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Product Name Polydatin
Other Name Piceid
CAS Number 65914-17-2
Molecular Formula C20H22O8
Molecular Weight 390.4 g/mol
Applications Personal Care, Dietary Supplements, Functional Foods, Animal Nutrition, etc.
Package 1kg,5kg/bag, 25kg/drum


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What Is Polydatin?

Polydatin is a natural compound and belongs to the stilbenoid polyphenol family. It is extracted from different plant families such as Vitaceae, Liliaceae, and Leguminosae. Its primary source of extraction is the rhizome and root of Polygonum cuspidatum, which has been traditionally used to treat inflammation, infection, jaundice, skin burns, and hyperlipemia. Reynoutria japonica is now the main source of polydatin on an industrial scale. Unfortunately, this plant is invasive and negatively affects the ecosystem and agricultural potential of remote mountain areas. It is also found in other plant sources such as red wine, nuts, vegetables, fruits, hop cones/pellets, and cocoa- and chocolate-containing products. Trans-polydatin is a glucoside derivative of resveratrol and has higher antioxidant and anti-inflammatory activity compared to resveratrol.

Bulk Polydatin Powder Specification Sheet


Dietary Supplement, Food


White Powder



Biological Activity

Anti-inflammatory, antioxidant, and apoptosis-modifying activities.


Kosher, Halal, GMP, etc.

Shell Life

24 months

Test Methods


MOQ (minimum order quantity)



Available (10-20g/bag)

OEM Service

Available, such as capsules, tablets, pills, etc.

ODM Service


Private Label


Contract Manufacturing


Polydatin Benefits

Polydatin is a potent natural polyphenol and resveratrol derivative with high bioavailability. This makes it an important phytochemical with many potential health benefits like:


Inflammation is a natural response of the immune system to protect the body against pathogens, injuries, and infections. Acute inflammation aids in the healing process while chronic inflammation can lead to severe diseases like atherosclerosis, arthritis, diabetes, neurodegenerative diseases, and cancer. Chronic inflammation occurs when the acute inflammatory response becomes uncontrolled due to the production of cytokines and recruitment of immune cells.


 Oxidative stress is harmful due to the production of reactive oxygen species and nitrogen species. It is an antioxidant that reduces lipid peroxidation and promotes antioxidant enzymatic activity to counteract liver damage. It has modulatory effects on ROS and RNS in central and peripheral diseases.


Apoptosis is a natural process of cell death that can cause diseases when uncontrolled.3,5,4′-Trihydroxystilbene 3-O-beta-D-glucoside, a compound found in plants, has been found to have anti-apoptotic effects. It reduces Bax expression and increases Bcl-2 expression in liver injury. Additionally, it reduces caspase-3 and Bax levels and increases Bcl-2 and D-cyclins expression in gastrointestinal injury.


Cancer has the most significant impact on the global population. The primary strategies to treat cancer are radiotherapy, surgery, and chemotherapy. Trans-Resveratrol-3-beta-mono-D-glucoside has been established to have anticancer properties against various cancer types.


It treats cardiovascular diseases, including AMI, atherosclerosis, pulmonary hypertension, vascular damages, and sepsis.

Applications and Uses

Polydatin, a natural active small molecule, has been commonly used to protect and treat liver disorders in preclinical studies. It can also be applied for various other purposes.

Food Industry: It is used as an additive to increase the shelf life of food products.

Pharmaceutical Industry: It is often used as a medicine supplement or incorporated as an ingredient in over-the-counter medications.

Cosmetics Industry: It is used to prevent premature aging and protect against UV radiation.

Dose Polydatin Have Side Effect?

It is a safe and effective natural medicine with multi-target and multi-system action. It treats atherosclerosis by mainly targeting three aspects.

  1. Anti-inflammatory
  2. Regulating lipid metabolism
  3. Anti-oxidative stress

Special Precautions and Warnings

The food supplement is safe, but precautions are necessary when taken by:

Mouth: Polydatin is safe for up to three months, with some people experiencing nausea. It is uncertain if PEA is safe for use beyond three months due to insufficient information.

Pregnancy and breast-feeding: Polydatin’s safety during pregnancy and breastfeeding is uncertain due to a lack of reliable information. It’s best to avoid using it.

Children: PEA is safe for children aged 4-17 when taken orally for up to 3 months.

Is Polydatin FDA-Approved?

Chinese FDA approved phase II clinical trials in China for anti-shock applications.

Polydatin: Treating Atherosclerosis Disease – How and Why?


  • Atherosclerosis is caused by smoking, drinking, high-fat, high-sugar diets, and other factors that increase oxidative stress and inflammation. This causes lipids to accumulate in the intima of arterial blood vessels, leading to bleeding and thrombosis. Fibrous tissue hyperplasia and calcification follow, which can narrow the vascular cavity. When an atherosclerotic plaque blocks the arterial lumen, tissues or organs supplied by the artery become ischemic or necrotic, significantly affecting people’s quality of life.


  • Polydatin regulates signaling pathways to prevent atherosclerosis by reducing LDL oxidation, inhibiting foam cell and SMC migration, and preventing necrotic core formation.

How to Store Polydatin Powder?

Storage Instruction: Store the container tightly closed in a cool, well-ventilated, and dry place away from light. Store at temperatures below 8°C. Specific end use(s) should be considered.

Where to Source Bulk Polydatin Powder?

Looking to source bulk chemical compound powder at a competitive price?  Nutri Avenue is a excellent choice! We specialize in natural raw materials for nutritional products and provide top-quality ingredients that meet strict standards. Nutri Avenue offers convenient access to our premium products with a global presence spanning the UK, France, Mexico, Poland, Hungary, and various South American countries, including Brazil, Argentina, Peru, Ecuador, Colombia, Chile, Uruguay, and Paraguay. Partnering with Nutri Avenue ensures reliable access to high-quality supplement ingredients for your production or research needs, backed by our exceptional customer service.


Polydatin is a more potent antioxidant and anti-inflammatory compound compared to resveratrol, as it is a glucoside derivative of it.

Polydatin is found in grapes, peanuts, red wine, and Polygonum cuspidatum.

It is recommended that a human should take 160 mg of polydatin per day as a dietary supplement.

Polydatin is a natural compound that protects and heals the liver from oxidative stress-associated diseases. Its molecular mechanisms include improving liver function, reducing inflammation, and preventing lipid accumulation, endoplasmic reticulum stress.

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