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5 HTP (5-Hydroxytryptophan)

Product Name 5 HTP
Other Names 5-Hydroxytryptophan
CAS Number 4350-09-8
Molecular Formula C11H12N2O3
Molecular Weight 220.22 g/mol
Applications Personal Care, Dietary Supplements, Functional Foods, Animal Nutrition, etc.
Package 1kg,5kg/bag, 25kg/drum

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5 HTP (5-Hydroxytryptophan)

What Is 5-HTP?

The compound is a tryptophan derivative that is an immediate precursor in the biosynthesis of the neurotransmitter serotonin. The structure of the compound is described as similar to tryptophan substituted by a hydroxy group at position 5. The compound is primarily used as an antidepressant to reduce anxiety. The product also helps improve sleep quality and quantity.

Fermented 5 HTP sources from

The more well-known source is Griffonia Simplicifolia seeds. Therefore, it is also called Griffonia Seed Extract, Griffonia Simplicifolia Extract, Griffonia Extract, Griffonia Simplicifolia Seed Extract, etc. It is natural 5 htp. To learn more about this natural source, click on this page.

Here, Nutri Avenue mainly introduces the sources of fermentation production.

  • Sugars such as glucose. As the main carbon source for microorganisms in the fermentation process, it provides energy and material basis to support the growth and metabolism of microorganisms.
  • Tryptophan. The direct precursor of 5-HTP, during the fermentation process, microorganisms convert tryptophan into 5-Hydroxytryptophan through enzymatic reactions.
  • Nutrients. In order to ensure the normal growth of microorganisms, nitrogen sources (such as amino acids or inorganic nitrogen compounds), phosphorus sources, vitamins, minerals, etc., are usually required.
  • Specific microorganisms. During fermentation, genetically modified or naturally 5 HTP-producing microorganisms (such as specific strains of Escherichia coli or yeast) are usually used for fermentation. These microorganisms can convert tryptophan into 5-HTP through enzymatic action.

The ingredient can be efficiently produced through this fermentation method, replacing traditional plant extraction methods (such as extraction from African black nettle seeds).

Tryptophan VS 5 HTP

Both are supplement ingredients used to increase serotonin levels, but they work in different ways.

5-Hydroxytryptophan is a direct intermediate in tryptophan metabolism that can quickly increase serotonin levels in the brain, helping to improve mood and relieve depression symptoms. L-tryptophan is a precursor to 5 HTP and needs to be converted to 5-HTP through enzymatic reactions in the body and then further converted to serotonin. Therefore, the effects of L-tryptophan may be more indirect and slower.

Overall, the effects of 5-Hydroxytryptophan may be more immediate and direct, while L-tryptophan requires additional metabolic steps.

Taking 5-HTP and tryptophan together increases the risk of a rare but serious condition called serotonin syndrome. This condition can include symptoms such as confusion, hallucinations, seizures, drastic changes in blood pressure, rapid heart rate, fever, excessive sweating, shaking or trembling, blurred vision, etc.

Specification sheet reference

5-Hydroxytryptophan comes in various forms and specifications. The most common forms of the product available in the market include 99% High Purity 5-HTP powder, 95% purity in granular form, etc.

These specifications may be bought wholesale from Nutri Avenue. Nutri Avenue uses paper drums with two layers of polybags as standard packaging material for bulk purchases. Nevertheless, we use a different packaging material upon the request of customers.

What Does 5 HTP Do?

The neurotransmitter Serotonin is essential as it is responsible for maintaining sleep, appetite, pain sensation, and sexual behavior. Studies show that it regulates serotonin production in the brain, influencing sleep and appetite.

Also, 5-Hydroxytryptophan may work in enhancing GABA action. GABA is the neurotransmitter responsible for promoting relaxation. Thus, this compound, in effect, may also promote relaxation.

5 HTP VS L Theanine

L-theanine is another popular option for depression and anxiety relief. It is a predominant amino acid that can potentially increase GABA and serotonin levels. The compound may be found in various food and drinks, including mushrooms and teas.

Essentially, both 5-HTP and L-theanine work to improve neurotransmitter action and prevent anxiety and depression. Nevertheless, these compounds vary in certain aspects. One study concluded that 5 HTP is more beneficial in improving the overall sense of well-being, while L-theanine works best in promoting relaxation. Also, while 5-Hydroxytryptophan works more on serotonin, L-theanine works on the neurotransmitter GABA.

Some experts say that L-theanine is a better option than 5-HTP as the latter is not always obtained from the diet. In contrast, L-theanine is naturally found in various food products.

5 HTP VS St. John’s wort

Both are commonly used supplements to improve mood and relieve depression symptoms. 5-hydroxytryptophan is a direct serotonin precursor that can increase serotonin levels in the brain, thereby improving mood. St. John’s wort is an herb that contains active ingredients such as hypericin, which works by inhibiting the reuptake of serotonin, norepinephrine, and dopamine.

While both can improve depression symptoms, 5-HTP has a more direct and specific mechanism of action, while St. John’s wort may have a broader effect and affect more neurotransmitters.

Research shows that 5-HTP should never be taken with St. John’s Wort as the said combination may cause drug interactions. It was established that combining these two ingredients may lead to a condition known as Serotonin syndrome, a disorder characterized by sudden changes in vital signs and muscle spasms.

5-HTP VS Ashwagandha

Both are supplements used to improve mood and reduce stress. However, their mechanisms of action and uses are different. 5-Hydroxytryptophan helps to elevate mood and relieve symptoms of depression by directly increasing serotonin levels in the brain. Ashwagandha is a traditional herb that is considered to have adaptogenic properties. It helps regulate the body’s stress response, reduce anxiety, and increase immunity.

While both can improve mental health, 5-HTP works directly on mood primarily by affecting neurotransmitters, while ashwagandha increases resilience to stress and supports overall health.

5 HTP: Benefits, Side Effects, And More

For sleep. Both Serotonin and GABA are known to influence sleeping patterns. By improving the production of these neurotransmitters, it is believed that it may promote sleep and help resolve insomnia.

For anxiety. Anxiety and stress may be controlled and reduced with healthy serotonin production in the brain. For example, 5 HTP may help reduce anxiety by regulating serotonin production.

For depression. The compound is used in antidepressants to improve overall mood and well-being.

For weight loss. Serotonin is also a factor that affects appetite. By regulating the production of the neurotransmitter, 5-Hydroxytryptophan may effectively promote healthy weight loss.

Side Effects: Is It Safe?

No serious side effects are associated with using 5-HTP in dietary supplement products. Nevertheless, it should be taken within recommended doses to avoid severe adverse reactions.

A 200 to 400 mg of 5 HTP dosage is considered safe and effective.

Order Fermented 5 HTP Near Me: Nutri Avenue

Our company is your best choice for ingredient needs as we offer several advantages. Aside from being registered with the FDA, we are also recognized by entities like Kosher, Halal, and GMP. Nutri Avenue is also third-party tested. We also have a large stock of our products to ensure that your needs for wholesale purchases are met.

You may avail of a free quote or ask any questions about our products and services by contacting our technical support staff.

FAQs

In scientific studies, its dosage taken at 150-800 mg daily is recommended.

It usually starts working immediately when taken at least 30 minutes before bedtime.

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