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Product Name Glabridin
Other Names Q-100692, LGB-GD 90, LGB-GD 40, GLABRIDIN, KB-289522, LS-176045, Aids096010, glabridine, Aids-096010, GLABRIDIN(RG)
CAS Number 59870-68-7
Molecular Formula C20H20O4
Molecular Weight 324.4 g/mol
Applications Personal Care, Dietary Supplements, Functional Foods, Animal Nutrition, etc.
Package 1kg,5kg/bag, 25kg/drum


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What Is Glabridin?

It is a natural whitening agent isolated from licorice flavonoids. They are extracted from the rhizomes of specific varieties of licorice plants, such as Ural Glycyrrhiza uralensis, Glycyrrhiza Inflata, Glycyrrhiza glabra, etc. They are perennial herbs that grow in southern Europe, Asia, and the Mediterranean region and are widely cultivated in Russia, Spain, Iran, and India. This ingredient is all-natural, pollution-free, and has no side effects on the human body.

At room temperature, Glabridin appears as a white to light brown powder. It is insoluble in water and easily soluble in organic solvents such as ethanol, propylene glycol, 1,3-butylene glycol, etc.

Specification Sheet Reference

TypeNatural active ingredient from plant extract
Sources fromLicorice roots
AppearanceWhite to light brown powder
Purity20%, 40%, 90%, etc.
CertificationsPlease contact our Sales Team to get
Test MethodsHPLC, etc.
MOQ (minimum order quantity)1kg
SampleAvailable (10-20g/bag)
OEM ServiceAvailable, such as capsules, tablets, pills, etc.
ODM ServiceAvailable
Private LabelAvailable
Contract ManufacturingAvailable

Glabridin For Skin Whitening

Since the Japanese company MARUZEN first used Glabridin as a skin whitening additive in 1989, its effect has become increasingly obvious. It is also popular in international high-end cosmetics. It is widely used in cosmetic brands in Japan, South Korea, and many European and American countries, such as Whoo, Estee Lauder, Lancome, Dior, Sonia Rykiel, Chanel, etc.

1. Whitening effect

Glabridin can penetrate deep into the skin and effectively inhibit the activity of multiple enzymes in melanin production, especially tyrosinase. Thereby reducing pigmentation and achieving a whitening effect.

2. Anti-inflammatory effect

It has anti-inflammatory properties and can reduce skin inflammation caused by ultraviolet radiation.

3. Anti-roughness and antibacterial properties

It helps prevent skin roughness and has antibacterial properties.

4. Skin protection

The natural ingredient also shows the potential to combat skin pigmentation, epidermal thickening, roughness, and inflammation caused by frequent UVA exposure. It suggests its potential application in skin care.

Human trials have shown that after 56 days of topical application of Glabridin, facial skin brightness increased significantly, and redness decreased. Glabridin may also help control skin oil, inhibit skin damage caused by UV rays, and control melanin production.

As a multi-functional natural ingredient, Glabridin has been shown to have multiple positive effects on the skin, especially in terms of whitening and anti-inflammatory effects.

Glabridin Factory: How To Manufacture it?

The manufacturing process of Glabridin powder mainly involves extraction and purification from the rhizomes of licorice.

  • Extraction. The active ingredient – Glabridin – is extracted from the licorice root using an organic solvent such as ethyl acetate by hot reflux extraction.
  • Separation. It may be necessary to separate the ingredients by chemical or physical methods to obtain the pure during the extraction processingredients.
  • Purification. Purity is further improved by methods such as chromatography. The purity of laboratory purification is usually above 90%.
  • Quality testing. Quality testing and purity verification are performed using HPLC (high-performance liquid chromatography) techniques.
  • Storage. The ingredient is usually in powder form and needs to be stored at 2-10°C.

These steps summarize the entire manufacturing process of Glabridin from extraction to application. With the advancement of technology, production methods are also being optimized to improve efficiency and reduce costs.

Glabridin: Benefits, Side Effects, And More

In addition to the obvious benefits for the skin, it has other benefits.

  • It regulates lipid and blood sugar metabolism by activating the expression of PPARγ and C/EBPα.
  • It has a protective effect on the nervous system. It may help prevent certain neurodegenerative diseases.
  • It helps maintain bone health and prevent osteoporosis.
  • It may help improve metabolic abnormalities such as obesity and diabetes.
  • This ingredient may help prevent cardiovascular disease.
  • Its inhibitory effect on certain metabolic enzymes can improve the pharmacokinetic properties of other drugs.
  • Italian research also confirmed that Glabridin has an appetite-suppressant effect. It can reduce fat without reducing weight.

It is worth noting that despite the potential benefits of this active ingredient found in licorice root, most of the research is based on cell and animal experiments. More clinical studies are needed in the future to confirm these pharmacological effects. In addition, its estrogenic effect is still controversial, and further research is needed to clarify its mechanism of action and safety.

Side effects on skin you should know

Like all cosmetic ingredients, Glabridin may have potential side effects on the skin.

  • Allergic reactions. Some people may be sensitive to this ingredient. Using products containing Glabridin may cause skin irritation, redness, or itching.
  • Increased photosensitivity. Although Glabridin has sunscreen properties, some people may experience increased sensitivity to the sun after using it.
  • Dry skin. This ingredient may affect the skin’s natural oils, causing dry skin.

Used for 6 application fields

1. Cosmetics industry. Glabridin is widely used in cosmetics, such as whitening creams, lotions, washes, shower gels, etc., due to its whitening, anti-inflammatory, and antioxidant properties.

2. Pharmaceutical field. The ingredient has various pharmacological effects, including anti-inflammatory, antioxidant, anti-tumor, antimicrobial, bone protection, cardiovascular protection, and neuroprotection.

3. Biochemistry and genetic engineering research. It is used in scientific research as a biochemical reagent and a reagent for genetic engineering research.

4. Food additive. Due to its antioxidant properties, it may be used as a food additive to extend the shelf life of food and protect food from oxidative damage.

5. Dietary supplements. As an active ingredient extracted from licorice, it has a place in the plant extract market and is used to develop new drugs and health products.

6. Anti-inflammatory and antibacterial products. Due to its anti-inflammatory and antibacterial properties, it can be used to develop anti-inflammatory and antibacterial products.

7. Cardiovascular protection. It may help improve cardiovascular health and may, therefore, be used in cardiovascular protection products.

8. Neuroprotection. Its neuroprotective effect makes it a potential application in treating diseases related to the nervous system.

These application areas demonstrate the diversity of this ingredient and its potential value in different industries. With the continuous deepening of research, its application range may be further expanded.

Buy Glabridin Bulk Here: Nutri Avenue

Glabridin is a bioactive ingredient extracted from licorice root valued for its multifaceted health benefits. Nutri Avenue offers an option if you want to purchase Glabridin in bulk. As a professional nutrition and health product supplier, Nutri Avenue is committed to providing high-quality ingredients to meet your needs.

You can expect to find Glabridin bulk products of high purity and reliable quality at Nutri Avenue. Whether you are a manufacturer of health products or looking to source ingredients for your business, Nutri Avenue may be your ideal partner. Visit our website or contact our customer service team today to learn more about purchasing and place your order.


As an active ingredient in licorice root extract, its effects on the skin include whitening, anti-inflammatory, antioxidant, antibacterial, photoprotection, anti-aging, etc. It is widely used in cosmetics such as creams, lotions, essences, and sunscreens. This ingredient is often called the “golden ingredient for skin whitening” in the cosmetics industry.

Yes, glabridin is a recognized antioxidant. Studies have shown that it can effectively penetrate the inner layers of the skin and exert a highly effective whitening effect while also having antioxidant properties. Its antioxidant properties are attributed to its ability to inhibit the activity of various enzymes, including tyrosinase, which is involved in the production of melanin, and neutralize free radicals that may cause oxidative stress and contribute to skin aging.

Its antioxidant capacity is so strong that it is often compared to well-known antioxidants such as vitamin E. Glabridin is reported to have a similar ability to vitamin E in scavenging oxygen free radicals. It prevents skin damage caused by environmental stressors and promotes overall skin health.

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