What Is Spermidine?
Spermidine, or spermidine trihydrochloride, was first discovered in human semen. In 1677, Dutch scientist Antony van Leeuwenhoek, the father of microscopy, discovered the existence of sperm from his semen using a homemade microscope and obtained a crystal of a compound, the precursor of spermidine.
For hundreds of years after this, spermidine was ignored. In 2009, researchers Frank Madeo and Tobias Eisenberg of the University of Graz, Austria, discovered in an experiment that after adding 0.2 mmol spermidine to the nematode diet, the life span of the experimental group was extended by 15% compared with the control group. This effect is even more significant in the yeast experimental model. The lifespan of the yeast experimental group with four mmol spermidine was 400% that of the control group. The experimental results were published in Cell Biology, a sub-journal of Nature.
Since then, spermidine has gone from being unknown to a life-extending treasure. In 2018, a review from the world’s top journal, “Science,” gave a solid record of the life-extending effect of this substance, which is both true and false. A review of 130 relevant scientific papers suggested that the substance’s life-extending hypothesis may be true.
Source from: https://pubmed.ncbi.nlm.nih.gov/19801973/
The Largest Human Experiment On Spermidine In Human History Proves
Long-term intake of spermidine can extend life span by 5.7 years!
In 2018, researchers selected 829 participants aged 45-84 and followed them for 20 years to analyze potential associations between dietary spermidine intake and human mortality.
The study divided the population into three groups according to spermidine intake.
- low intake group (<62.2 µmol/d)
- medium intake group (62.2–79.8 µmol/d)
- high intake group (>79.8 µmol/d)
341 deaths were recorded during the follow-up period, including 137 from vascular disease, 94 from cancer, and 110 from other causes. The calculated crude mortality rates for the low, middle, and high groups were 40.5%, 23.7%, and 15.1% respectively. These data indicate a significant inverse association between spermidine intake and all-cause mortality.
The similarity in mortality risk between the highest and lowest spermidine intakes, associated with being 5.7 years younger, supports the belief that long-term spermidine intake contributes to longevity.
Pure Spermidine Trihydrochloride Powder Specification
The purity of Spermidine Trihydrochloride Powder is ≥98.0% in general. If this ingredient is extracted from wheat germ, the purity is only 1%.
| Type | Natural nutritional ingredient |
| Appearance | Pure white powder |
| Purity | ≥98.0% |
| Other Ingredient | None |
| Water Content | ≤0.5% |
| MOQ (minimum order quantity) | 1kg |
| Sample | Available (10-20g/bag) |
| OEM Service | Available, such as capsules, tablets, pills, etc. |
| ODM Service | Available |
| Private Label | Available |
| Contract Manufacturing | Available |
Spermidine Powder Sources And Its Manufacturing Processes
Spermidine is a natural nutrient commonly found in different foods, including animals, plants, and microorganisms. The spermidine levels in them differ significantly. Spermidine is found in higher amounts in plants and fungi than in animal sources. Therefore, a daily diet containing a variety of food sources can provide humans with certain amounts of spermidine. However, there are certain problems with this supplement method, such as how to achieve an effective dose and whether it is easy to face many allergens if consumed in large quantities.
There are two manufacturing processes for this ingredient.
- Food Extraction
There are many dietary sources of spermidine, including wheat, beans, aged cheeses, and mushrooms. Extractions of this ingredient from traditional food sources are limited in purity and potency. Potential allergens, such as gluten, are another common concern among consumers.
- Biosynthesis
Advanced biotechnology synthesis replaces the traditional spermidine extraction method. Biosynthesized spermidine solves the allergen problem. High concentrations of synthetic spermidine can unleash its full health potential in longevity. Consumers can now enjoy safe spermidine without any worries.
Spermidine VS NMN
Although spermidine is a new player in aging management, many studies have confirmed its effectiveness in fighting aging. The well-known NMN and spermidine are both anti-aging substances, but their anti-aging pathways differ. NMN responds to aging signals. Spermidine starts by renewing damaged cells and fundamentally solves the problem of aging.
As we age, our ability to produce natural spermidine levels through our gut microbiota or diet decreases significantly. This decline causes the autophagy process in our bodies to stall, preventing cell regeneration. Ingesting spermidine can promote autophagy, trigger mitophagy, etc., making it a golden choice for longevity supplements.
What Is Autophagy: Old cells transform into young cells
The ability of the body’s cells to clean themselves and remove waste is very important because degraded or damaged cells can produce toxins that damage our bodies.
You can think of autophagy as your body’s natural recycling process. The name comes from Latin, meaning “self-eating”.
Autophagy is a natural process in the body that involves breaking down unwanted or damaged components within cells. And reuse them as building blocks for cell repair or to form new cells.
Other Spermidine Benefits
In addition to promoting autophagy, studies in top journals such as Science have emphasized the physiological regulatory effects of spermidine, including anti-inflammatory, antioxidant, cardioprotective, and neuroprotective effects.
- cardioprotection
It can promote cell respiration, thereby increasing the mitochondrial content in heart cells.
(According to a study published in Nature Medicine, dietary supplementation with spermidine extends lifespan and reverses aging-related cardiac dysfunction by inducing autophagy.)
- neuroprotection
It reduces inflammatory factors and increases the formation of memory cells. And triggers the preventive clearance of toxic protein aggregates in cells.
- Effectively prevent obesity
Scientific research shows spermidine intake is inversely related to obesity in humans and mice.
Spermidine Products In The Market
Most spermidine brands on the market choose wheat germ as the source of spermidine. Typically, the finished product using this traditional extraction method contains only 1% spermidine. Because of its insufficient purity, it will cause the related finished products to be beige or off-white. For consumers, the impression is average.
In order to solve this problem, biosynthetic technology can be used to produce pure spermidine powder with a concentration of up to 98%. This method is nearly 100 times more effective than products extracted from wheat germ.
Simply put, high concentration means fewer additives, impurities and less chance of poisons accumulating in the body, especially when the recommended daily spermidine dosage is up to 13 mg.
In addition, there is an ammonia smell in spermidine powder. Biosynthetic technology also solves this problem.
This ingredient can be used in facial and eyelash essences, granules, hair growth or hair care products, etc.
Buy Spermidine On Nutri Avenue
Nutri Avenue is the best raw ingredients supplier to offer Spermidine powder with high purity. Each batch of this ingredient passes rigorous self-inspection and third-party testing. It has obtained ISO 9001, HALAL, HACCP, Micro quality labs, and other qualification certifications.
FAQs
Yes. Spermidine trihydrochloride is the trihydrochloride form of spermidine. This form is more stable. Because spermidine is very sensitive to air, both have the same effect.
Yes. The U.S. FDA and the European Commission do not ban spermidine. In 2020, this ingredient obtained GRAS qualification (GRAS: Notice No. 889). Also passed Novel Food certification (EU) 2020/443.
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