kg
• Vitamin D3 (100,000 IU): $10.5–13.5/kg
• Vitamin B5: $10–13/kg
• Ascorbyl Palmitate: $19–22.5/kg
• Vitamin C: $4.5–6/kg
• Vitamin B6: $29.5–34/kg
• Vitamin B12 Methylcobalamin: $1,980–2,100/kg
• NMN Powder: $ 105-107/kg
• Ubiquinol: $680–688/kg
• NADH: $625–636/kg
• NAD: $174–179/kg
• P5P Powder: $148–156/kg

Popular Supplement Ingredient Market Update | Week of March 17, 2025

Spotlight on Popular supplement Raw Material Pricing & Limited-Time Promotions from Nutri Avenue

This week’s pricing snapshot highlights key supplement raw materials across sports nutrition, nootropics, amino acids, and botanical extracts. As demand continues to shift globally, here’s where the market stands for some of the most in-demand supplement raw materials:

Limited-Time Promotional Ingredient List | Valid: March 17–23, 2025

Despite recent upward pricing trends driven by tariff changes, Nutri Avenue continues to support product developers by offering exclusive weekly promotions on select supplement raw materials. This includes a variety of amino acids, food additives, and botanical extracts to help reduce your formulation costs without compromising on quality.

Discount rates vary depending on order quantity. The prices below are market references only. For personalized quotes and promotional pricing, please contact our Nutri Avenue sales representative.

Looking to optimize your formula cost-efficiency or plan your next ingredient order? Contact Nutri Avenue’s team today for customized quotes, technical specs, and product documentation.

Market Outlook Summary

As global market dynamics continue to shift, the supplement raw material industry is witnessing notable fluctuations across both mainstream and specialty ingredients. From classic sports nutrition supplement raw material staples like Creatine Monohydrate and L-Carnitine to high-value nootropics such as Citicoline, Magnesium L-Threonate, and Huperzine A, pricing trends reflect not only growing demand but also the impact of external factors such as tariffs and sourcing challenges. Particularly, the sharp price increase in Alpha Yohimbine and tariff-driven adjustments in vitamin and amino acid sectors signal the need for proactive procurement strategies.

To support brands and formulators navigating these changes, Nutri Avenue provides a competitive edge through selective weekly ingredient promotions, helping businesses maintain cost-effective development pipelines. As we move further into Q2, staying ahead of market updates and sourcing opportunities will be essential in sustaining product innovation and profitability.

Stay tuned for next week’s ingredient market insights. For pricing inquiries, bulk quotes, or formulation support, contact your Nutri Avenue account representative.