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Product Name L-Ergothioneine Powder
Other Names EGT
CAS Number 497-30-3
Molecular Formula C9H15N3O2S
Molecular Weight 229.3 g/mol
Applications Personal Care, Dietary Supplements, Functional Foods, Animal Nutrition, etc.
Package 1kg,5kg/bag, 25kg/drum


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L-Ergothioneine(Fit21™) From Nutri Avenue


What Is L-Ergothioneine?

L-ergothioneine is a naturally occurring amino acid and antioxidant that certain fungi, bacteria, and plants produce. It is primarily found in high concentrations in mushrooms, such as shiitake and oyster mushrooms, and in other food sources like beans, liver, and kidney.

Research on L-ergothioneine is still ongoing, and its exact mechanisms of action and a full range of potential health benefits are not yet fully understood. However, it is considered a promising compound with potential applications in various areas of health and wellness.

L-Ergothioneine History

  1. In 1909, L Ergothioneine was isolated from ergot.
  2. In 1911, its structure was determined, and confirmed that this ingredient is a derivative of histidine betaine.
  3. Due to poor research results, it was once considered inert to the human body for a long time in the middle.
  4. In 2005, the exclusive transporter OCTN1 was discovered, bringing L-Ergothioneine back into the field of research.
  5. In 2009, research proved its effectiveness for skin care.
  6. In 2014, this ingredient was included in the “Catalogue of Used Cosmetic Raw Materials” issued by the China Food and Drug Administration.
  7. In 2017, Europe approved it as a new food ingredient.
  8. In 2019, it passed the GRAS certification of the US FDA. Japan launched functional food containing this ingredient.
  9. In 2021, Japan approved its use in healthcare products and general food.

Since then, L-Ergothioneine has entered the public eye. Become one of the new ingredients that major brands worldwide are willing to use. Consumers and businesses are also starting to pay attention to the development of this ingredient.

Pure Bulk L-Ergothioneine Powder Specifications

  • ≥99.9% pure bulk L-Ergothioneine powder
TypeRare natural chiral amino acids
AppearanceWhite crystal
Melting Point275~277℃
Other IngredientNone
Water ContentYes
MOQ (minimum order quantity)1kg
SampleAvailable (10-20g/bag)
OEM ServiceAvailable, such as capsules, tablets, pills, etc.
ODM ServiceAvailable
Private LabelAvailable
Contract ManufacturingAvailable

L-Ergothioneine Powder Manufacturing Process

There are generally three production processes for this ingredient, namely fermentation, natural extraction, and chemical synthesis. Among them, the natural extraction method has a low yield and many impurities, and it is difficult to extract products with high purity. The synthetic route of the chemical synthesis method is long, and there are many by-products. And the cost is high. It is also difficult to obtain high-purity products.

Therefore, the fermentation method has become one of the mainstream directions for large-scale production of L-Ergothioneine powder at low cost. This process belongs to biotechnology and has good safety.

More Information

L Ergothioneine Mechanism Action

  • Effective for different organs.

EGT is a water-soluble amino acid molecule that can be delivered to red blood cells, bone marrow, liver, kidneys, eyes and other tissues and organs through the OCTN1 transporter.

  • Enter the cell membrane.

EGT is a membrane-impermeable substance that requires specific transporters to enter cells. The OCTN1 transporter is distributed on the cell membranes of different tissues, especially in the kidney, trachea, bone marrow, and skeletal muscle. In addition, the mitochondria also contain OCTN1 protein, so EGT can enter the mitochondria to play an antioxidant role very easily.

L-Ergothioneine Benefits

  1. Eye protection
  2. Cardiovascular health
  3. Muscle repair
  4. Treat inflammation
  5. Prevent UV Damage
  6. Prevent neurodegenerative diseases

Studies have shown that EGT can break through the blood-brain barrier, and can regulate neuronal differentiation, neurogenesis, and microglial activation, and can also prevent neurotoxicity caused by pathogenic proteins or chemicals. The latest research shows that long-term supplementation of EGT has a positive effect on the prevention of neurodegenerative diseases such as senile dementia and Alzheimer’s disease.

Antioxidant Comparison

  • First Generation Antioxidants: Vitamins A, C, E
  • Second-generation antioxidants: beta-carotene, SOD, CoQ10 (derivative changed to Idebenzyme)
  • Third-generation antioxidants: glutathione GSH, flavonoids (Lutein), polyphenols (resveratrol), anthocyanins (OPC), grape seed, blueberry extract, green tea, alpha lipoic acid, lycopene Astaxanthin
  • The fourth generation of antioxidants: glabridin, ectoine, carnosine, EUK134, fullerene

The biological and pharmacological properties of ergothioneine are safe and stable. Therefore, adding this ingredient to a product can maintain the stability of other ingredients and promote the absorption of active ingredients by cells. It has a good synergy. It is a good partner for anti-oxidation.

Product cases:

The US subsidiary Essenat Health, LLC specializes in the field of antioxidants. Vita ErgoTM specializes in ergothioneine products.

In addition, Estee Lauder, Dior, Elizabeth Arden, Givenchy, DHC, and other cosmetic brands have added this ingredient to their products.

Antioxidant formulation research reference

L-Ergothioneine + glutamyl cysteine (glutathione precursor) + vitamin C

L-Ergothioneine Application Areas Introduction

Skin care products: Mainly whitening, anti-wrinkle, anti-allergic, anti-acne, anti-aging and other effects. And protective skin care products.

L-Ergothioneine Supplements: Enhance immunity, prevent Alzheimer’s disease, assist in lowering blood sugar and other functional foods or drinks

Drugs: It can treat inflammation, senile dementia, eye drops, and other drugs.

Food: In 2017, the European Food Safety Authority used it as a new resource food in the diet of infants, pregnant women, and lactating women

L Ergothioneine Dosage: 0.1%-1.0%

L-Ergothioneine Research

In recent years, researchers have become increasingly interested in this ingredient. Since 2011, more than 300 articles about L Ergothioneine have been published on PubMed. This figure exceeds the sum of data before 2000.

L-Ergothioneine Market

Ergothioneine has gradually attracted market attention and has continuously optimized the process. In the next five years, the global production capacity and market demand are expected to continue to expand.

According to the forecast of Global Info Research, the global market size will reach 5 tons in 2027. According to the “Global and Chinese Ergothioneine Industry Development Status Survey and Investment Prospect Analysis Report,” the global L-ergothioneine market size will reach $53 million in 2026.

Who Is The Bulk L-Ergothioneine Supplier?

Nutri Avenue offers this ingredient at wholesale price. We use ferment way to produce it, and make sure the powder purity is more than 99.9%. Welcome to get a free quote.


This component is widely distributed in the human body, including the brain, eye, endocrine tissue, lung, proximal digestive tract, gastrointestinal tract, etc. However, as age increases, its content in the human body will become less and less, and it cannot be synthesized in the body. Therefore, the human body must rely on external input to replenish the necessary ergothioneine.

Yes. L-ergothioneine is non-GMO.

Yes. L-ergothioneine belongs to one of the rare natural chiral amino acids.


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