Your One-Stop Bulk Powder Supplier

Nutri Avenue Inc

5-HTP Ferment

Product Name 5-HTP
Other Names 5-Hydroxytryptophan
CAS Number 4350-09-8
Molecular Formula C11H12N2O3
Molecular Weight 220.22 g/mol
Applications Personal Care, Dietary Supplements, Functional Foods, Animal Nutrition, etc.
Package 1kg,5kg/bag, 25kg/drum


Get a Free Quote

What Is 5-HTP?

The compound 5-HTP is a tryptophan derivative that is an immediate precursor in the biosynthesis of the neurotransmitter serotonin. The structure of the compound is described as similar to tryptophan substituted by a hydroxy group at position 5. The compound is primarily used as an antidepressant to reduce anxiety. The product also helps improve sleep quality and quantity.

The terms 5 htp,  5-Hydroxytryptophan, Griffonia Seed Extract, Griffonia Simplicifolia, Griffonia Simplicifolia Extract, Griffonia Extract, Griffonia Simplicifolia Seed Extract, L-5-Hydroxytryptophan, and L-5 Hydroxy Tryptophan are also used to identify the compound. It is further described as having CAS number 56-69-9, molecular formula of C11H12N2O3, and a molecular weight of 220.22 g/mol.

5-HTP Sources

The compound 5-HTP is converted from another compound known as L-tryptophan. Natural dietary sources for L-tryptophan include turkey, chicken, and milk. It may also be found in seaweeds, potatoes, pumpkins, and sunflower seeds.

The major source of natural 5-HTP is the product Griffonia Simplicifolia Seed Extract. The 5-HTP component of the said extract is claimed to be why it helps promote overall mood.

Constituents of Griffonia Simplicifolia Seed Extract

Griffonia Simplicifolia Seed Extract is a product derived from the seeds of a plant in the western African region known as Griffonia simplicifolia. The extract has long been used in traditional medicine to treat insomnia, promote weight loss and reduce anxiety.

The key ingredient in the extract is the compound 5-Hydroxytryptophan or 5-HTP. The compound also contains relative amounts of minerals such as iron, zinc, magnesium, copper, and phosphorus.

5-HTP Forms and Specifications

5-HTP comes in various forms and specifications. The most common forms of the product available in the market include 99% High Purity 5-HTP powder, Purified 98%+ Griffonia Seed Extract, 95% 5-HTP granules, and Custom standardized 10-99% 5-HTP powder extract.

These specifications may be bought wholesale from Nutri Avenue. Nutri Avenue uses paper drums with two layers of polybags as standard packaging material for bulk purchases. Nevertheless, we use a different packaging material upon the request of customers.

Compare With 5-HTP

  • 5-HTP VS L-theanine

L-theanine is another popular option for depression and anxiety relief. It is a predominant amino acid that can potentially increase GABA and serotonin levels. The compound may be found in various food and drinks, including mushrooms and teas.

Essentially, both 5-HTP and L-theanine work to improve neurotransmitter action and prevent anxiety and depression. Nevertheless, these compounds vary in certain aspects. One study concluded that 5-HTP is more beneficial in improving the overall sense of well-being, while L-theanine works best in promoting relaxation. Also, while 5-HTP works more on serotonin, L-theanine works on the neurotransmitter GABA.

Some experts say that L-theanine is a better option than 5-HTP as the latter is not always obtained from the diet. In contrast, L-theanine is naturally found in various food products.

  • 5-HTP VS St. John’s wort

Research shows that 5-HTP should never be taken with St. John’s Wort as the said combination may cause drug interactions. It was established that combining 5-HTP and St. John Wort may lead to a condition known as Serotonin syndrome, a disorder characterized by sudden changes in vital signs and muscle spasms.

  • Ashwagandha VS 5-HTP

Ashwagandha is another ingredient that may increase GABA and Serotonin levels.

While no interactions are yet established on using Ashwagandha and 5-HTP, many experts say combining the said products should be under a physician’s prescription and recommendation.

How Does 5-HTP Work?

The neurotransmitter Serotonin is essential as it is responsible for maintaining sleep, appetite, pain sensation, and sexual behavior. Studies show that 5-HTP regulates serotonin production in the brain, influencing sleep and appetite.

Also, 5-HTP may work in enhancing GABA action. GABA is the neurotransmitter responsible for promoting relaxation. Thus, 5-HTP, in effect, may also promote relaxation.

5-HTP Powder Manufacturing Process

In the production of 5-HTP, the raw materials used are the seeds of Griffonia Simplicifolia.

  1. The raw materials are first crushed and soaked in acidic water and sodium pyrosulfite for extraction.
  2. After that, the extract is adsorbed by adding it to a cation exchange resin column and washing it with deionized water.
  3. The product is then eluted and added to a macroporous resin column.
  4. The eluate is then collected and added to active carbon.
  5. The decoloring liquid is, after that, concentrated and crystallized.
  6. The next step comprises filtering and drying the crystal to obtain the product.

5-HTP Benefits

Taking supplements with 5-HTP provides health benefits which include the following:

  • 5-HTP for sleep

Both Serotonin and GABA are known to influence sleeping patterns. By improving the production of these neurotransmitters, it is believed that 5-HTP may promote sleep and help resolve insomnia.

  • 5-HTP for anxiety

Anxiety and stress may be controlled and reduced with healthy serotonin production in the brain. For example, 5-HTP may help reduce anxiety by regulating serotonin production.

  • 5-HTP for depression

The compound 5-HTP is used in antidepressants to improve overall mood and well-being.

  • 5-HTP for weight loss

Serotonin is also a factor that affects appetite. By regulating the production of the neurotransmitter, 5-HTP may effectively promote healthy weight loss.

Is 5-HTP Safe?

No serious side effects are associated with using 5-HTP in dietary supplement products. Nevertheless, it should be taken within recommended doses to avoid severe adverse reactions.

A 200 to 400 mg of 5-HTP dosage is considered safe and effective.

Our company is your best choice for ingredient needs as we offer several advantages. Aside from being registered with the FDA, we are also recognized by entities like Kosher, Halal, and GMP. Nutriavenue is also third-party tested. We also have a large stock of our products to ensure that your needs for wholesale purchases are met.

You may avail of a free quote or ask any questions about our products and services by contacting our technical support staff.


Natural 5-HTP is also called Griffonia Simplicifolia seed extract. It is considered safe.

The half-life of the compound is 2.2 to 7.4 hours.

In scientific studies, 5-HTP taken at 150-800 mg daily is recommended.

It usually starts working immediately when taken at least 30 minutes before bedtime.

The wholesale 5-HTP powder is available at Nutri Avenue, a manufacturer that has established its reputation in ingredient supply for several years.

Bulk raw Ingredients Supplier

Nutri Avenue

Leave your details below, and let us help you get fresh, high-quality ingredients ASAP.

Nutri Avenue

how can we help ?