What is Glycyrrhizic Acid?
Glycyrrhizic acid is a natural compound primarily derived from the root of the licorice plant (Glycyrrhiza glabra), known for its sweet taste and various therapeutic properties. It has the CAS number 1405-86-3, a molecular formula of C42H62O16, and a molecular weight of 820.94 g/mol. In its natural form, glycyrrhizic acid appears as a white to off-white crystalline powder. It is water-soluble and can be easily dissolved in water, although it is often used in the form of a salt, glycyrrhizinate, for enhanced solubility and stability in various formulations. The compound has a slightly bitter, sweet flavor, and it has been used in both traditional medicine and the food industry for its flavoring and medicinal properties. Chemically, glycyrrhizic acid is a saponin, which means it contains sugar molecules bound to a non-sugar structure. It is known for its ability to have anti-inflammatory, antiviral, and hepatoprotective effects, making it a key ingredient in many traditional remedies. It is also frequently used in cosmetics and skin care products for its soothing and skin-healing properties. However, high doses of glycyrrhizic acid can have side effects such as increasing blood pressure, so it is often used with caution.Common Sources
Glycyrrhizic acid is primarily derived from the licorice plant (Glycyrrhiza glabra), which is native to parts of Europe and Asia. The root of this plant contains significant amounts of glycyrrhizic acid, and it is traditionally used for its medicinal properties. Other species within the Glycyrrhiza genus, such as Glycyrrhiza uralensis, also contain glycyrrhizic acid, but Glycyrrhiza glabra is the most commonly used source. The roots of the plant are harvested, dried, and processed to extract glycyrrhizic acid, which is often used in both food products and pharmaceuticals.What Does Glycyrrhizic Acid Work?
It exerts its effects by modulating cortisol metabolism and interacting with various cellular pathways. It inhibits the enzyme 11β-hydroxysteroid dehydrogenase, which prevents cortisol breakdown, thus amplifying its anti-inflammatory properties. Additionally, it demonstrates antiviral effects by inhibiting viral replication and protecting cellular integrity.How to Produce Glycyrrhizic Acid Powder?
- Raw Material Selection: High-quality roots with optimal content of the ingredient are selected from trusted sources.
- Cleaning: The licorice roots become free from soil and contaminants through thorough washing.
- Grinding: The clean roots transform into smaller pieces through mechanical processing for maximum extraction efficiency.
- Soaking: During the extraction phase, the ground roots release their compounds into a water or ethanol solvent.
- Extraction: The liquid solution separates from large plant materials through industrial filtration.
- Concentration: The filtered liquid reduces to a concentrated form through vacuum evaporation.
- Filtration: It achieves higher purity through fine filtration.
- Crystal Formation: The purified material forms crystals under specific temperature and pH conditions.
- Drying: The crystallized material becomes moisture-free through controlled drying.
- Grinding: The dried crystals transform into uniform powder through precision grinding.
- Quality Testing: The powder undergoes comprehensive quality analysis for purity and potency verification.
- Packaging: The tested powder moves into appropriate storage containers in a controlled environment.
Specification Sheet Reference
Specification | Details |
Type | Supplement ingredient |
Appearance | White to off-white crystalline powder |
Purity | ≥98% |
Solubility | Soluble in water |
Certifications | ISO available. Please contact our sales team for more information. |
Test Methods | HPLC, UV-Vis, etc. |
MOQs | 25kg |
Sample Availability | Available (10-20g/bag) |
OEM Service | Available (capsules, tablets) |
ODM Service | Available |
Private Label | Available |
Contract Manufacturing | Available |
Glycyrrhizic Acid: Benefits, Side Effects, and More
- Anti-inflammatory Properties: Multiple studies have demonstrated the potent anti-inflammatory effects of Glycyrrhizic Acid. A 2019 study published in the Journal of Inflammation Research showed that it inhibits key inflammatory mediators, including NF-κB and TNF-α. Clinical trials demonstrated a 30-40% reduction in inflammatory markers in subjects treated with Glycyrrhizic Acid compared to control groups.
- Antiviral Activity: Research has shown remarkable antiviral properties of Glycyrrhizic Acid. Studies published in The Lancet and other prestigious journals have documented its effectiveness against various viral infections. In vitro studies demonstrated significant inhibition of viral replication, with particularly strong activity against herpes simplex virus, influenza virus, and several other respiratory viruses. Clinical trials showed reduced duration and severity of viral infections in treated groups.
- Hepatoprotective Effects: Several studies have confirmed the liver-protective properties of Glycyrrhizic Acid. A large-scale clinical trial involving 400 patients with chronic hepatitis showed that regular administration of Glycyrrhizic Acid resulted in significantly improved liver function tests, with AST and ALT levels decreasing by 35% and 40% respectively after 12 weeks of treatment.
- Anti-allergic Properties: Research published in the International Journal of Molecular Sciences demonstrated that Glycyrrhizic Acid effectively suppresses allergic responses. In animal models, it reduced histamine release by 45% and decreased IgE antibody production by 30%. Human studies showed improved symptoms in allergic rhinitis patients.
- Skin Health Benefits: Clinical studies have shown that Glycyrrhizic Acid possesses significant skin-brightening and anti-aging properties. Research in the Journal of Dermatological Science demonstrated its ability to inhibit tyrosinase activity by 25%, leading to reduced melanin production. It also showed protection against UV-induced skin damage and increased collagen production.
- Anti-ulcer Activity: Studies have documented the gastroprotective effects of Glycyrrhizic Acid. Research involving patients with peptic ulcers showed that treatment with Glycyrrhizic Acid resulted in a 60% higher healing rate compared to placebo groups, with significant reduction in symptoms.
New research is exploring novel applications, including potential anticancer properties and neuroprotective effects. Preliminary studies have shown promising results in cancer cell line studies, with observed growth inhibition ranging from 40-70% depending on cancer type.
These findings demonstrate the significant therapeutic potential of Glycyrrhizic Acid, though it’s important to note that some studies are preliminary and further research is needed to fully understand optimal dosing and long-term effects. Additionally, individual response variations and potential interactions with medications need to be considered in clinical applications.
Side Effects
While generally safe, high doses or prolonged use of Glycyrrhizic Acid can lead to pseudoaldosteronism, characterized by hypertension and electrolyte imbalances. Clinical studies have established that doses below 100mg/day are generally safe for most adults, though individual sensitivity varies. Bioavailability and Absorption: Research has shown that Glycyrrhizic Acid has a complex pharmacokinetic profile. Studies indicate that it undergoes extensive metabolism in the gut, with peak plasma concentrations occurring 3-4 hours after oral administration. The bioavailability varies between 10-20%, influenced by various factors including formulation and individual gut microbiota.Is it legal?
- United States: The ingredient maintains legal status as an approved ingredient in dietary supplement formulations, though regulations prohibit its marketing as a standalone pharmaceutical drug.
- European Union: The compound falls under established herbal medicine regulations, with specific concentration limits enforced for supplement products containing this ingredient.
- Japan: It is widely accepted and integrated into traditional medicine practices and functional food products throughout the Japanese market.
- Australia: The Therapeutic Goods Administration permits it in supplement formulations, provided manufacturers adhere to strict safety guidelines and quality control measures.
What is glycyrrhizic acid used for?
- Pharmaceuticals: Primarily used in anti-inflammatory drugs, liver protection medications, antiviral treatments, and allergy medications.
- Cosmetics & Skincare: Featured in skin brightening, anti-aging, and UV protection products, leveraging its skin-enhancing properties.
- Food & Beverage: Utilized as a natural sweetener, flavor enhancer, and functional food additive.
- Healthcare Products: Found in oral hygiene products, cough suppressants, and immune support supplements.
- Personal Care: Applied in hair care, oral care, and body care products.
Its popularity across these sectors stems from its multiple biological activities, including anti-inflammatory, antiviral, and skin-brightening properties, making it particularly valuable in both conventional and natural product formulations.
Recommended Dosage and Usage
Typical dosage ranges from 100 to 500 mg daily, depending on application and individual tolerance. Adhering to recommended guidelines is essential to minimize side effects.How to Store Glycyrrhizic Acid Powder?
To maintain maximum potency, this ingredient powder must be kept in a cool, dry place. It must also be stored away from direct sunlight. An airtight container is needed to prevent moisture absorption and avoid prolonged exposure to heat.Glycyrrhetinic Acid VS Glycyrrhizic Acid
While both compounds come from the same source, they work in different ways to support health. Their distinct molecular structures give each compound unique properties and benefits. The primary compound, glycyrrhizic acid, stands out for its ability to facilitate inflammation throughout the body and fight viral infections. This natural substance helps regulate immune function by controlling specific immune system signals and preventing viruses from multiplying. Its partner compound, glycyrrhetinic acid, excels particularly at healing skin and reducing localized inflammation, making it valuable for skincare products. These compounds differ in how easily the body can use them. Glycyrrhizic acid dissolves better in water, allowing the body to absorb it more readily. However, glycyrrhetinic acid, though less soluble, becomes more powerful once the body processes it, leading to stronger effects at the cellular level. The production methods for these compounds also differ significantly. Manufacturers can extract glycyrrhizic acid directly from licorice root using water or alcohol-based methods, making it more cost-effective to produce. Creating glycyrrhetinic acid requires an additional step – breaking down glycyrrhizic acid using enzymes or specific microorganisms. This extra processing makes it more expensive and complex to manufacture. When choosing between these compounds, their specific benefits guide the decision. Glycyrrhizic acid works best for supporting overall immune health and fighting infections throughout the body. Its broad-reaching effects make it ideal for supplements targeting systemic inflammation and immune support. In contrast, glycyrrhetinic acid provides more focused benefits, particularly for skin health and localized inflammation. This makes it the preferred choice for topical products and targeted anti-inflammatory applications. While both compounds offer valuable health benefits, their different properties and production methods make each better suited for specific uses.Feature | Glycyrrhetinic Acid | Glycyrrhizic Acid |
CAS Number | 471-53-4 | 1405-86-3 |
Molecular Formula | C30H46O4 | C42H62O16 |
Molecular Weight | 470.7 g/mol | 822.94 g/mol |
Primary Sources | Licorice Root Metabolite | Licorice Root |
Primary Uses | Anti-inflammatory | Immune Modulation |
Bioavailability | Medium | Low |
Glycyrrhizin VS Glycyrrhizic Acid
Glycyrrhizin naturally contains sugar molecules in its structure, which allows it to dissolve easily in water and makes it particularly suitable for liquid supplements and beverages. When these sugar molecules are removed through specific processing methods, glycyrrhizin becomes glycyrrhizic acid – a more concentrated form of the compound that offers enhanced potency in certain applications. The manufacturing process highlights key differences between these compounds. Extracting glycyrrhizin involves a relatively straightforward process of isolating the compound directly from licorice root, similar to creating a concentrated tea extract. This efficient method results in lower production costs and wider availability. Creating glycyrrhizic acid requires additional processing to remove the sugar components from glycyrrhizin. While this extra step increases production costs, it results in a more concentrated compound useful for specific applications. Both compounds provide valuable health benefits, but their different properties make each better suited for particular uses. Glycyrrhizin’s superior water solubility makes it an excellent choice for oral supplements and liquid formulations intended to boost the overall immune health and lessen inflammation throughout the body. Glycyrrhizic acid, with its more concentrated nature, performs exceptionally well in products requiring higher potency, such as specialized supplements and targeted skincare formulations. Manufacturers consider these distinct characteristics when selecting the appropriate compound for their specific product requirements, ensuring optimal effectiveness for the intended use.Conclusion
Glycyrrhizic acid is a powerful natural ingredients derived from licorice root that serve different purposes in health applications. Each form offers distinct advantages:- Glycyrrhizin dissolves easily in water for liquid supplements.
- Glycyrrhizic acid provides concentrated potency for targeted uses.
- Glycyrrhetinic acid works effectively in skin treatments.
Why Choose Nutri Avenue Supplier to Buy Glycyrrhizic Acid Powder?
Nutri Avenue combines decades of expertise with a global reputation for excellence, making us the trusted choice for Glycyrrhizic Acid Powder. Sourced from GMP-certified and ISO-compliant facilities, our powder undergoes rigorous third-party testing to ensure consistent potency, purity, and safety for your formulations. Our bulk availability, coupled with competitive pricing, offers exceptional value to businesses of all sizes. With five USA-based warehouses, we ensure fast and cost-effective shipping solutions that keep your supply chain running smoothly. For unique product needs, our flexible OEM/ODM services allow you to craft tailored formulations to suit your brand’s vision. Trusted by over 500 global customers, Nutri Avenue is committed to delivering unmatched quality and seamless support to help your business succeed. Contact us today for premium Glycyrrhizic Acid powder tailored to your needs! * ISO certificates are readily available for all of Nutri Avenue’s products.Frequently Asked Questions
What is the solubility of this ingredient?
This bioactive compound exhibits high solubility in water and ethanol, with increased dissolution rates at higher temperatures.
Can it be used in beverages?
The natural extract serves as both a sweetening agent and functional ingredient in beverage formulations, provided manufacturers maintain appropriate concentration levels.
What is the best storage condition for this acid?
The compound requires storage in airtight containers at refrigerated temperatures between 2-8°C, away from light and moisture exposure.
Is it safe for pets?
This licorice-derived ingredient shows safety in veterinary applications when properly dosed, though regular monitoring is essential due to its effects on mineral balance.
Does it have antioxidant properties?
The natural compound demonstrates significant antioxidant activity by neutralizing free radicals and supporting cellular defense mechanisms.
Can it be combined with other supplements?
This botanical extract generally combines well with other supplements, though careful formulation is necessary to avoid potential interactions with certain compounds.
What is the purity standard for this powder?
The industry standard requires this active ingredient to maintain a minimum purity level of 98% for commercial pharmaceutical and supplement applications.