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5-Hydroxytryptophan (5-HTP)

Chemical Name: 5-Hydroxytryptophan (5-HTP)
CAS Number: 4350-09-8
Molecular Formula: C11H12N2O3
Molecular Weight: 220.22 g/mol
Packaging: In paper-drums and two layers of poly bags inside. Net weight: 25kg/drum
Main Benefits: It is believed to help improve mood and treat anxiety and depression.
Application: Dietary Supplements


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5-Hydroxytryptophan (5-HTP)

What is 5-HTP?

5-HTP good for sleep

The compound 5-HTP is a tryptophan derivative that is an immediate precursor in the biosynthesis of the neurotransmitter serotonin. The structure of the compound is described as similar to tryptophan substituted by a hydroxy group at position 5. The compound is primarily used as an antidepressant, and a compound to reduce anxiety. The product also helps improve sleep quality and quantity.

The terms 5-htp,  5-Hydroxytryptophan, Griffonia Seed Extract, Griffonia Simplicifolia, Griffonia Simplicifolia Extract, Griffonia Extract, Griffonia Simplicifolia Seed Extract, L-5-Hydroxytryptophan, and L-5 Hydroxy Tryptophan are also used to identify the compound. It is further described as having CAS number 56-69-9, molecular formula of C11H12N2O3, and molecular weight of 220.22 g/mol.

5-HTP Sources

The compound 5-HTP is converted from another compound known as L-tryptophan. Natural dietary sources for L-tryptophan include turkey, chicken, and milk. It may also be found in seaweeds, potatoes, pumpkins, and sunflower seeds.

The major source for 5-HTP is the product Griffonia Simplicifolia Seed Extract. The 5-HTP component of the said extract is claimed to be why it helps promote overall mood.

5-HTP promote mood in NutriAvenue

Constituents of Griffonia Simplicifolia Seed Extract

Griffonia Simplicifolia Seed Extract is a product derived from the seeds of a plant found in the western African region known as Griffonia simplicifolia. The extract has long been used in traditional medicine to treat insomnia, promote weight loss and reduce anxiety.

The key ingredient in the extract is the compound 5-Hydroxytryptophan or 5-HTP. The compound also contains relative amounts of minerals such as iron, zinc, magnesium, copper, and phosphorus.

5-HTP Forms and Specifications

5-HTP comes in various forms and specifications. The most common forms of the product which are available in the market include 99% High Purity 5-HTP powder, Purified 98%+ Griffonia Seed Extract, 95% 5-HTP granules, and Custom standardized 10-99% 5-HTP powder extract.

These specifications may be bought wholesale from Nutriavenue. At Nutriavenue, we use paper drums with two layers of polybags inside as standard packaging material for bulk purchases. Nevertheless, we use a different packaging material upon the request of customers.

1. 5-HTP vs L-theanine

L-theanine is another popular option for depression and anxiety relief. It is a predominant amino acid that is found to increase GABA and serotonin levels potentially. The compound may be found in various food and drinks, including mushrooms and teas.

5-HTP vs L-theanine

Essentially, both 5-HTP and L-theanine work to improve neurotransmitter action and prevent anxiety and depression. Nevertheless, these compounds vary in certain aspects. In one study, it was concluded that 5-HTP is more beneficial in terms of improving the overall sense of well-being, while L-theanine works best in promoting relaxation. Also, while 5-HTP works more on serotonin, L-theanine works on the neurotransmitter GABA.

Some experts say that L-theanine is a better option than 5-HTP as the latter is not always obtained from the diet. In contrast, L-theanine is naturally found in various food products.

2. 5-HTP and St. John’s wort

Many pieces of research show that 5-HTP should never be taken with St. John’s Wort as the said combination may cause drug interactions. It was established that combining 5-HTP and St. John Wort may lead to a condition known as Serotonin syndrome, a disorder characterized by sudden changes in vital signs and muscle spasms.

3. Ashwagandha and 5-HTP

Ashwagandha in NutriAvenue




Ashwagandha is another ingredient that may increase GABA and Serotonin levels.

While no interactions are yet established on the use of Ashwagandha and 5-HTP, many experts say that combining the said products should be under a physician’s prescription and recommendation.

How does 5-HTP work?

The neurotransmitter Serotonin is essential as it is responsible for the maintenance of sleep, appetite, pain sensation, and sexual behavior. Based on studies, 5-HTP works by regulating serotonin production in the brain, thereby influencing sleep and appetite.

Also, 5-HTP may work in enhancing GABA action. GABA is the neurotransmitter responsible for promoting relaxation. Thus, 5-HTP, in effect, may also promote relaxation.

5-HTP Manufacturing Process

In the production of 5-HTP, the raw materials used are the seeds of the plant Griffonia Simplicifolia.

The raw materials are first crushed and soaked in acidic water and sodium pyrosulfite for extraction. Thereafter, the extract is adsorbed by adding it into a cation exchange resin column and washing the same with deionized water. The product is then eluted and added into a macroporous resin column. The eluate is then collected and added to active carbon. The decoloring liquid is thereafter concentrated and crystallized. The next step comprises filtering the crystal and drying the crystal to obtain the product.

5-HTP Benefits

Taking supplements with 5-HTP provides health benefits which include the following:

  • 5-HTP for sleep

Both Serotonin and GABA are known to influence sleeping patterns. By improving the production of these neurotransmitters, it is believed that 5-HTP may promote sleep and help resolve insomnia.

  • 5-HTP for anxiety

Anxiety and stress may be controlled and reduced with healthy serotonin production in the brain. For example, the compound 5-HTP may help reduce anxiety by regulating serotonin production.

  • 5-HTP for depression

The compound 5-HTP is used in antidepressants as it works to improve overall mood and sense of well-being.

  • 5-HTP for weight loss

Serotonin is also a factor that affects appetite. By regulating the production of the neurotransmitter, 5-HTP may effectively promote healthy weight loss.

5-HTP for healthy weight loss

5-HTP Side Effects

No serious side effects are associated with the use of 5-HTP in dietary supplement products. Nevertheless, it should be taken within recommended doses to avoid serious adverse reactions.

5-HTP Dosage

A dose of about 200 to 400 mg of 5-HTP is considered safe and effective. However, the recommended dosage may vary depending on the weight, age, and overall physical condition of the individual user, as prescribed by a physician.


Q1: Is 5-HTP natural(safe)?

5-HTP obtained from Griffonia Simplicifolia seed extract is considered safe, and it is from a natural source.

Q2: How long does 5-htp stay in your system?

The half-life of the compound is 2.2 to 7.4 hours.

Q3: How much 5-htp is to take for depression?

In scientific studies, 5-HTP taken at a dose of 150-800 mg daily is recommended.

Q4: How long does 5-htp take to work?

It usually starts working after immediately when taken at least thirty (30) minutes before bedtime.

Q5: Is 5-htp effective for anxiety?


Q6: Does 5-htp increase dopamine?


Q7: Where to buy bulk 5-HTP powder?

Wholesale 5-HTP powder is available at Nutriavenue, a manufacturer that has established its reputation in ingredient supply for several years.

Our company is your best choice for ingredient needs as we offer several advantages. Aside from being registered with the FDA, we are also recognized by entities like Kosher, Halal, and GMP. Nutriavenue is also third-party tested. We also have a large stock of our products to ensure that your needs for wholesale purchases are met.

You may avail of a free quote or ask any questions about our products and services by contacting our technical support staff.

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