Acetyl Zingerone

What Is Acetyl Zingerone?

Acetyl Zingerone is a derivative of the natural compound Gingerolone found in ginger. This ingredient is known for its antioxidant properties. It is synthesized by acetylating ginger oil ketone, resulting in a compound with enhanced bioavailability and stability.

Ginger oil ketone is one of the antioxidant components of ginger and has been studied in mice and humans for its various properties. Ancient oriental medicine experiments pointed to roasted ginger to better relieve various symptoms. Interestingly, fresh ginger has been found to contain high levels of a compound called gingerolone. This compound is converted to Gingerone when dried or cooked. 

Both Gingerone and Zingerone have the same structure as Curcumin (the active ingredient in turmeric). Therefore, they have similar pharmacological effects. Acetyl Gingerone has an added acetyl group (a methyl single bond attached to a carbonyl group). It confers additional scavenging, chelating, and stabilizing potential to Acetyl Zingerone.

Through careful design, it can neutralize UVR-induced critical radical oxygen species (ROS), non-radical oxygen species (mono-linear oxygen species), and strong nucleophilic reagents (peroxynitrite). 

Specification Sheet

Acetyl Zingerone Benefits

• Acts as a multi-targeted antioxidant
• Minimizes lipid, protein, and DNA damage
• Reduces inflammation
• Strengthens extracellular matrix and prevents collagen degradation
• Clinically proven to improve signs of photoaging

A Near-All-Around Antioxidant Mastermind – Acetyl Zingerone For Skincare

This ingredient contains a variety of functional groups, including a phenolic group that donates hydrogen ions, a methoxy group that physically bursts unilinear oxygen, and a carbonyl group that scavenges peroxynitrite.

In addition, it can selectively chelate free divalent iron and inhibit the Fenton reaction. In turn, it prevents further production of the most destructive hydroxyl radicals in the skin.

It has been shown that Acetyl Zingerone is highly effective in extracting or scavenging unilinear oxygen, hydrogen peroxide, hydroxyl radicals, and peroxynitrite. It is 18-127 times more effective than Vitamin E and 158-470 times more effective than Resveratrol.

3 Reasons To Choose It From Nutri Avenue

Purity. Acetyl Zingerone is available in high purity through a refined manufacturing process. High purity means better bioavailability and fewer adverse reactions.

Safer. The safety of the ingredients is high. It has fewer adverse reactions.

Stable status. It has good stability. It maintains its activity and effect under different environmental and storage conditions.

* Only for Research

Acetyl Zingerone Uses & Formula Recommendation

The potential applications of Acetyl Zingerone go beyond its health benefits. Its stability and bioavailability make it a valuable ingredient for the pharmaceutical and nutraceutical industries. It can be incorporated into a variety of formulations, such as dietary supplements, skin care products, and pharmaceuticals.

* For now, Nutri Avenue is offering this product for laboratory and scientific research only due to international policy uncertainties and limited research on the ingredient itself.

It is worth noting that superoxide anion is the only shortcoming of the ingredient. Therefore, adding ingredients that destroy superoxide anions to your skincare products would be perfect. Some of the more familiar ingredients in this category are SOD, EUK-134, Ferulic Acid, and Psoralen.

Acetyl Zingerone Dosage

If its main goal is antioxidant benefits, usage in cosmetics ranges from 0.5-1%. This ingredient is also a chelating agent when used at 0.1-0.2%.

Although this ingredient is derived from ginger, it is considered synthetic because its molecular structure contains elements of a compound in ginger called zingerone and the plant-derived soothing agent curcumin.

Essentially, it is a laboratory-engineered antioxidant. It is more potent and stable than the antioxidants found in the ginger plant.

Related Research:

• Acetyl Zingerone: A Photostable Multifunctional Skincare Ingredient That Combats Features of Intrinsic and Extrinsic Skin Aging
• A potent, multifunctional ingredient that continues to protect against ongoing DNA damage in melanocytes long after the sun has ended.