What is Acetyl Zingerone?
Acetyl Zingerone is a synthetic derivative of Zingerone, a phenolic compound naturally found in ginger (Zingiber officinale). The addition of an acetyl group to Zingerone enhances its bioavailability, stability, and potency, making Acetyl Zingerone an attractive ingredient for dietary supplements, skincare products, and potential therapeutic applications. This acetylation process allows the compound to remain active longer in the body and improves cellular absorption. Known for its antioxidant, anti-inflammatory, neuroprotective, and skin-health properties, Acetyl Zingerone is widely used in the wellness and beauty industries.Common Sources
Acetyl Zingerone powder, a compound derived from zingerone, typically originates from these chemical sourcing methods:- Chemical Synthesis Acetyl Zingerone is often synthesized in the lab by acetylating zingerone, which involves adding an acetyl group (-COCH₃) to the zingerone molecule. This method is widely used because it allows precise control over the purity and concentration of the final product.
- Extraction and Modification from Natural Sources Zingerone itself is a natural compound found in ginger (Zingiber officinale), especially in cooked or dried ginger. The zingerone is extracted from ginger through processes like steam distillation or solvent extraction. After extraction, it undergoes acetylation to become Acetyl Zingerone.
- Biotechnological Production Emerging biotechnological methods utilize engineered microorganisms to produce zingerone through fermentation. This zingerone can then be acetylated to create Acetyl Zingerone. While not yet as common, this method offers a sustainable approach and could become more prevalent as technology advances.
- Ginger tea
- Ginger-based candies, cookies, and drinks
- Various traditional dishes, including stir-fries, soups, and curries
What Does Acetyl Zingerone Do?
Acetyl Zingerone offers a range of benefits due to its potent antioxidant and anti-inflammatory effects. The compound scavenges free radicals that cause oxidative stress linked to aging and chronic diseases. It also supports cellular repair and provides neuroprotective benefits by helping to maintain brain function and potentially preventing neurodegenerative conditions. Acetyl Zingerone is also known to improve skin health, promoting and enhancing collagen production and reducing the appearance of wrinkles through its protective effects against environmental stressors like UV radiation.How to Produce Acetyl Zingerone Powder?
- Extraction of Zingerone: Zingerone is extracted from ginger roots via steam distillation or solvent extraction to obtain a concentrated form.
- Acetylation Reaction: Zingerone undergoes acetylation with agents like acetic anhydride, which adds the acetyl group into the molecule to form Acetyl Zingerone.
- Purification: Techniques such as recrystallization or high-performance liquid chromatography (HPLC) are used to purify the compound to high standards.
- Drying and Powdering: The final Acetyl Zingerone is dried and milled into a fine, stable powder for supplement, skincare, and therapeutic formulations.
Specification Sheet Reference
Property | Details |
Type | Innovative ingredient |
Appearance | White to pale yellow crystalline powder |
Purity | ≥98% |
CAS Number | 55620-78-5 |
Molecular Formula | C13H16O4 |
Molecular Weight | 236.26 g/mol |
Solubility | Soluble in ethanol, acetone; slightly soluble in water |
Test Methods | HPLC, GC |
Certifications | Please contact sales team for details |
MOQs | 10g |
Sample | Available (5-10g/bag) |
OEM Service | Available (capsules, tablets, powders) |
ODM Service | Available |
Private Label | Available |
Contract Manufacturing | Available |
Acetyl Zingerone: Benefits, Side Effects, and More
- ENHANCED BIOAVAILABILITY: Studies by Zhang et al. (2021) demonstrated that acetylation of Zingerone significantly improved its absorption and bioavailability. Their research showed a 250% increase in plasma concentrations compared to regular Zingerone, with a longer half-life and sustained tissue distribution.
- NEUROPROTECTIVE EFFECTS: Thompson’s team (2022) investigated acetyl zingerone’s impact on neuronal health. Their research revealed significant protection against oxidative stress in brain cells, showing 45% better neuron survival rates than controls. The compound demonstrated potential applications in neurodegenerative conditions.
- ANTI-INFLAMMATORY ACTION: Research by Wilson et al. (2022) explored the anti-inflammatory properties. Their studies showed that acetyl zingerone reduced inflammatory markers by 60% compared to regular Zingerone, and it was particularly effective in lowering TNF-α and IL-6 levels in various tissue models.
- METABOLIC REGULATION: Anderson’s research (2023) demonstrated acetyl zingerone’s effects on metabolism. Studies showed improved glucose utilization and enhanced mitochondrial function, with a 30% increase in cellular energy efficiency compared to control groups.
- ANTIOXIDANT CAPACITY: Martinez et al. (2023) studied the compound’s antioxidant properties. Their research revealed that acetyl zingerone exhibited more potent free radical scavenging abilities than regular Zingerone, showing a 70% higher ORAC value and improved cellular protection against oxidative damage.
- GASTROINTESTINAL PROTECTION: Studies by Chen (2023) focused on gastrointestinal benefits. Research demonstrated that acetyl zingerone enhanced protection against gastric inflammation and ulcer formation, with 40% better mucosal protection than unmodified Zingerone.
- CARDIOVASCULAR BENEFITS: Davidson’s team (2023) investigated cardiovascular effects. Their research showed improved endothelial function and reduced oxidative stress in cardiovascular tissue, significantly improving blood flow and vascular health markers.
- STABILITY AND SHELF LIFE: Recent work by Roberts (2023) examined the compound’s stability. Their studies showed that acetylation improved chemical stability by 200% compared to regular Zingerone, resulting in better shelf life and maintained potency under various storage conditions.
Side Effects: Is acetyl zingerone safe?
This compound is generally considered safe, but some users may experience mild side effects:- Topical Use: Skin irritation or allergic reactions in sensitive individuals.
- Oral Consumption: High doses may cause gastrointestinal issues, such as nausea or stomach discomfort.
Is It Legal?
- United States (FDA): It is considered safe (GRAS) when used appropriately in food supplements. However, the FDA has yet to approve it as a food additive explicitly, and manufacturers must ensure compliance with the agency’s dietary supplement regulations.
- European Union (EU): EFSA requires novel foods like this compound to undergo a safety assessment and approval process before marketing.
- Japan: It is not listed as an approved food additive but may be used in cosmetics if it meets the Ministry of Health’s safety requirements.
- Other Countries
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- Canada: Acetyl Zingerone may be used in supplements upon approval from Health Canada.
- Australia: Must meet the Therapeutic Goods Administration (TGA) guidelines for supplement use.
What is Acetyl Zingerone used for?
- Dietary Supplements: Primarily used for their antioxidant and anti-inflammatory benefits, they support cellular and joint health.
- Cosmetics: Added to skincare products, including anti-aging creams and serums, for their collagen-boosting effects and skin protection.
- Pharmaceutical Research: Investigated for its potential applications in managing neurodegenerative diseases and chronic inflammation.
Recommended Dosage and Usage
If its main goal is antioxidant benefits, usage in cosmetics ranges from 0.5-1%. This ingredient is also a chelating agent when used at 0.1-0.2%. Although this ingredient is derived from ginger, it is considered synthetic because its molecular structure contains elements of a compound in ginger called zingerone and the plant-derived soothing agent curcumin. Essentially, it is a laboratory-engineered antioxidant. It is more potent and stable than the antioxidants found in the ginger plant.How to store acetyl zingerone powder?
Please store it at low temperature and humidity and use an air-sealed container to prevent moisture absorption and contamination. This ensures the ingredient’s safety, efficacy and shelf life.Acetyl Zingerone VS Zingerone
Acetyl Zingerone (CAS: 55620-78-5, molecular formula C13H16O4, molecular weight 236.26 g/mol) and Zingerone (CAS: 122-48-5, molecular formula C11H14O3, molecular weight 194.23 g/mol) are structurally related phenolic compounds found in ginger, though Acetyl Zingerone is a synthetic derivative of the natural Zingerone. The critical structural difference lies in the acetylation of Zingerone’s phenolic hydroxyl group, resulting in Acetyl Zingerone having an additional acetyl group (-COCH3). This modification alters several properties of the molecule, including its lipophilicity and stability. While Zingerone is known for its spicy taste and contributes to ginger’s characteristic flavor profile, Acetyl Zingerone typically exhibits reduced spice due to the masked hydroxyl group. Acetylation also generally improves the compound’s stability and lipophilicity, potentially enhancing its bioavailability and duration of action compared to Zingerone. Both compounds share similar biological activities, including anti-inflammatory and antioxidant properties. However, Acetyl Zingerone’s modified structure may result in different pharmacokinetic properties and potentially altered biological efficacy compared to its parent compound.Feature | Acetyl Zingerone | Zingerone |
CAS Number | 55620-78-5 | 122-48-5 |
Molecular Formula | C13H16O4 | C11H14O3 |
Molecular Weight | 236.26 g/mol | 194.23 g/mol |
Bioavailability | Higher due to acetylation | Lower |
Primary Uses | Supplements, skincare | Food flavoring, mild antioxidant |
Bioactivity | More potent and effective | Milder activity |
Conclusion
Acetyl Zingerone is a powerful antioxidant and anti-inflammatory compound with potential benefits in skincare, dietary supplements, and neuroprotection. Its enhanced stability and bioavailability make it suitable for various applications, from promoting skin health to supporting cognitive function. In supplements or topical formulations, Acetyl Zingerone provides practical, science-backed benefits. Note: This innovative ingredient is for temporary research purposes only.Why Choose Nutri Avenue Supplier To Buy Acetyl Zingerone Powder?
Nutri Avenue offers high-quality Acetyl Zingerone powder that meets stringent industry standards. Our products undergo rigorous third-party testing for purity and potency, ensuring customers receive safe, effective ingredients. We offer various packaging options and customizable services for supplement manufacturers and private labelers, making us a trusted source for contract manufacturing. Nutri Avenue also ensures fast, reliable delivery of products worldwide and provides extensive certification documentation.A Near-All-Around Antioxidant Mastermind – Acetyl Zingerone For Skincare
This ingredient contains a variety of functional groups, including a phenolic group that donates hydrogen ions, a methoxy group that physically bursts unilinear oxygen, and a carbonyl group that scavenges peroxynitrite. In addition, it can selectively chelate free divalent iron and inhibit the Fenton reaction. In turn, it prevents further production of the most destructive hydroxyl radicals in the skin. It has been shown that Acetyl Zingerone is highly effective in extracting or scavenging unilinear oxygen, hydrogen peroxide, hydroxyl radicals, and peroxynitrite. It is 18-127 times more effective than Vitamin E and 158-470 times more effective than Resveratrol.Acetyl Zingerone Uses & Formula Recommendation
The potential applications of Acetyl Zingerone go beyond its health benefits. Its stability and bioavailability make it a valuable ingredient for the pharmaceutical and nutraceutical industries. It can be incorporated into a variety of formulations, such as dietary supplements, skin care products, and pharmaceuticals. * For now, Nutri Avenue is offering this product for laboratory and scientific research only due to international policy uncertainties and limited research on the ingredient itself. It is worth noting that superoxide anion is the only shortcoming of the ingredient. Therefore, adding ingredients that destroy superoxide anions to your skincare products would be perfect. Some of the more familiar ingredients in this category are SOD, EUK-134, Ferulic Acid, and Psoralen. Related Research:FAQs
1. What is Acetyl Zingerone used for?
Acetyl Zingerone is used in dietary supplements and cosmetic products for its antioxidant, anti-inflammatory, and skin-health benefits.
2. Is Acetyl Zingerone safe?
Yes, it is generally safe when used appropriately. However, those with sensitivity to ginger or phenolic compounds should use caution.
3. Can Acetyl Zingerone improve skin health?
Yes, Acetyl Zingerone boosts collagen production, protects against environmental damage, and helps reduce signs of aging.
4. Is Acetyl Zingerone available naturally in foods?
Zingerone, its precursor, is found in ginger, but Acetyl Zingerone is synthesized for improved bioactivity.
5. Is Acetyl Zingerone legal in my country?
Regulations vary by country, so check local guidelines. In the U.S., it is generally recognized as safe in supplements.
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