The Monoamine Oxidase Inhibitor: What Is Hordenine HCL?

What is Hordenine HCL?

Hordenine HCl is an alkaloid substance in various plants, including sour oranges (Citrus aurantium). It is a dietary supplement promoted as a weight reduction help, mood booster, and performance enhancer.

Hordenine increases the release of norepinephrine, a neurotransmitter that regulates mood, attention, and energy levels. It is also believed to have a stimulatory effect on the central nervous system, which may contribute to its purported benefits for athletic performance and weight loss.

Hordenine HCL History

Hordenine HCl is a natural compound first isolated from barley sprouts (Hordeum vulgare) in 1894 by the German chemist Arthur Heffter. It was later found in other plants, including Citrus aurantium, commonly known as bitter orange.

Hordenine has a long history of use in traditional medicine practices, particularly in China, where it is known as “mao gen.” It has been used as a bronchodilator to treat respiratory conditions and as a treatment for various other ailments, including gastrointestinal disorders and circulatory problems.

In recent years, hordenine has gained popularity as a dietary supplement due to its potential effects on weight loss, athletic performance, and mood enhancement.

What Is The Source Of Hordenine HCL Powder?

Hordenine HCl is a naturally occurring alkaloid compound that is found in various plants, including:

1. Barley (Hordeum vulgare)
2. Bitter orange (Citrus aurantium)
3. Cassia bark (Cinnamomum cassia)
4. Nandina domestica (commonly known as heavenly bamboo)
5. Acacia rigidula

The most common source of hordenine used in dietary supplements is bitter orange (Citrus aurantium) extract. It is because bitter orange extract contains relatively high amounts of hordenine and other compounds that are believed to have weight loss and performance-enhancing effects, such as synephrine and octopamine.

Hordenine HCL Powder Manufacturing Process

The manufacturing process of hordenine HCl involves several steps, including extraction, purification, and synthesis. Here is a general overview of the manufacturing process:

1. Extraction: Hordenine HCl can be extracted from natural sources, such as bitter orange, or synthesized in a laboratory. If extracted from natural sources, the plant material is typically dried, ground, and extracted using a solvent, such as ethanol or methanol. The extract is then concentrated to yield a crude hordenine HCl extract.
2. Purification: The crude hordenine HCl extract is then purified using various techniques, such as column chromatography or liquid-liquid extraction. This process removes impurities and isolates the hordenine HCl compound.
3. Synthesis: Hordenine HCl can also be synthesized in a laboratory using various chemical reactions. One common synthesis method starts with the amino acid tyramine, converted into hordenine HCl through a series of chemical reactions.
4. Final processing: The purified hordenine HCl is dried and milled into a fine powder. The powder is then packaged into capsules or tablets or sold as a bulk powder for use in dietary supplements.

How Does Hordenine HCL Powder Work?

Hordenine HCl increases the release of norepinephrine, a neurotransmitter that regulates mood, attention, and energy levels. It achieves this by inhibiting the enzyme monoamine oxidase (MAO), which breaks down norepinephrine and other neurotransmitters.

By inhibiting MAO, hordenine HCl can increase the levels of norepinephrine in the brain and other parts of the body. This increased release of norepinephrine can lead to a variety of effects, including:

1. Increased energy: Norepinephrine is involved in the body’s “fight or flight” response, which can increase energy and alertness.
2. Improved mood: Norepinephrine also regulates mood and can have mood-enhancing effects.
3. Appetite suppression: Norepinephrine has been shown to reduce appetite, which may contribute to hordenine HCl’s purported weight loss effects.
4. Athletic performance: Norepinephrine can also stimulate the central nervous system, which may contribute to hordenine HCl’s purported performance-enhancing effects.

What Ingredients Can Be Used With Hordenine HCL?

Hordenine HCl is often combined with other dietary supplements to enhance its effects or provide synergistic benefits. Here are some examples of supplements that are commonly used with hordenine HCl:

1. Caffeine: Hordenine HCl is often combined with caffeine to enhance its stimulatory effects and improve focus and energy levels.
2. Synephrine: Synephrine is another natural compound found in bitter orange and is often used with hordenine HCl to promote weight loss and improve athletic performance.
3. L-tyrosine: An amino acid that helps to make norepinephrine and other hormones. It is frequently mixed with hordenine HCl to boost its mood-boosting benefits.
4. Yohimbine: A natural compound found in the bark of the Yohimbe tree that is frequently used in conjunction with hordenine HCl to aid in weight reduction and physical performance.

Hordenine HCl is available for purchase in a variety of forms, including:

1. Capsules: Hordenine HCl is often sold in capsule form, which can be easily swallowed with water.
2. Powder: Hordenine HCl powder can be mixed into water or other beverages or added to smoothies or other foods.
3. Tablets: Hordenine HCl tablets are another option for those who prefer not to take capsules.
4. Pre-workout supplements: Hordenine HCl is often included as an ingredient in pre-workout supplements, which are designed to increase energy, focus, and athletic performance.
5. Combination supplements: Hordenine HCl may also be included in combination supplements with other ingredients, such as caffeine or synephrine.

Hordenine HCL Applications

Hordenine HCl is a natural compound commonly used as an ingredient in dietary supplements. Here are some examples of supplements that may contain hordenine HCl:

1. Pre-workout supplements: Hordenine HCl is often included in pre-workout supplements due to its purported ability to enhance athletic performance and improve focus and energy levels.
2. Weight loss supplements: Hordenine HCl is often marketed as a weight loss supplement due to its purported ability to reduce appetite and promote fat burning.
3. Nootropic supplements: Hordenine HCl may be included in nootropic supplements due to its purported ability to enhance cognitive function, including attention and focus.
4. Mood enhancement supplements: Hordenine HCl may be included in mood enhancement supplements due to its purported ability to enhance mood and have antidepressant effects.

What Are Hordenine HCL Benefits?

Hordenine HCL (hydrochloride) and PEA (phenylethylamine) are natural compounds often used in dietary supplements for their potential effects on energy, focus, and mood. Some of the potential benefits of combining hordenine HCL and PEA in a dietary supplement may include the following:

1. Energy and focus: Hordenine HCL is thought to increase levels of norepinephrine, a stimulating neurotransmitter in the brain, which may lead to increased energy, focus, and concentration. PEA is also thought to increase levels of norepinephrine and other stimulating neurotransmitters, which may enhance the effects of hordenine HCL.
2. Mood enhancement: PEA is believed to boost dopamine and other neurotransmitters in the brain, which may result in a better mood and pleasure emotions. The combination of PEA and hordenine HCL may increase these effects by boosting the release of neurotransmitters involved in mood modulation.
3. Fat loss: Hordenine HCL is sometimes used in weight loss supplements due to its potential ability to increase metabolism and fat burning. PEA is sometimes used in weight loss supplements due to its potential appetite-suppressing effects. Combining hordenine HCL and PEA may enhance these effects by increasing metabolism and reducing appetite.
4. Athletic performance: Hordenine HCL and PEA are sometimes used by athletes and bodybuilders due to their potential stimulant and performance-enhancing effects. Combining these compounds may enhance these effects by increasing energy, focus, and stamina.

Phenylethylamine And HCL Side Effects

Phenylethylamine (PEA) is a natural compound that acts as a neurotransmitter in the brain and is often used in dietary supplements for its potential mood-enhancing effects. PEA HCL refers to the hydrochloride salt form of phenylethylamine, often used to improve its solubility and absorption in the body.

While PEA and PEA HCL are generally considered safe when taken at recommended doses, some people may experience side effects, including:

1. Headache: PEA may cause headaches in some individuals, particularly at higher doses.
2. Nausea and vomiting: PEA may cause nausea and vomiting in some individuals, particularly if taken on an empty stomach.
3. Irritability and anxiety: PEA may cause irritability and anxiety in some individuals, particularly if taken in high doses.
4. Increased heart rate and blood pressure: PEA can cause a rise in heart rate and blood pressure, especially if consumed in large doses or by people who already have cardiovascular problems.

Hordenine MAOi Dosage Recommendations

The recommended dosage of hordenine HCl can vary depending on the product and the intended use. However, typical dosages range from 20 to 50 milligrams per day. It’s important to note that the specific dosage recommendations for hordenine HCl can vary depending on the manufacturer and the specific product.

It’s best to begin with a lower dose and progressively raise it as required while examining any possible side effects. Before beginning a new dietary supplement regimen, observing the manufacturer’s directions and conferring with a healthcare professional is critical.

Additionally, hordenine HCl may be included in combination supplements with other ingredients, such as caffeine or synephrine. In these cases, it’s important to carefully read the label and follow the manufacturer’s recommended dosage instructions.

Hordenine HCL Most Recent Studies

Some recent studies have investigated hordenine HCl’s potential benefits and safety as a supplement, particularly in weight loss and athletic performance.

Additionally, regulatory agencies such as the US Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA) do not currently approve or regulate hordenine HCl as a dietary supplement. It means that hordenine HCl supplements’ safety, quality, and efficacy can vary depending on the manufacturer and the specific product.

Hordenine HCL And Phenylethylamine

Hordenine HCl and Phenylethylamine (PEA) are natural compounds often marketed as dietary supplements for their potential mood-enhancing and energy-boosting effects. While they share a few similarities, their mechanisms of action and possible impacts on the body vary significantly.

Hordenine HCl works by inhibiting the enzyme monoamine oxidase (MAO), which breaks down norepinephrine and other neurotransmitters. By inhibiting MAO, hordenine HCl can increase the levels of norepinephrine in the brain and other parts of the body, leading to potential mood-enhancing and energy-boosting effects.

On the other hand, PEA works by stimulating dopamine release and inhibiting its reuptake, which can increase dopamine levels in the brain. It can lead to potential mood-enhancing, energy-boosting effects, and potential appetite suppression.

Both hordenine HCl and PEA may have potential benefits as dietary supplements, but their safety and efficacy still need to be fully understood. Additionally, both compounds may carry potential risks and side effects, particularly when taken in high doses or combined with other supplements or medications.

Is MAO-B Inhibitor Supplement the same as Hordenine Capsules?

MAO-B inhibitor supplements and hordenine capsules are not the same things.

MAO-B inhibitor supplements contain natural compounds that can inhibit the activity of the enzyme monoamine oxidase-B, which can lead to increased dopamine levels and potential benefits for brain function and mood. These supplements may contain various natural compounds, such as the seeds of the Peganum harmala plant or the bark of the Uncaria tomentosa plant.

On the other hand, Hordenine capsules contain a specific natural compound called hordenine, found in certain plants, such as barley. Hordenine is a natural stimulant affecting energy, focus, and metabolism. 

It has been suggested that hordenine may have some MAO-B inhibiting properties, but this has yet to be extensively studied and is not a primary function of hordenine.

MAO-i & MAO-b Comparison

MAO stands for monoamine oxidase, an enzyme that breaks down certain neurotransmitters in the brain. MAO inhibitors (MAO-i) are a class of drugs that block the activity of this enzyme, leading to increased levels of neurotransmitters like dopamine, serotonin, and norepinephrine in the brain. There are two main types of MAO inhibitors: MAO-A inhibitors and MAO-B inhibitors.

As the name suggests, MAO-A inhibitors primarily inhibit the activity of MAO-A, which breaks down serotonin and norepinephrine. These inhibitors are used to treat depression and anxiety disorders. Examples of MAO-A inhibitors include tranylcypromine and phenelzine.

On the other hand, MAO-B inhibitors primarily inhibit the activity of MAO-B, which breaks down dopamine. These inhibitors are used to treat Parkinson’s disease, as dopamine is a neurotransmitter depleted in the brains of people with this condition. Examples of MAO-B inhibitors include selegiline and rasagiline.

It’s important to note that MAO inhibitors can significantly interact with certain foods and other medications and can cause serious side effects if not used properly. Therefore, they should only be used under the close supervision of a healthcare professional.

Is Hordenine HCL Illegal?

Hordenine is legal as a dietary supplement in many countries and is widely available online and in health food stores. However, it’s important to note that the legal status of hordenine HCl can vary depending on the country and the specific regulations governing dietary supplements.

Does Hordenine HCL Contain Caffeine?

Hordenine HCL does not contain caffeine naturally, as it is a separate compound. However, some dietary supplements that contain hordenine HCL may also contain caffeine or other stimulants, as these ingredients are sometimes combined to enhance their effects on energy, focus, and metabolism.

Is Hordenine HCL A Stimulant?

Hordenine HCl is often marketed as a natural stimulant due to its purported ability to increase energy levels, focus, and athletic performance. It works by increasing the release of norepinephrine, a neurotransmitter involved in regulating mood, attention, and energy levels, by inhibiting the enzyme monoamine oxidase (MAO). It can lead to mood-enhancing and energy-boosting effects.

Does Hordenine HCL Affect Dopamine Levels?

Hordenine HCl may indirectly increase dopamine levels by inhibiting the enzyme monoamine oxidase (MAO), which breaks down dopamine in the brain. By inhibiting MAO, hordenine HCl can increase dopamine levels in the brain and other body parts.

What Are Other Natural Inhibitors That Are Available In The Market?

Natural MAO inhibitors include curcumin, green tea powder, Rhodiola rosea EXT powder, Berberine powder, and Ginkgo biloba bulk powder, which have been shown to have MAO-inhibiting properties in some studies.

Because of FDA policy, Nutri Avenue can not sell Hordenine hcl bulk powder now. You can choose other natural MAOi ingredients mentioned above, which are available on our website.

Where To Buy Hordenine HCL Powder?

Hordenine is on the DoD Prohibited Dietary Supplement Ingredients list and the National Collegiate Athletic Association’s (NCAA) list of banned substances.

We have decided not to sell this product for the time being. We are very sorry for the inconvenience. If there are any changes, Nutri Ave will update you in time.

And Nutri Avenue Offers other MAO Natural Inhibitors, and you are always welcome to get a free quote.